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1. 发明授权

US06291165B1 Shuffling of heterologous DNA sequences 失效
标题翻译：改组异源DNA序列
公开(公告)号：US06291165B1
公开(公告)日：2001-09-18
申请号：US09040025
申请日：1998-03-17
申请人： Torben Vedel Borchert , Titus Kretzschmar , Joel R. Cherry
发明人： Torben Vedel Borchert , Titus Kretzschmar , Joel R. Cherry
IPC分类号： C12Q168
CPC分类号： C12N15/1027
摘要： The present invention relates to a new method of shuffling especially heterologous polynucleotide sequences, screening and/or selection of new recombinant proteins resulting therefrom having a desired biological activity, and especially to production and identification of novel proteases exhibiting desired properties.
摘要翻译：本发明涉及一种混合洗涤方法，特别是异源多核苷酸序列，筛选和/或选择由此产生的新的重组蛋白质具有所需的生物学活性，特别是涉及产生和鉴定出具有所需性质的新型蛋白酶。

2. 发明授权

US6159688A Methods of producing polynucleotide variants 失效
公开(公告)号：US6159688A
公开(公告)日：2000-12-12
申请号：US40698
申请日：1998-03-18
申请人： Torben Vedel Borchert , Titus Kretzschmar , Joel R. Cherry , Jesper Vind
发明人： Torben Vedel Borchert , Titus Kretzschmar , Joel R. Cherry , Jesper Vind
IPC分类号： C12N9/20 , C12N9/28 , C12N9/56 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1093 , C12N9/20 , C12N9/2417 , C12N9/54 , C12N15/1027
摘要： A method for the construction of a library of recombined polynucleotides from a number of different starting single or double stranded parental DNA templates is disclosed, wherein the starting single or double stranded parental DNA templates represent discrete points in a population of genes encoding evolutionary or synthetic homologues of a peptide having homologies ranging over a broad spectrum from less than 15% to more than 80%, said population exhibiting at least one identification sequence, and whereby said genes are subjected to a gene shuffling procedure to generate shuffled mutants of said population of genes representing additional discrete points between those of said starting templates.

3. 发明授权

US06368805B1 Methods of producing polynucleotide variants 失效
标题翻译：产生多核苷酸变体的方法
公开(公告)号：US06368805B1
公开(公告)日：2002-04-09
申请号：US09644953
申请日：2000-08-23
申请人： Torben Vedel Borchert , Titus Kretzschmar , Joel R. Cherry , Vind Jesper
发明人： Torben Vedel Borchert , Titus Kretzschmar , Joel R. Cherry , Vind Jesper
IPC分类号： C12Q168
CPC分类号： C12N15/1093 , C12N9/20 , C12N9/2417 , C12N9/54 , C12N15/1027
摘要： A method for the construction of a library of recombined polynucleotides from a number of different starting single or double stranded parental DNA templates is disclosed, wherein the starting single or double stranded parental DNA templates represent discrete points in a population of genes encoding evolutionary or synthetic homologues of a peptide having homologies ranging over a broad spectrum from less than 15% to more than 80%, said population exhibiting at least one identification sequence, and whereby said genes are subjected to a gene shuffling procedure to generate shuffled mutants of said population of genes representing additional discrete points between those of said starting templates.
摘要翻译：公开了从许多不同的起始单链或双链亲本DNA模板构建重组多核苷酸文库的方法，其中起始单链或双链亲本DNA模板代表编码进化或合成同源物的基因群体中的离散点具有在小于15％至大于80％的广谱范围内的同源性的肽，所述群体显示至少一种鉴定序列，并且其中所述基因经历基因改组程序以产生所述基因群体的混洗突变体代表所述起始模板之间的额外离散点。

4. 发明授权

US08329886B2 Nucleic acid molecules encoding anti-amyloid beta antibodies 有权
标题翻译：编码抗淀粉样β抗体的核酸分子
公开(公告)号：US08329886B2
公开(公告)日：2012-12-11
申请号：US13472781
申请日：2012-05-16
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
IPC分类号： C07H21/00
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译：本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

5. 发明授权

US07157262B2 Lipolytic enzymes 失效
标题翻译：脂肪分解酶
公开(公告)号：US07157262B2
公开(公告)日：2007-01-02
申请号：US10232544
申请日：2002-08-30
申请人： Claus Crone Fuglsang , Jens Sigurd Okkels , Dorte Aaby Petersen , Shamkant Anant Patkar , Marianne Thellersen , Allan Svendsen , Kim Borch , John C. Royer , Titus Kretzschmar , Torben Halkier , Jesper Vind , Steen Troels Jorgensen
发明人： Claus Crone Fuglsang , Jens Sigurd Okkels , Dorte Aaby Petersen , Shamkant Anant Patkar , Marianne Thellersen , Allan Svendsen , Kim Borch , John C. Royer , Titus Kretzschmar , Torben Halkier , Jesper Vind , Steen Troels Jorgensen
IPC分类号： C12N9/20 , C12N9/16 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to a modified enzyme with lipolytic activity, a lipolytic enzyme capable of removing a substantial amount of fatty matter during a one cycle wash, a DNA sequence encoding said enzymes, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said enzymes with lipolytic activity.
摘要翻译：本发明涉及具有脂肪分解活性的修饰酶，能够在一次循环洗涤期间除去大量脂肪物质的脂肪分解酶，编码所述酶的DNA序列，包含所述DNA序列的载体，携带所述DNA的宿主细胞序列或所述载体，以及用于产生具有脂肪分解活性的所述酶的方法。

