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1. 发明授权

US07439075B2 Method and device for withdrawing suspended microparticles from a fluidic microsystem 失效
标题翻译：从流体微系统中取出悬浮微粒的方法和装置
公开(公告)号：US07439075B2
公开(公告)日：2008-10-21
申请号：US10203168
申请日：2001-02-08
申请人： Gunter Fuhr , Stephen Graham Shirley , Torsten Muller , Thomas Schnelle , Rolf Hagedorn
发明人： Gunter Fuhr , Stephen Graham Shirley , Torsten Muller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： G01N1/10 , G01N15/06 , G01N21/00 , G01N31/00 , G01N33/00 , G01N27/26 , B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , G01L9/18 , G01L1/20 , G01F1/64 , C02F1/469 , C02F1/40 , C02F11/00 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/00891 , B01L3/0241 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , G01N15/1404 , G01N27/44791 , G01N2015/1409 , Y10T436/2575
摘要： A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the microsystem, and the discharge flow is delivered through a conduction element (19). A microsystem with a flow output device for implementation of this method is also described.
摘要翻译：描述了从流体微系统（10）排出具有悬浮微粒的流体流的方法，由此流体流与至少一个输出流收敛以在微系统的排放通道（14）的端部处形成排出流，并且通过导电元件（19）输送排出流。还描述了具有用于实现该方法的流输出装置的微系统。

2. 发明申请

US20060289341A1 Methods and devices for separting particles in a liquid flow 有权
标题翻译：在液体流中分离颗粒的方法和装置
公开(公告)号：US20060289341A1
公开(公告)日：2006-12-28
申请号：US10549886
申请日：2004-03-17
申请人： Torsten Muller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Muller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B03C7/00 , B03B5/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

3. 发明授权

US6113768A Ultraminiaturized surface structure with controllable adhesion 失效
标题翻译：超强化表面结构，具有可控的粘附力
公开(公告)号：US6113768A
公开(公告)日：2000-09-05
申请号：US666480
申请日：1996-09-08
申请人： Gunter Fuhr , Andreas Voigt , Torsten Muller , Rolf Hagedorn , Bernd Wagner , Thomas Lisec
发明人： Gunter Fuhr , Andreas Voigt , Torsten Muller , Rolf Hagedorn , Bernd Wagner , Thomas Lisec
IPC分类号： B01F13/00 , B01J19/00 , B03C5/00 , B03C5/02 , C12M1/00 , C12M3/04 , G01N33/483 , G01N33/487 , G01N33/50 , G01N27/26 , G01N27/447
CPC分类号： B01F13/0077 , B01F13/0076 , B01J19/0093 , B03C5/005 , B03C5/028 , G01N33/48735 , B01J2219/00783 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00844 , B01J2219/00853
摘要： An ultra-miniaturized surface structure with controllable adhesion having extremely miniaturized (in the sub atomic range) planar electrode strips applied to the surface to which high frequency pulse trains may be applied to generate progressive or stationary standing waves. The electrodes in themselves are combined with dielectric insulating materials with controlled bio-compatibility. The type of electric drive, together with the properties of the surface layers that cover the electrodes, determines the adhesion properties of the surface to a large extent regardless of the used base material. Particle movement is gently influenced, so that for the first time it becomes possible to influence particles in highly physiological nutritive solutions.
摘要翻译： PCT No.PCT / DE94 / 01530 Sec。 371日期1996年9月9日 102（e）1996年9月9日PCT 1994年12月23日PCT公布。公开号WO95 / 17258 日期1995年6月29日具有可控制粘附的超小型化表面结构，其具有极小的（在亚原子范围内）平面电极条，其被施加到可以施加高频脉冲串的表面上以产生渐进或固定的驻波。电极本身与具有受控生物相容性的介电绝缘材料组合。电驱动的类型以及覆盖电极的表面层的性质决定了表面的粘附性，而与所使用的基材无关。颗粒运动受到轻微的影响，因此可以首次影响高度生理营养液中的颗粒。

