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1. 发明授权

US08242118B2 Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders 有权
标题翻译：用作CCR3拮抗剂治疗炎症和免疫疾病的芳基磺酰胺衍生物
公开(公告)号：US08242118B2
公开(公告)日：2012-08-14
申请号：US12763072
申请日：2010-04-19
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/535 , A61K31/44 , A61K31/195 , A61K31/275 , A01N43/40 , A01N37/12 , A01N37/44 , A01N37/34 , C07D239/02 , C07D213/00 , C07C255/00 , C07C315/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译：本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。

2. 发明授权

US08173841B2 Tetrahydro-naphthalene derivatives 失效
标题翻译：四氢萘衍生物
公开(公告)号：US08173841B2
公开(公告)日：2012-05-08
申请号：US13052482
申请日：2011-03-21
申请人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
发明人： Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
IPC分类号： C07C273/00 , A61K31/17
CPC分类号： C07D295/088 , C07C233/29 , C07C233/75 , C07C235/42 , C07C237/40 , C07C275/32 , C07C275/38 , C07C275/40 , C07C275/42 , C07C317/32 , C07C323/44 , C07C2602/10 , C07D207/27 , C07D211/22 , C07D211/46 , C07D211/62 , C07D295/135
摘要： This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢萘衍生物及其盐。本发明的四氢萘衍生物作为VR1拮抗剂具有优异的活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁，膀胱过度活动症，急迫性尿失禁，慢性疼痛，神经性疼痛，手术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风，炎症性疾病，哮喘和COPD。

3. 发明授权

US07700586B2 Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效
标题翻译：用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物
公开(公告)号：US07700586B2
公开(公告)日：2010-04-20
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/55 , A01N43/62 , A61K31/497 , C07D243/08 , C07D241/04 , C07D295/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译：本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。

4. 发明授权

US07615557B2 Tetrahydro-naphthalene and urea derivatives 失效
标题翻译：四氢萘和脲衍生物
公开(公告)号：US07615557B2
公开(公告)日：2009-11-10
申请号：US10574122
申请日：2004-09-22
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi , Hiroaki Yuasa , Jang Gupta , Fumihiko Hayashi
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi , Hiroaki Yuasa , Jang Gupta , Fumihiko Hayashi
IPC分类号： A01N43/40 , A61K31/445 , A61K31/4965 , C07D295/00 , C07D241/04
CPC分类号： C07D295/215 , C07D211/62 , C07D401/04
摘要： This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.
摘要翻译：本发明涉及用作药物制剂活性成分的羟基 - 四氢 - 萘或脲衍生物式（I）及其盐，其中A表示式（II）或（III），其中＃表示与分子和Q1a，Q2a，Q3a和Q4a，E表示式（IV）或（V），其中＃表示与分子的连接位置，Q1b，Q2b，Q3b，Q4b，Q5b，R1b，na，ma，Xa 和Ra。

5. 发明申请

US20070129355A1 Pyrimidine derivatives useful for the treatment of diseases mediated by crth2 有权
标题翻译：可用于治疗由crth2介导的疾病的嘧啶衍生物
公开(公告)号：US20070129355A1
公开(公告)日：2007-06-07
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

