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1. 发明申请

US20060152708A1 Multiparametric detection in a fluidic microsystem 审中-公开
标题翻译：流体微系统中的多参数检测
公开(公告)号：US20060152708A1
公开(公告)日：2006-07-13
申请号：US10544423
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Thomas Schnelle , Rudiger Meyer
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： Disclosed is a method for measuring properties of particles that move through a fluidic microsystem, the particles being suspended in a liquid. According to the inventive method, a first parameter of a specific particle is first measured at a first test station (11). A second parameter of the particle is then measured at an interval from the first measurement at a second test station (12) which is spatially separated from the first test station (11), and the first and second parameters are jointly evaluated in a correlated manner, the first and second parameters being characteristic of different properties of the tested particle. The evaluation comprises a comparison of the first and second parameters with predetermined expected values. Another measurement is taken or manipulations are performed on the tested particle according to the result of the comparison. Also disclosed is a fluidic microsystem that is designed for implementing the inventive method.
摘要翻译：公开了一种用于测量移动通过流体微系统的颗粒的性质的方法，所述颗粒悬浮在液体中。根据本发明的方法，首先在第一测试台（11）测量特定颗粒的第一参数。然后在与第一测试站（11）在空间上分离的第二测试站（12）以与第一测量的间隔的间隔测量颗粒的第二参数，并且以相关方式联合评估第一和第二参数，第一和第二参数是测试颗粒的不同性质的特征。评估包括第一和第二参数与预定预期值的比较。根据比较的结果，对测试的颗粒进行另一测量或操作。还公开了被设计用于实施本发明方法的流体微系统。

2. 发明申请

US20060139638A1 Multiparametric cell identification and sorting method and associated device 审中-公开
标题翻译：多参数细胞识别和分选方法及相关装置
公开(公告)号：US20060139638A1
公开(公告)日：2006-06-29
申请号：US10544463
申请日：2004-02-04
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Rudiger Meyer
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig , Gabriele Gradl , Axel Bonsen , Rudiger Meyer
IPC分类号： G01N21/00 , G01N21/64 , G01N15/02
CPC分类号： G01N15/1459 , C12M47/04 , G01N15/1056 , G01N15/12 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , G01N2035/00158
摘要： The invention relates to an method of analysing biological particles, in particular to be conducted in a cell sorter, with following steps: placing the particles to be analysed into a carrier flow, carrying out a first analysis of the particles moving with the carrier flow, selecting at least one particle in dependence on the result of the first analysis, carrying out a second analysis of the selected particle in a decelerated condition. Furthermore, the invention comprises a corresponding analysis device.
摘要翻译：本发明涉及一种分析生物颗粒的方法，特别是在细胞分选器中进行分析，其步骤如下：将要分析的颗粒放入载体流中，对载体流动的颗粒进行第一次分析，根据第一次分析的结果选择至少一个粒子，在减速条件下进行所选粒子的第二次分析。此外，本发明包括相应的分析装置。

3. 发明申请

US20070163883A1 Microfluidic system comprising an electrode arrangement and associated control method 审中-公开
标题翻译：微流体系统包括电极装置和相关联的控制方法
公开(公告)号：US20070163883A1
公开(公告)日：2007-07-19
申请号：US10597674
申请日：2005-02-03
申请人： Thomas Schnelle , Annette Pfennig , Torsten Muller
发明人： Thomas Schnelle , Annette Pfennig , Torsten Muller
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B03C5/026 , G01N15/1056 , G01N2015/105 , G01N2015/1495
摘要： The invention relates to a microfluidic system, in particular in a cell sorter, including a first carrier power supply (1) which is used to supply a first carrier flow having particles (4) suspended therein, a first carrier power output line (15) which is used to withdraw at least one part of the carrier flow having particles (4) suspended therein, a process chamber (3) which is used to examine, observe, manipulate and/or select the particle (4). The first carrier power supply (1) flows into the process chamber (3) when the first carrier power output line (15) is discharged from the process chamber (3). According to the invention, at least one second carrier power supply (2) flows into the process chamber (3) in order to supply a second carrier flow having particles (5) suspended therein. The invention also relates to a corresponding operational method.
摘要翻译：本发明涉及微流体系统，特别是在细胞分选机中，包括用于提供悬浮在其中的颗粒（4）的第一载体流的第一载体电源（1），第一载体功率输出线（15）其用于抽出具有悬浮在其中的颗粒（4）的载体流的至少一部分，用于检查，观察，操纵和/或选择颗粒（4）的处理室（3）。当第一载体动力输出管线（15）从处理室（3）排出时，第一载体电源（1）流入处理室（3）。根据本发明，至少一个第二载体电源（2）流入处理室（3），以便提供具有悬浮在其中的颗粒（5）的第二载体流。本发明还涉及相应的操作方法。

