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1. 发明专利

JPS59101408A Plant growth regulator 失效
标题翻译：植物生长调节剂
公开(公告)号：JPS59101408A
公开(公告)日：1984-06-12
申请号：JP21254882
申请日：1982-12-02
申请人： Junichi Iwamura , Kinkidaigaku , Koichiro Komai
发明人： IWAMURA JIYUNICHI , KOMAI KOUICHIROU
IPC分类号： A01N63/02
摘要： PURPOSE: To provide the titled agent composed of a liquid obtained by the cultivation of microorganism belonging to Fusarium genus incapable or producing gibberellin in a medium added with glycoside containing steviol as an euaglycone, or a liquid obtained by removing the microbial cells from the above liquid, concentrated product of the above liquids, or extract prepared therefrom.
CONSTITUTION: The objective plant growth regulator is composed of a culture liquid obtained by the cultivation of a bacterial strain belonging to Fusarium genus and capable of metabolizing steviol glycoside in a medium added with steviol glycoside. The cultivation is carried out by adding the steviol glycoside to a medium containing glucose, starch, etc. as carbon source, meat extract, peptone, etc. as nitrogen source, and metallic salts, phosphates, etc., at the beginning of or during the cultivation, and performing the cultivation at about 30°C for 20W200hr. The obtained culture liquid is used as it is after sterilization, or is subjected to the removal of microbial cells, and concentrated, freeze-dried, or extracted with an organic solvent followed by the distilling out of the solvent to obtain an extract.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：提供由在不加入镰刀菌属的微生物培养得到的液体或在加入含有甜菊糖苷作为水母配糖的糖苷的培养基中制备的液体的标题试剂，或通过从上述液体中除去微生物细胞得到的液体，上述液体的浓缩产物或由其制备的提取物。构成：目的植物生长调节剂由栽培属于镰刀菌属的菌株得到的培养液组成，能够在加入甜菊糖苷的培养基中代谢甜菊糖苷。通过在含葡萄糖，淀粉等作为碳源，肉提取物，蛋白胨等作为氮源的金属盐和金属盐，磷酸盐等的添加剂中加入甜菊糖苷，进行培养培养，并在约30℃下进行培养20-200小时。所获得的培养液在灭菌后直接使用，或者进行微生物细胞的除去，浓缩，冷冻干燥，或用有机溶剂萃取，然后从溶剂中蒸出，得到提取物。

2. 发明授权

US07884265B2 High Rebaudioside-A plant 有权
标题翻译：高效甜菊苷 - 植物
公开(公告)号：US07884265B2
公开(公告)日：2011-02-08
申请号：US11815400
申请日：2006-03-02
申请人： Toyoshige Morita , Koji Morita , Koichiro Komai
发明人： Toyoshige Morita , Koji Morita , Koichiro Komai
IPC分类号： A01H1/00 , A23L1/236
CPC分类号： A01H5/10 , A01H5/12 , A23L27/36
摘要： A novel plant belonging to the Stevia Rebaudiana Bertoni variety which contains at least 4 parts by weight or more of Rebaudioside A with respect to one part by weight of Stevioside, and allows a sweetener of a good quality to be easily produced from said plant or dried leaves thereof.
摘要翻译：一种属于甜菊甜叶菊品种的新植物，相对于1重量份的甜菊苷，含有至少4重量份或更多的雷鲍迪甙A，并且允许从所述植物容易地产生高质量的甜味剂或干燥叶子。

3. 发明申请

US20090214753A1 High Rebaudioside-A Plant 有权
标题翻译：高效甜菊苷A植物
公开(公告)号：US20090214753A1
公开(公告)日：2009-08-27
申请号：US11815400
申请日：2006-03-02
申请人： Toyoshige Morita , Koji Morita , Koichiro Komai
发明人： Toyoshige Morita , Koji Morita , Koichiro Komai
IPC分类号： A23L1/28
CPC分类号： A01H5/10 , A01H5/12 , A23L27/36
摘要： A novel plant belonging to the Stevia Rebaudiana Bertoni variety which contains at least 4 parts by weight or more of Rebaudioside A with respect to one part by weight of Stevioside, and allows a sweetener of a good quality to be easily produced from said plant or dried leaves thereof.
摘要翻译：一种属于甜菊甜叶菊品种的新植物，相对于1重量份的甜菊苷，含有至少4重量份或更多的雷鲍迪甙A，并且允许从所述植物容易地产生高质量的甜味剂或干燥叶子。