6. 发明授权

US07094911B2 Biphenyl and biphenyl-analogous compounds as integrin antagonists 失效
标题翻译：联苯和联苯类似物作为整联蛋白拮抗剂
公开(公告)号：US07094911B2
公开(公告)日：2006-08-22
申请号：US10285073
申请日：2002-10-31
申请人： Markus Albers , Klaus Urbahns , Andrea Vaupel , Michael Härter , Delf Schmidt , Beatrix Stelte-Ludwig , Christoph Gerdes , Elke Stahl , Jörg Keldenich , Ulf Brueggemeier , Klemens Lustig
发明人： Markus Albers , Klaus Urbahns , Andrea Vaupel , Michael Härter , Delf Schmidt , Beatrix Stelte-Ludwig , Christoph Gerdes , Elke Stahl , Jörg Keldenich , Ulf Brueggemeier , Klemens Lustig
IPC分类号： C07D333/24 , C07D333/36 , C07D409/06 , A61K31/38 , A61P19/10
CPC分类号： C07D213/40 , C07C237/36 , C07C271/22 , C07C275/42 , C07C311/06 , C07C311/09 , C07C311/10 , C07C311/11 , C07C311/13 , C07C311/19 , C07C311/29 , C07C311/43 , C07C311/47 , C07C317/14 , C07C323/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/34 , C07D213/38 , C07D213/55 , C07D213/74 , C07D213/75 , C07D213/82 , C07D231/18 , C07D233/64 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/30 , C07D235/32 , C07D261/10 , C07D263/58 , C07D277/42 , C07D277/54 , C07D277/82 , C07D285/10 , C07D285/135 , C07D285/14 , C07D295/096 , C07D295/13 , C07D295/15 , C07D295/215 , C07D307/52 , C07D333/34 , C07D333/48 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have the formula (1) wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.
摘要翻译：本发明涉及联苯和联苯类似物，其作为药物组合物的制备和用途，作为整联蛋白拮抗剂，特别涉及用于治疗和预防癌症，动脉硬化，再狭窄，溶骨性疾病如骨质疏松和眼科疾病根据本发明的化合物具有式（1）其中R 1，R 2，U，V，A，B，W，R 3， SUP，C和R 4具有如权利要求中所定义的含义。

7. 发明申请

US20060166989A1 2-naphthamide derivatives 审中-公开
标题翻译： 2-萘甲酰胺衍生物
公开(公告)号：US20060166989A1
公开(公告)日：2006-07-27
申请号：US10517677
申请日：2003-05-30
申请人： Makoto Shimazaki , Osamu Sakurai , Toshiki Murata , Klaus Urbahns , Noriyuki Yamamoto , Satoru Yoshikawa , Masaomi Umeda , Masaomi Tajimi , Tsutomu Masuda , Takuya Shintani , Haruka Shimizu
发明人： Makoto Shimazaki , Osamu Sakurai , Toshiki Murata , Klaus Urbahns , Noriyuki Yamamoto , Satoru Yoshikawa , Masaomi Umeda , Masaomi Tajimi , Tsutomu Masuda , Takuya Shintani , Haruka Shimizu
IPC分类号： A61K31/537 , A61K31/44 , A61K31/195 , C07D213/55 , C07D265/30 , C07C237/40
CPC分类号： C07C235/66
摘要： The present invention relates to 2-naphthamides, which are useful as an active ingredient of pharmaceutical preparations. The 2-naphthamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benign prostatic hypertrophy (BPH), pro-statitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the disease is also alleviated by treatment with an IP receptor antagonist.
摘要翻译：本发明涉及可用作药物制剂活性成分的2-萘甲酰胺。本发明的2-萘甲酰胺具有IP受体拮抗活性，可用于预防和治疗与IP受体活性相关的疾病。这些疾病包括尿路疾病或病症如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大），pro-statitis，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺增生症，膀胱炎或自发性膀胱过敏反应。本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压血友病和出血; 和炎症，因为该疾病也通过用IP受体拮抗剂治疗而缓解。