4. 发明申请

US20060012167A1 Device and method for coupling lines to fluidic microsystems 失效
标题翻译：将线耦合到流体微系统的装置和方法
公开(公告)号：US20060012167A1
公开(公告)日：2006-01-19
申请号：US10509190
申请日：2003-03-25
申请人： Torsten Muller , Annette Pfennig , Stephen Shirley , Stefan Hummel , Martin Reichel
发明人： Torsten Muller , Annette Pfennig , Stephen Shirley , Stefan Hummel , Martin Reichel
IPC分类号： F16L41/00
CPC分类号： F16L37/05
摘要： A coupling device (100), particularly for liquid-tight coupling of at least one liquid line (10) to a fluidic system (20), is described, which comprises: at least one sealing device (30), which is implemented to receive an end region (11) of the liquid line (10) and has a first sealing surface (31) for placement on an external surface (22) of the fluidic system in such a way that the end of the liquid line (10) is laterally enclosed by the first sealing surface (31) and points toward an opening (23) in the external surface (22), and a clamping device (40), using which the sealing device (30) may be pressed against the fluidic system (20), so that the first sealing surface (31) produces a liquid-tight connection with the external surface (22).
摘要翻译：描述了一种尤其用于至少一条液体管线（10）与流体系统（20）的液密耦合的联接装置（100），其包括：至少一个密封装置（30），其被实施为接收液体管线（10）的端部区域（11），并且具有用于放置在流体系统的外表面（22）上的第一密封表面（31），使得液体管线（10）的端部为由第一密封表面（31）横向包围并指向外表面（22）中的开口（23）的夹紧装置（40），密封装置（30）可以被压靠流体系统 20），使得第一密封表面（31）产生与外表面（22）的液密连接。

5. 发明申请

US20060198766A1 Docking device for a fluidic microsystem 审中-公开
标题翻译：流体微系统的对接装置
公开(公告)号：US20060198766A1
公开(公告)日：2006-09-07
申请号：US10556095
申请日：2004-05-10
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig
IPC分类号： B01L9/00
CPC分类号： B01L9/523 , B01J2219/00804 , B01J2219/0081 , B01L9/52 , B01L13/02 , B01L2200/025 , B01L2200/027 , B01L2200/028
摘要： The invention relates to a docking device (100) for retaining a fluidic microsystem (10), comprising a base plate (20) and a retaining frame (30), movable relative to the base plate (20) and used to fasten the microsystem (10) on the base plate (20). The retaining frame (30) is adapted to detachably receive the microsystem (10) and can be detached from the base plate (20) together with the microsystem (10). The device is also provided with a clamping device (40) with which the microsystem (10) on the retaining frame (30) can be pushed against the base plate (20). The invention also relates to methods for operating a fluidic microsystem (10) using said docking device (100).
摘要翻译：本发明涉及一种用于保持流体微系统（10）的对接装置（100），其包括可相对于基板（20）移动并用于紧固微系统（20）的基板（20）和保持框架（30） 10）在基板（20）上。保持框架（30）适于可拆卸地接收微系统（10）并且可以与微系统（10）一起从基板（20）拆下。该装置还设置有夹紧装置（40），保持框架（30）上的微系统（10）可以通过该夹紧装置推靠在基板（20）上。本发明还涉及使用所述对接装置（100）操作流体微系统（10）的方法。

6. 发明申请

US20070111298A1 Sample depositing device for a cell sorter 审中-公开
标题翻译：细胞分选机的样品沉积装置
公开(公告)号：US20070111298A1
公开(公告)日：2007-05-17
申请号：US10556140
申请日：2004-05-10
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig
IPC分类号： C12M3/00
CPC分类号： B01L3/50851 , B01L3/0241 , B01L2300/046 , G01N2015/149 , G01N2035/0424
摘要： The invention relates to a sample depositing device, particularly for a cell sorter, comprising a sample supply (38, 39) for supplying samples to be deposited and comprising a sample storage element (36) for storing the samples. Said sample storage element (36) has a number of sample containers for storing the samples separately. The invention provides that the sample storage element (36) is mounted in a displaceable manner in order to select a sample container whereas the sample supply (38, 39) is stationary.
摘要翻译：本发明涉及一种样品沉积装置，特别是用于细胞分选机的样品沉积装置，其包括用于提供待沉积样品的样品供应源（38,39），并包括用于储存样品的样品存储元件（36）。所述样品存储元件（36）具有用于分别存储样品的多个样品容器。本发明提供了样品存储元件（36）以可移位的方式安装，以便选择样品容器，而样品供应（38,39）是静止的。