4. 发明申请

US20060257441A1 Natural essential oil sanitary insect pest repellent and its use 审中-公开
标题翻译：天然精油卫生防虫驱虫剂及其用途
公开(公告)号：US20060257441A1
公开(公告)日：2006-11-16
申请号：US11125204
申请日：2005-05-10
申请人： Koichiro Komai , Satoko Hayase , Osamu Hayase , Masayasu Miwata , Osamu Sakurai , Osamu Kuroki , Masaaki Mizuguchi , Michiyo Ichihara
发明人： Koichiro Komai , Satoko Hayase , Osamu Hayase , Masayasu Miwata , Osamu Sakurai , Osamu Kuroki , Masaaki Mizuguchi , Michiyo Ichihara
IPC分类号： A01N25/00 , A01N65/00
CPC分类号： A01N65/20 , A01N25/04
摘要： [Object] This invention provides a dispersion containing an insect pest repellent active substance, and an adhesive or bond, ink, resin pellets, a resin product, and a sheet or a film which can exhibit a long term repellent active effect by the particles carrying the dispersion. [Means for achieving the object] The invention also concerns with a natural essential oil having a sanitary pest repellent activity; a dispersion containing, as an active component, at least one of: a first fraction of copaiba oil given by silica gel column chromatography using hexane as an elution solvent, a second fraction given by silica gel column chromatography using a 4:4:1 mixture of hexane/chloroform/ethyl acetate as an elution solvent, and a third fraction given by fractionating the remnant of the second fraction using a 1:1 mixture of ethyl acetate/chloroform as an elution solvent; a dispersion thereof containing a sedimentation inhibitor, particles carrying these dispersions, and a sanitary insect pest repellent active adhesive or bond, ink, resin pellets, resin particles, resin product, sheet or film, and device containing the same.
摘要翻译：本发明提供一种含有昆虫驱避活性物质的分散体，以及粘合剂或粘合剂，油墨，树脂颗粒，树脂产品和片材或膜，其可以通过携带的颗粒表现出长期驱避活性作用分散体。实现该目的的手段本发明还涉及具有卫生防虫活性的天然精油; 作为活性成分的分散液含有以下物质中的至少一种：通过硅胶柱色谱法，使用己烷作为洗脱溶剂，得到的第一馏分油，通过硅胶柱色谱法使用4:4:1混合物的己烷/氯仿/乙酸乙酯作为洗脱溶剂，第三馏分通过使用1:1的乙酸乙酯/氯仿混合物作为洗脱溶剂分馏第二馏分的残留物; 其含有沉降抑制剂的分散体，携带这些分散体的颗粒，以及卫生防虫驱虫剂活性粘合剂或粘合剂，油墨，树脂颗粒，树脂颗粒，树脂产品，片材或薄膜以及含有它们的装置。

5. 发明授权

US07514211B2 Genomic DNAs participating in rheumatoid arthritis, method of diagnosing the same, method of judging onset risk and diagnostic kit for detecting the same 有权
标题翻译：参与类风湿关节炎的基因组DNA，诊断方法，判断发病风险的方法及检测相关的诊断试剂盒
公开(公告)号：US07514211B2
公开(公告)日：2009-04-07
申请号：US10473368
申请日：2002-03-29
申请人： Shunichi Shiozawa , Koichiro Komai , Hirofumi Yagi , Nao Matsuura
发明人： Shunichi Shiozawa , Koichiro Komai , Hirofumi Yagi , Nao Matsuura
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid arthritis or judging onset risk of rheumatoid arthritis, which genomic DNA comprises at least one of the following mutations in genomic DNA consisting of the base sequence of SEQ ID NO: 1: (1) substitution of thymine (t) for cytosine (c) at the position-1987; (2) substitution of guanine (g) for thymine (t) at the position-3664; and (3) substitution of cytosine (c) for adenine (a) at the position-3769.
摘要翻译：涉及类风湿性关节炎的基因组DNA，诊断类风湿性关节炎的方法或评估类风湿性关节炎的发病风险的方法，以及用于诊断类风湿性关节炎或判断类风湿性关节炎的起始风险的诊断试剂盒，所述基因组DNA包含至少一种以下由SEQ ID NO：1的碱基序列组成的基因组DNA中的突变：（1）在1987年位置用胸腺嘧啶（t）取代胞嘧啶（c）; （2）在-3664位置替换鸟嘌呤（g）胸腺嘧啶（t）; 和（3）在3769位置取代胞嘧啶（c）腺嘌呤（a）。

