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1. 发明授权

US6100403A Production of benzaldehyde compounds 有权
标题翻译：生产苯甲醛化合物
公开(公告)号：US6100403A
公开(公告)日：2000-08-08
申请号：US292384
申请日：1999-04-12
申请人： Yuzuru Saito , Hideya Mizufune , Makoto Yamashita
发明人： Yuzuru Saito , Hideya Mizufune , Makoto Yamashita
IPC分类号： C07D213/30 , C07D417/00 , C07D417/12
CPC分类号： C07D213/30 , C07D417/12
摘要： A method of producing a compound represented by the formula: ##STR1## wherein R.sup.1 stands for hydrogen or an optionally substituted alkyl or acyl group, which comprises reacting a compound represented by the formula: ##STR2## wherein R.sup.1 is of the same meaning as defined above, and R.sup.2 stands for an optionally halolgenated alkyl group or an optionally substituted phenyl group with a compound represented by the formula: ##STR3## in a lower alcohol in the presence of an alkali metal or alkaline earth metal carbonate; the compound (III) being useful as starting compounds for producing thiazolidinedione derivatives having hypoglycemic and hypolipidemic activities.
摘要翻译：一种制备由下式表示的化合物的方法：其中R1代表氢或任选取代的烷基或酰基，其包括使下式表示的化合物：其中R 1具有与上述相同的含义，R 2表示任选卤化的烷基或任选取代的苯基与下式表示的化合物在低级醇中在碱金属或碱土金属碳酸盐存在下反应; 化合物（III）可用作具有降血糖和降血脂活性的噻唑烷二酮衍生物的起始化合物。

2. 发明授权

US5952509A Production of benzaldehyde compounds 失效
公开(公告)号：US5952509A
公开(公告)日：1999-09-14
申请号：US880638
申请日：1997-06-23
申请人： Yuzuru Saito , Hideya Mizufune , Makoto Yamashita
发明人： Yuzuru Saito , Hideya Mizufune , Makoto Yamashita
IPC分类号： C07D213/30 , C07D417/00 , C07D417/12
CPC分类号： C07D213/30 , C07D417/12
摘要： A method of producing a compound represented by the formula: ##STR1## wherein R.sup.1 stands for hydrogen or an optionally substituted alkyl or acyl group, which comprises reacting a compound represented by the formula: ##STR2## wherein R.sup.1 is of the same meaning as defined above, and R.sup.2 stands for an optionally halolgenated alkyl group or an optionally substituted phenyl group with a compound represented by the formula: ##STR3## in a lower alcohol in the presence of an alkali metal or alkaline earth metal carbonate; the compound (III) being useful as starting compounds for producing thiazolidinedione derivatives having hypoglycemic and hypolipidemic activities.

3. 发明申请

US20110306769A1 PROCESS FOR PRODUCING PYRROLE COMPOUND 有权
标题翻译：生产吡咯化合物的方法
公开(公告)号：US20110306769A1
公开(公告)日：2011-12-15
申请号：US13203441
申请日：2010-02-24
申请人： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
发明人： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
IPC分类号： C07D401/12 , C07D207/36
CPC分类号： C07D207/337 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
摘要： The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
摘要翻译：本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应得到化合物（Ⅵ），并使化合物（VI）进行胺化反应。

4. 发明申请

US20090326229A1 ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF 审中-公开
标题翻译： ALPHA-CARBOLINE衍生物及其制备方法
公开(公告)号：US20090326229A1
公开(公告)日：2009-12-31
申请号：US12376068
申请日：2007-08-02
申请人： Masahiro Mizuno , Hideya Mizufune , Misayo Sera , Masahiro Mineno , Tsuyoshi Ueda
发明人： Masahiro Mizuno , Hideya Mizufune , Misayo Sera , Masahiro Mineno , Tsuyoshi Ueda
IPC分类号： C07D471/02 , C07D213/72
CPC分类号： C07D471/04 , C07D213/74 , C07D213/75 , C07D405/12
摘要： To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously. A method for preparation of a compound represented by Formula (II) or a salt thereof, comprising subjecting a compound represented by Formula (I) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base; a method for preparation of a compound represented by Formula (IX) or a salt thereof, comprising subjecting a compound represented by Formula (VII) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base, and subsequently to an aromatization reaction; and methods for preparation of compounds represented by Formulae (XV), (XVII), and (XIX) or a salt thereof, comprising subjecting respective compounds represented by Formulae (II) and (IX) or a salt thereof to a reaction for introducing a leaving group when necessary, and subsequently to a coupling reaction: wherein the symbols respectively represent the same meaning as defined in the present specification.
摘要翻译：提供在几个步骤中以及方便和工业上有利地制备α-咔啉衍生物的方法。一种制备由式（II）表示的化合物或其盐的方法，包括在钯催化剂，配体和配体存在下，将式（I）表示的化合物或其盐进行闭环反应基础; 一种制备由式（Ⅸ）表示的化合物或其盐的方法，包括在钯催化剂，配体和配体存在下使式（Ⅶ）表示的化合物或其盐进行闭环反应碱，然后进行芳构化反应; 以及由式（XV），（XVII）和（XIX）表示的化合物或其盐制备化合物或其盐的方法，包括使由式（Ⅱ）和（Ⅸ）表示的各种化合物或其盐进行引入在必要时离去基团，随后进行偶联反应：其中符号分别表示与本说明书中定义的相同的含义。

5. 发明申请

US20060148858A1 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity 审中-公开
标题翻译： 1，具有低血糖和降血脂活性的2-唑衍生物
公开(公告)号：US20060148858A1
公开(公告)日：2006-07-06
申请号：US10517214
申请日：2003-05-22
申请人： Tsuyoshi Maekawa , Ryoma Hara , Hiroyuki Odaka , Hiroyuki Kimura , Hideya Mizufune , Kohji Fukatsu
发明人： Tsuyoshi Maekawa , Ryoma Hara , Hiroyuki Odaka , Hiroyuki Kimura , Hideya Mizufune , Kohji Fukatsu
IPC分类号： A61K31/4439 , A61K31/42 , C07D413/02 , C07D403/02
CPC分类号： C07D231/12 , C07D231/14 , C07D231/20 , C07D231/22 , C07D261/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D417/04
摘要： A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, —O—, —S— and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents —OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：由式（1）表示的化合物，其中环A是任选具有1至3个取代基的环; 环B是可以进一步具有1至3个取代基的1,2-吡咯环; Xa，Xb和Xc相同或不同，各自为键，-O - ， - S-等; Ya是具有1至20个碳原子的二价脂族烃残基; Yb和Yc相同或不同，各自为键或碳原子数1〜20的二价脂肪族烃残基; 环C是可以进一步具有1至3个取代基的单环芳环; 和R表示-OR 4（R 4是氢原子或任选取代的烃基）等，或其盐或其前药可用作预防或治疗糖尿病等。

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