会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 7. 发明授权
    • Geometrical isomers of acrylonitrile compounds, mixture thereof, and process for producing these
    • 丙烯腈化合物的几何异构体,其混合物,及其制备方法
    • US06624179B1
    • 2003-09-23
    • US10030122
    • 2002-01-24
    • Toru KoyanagiYuji NakamuraMasayuki MoritaTsuyoshi UedaAkihiro HisamatsuMayumi Kanamori
    • Toru KoyanagiYuji NakamuraMasayuki MoritaTsuyoshi UedaAkihiro HisamatsuMayumi Kanamori
    • A61K3144
    • C07C329/16C07B2200/09C07C255/34C07C255/38C07C329/04C07C329/06
    • A geometrical isomer of an acrylonitrile compound represented by the formula (I) or of its salt, or a mixture thereof: [wherein T is phenyl or pyridyl, which is substituted by R2, Q is phenyl, thienyl, pyridyl or benzyl, which may be substituted by R3, R1 is —C(═O)R4 or —C(═S)R4, R4 is alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, cycloalkyl, cycloalkyloxy, cycloalkylthio, —N(R5)R6, phenyl, phenoxy, phenylthio, benzyl, benzyloxy, benzylthio, —J, —O—J or —S—J], wherein the geometrical isomer has a longer retention time when analyzed by reversed phase liquid chromatography in which a packing comprising silica having chemically bonded thereto an alkyl group selected from trimethyl, octyl and octadecyl, is used as the stationary phase, and a polar solvent selected from water, methanol and acetonitrile, is used as the mobile phase, and the geometrical isomer mixture contains such geometrical isomer in a larger proportion.
    • 由式(I)表示的丙烯腈化合物或其盐的几何异构体或其混合物:[其中T是被R 2取代的苯基或吡啶基,Q是苯基,噻吩基,吡啶基或苄基,其可以 被R 3取代,R 1是-C(= O)R 4或-C(= S)R 4,R 4是烷基,烯基,炔基,烷氧基,烯氧基,炔氧基,烷硫基,链烯硫基,炔硫基,环烷基,环烷氧基, N(R 5)R 6,苯基,苯氧基,苯硫基,苄基,苄氧基,苄硫基,-J,-OJ或-SJ],其中几何异构体在通过反相液相色谱分析时具有更长的保留时间, 化学键合有选自三甲基,辛基和十八烷基的烷基作为固定相,使用选自水,甲醇和乙腈的极性溶剂作为流动相,几何异构体混合物含有这种几何异构体 比例较大。