6. 发明申请

US20050176004A1 Rheumatoid arthritis disease sensitive gene, its protein, method and kit of judging the onset of rheumatoid arthritis using the same, and method and drugs for treating rheumatoid arthritis 有权
标题翻译：类风湿关节炎疾病敏感基因，其蛋白质，使用其类风湿性关节炎发作判断方法和试剂盒，以及用于治疗类风湿性关节炎的方法和药物
公开(公告)号：US20050176004A1
公开(公告)日：2005-08-11
申请号：US10501259
申请日：2003-01-08
申请人： Shunichi Shiozawa , Koichiro Komai , Mikiko Nakatsukasa
发明人： Shunichi Shiozawa , Koichiro Komai , Mikiko Nakatsukasa
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61P19/02 , A61P29/00 , C07K14/47 , C07K14/515 , C12N15/12 , C12Q1/68 , G01N33/564 , C07H21/04 , C07K14/705
CPC分类号： G01N33/564 , C07K14/47 , C07K14/4713 , C12Q1/6883 , C12Q2600/156 , G01N2800/102
摘要： An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO. 1 and that has such mutation that glycine is inserted as a 269th amino acid in the sequence. Moreover, it was found that mutation of the gene and the protein relate to onset of RA. Achieved is a method of evaluating with high accuracy the onset or onset possibility of RA by using the mutation.
摘要翻译：在人染色体8上将基因鉴定为RA疾病易感基因，编码具有SEQ ID NO：1所示氨基酸序列的蛋白质的基因。证件号码。 1，并且具有这样的突变，甘氨酸作为序列中的第269个氨基酸被插入。此外，发现基因和蛋白质的突变与RA的发病有关。实现是通过使用突变以高精度评估RA的发作或发作可能性的方法。

7. 发明授权

US07615341B2 Disease susceptibility gene for rheumatoid arthritis, protein thereof, evaluation method and evaluation kit for evaluating onset possibility of rheumatoid arthritis by using those, and remedy and curing medicine for rheumatoid arthritis 有权
标题翻译：用于类风湿关节炎的疾病易感基因，其蛋白质，评估方法和用于评估类风湿性关节炎发作可能性的评价试剂盒，以及用于治疗类风湿性关节炎药物
公开(公告)号：US07615341B2
公开(公告)日：2009-11-10
申请号：US10501259
申请日：2003-01-08
申请人： Shunichi Shiozawa , Koichiro Komai , Mikiko Nakatsukasa
发明人： Shunichi Shiozawa , Koichiro Komai , Mikiko Nakatsukasa
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： G01N33/564 , C07K14/47 , C07K14/4713 , C12Q1/6883 , C12Q2600/156 , G01N2800/102
摘要： An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO. 1 and that has such mutation that glycine is inserted as a 269th amino acid in the sequence. Moreover, it was found that mutation of the gene and the protein relate to onset of RA. Achieved is a method of evaluating with high accuracy the onset or onset possibility of RA by using the mutation.
摘要翻译：在人染色体8上将基因鉴定为RA疾病易感基因，编码具有SEQ ID NO：1所示氨基酸序列的蛋白质的基因。证件号码。 1，并且具有这样的突变，甘氨酸作为序列中的第269个氨基酸被插入。此外，发现基因和蛋白质的突变与RA的发病有关。实现是通过使用突变以高精度评估RA的发作或发作可能性的方法。