7. 发明申请

US20060115890A1 Particle injector for a cell sorter 失效
公开(公告)号：US20060115890A1
公开(公告)日：2006-06-01
申请号：US10556017
申请日：2004-05-10
申请人： Torsten Muller , Stefan Hummel , Annette Pfennig
发明人： Torsten Muller , Stefan Hummel , Annette Pfennig
IPC分类号： C12M1/34
CPC分类号： G01N15/1404 , G01N2015/1409 , G01N2015/1413 , G01N2015/1418
摘要： The invention relates to a particle injector for introducing particles into a carrier flow of a microfluidic system, especially for injecting biological cells into the carrier flow of a cell sorter. The particle injector includes an inlet for receiving the carrier flow, an outlet for discharging the carrier flow including the introduced particles, a carrier flow channel which connects the inlet to the outlet, and an injection channel flowing into the carrier flow channel for introducing the particles into the carrier flow. The inventive particle injector is characterized in that the carrier flow channel has substantially no dead volume.

8. 发明申请

US20070221501A1 Method and Device for Collecting Suspended Particles 失效
标题翻译：收集悬浮颗粒的方法和装置
公开(公告)号：US20070221501A1
公开(公告)日：2007-09-27
申请号：US11568895
申请日：2005-05-06
申请人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
发明人： Thomas Schnelle , Torsten Muller , Jorg Kentsch , Frank Grom , Martin Stelzle
IPC分类号： B01D57/02
CPC分类号： B03C5/026
摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.
摘要翻译：给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中，，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流（30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环）。还描述了用于收集颗粒的相应装置。

9. 发明申请

US20080246489A1 Measuring Device For Impedance Spectroscopy and Associated Measuring Method 审中-公开
标题翻译：用于阻抗谱和相关测量方法的测量装置
公开(公告)号：US20080246489A1
公开(公告)日：2008-10-09
申请号：US10599649
申请日：2005-04-07
申请人： Hans Gerard Leonard Coster , Terry Calvin Chilcott , Stefan Lupke , Torsten Muller , Thomas Schnelle
发明人： Hans Gerard Leonard Coster , Terry Calvin Chilcott , Stefan Lupke , Torsten Muller , Thomas Schnelle
IPC分类号： G01N27/02
CPC分类号： B03C5/026 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/0415 , B01L2400/0454 , B03C2201/24 , G01N15/1031
摘要： The invention relates to a measuring device and a measuring method for investigating particles which are suspended in a carrier liquid, including several measuring electrodes for carrying out electrical measuring of the particles. It is proposed that during electrical measuring, the particles be fixed in a field cage (4).
摘要翻译：本发明涉及一种用于研究悬浮在载液中的颗粒的测量装置和测量方法，包括用于进行颗粒电测量的多个测量电极。提出在电测量期间，将颗粒固定在场笼（4）中。

10. 发明授权

US07399395B2 Method and device for generating microconvections 失效
标题翻译：用于产生微对流的方法和装置
公开(公告)号：US07399395B2
公开(公告)日：2008-07-15
申请号：US10416054
申请日：2001-11-09
申请人： Thomas Schnelle , Torsten Muller
发明人： Thomas Schnelle , Torsten Muller
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01F3/08 , B01F5/0403 , B01F13/0001 , B01F13/0006 , B01F13/001 , B01F13/0077 , B01F2003/125 , B01L3/50273 , B01L2300/0867 , B01L2400/0415 , B01L2400/0442 , B03C5/028
摘要： The invention relates to a method for generating a convective liquid motion in a fluidic microsystem. According to this method, a liquid in a microsystem is simultaneously exposed to an electrical field and a thermal gradient. The electrical field is generated by means of an electrode arrangement which is subjected to a time-variant voltage. In this way, a time variant electrical field is formed in the liquid volume. The thermal gradient is produced by means of at least one radiation absorber located in the compartment which is exposed to at least one external radiation field.
摘要翻译：本发明涉及在流体微系统中产生对流液体运动的方法。根据该方法，微系统中的液体同时暴露于电场和热梯度。电场通过经历时变电压的电极装置产生。以这种方式，在液体体积中形成时变电场。热梯度是通过位于室内的至少一个辐射吸收器产生的，其暴露于至少一个外部辐射场。

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