4. 发明授权

US5925511A Cryopreserving and cryogenically processing biological objects 失效
标题翻译：冷冻保存和低温处理生物体
公开(公告)号：US5925511A
公开(公告)日：1999-07-20
申请号：US836092
申请日：1997-08-29
申请人： Gunter Fuhr , Jan Hornung , Rolf Hagedorn , Torsten Muller , Steffen Howitz , Bernd Wagner , Ulrich Hofmann
发明人： Gunter Fuhr , Jan Hornung , Rolf Hagedorn , Torsten Muller , Steffen Howitz , Bernd Wagner , Ulrich Hofmann
IPC分类号： A01N1/00 , A01N1/02 , A01N3/00
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0278 , A01N1/0294
摘要： For the fixated cryopreservation of single living biological objects or s objects compiled in a given number (for example cells) a cryogenically cooled substrate (13) is jetted therewith in a enveloping solution in microdroplet form (12) from a storage vessel, for example by means of a microdroplet jetting device (11). The substrate is temperature-controlled via a coolant (15), the surface to be jetted being located in a gas atmosphere or in vacuum (14). The substrate surface is maintained at a temperature T1 resulting in freezing of the impinging microdroplet, the substrate surface being possibly supportingly microstructured and comprising sensing elements. By controlled movement of either the substrate or the microdroplet jetting device the microdroplets can be applied singly and in patterns in arrays freely selectable or predetermined by the structuring of the substrate. The substrate with the applied microdroplets and the cells frozen therein are stored and/or processed by a processing means (17) ablating the material or applying said material at temperatures T2 of down to -273.degree. C. In the cryogenic condition manipulations such as removal by mechanical ablation or addition of solutions or substances to the surface of the substrate can be undertaken. During thawing the substrate surface is brought to a temperature T1 above the freezing point of the enveloping solution and the microdroplet array thawed in a predefined manner.
摘要翻译： PCT No.PCT / DE95 / 01490 Sec。 371日期1997年8月29日 102（e）日期1997年8月29日PCT提交1995年10月26日PCT公布。第WO96 / 13159号公报日期1996年5月9日对于以一定数量（例如细胞）编制的单一活生物体或此类物体的固定式低温保存，将低温冷却的基底（13）以微滴形式（12）的包封溶液从储存容器，例如通过微滴喷射装置（11）。衬底通过冷却剂（15）进行温度控制，待喷射的表面位于气体气氛或真空中（14）。衬底表面保持在温度T1，导致撞击微滴的冻结，衬底表面可能被支撑地微结构化并且包括感测元件。通过基板或微滴喷射装置的受控运动，微滴可以单独施加，并且可以通过基板的结构自由选择或预定的阵列中的图案施加。具有施加的微滴和在其中冷冻的细胞的基质通过处理装置（17）储存和/或处理，该处理装置（17）在低至-273℃的温度T2下烧蚀材料或施加所述材料。在低温条件下操作，例如去除可以通过机械消融或将溶液或物质添加到基材表面进行。在解冻期间，将衬底表面的温度T1提高到高于包络溶液的凝固点并且微滴阵列以预定方式解冻。

5. 发明授权

US5454472A Method of continuously separating mixtures of microscopic dielectric particles and apparatus for carrying through this method 失效
标题翻译：连续分离微观电介质颗粒的混合物的方法和用于承载该方法的装置
公开(公告)号：US5454472A
公开(公告)日：1995-10-03
申请号：US196093
申请日：1994-02-18
申请人： Wolfgang Benecke , Bernd Wagner , Rolf Hagedorn , Gunter Fuhr , Torsten Muller
发明人： Wolfgang Benecke , Bernd Wagner , Rolf Hagedorn , Gunter Fuhr , Torsten Muller
IPC分类号： B01J19/00 , B03C5/00 , B03C5/02 , G01N27/447 , G01N30/00 , B03C1/30
CPC分类号： B03C5/028 , B01J19/0093 , B03C5/005 , B03C5/022 , B03C5/026 , G01N30/0005 , B01J2219/00828 , B01J2219/00853 , B01J2219/00905 , B01J2219/0093 , G01N2030/0035
摘要： A method of separating mixtures of microscopic dielectric particles in sunsions in an apparatus for carrying the method. A mixture of particles is forced onto guide paths by dielectrophoretic forces or by a flow of the suspension medium with an additional force, which is provided to compensate the force causing the particles to move along the guide paths for specific particle species causing the specific particle species to be fed out from the mixture of particles. The apparatus may be integrated on surfaces of silicon wafers at low cost and in mass-production numbers, and is suitable for isolating minute particles such as biological cells, cell organelles, bio molecules as well as organic dielectric particles.
摘要翻译： PCT No.PCT / DE92 / 00694 Sec。 371日期1994年2月18日 102（e）1994年2月18日PCT PCT 1992年8月19日PCT公布。出版物WO93 / 03850 日期1993年3月4日。一种在用于携带该方法的装置中分离悬浮液中的微观电介质颗粒的混合物的方法。通过介电电泳力或通过附加力的悬浮介质的流动将粒子的混合物强制到引导路径上，附加的力被提供以补偿导致颗粒沿着引导路径移动的力，以产生特定的颗粒物质从颗粒混合物中送出。该设备可以以低成本和批量生产数量集成在硅晶片的表面上，并且适用于分离微粒，例如生物细胞，细胞器，生物分子以及有机电介质颗粒。

6. 发明申请

US20070221501A1 Method and Device for Collecting Suspended Particles 失效
标题翻译：收集悬浮颗粒的方法和装置
公开(公告)号：US20070221501A1
公开(公告)日：2007-09-27
申请号：US11568895
申请日：2005-05-06
申请人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
发明人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
IPC分类号： B01D57/02
CPC分类号： B03C5/026
摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.
摘要翻译：给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中，，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流（30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环）。还描述了用于收集颗粒的相应装置。

