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    • 1. 发明授权
    • Geometrical isomers of acrylonitrile compounds, mixture thereof, and process for producing these
    • 丙烯腈化合物的几何异构体,其混合物,及其制备方法
    • US06624179B1
    • 2003-09-23
    • US10030122
    • 2002-01-24
    • Toru KoyanagiYuji NakamuraMasayuki MoritaTsuyoshi UedaAkihiro HisamatsuMayumi Kanamori
    • Toru KoyanagiYuji NakamuraMasayuki MoritaTsuyoshi UedaAkihiro HisamatsuMayumi Kanamori
    • A61K3144
    • C07C329/16C07B2200/09C07C255/34C07C255/38C07C329/04C07C329/06
    • A geometrical isomer of an acrylonitrile compound represented by the formula (I) or of its salt, or a mixture thereof: [wherein T is phenyl or pyridyl, which is substituted by R2, Q is phenyl, thienyl, pyridyl or benzyl, which may be substituted by R3, R1 is —C(═O)R4 or —C(═S)R4, R4 is alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, cycloalkyl, cycloalkyloxy, cycloalkylthio, —N(R5)R6, phenyl, phenoxy, phenylthio, benzyl, benzyloxy, benzylthio, —J, —O—J or —S—J], wherein the geometrical isomer has a longer retention time when analyzed by reversed phase liquid chromatography in which a packing comprising silica having chemically bonded thereto an alkyl group selected from trimethyl, octyl and octadecyl, is used as the stationary phase, and a polar solvent selected from water, methanol and acetonitrile, is used as the mobile phase, and the geometrical isomer mixture contains such geometrical isomer in a larger proportion.
    • 由式(I)表示的丙烯腈化合物或其盐的几何异构体或其混合物:[其中T是被R 2取代的苯基或吡啶基,Q是苯基,噻吩基,吡啶基或苄基,其可以 被R 3取代,R 1是-C(= O)R 4或-C(= S)R 4,R 4是烷基,烯基,炔基,烷氧基,烯氧基,炔氧基,烷硫基,链烯硫基,炔硫基,环烷基,环烷氧基, N(R 5)R 6,苯基,苯氧基,苯硫基,苄基,苄氧基,苄硫基,-J,-OJ或-SJ],其中几何异构体在通过反相液相色谱分析时具有更长的保留时间, 化学键合有选自三甲基,辛基和十八烷基的烷基作为固定相,使用选自水,甲醇和乙腈的极性溶剂作为流动相,几何异构体混合物含有这种几何异构体 比例较大。
    • 8. 发明授权
    • Vehicle body conveyance in assembly line
    • 装配线车身运输
    • US4693358A
    • 1987-09-15
    • US835943
    • 1986-03-04
    • Tetsuro KondoTsuyoshi Ueda
    • Tetsuro KondoTsuyoshi Ueda
    • B62D65/00B62D65/18B65G17/48B21B39/14
    • B62D65/18Y10T29/49829Y10T29/49998Y10T29/53548
    • A conveyor system in an automobile assembly line which comprises a slat conveyor for conveying a vehicle body structure past a door fitting position at which at least one door assembly is fitted to the body structure being conveyed, and having at least one engagement member movable together therewith, a pair of side carriages arranged on respective sides of the slat conveyor for movement between initial and end positions along the slat conveyor, and a cylinder for forcibly returning the carriages, once moved to the end position to the accompaniment of the movement of the slat conveyor, to the initial position. Each of the carriages includes a plurality of lift cylinders operable to lift the body structure a predetermined height above the slat conveyor during the passage of the body structure being conveyed through the door fitting station.
    • 一种汽车装配线中的传送系统,包括用于将车体结构传送通过门装配位置的板条输送机,在门装配位置,至少一个门组件被安装到正被传送的主体结构上,并且具有可与其一起移动的至少一个接合构件 ,一对侧滑架,其布置在板条输送机的相应侧面上,用于沿着板条输送机在初始位置和结束位置之间移动,以及一个用于强制返回滑架的气缸,一旦移动到最终位置,伴随着板条的运动 输送机,到初始位置。 每个托架包括多个提升缸,其可操作以在通过门装配工位传送的主体结构的通过期间将主体结构提升到板条输送机上方的预定高度。
    • 10. 发明申请
    • ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF
    • ALPHA-CARBOLINE衍生物及其制备方法
    • US20090326229A1
    • 2009-12-31
    • US12376068
    • 2007-08-02
    • Masahiro MizunoHideya MizufuneMisayo SeraMasahiro MinenoTsuyoshi Ueda
    • Masahiro MizunoHideya MizufuneMisayo SeraMasahiro MinenoTsuyoshi Ueda
    • C07D471/02C07D213/72
    • C07D471/04C07D213/74C07D213/75C07D405/12
    • To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously. A method for preparation of a compound represented by Formula (II) or a salt thereof, comprising subjecting a compound represented by Formula (I) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base; a method for preparation of a compound represented by Formula (IX) or a salt thereof, comprising subjecting a compound represented by Formula (VII) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base, and subsequently to an aromatization reaction; and methods for preparation of compounds represented by Formulae (XV), (XVII), and (XIX) or a salt thereof, comprising subjecting respective compounds represented by Formulae (II) and (IX) or a salt thereof to a reaction for introducing a leaving group when necessary, and subsequently to a coupling reaction: wherein the symbols respectively represent the same meaning as defined in the present specification.
    • 提供在几个步骤中以及方便和工业上有利地制备α-咔啉衍生物的方法。 一种制备由式(II)表示的化合物或其盐的方法,包括在钯催化剂,配体和配体存在下,将式(I)表示的化合物或其盐进行闭环反应 基础; 一种制备由式(Ⅸ)表示的化合物或其盐的方法,包括在钯催化剂,配体和配体存在下使式(Ⅶ)表示的化合物或其盐进行闭环反应 碱,然后进行芳构化反应; 以及由式(XV),(XVII)和(XIX)表示的化合物或其盐制备化合物或其盐的方法,包括使由式(Ⅱ)和(Ⅸ)表示的各种化合物或其盐进行引入 在必要时离去基团,随后进行偶联反应:其中符号分别表示与本说明书中定义的相同的含义。