8. 发明授权

US06620593B1 Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome P450 失效
标题翻译：使用表达人细胞色素P450的重组酵母对化合物进行安全性评估的方法
公开(公告)号：US06620593B1
公开(公告)日：2003-09-16
申请号：US08277031
申请日：1994-07-19
申请人： Koji Hayashi , Toshiyuki Sakaki , Yoshiyasu Yabusaki , Koichiro Komai , Hideo Kaneko , Iwao Nakatsuka
发明人： Koji Hayashi , Toshiyuki Sakaki , Yoshiyasu Yabusaki , Koichiro Komai , Hideo Kaneko , Iwao Nakatsuka
IPC分类号： C12Q126
CPC分类号： C12Y106/02004 , C12N9/0038 , C12N9/0077 , C12Q1/025
摘要： There is disclosed a method for evaluation of the safety of a chemical compound, which includes the steps of: (a) reacting a chemical compound with recombinant yeast cells expressing, or in other words producing, human cytochrome P450 molecular species P450 1A2, P450 2C9, P450 2E1 and P450 3A4 together with a yeast NADPH-P450 reductase, which may be in the form of a fused enzyme with each of said human cytochrome P450 molecular species, or with the cell free extracts of the yeast cells; and (b) analyzing the resulting metabolite to determine the safety of the compound. According to this method, it can be determined whether a test compound will be converted into a carcinogenic or mutagenic form through the metabolism in the human liver, and whether the test compound or its metabolite has mutagenicity.
摘要翻译：公开了一种用于评估化合物安全性的方法，其包括以下步骤：（a）使化学化合物与表达或换句话说，生成人细胞色素P450分子种类P450 1A2，P450 2C9的重组酵母细胞，P450 2E1和P450 3A4以及酵母NADPH-P450还原酶，其可以是与每种所述人细胞色素P450分子种类的融合酶的形式，或与酵母细胞的无细胞提取物; 和（b）分析得到的代谢物以确定化合物的安全性。根据该方法，可以确定试验化合物是否将通过人肝脏中的代谢转化为致癌或诱变形式，以及试验化合物或其代谢物是否具有致突变性。

9. 发明授权

US6034120A Insect antifeedant for agriculture 失效
标题翻译：农业用杀虫剂
公开(公告)号：US6034120A
公开(公告)日：2000-03-07
申请号：US28879
申请日：1998-02-24
申请人： Koichiro Komai , Masanori Morimoto , Toyoshige Morita
发明人： Koichiro Komai , Masanori Morimoto , Toyoshige Morita
IPC分类号： A01N43/12 , A01N43/20 , A01N43/90 , A01N65/00 , A01P7/04 , A01P17/00 , A61K31/35 , A61K31/34 , C07D307/00 , C07D317/70 , C07D493/00
CPC分类号： A01N43/20 , A01N43/12 , A01N43/90
摘要： The present invention provides an antifeedant and a contact insecticide using the components contained in Cyperaceae species. In particular, the present invention provides an insect antifeedant and a contact insecticide comprising as an active ingredient at least one compound selected from the group consisting of scabequinone, remirol, cyperaquinone and the derivatives thereof.
摘要翻译：本发明提供了使用莎草科种中所含组分的拒食和接触杀虫剂。特别地，本发明提供了一种杀虫剂和一种接触杀虫剂，其包含至少一种选自由scabequinone，remirol，cyperaquinone及其衍生物组成的组中的活性成分。

10. 发明授权

US4449997A Plant growth regulator 失效
标题翻译：植物生长调节剂
公开(公告)号：US4449997A
公开(公告)日：1984-05-22
申请号：US308970
申请日：1981-10-06
申请人： Junichi Iwamura , Koichiro Komai
发明人： Junichi Iwamura , Koichiro Komai
IPC分类号： A01N43/14 , A01N43/00 , A01N45/00 , A01N43/16
CPC分类号： A01N45/00
摘要： A plant growth regulating composition which comprises as an active ingredient at least one diterpene glucoside of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or any other cation and R.sup.2 is .beta.-glucopyranosyl-(1-2)-.beta.-glucopyranosyl or 2,3-di-O-(.beta.-glucopyranosyl-.beta.-glucopyranosyl, or R.sup.1 is .beta.-glucopyranosyl and R.sup.2 is .alpha.-rhamnopyranosyl-(1-2)-.beta.-glucopyranosyl, .beta.-glucopyranosyl-(1-2)-.beta.-glucopyranosyl, 2,3-di-O-(.beta.-glucopyranosyl)-.beta.-glucopyranosyl or (3-O-.beta.-glucopyranosyl)-(2-O-.alpha.-rhamnosyl-.beta.-glcopyranosyl).
摘要翻译：一种植物生长调节组合物，其包含作为活性成分的至少一种下式的二萜糖苷：其中R1是氢原子或任何其它阳离子，R2是β-吡喃葡萄糖基 - （1-2）-β - 吡喃葡萄糖基或2,3-二-O-（β-吡喃葡萄糖基-β-吡喃葡萄糖基，或R1是β-吡喃葡萄糖基，R2是α-鼠李糖吡喃糖基 - （1-2）-β-吡喃葡萄糖基，β-吡喃葡萄糖基 - （1- 2）-β-吡喃葡萄糖基，2,3-二-O-（β-吡喃葡萄糖基）-β-吡喃葡萄糖基或（3-O-β-吡喃葡萄糖基） - （2-O-α-鼠李糖基-β-吡喃葡萄糖基）。

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