7. 发明申请

US20080246489A1 Measuring Device For Impedance Spectroscopy and Associated Measuring Method 审中-公开
标题翻译：用于阻抗谱和相关测量方法的测量装置
公开(公告)号：US20080246489A1
公开(公告)日：2008-10-09
申请号：US10599649
申请日：2005-04-07
申请人： Hans Gerard Leonard Coster , Terry Calvin Chilcott , Stefan Lupke , Torsten Muller , Thomas Schnelle
发明人： Hans Gerard Leonard Coster , Terry Calvin Chilcott , Stefan Lupke , Torsten Muller , Thomas Schnelle
IPC分类号： G01N27/02
CPC分类号： B03C5/026 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/0415 , B01L2400/0454 , B03C2201/24 , G01N15/1031
摘要： The invention relates to a measuring device and a measuring method for investigating particles which are suspended in a carrier liquid, including several measuring electrodes for carrying out electrical measuring of the particles. It is proposed that during electrical measuring, the particles be fixed in a field cage (4).
摘要翻译：本发明涉及一种用于研究悬浮在载液中的颗粒的测量装置和测量方法，包括用于进行颗粒电测量的多个测量电极。提出在电测量期间，将颗粒固定在场笼（4）中。

8. 发明授权

US07399395B2 Method and device for generating microconvections 失效
标题翻译：用于产生微对流的方法和装置
公开(公告)号：US07399395B2
公开(公告)日：2008-07-15
申请号：US10416054
申请日：2001-11-09
申请人： Thomas Schnelle , Torsten Muller
发明人： Thomas Schnelle , Torsten Muller
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01F3/08 , B01F5/0403 , B01F13/0001 , B01F13/0006 , B01F13/001 , B01F13/0077 , B01F2003/125 , B01L3/50273 , B01L2300/0867 , B01L2400/0415 , B01L2400/0442 , B03C5/028
摘要： The invention relates to a method for generating a convective liquid motion in a fluidic microsystem. According to this method, a liquid in a microsystem is simultaneously exposed to an electrical field and a thermal gradient. The electrical field is generated by means of an electrode arrangement which is subjected to a time-variant voltage. In this way, a time variant electrical field is formed in the liquid volume. The thermal gradient is produced by means of at least one radiation absorber located in the compartment which is exposed to at least one external radiation field.
摘要翻译：本发明涉及在流体微系统中产生对流液体运动的方法。根据该方法，微系统中的液体同时暴露于电场和热梯度。电场通过经历时变电压的电极装置产生。以这种方式，在液体体积中形成时变电场。热梯度是通过位于室内的至少一个辐射吸收器产生的，其暴露于至少一个外部辐射场。

9. 发明申请

US20070119714A1 Methods and devices for analysing a deformable object 审中-公开
标题翻译：用于分析可变形物体的方法和装置
公开(公告)号：US20070119714A1
公开(公告)日：2007-05-31
申请号：US10595771
申请日：2004-11-10
申请人： Thomas Schnelle , Torsten Muller , Andre Homke
发明人： Thomas Schnelle , Torsten Muller , Andre Homke
IPC分类号： B03C5/02
CPC分类号： G01N15/1056 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2400/0415 , B01L2400/0424 , G01N15/1456 , G01N15/1459 , G01N2015/105 , G01N2015/1495 , G01N2015/1497
摘要： Methods are described for analyzing at least one deformable object (O) in a suspension fluid, including the following steps: generation of an electric positioning field and positioning of the object (O) in a potential minimum of the positioning field, generation of an electric deformation field in such a way that a deformation force is exerted on the object (O), and detection of at least one property selected from the group including the dielectric, geometric and optical properties of the object (O), wherein the positioning field is generated in a compartment (12) of a fluidic microsystem (10) and the positioning of the object (O) takes place in a contactless manner in a freely suspended state. Measuring apparatuses for carrying out this method are also described.
摘要翻译：描述了用于分析悬浮液中的至少一个可变形物体（O）的方法，包括以下步骤：产生电定位区域和将物体（O）定位在定位区域的潜在最小值中，产生电变形场，使得变形力施加在物体（O）上，以及检测从包括物体（O）的电介质，几何和光学性质的组中选择的至少一种性质，其中定位场是产生在流体微系统（10）的隔室（12）中，并且物体（O）的定位以无接触的方式在自由悬挂状态下进行。还描述了用于执行该方法的测量装置。

10. 发明申请

US20060152708A1 Multiparametric detection in a fluidic microsystem 审中-公开
标题翻译：流体微系统中的多参数检测
公开(公告)号：US20060152708A1
公开(公告)日：2006-07-13
申请号：US10544423
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.
摘要翻译：公开了一种用于测量移动通过流体微系统的颗粒的性质的方法，所述颗粒悬浮在液体中。根据本发明的方法，首先在第一测试台（11）测量特定颗粒的第一参数。然后在与第一测试站（11）在空间上分离的第二测试站（12）以与第一测量的间隔的间隔测量颗粒的第二参数，并且以相关方式联合评估第一和第二参数，第一和第二参数是测试颗粒的不同性质的特征。评估包括第一和第二参数与预定预期值的比较。根据比较的结果，对测试的颗粒进行另一测量或操作。还公开了被设计用于实施本发明方法的流体微系统。

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