8. 发明申请

US20060089371A1 Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist 审中-公开
标题翻译：苯基或杂芳基氨基烷烃衍生物作为ip受体拮抗剂
公开(公告)号：US20060089371A1
公开(公告)日：2006-04-27
申请号：US10534174
申请日：2003-10-29
申请人： Toshiki Murata , Masami Umeda , Satoru Yoshikawa , Klaus Urbahns , Jang Gupta , Osamu Sakurai
发明人： Toshiki Murata , Masami Umeda , Satoru Yoshikawa , Klaus Urbahns , Jang Gupta , Osamu Sakurai
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D213/64 , C07C229/36 , C07D213/74 , C07D231/38 , C07D239/42 , C07D241/20 , C07D261/14 , C07D277/42 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/10
摘要： The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I) in which the groups Q1-Q4, Ar, and R1-R7 are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.
摘要翻译：本发明涉及式（I）的苯基或杂芳基氨基烷烃衍生物，其中基团Q 1，Q 4，Ar和R 1， SUP> -R 7如说明书和权利要求中所定义。这些材料可用作药物制剂的活性成分。本发明的苯基或杂芳基氨基烷烃具有IP受体拮抗活性，可用于预防和治疗与IP受体拮抗活性相关的疾病。这些疾病包括泌尿系统疾病或疾病如下：膀胱出口阻塞，膀胱过度活动，尿失禁，逼尿肌反射反射，逼尿肌不稳定，膀胱容量减少，排尿频率，急迫性尿失禁，压力性尿失禁，膀胱高反应性，良性前列腺肥大），前列腺炎，尿频，夜尿症，尿急，盆腔超敏反应，尿道炎，盆腔疼痛综合征，前列腺痛，膀胱炎或自发性膀胱过敏。本发明的化合物还可用于治疗疼痛，包括但不限于炎性疼痛，神经性疼痛，急性疼痛，慢性疼痛，牙痛，经前痛，内脏痛，头痛等; 低血压血友病和出血; 和炎症，因为这些疾病也通过用IP受体拮抗剂治疗而缓解。本申请要求化合物，含有它们的药物组合物和使用它们的治疗方法。

9. 发明授权

US6147087A Use of 1,2-Bridged 1,4-dihydropyridines as medicaments 失效
标题翻译：使用1,2-桥联的1,4-二氢吡啶作为药物
公开(公告)号：US6147087A
公开(公告)日：2000-11-14
申请号：US362409
申请日：1999-07-28
申请人： Klaus Urbahns , Hans-Georg Heine , Bodo Junge , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor De Vry , Henning Sommermeyer
发明人： Klaus Urbahns , Hans-Georg Heine , Bodo Junge , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor De Vry , Henning Sommermeyer
IPC分类号： C07D417/04 , A61K31/435 , A61K31/4422 , A61K31/47 , A61K31/55 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , C07D455/02 , C07D455/03 , C07D455/04 , C07D471/04 , A61K31/44 , C07D221/02
CPC分类号： C07D471/04 , C07D455/02 , C07D455/04
摘要： The present invention relates to the new use of 1,2-bridged 1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 and a have the meaning indicated in the description, processes for their preparation and their use as medicaments, as selective potassium channel modulators, in particular for the treatment of the central nervous system.
摘要翻译：本发明涉及在一些情况下已知的具有通式（I）的1,2-桥连的1,4-二氢吡啶的新用途，其中R1至R4和a具有说明书所示的含义，方法它们的制备和作为药物的用途，作为选择性钾通道调节剂，特别是用于治疗中枢神经系统。

10. 发明授权

US5760073A Substituted 4H-pyrans 失效
标题翻译：取代4H-吡喃
公开(公告)号：US5760073A
公开(公告)日：1998-06-02
申请号：US692964
申请日：1996-08-07
申请人： Klaus Urbahns , Hans-Georg Heine , Bodo Junge , Frank Mauler , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor De Vry
发明人： Klaus Urbahns , Hans-Georg Heine , Bodo Junge , Frank Mauler , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor De Vry
IPC分类号： A61K31/35 , A61K31/351 , A61K31/44 , A61K31/443 , A61P3/04 , A61P3/08 , A61P7/06 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P37/04 , A61P43/00 , C07D309/32 , C07D405/04 , C07D315/00
CPC分类号： C07D309/32
摘要： The substituted 4H-pyrans are prepared by reacting either aldehydes or ylidene compounds with suitably substituted .beta.-diketones. The substituted 4H-pyrans according to the invention are suitable as active compounds in medicaments, in particular for the treatment of disorders of the central nervous system.
摘要翻译：取代的4H-吡喃通过使醛或亚基化合物与适当取代的β-二酮反应来制备。根据本发明的取代的4H-吡喃适合作为药物中的活性化合物，特别是用于治疗中枢神经系统疾病。

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