6. 发明授权

US06495357B1 Lipolytic enzymes 失效
标题翻译：脂肪分解酶
公开(公告)号：US06495357B1
公开(公告)日：2002-12-17
申请号：US09007288
申请日：1998-01-14
申请人： Claus Crone Fuglsang , Jens Sigurd Okkels , Dorte Aaby Petersen , Shamkant Anant Patkar , Marianne Thellersen , Allan Svendsen , Kim Borch , John C. Royer , Titus Kretzschmar , Torben Halkier , Jesper Vind , Steen Troels Jorgensen
发明人： Claus Crone Fuglsang , Jens Sigurd Okkels , Dorte Aaby Petersen , Shamkant Anant Patkar , Marianne Thellersen , Allan Svendsen , Kim Borch , John C. Royer , Titus Kretzschmar , Torben Halkier , Jesper Vind , Steen Troels Jorgensen
IPC分类号： C12N920
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to a modified enzyme with lipolytic activity, a lipolytic enzime capable of removing a substantial amount of fatty matter a one cycle wash, a DNA sequence encoding said enzymes, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said enzymes with lipolytic activity.
摘要翻译：本发明涉及一种具有脂肪分解活性的修饰酶，能够一周期洗涤大量脂肪物质的脂肪分解酶，编码所述酶的DNA序列，包含所述DNA序列的载体，携带所述DNA序列的宿主细胞或所述载体，以及用于产生具有脂肪分解活性的所述酶的方法。

7. 发明申请

US20120225478A1 ANTI-AMYLOID BETA ANTIBODIES AND THEIR USE 有权
标题翻译：抗氨基酸抗体和其使用
公开(公告)号：US20120225478A1
公开(公告)日：2012-09-06
申请号：US13472781
申请日：2012-05-16
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
IPC分类号： C12N5/10 , C12N15/63 , C12N15/64 , C12N15/13
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译：本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

8. 发明授权

US08216577B2 Anti-Aβ antibodies and their use 有权
标题翻译：反A＆BGR 抗体及其用途
公开(公告)号：US08216577B2
公开(公告)日：2012-07-10
申请号：US12462119
申请日：2009-07-28
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译：本发明涉及能够特异性识别β-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含如SEQ ID NO：2所示的氨基酸序列VHHQKLVFFAEDVG或其片段。此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

9. 发明授权

US06653068B2 Generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs 有权
标题翻译：生成与基因组DNA片段或EST编码的（多）肽结合的特异性结合配偶体
公开(公告)号：US06653068B2
公开(公告)日：2003-11-25
申请号：US09795872
申请日：2001-02-28
申请人： Christian Frisch , Titus Kretzschmar , Adolf Höss , Thomas Von Rüden
发明人： Christian Frisch , Titus Kretzschmar , Adolf Höss , Thomas Von Rüden
IPC分类号： C12Q170
CPC分类号： C40B40/02 , C07K16/1018 , C07K16/2845 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C12N15/1037
摘要： The present invention relates to the generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs. The (poly)peptides are expressed as part of fusion proteins which are forming inclusion bodies on expression in host cells. The inclusion bodies are used to generate binding partners which bind specifically to said (poly)peptides. The specific binding partners, in particular immunoglobulins or fragments thereof, are useful for analysis and functional characterization of proteins encoded by nucleic acid sequences comprising the corresponding genomic DNA fragments or ESTs. The invention further relates to nucleic acid molecules, vectors and host cells to be used in the methods of the present invention. The invention further relates to the use of fusion proteins comprising the first N-terminal domain of the geneIII protein of filamentous phage as fusion partner for the expression of a (poly)peptide/protein fused to said fusion partner, and to methods for the expression of (poly)peptide/proteins.
摘要翻译：本发明涉及与由基因组DNA片段或EST编码的（多）肽结合的特异性结合配偶体的产生。（多）肽被表达为在宿主细胞中在表达上形成包涵体的融合蛋白的一部分。包涵体用于产生特异性结合所述（多）肽的结合配偶体。特异性结合配偶体，特别是免疫球蛋白或其片段，可用于由包含相应基因组DNA片段或EST的核酸序列编码的蛋白质的分析和功能表征。本发明还涉及用于本发明方法的核酸分子，载体和宿主细胞。本发明还涉及包含丝状噬菌体的基因III蛋白的第一N末端结构域的融合蛋白在与所述融合伴侣融合的（多）肽/蛋白质的表达的融合伴侣中的用途，以及表达方法的（多）肽/蛋白质。

10. 发明授权

US07794719B2 Anti-amyloid β antibodies 有权
标题翻译：抗淀粉样蛋白抗体
公开(公告)号：US07794719B2
公开(公告)日：2010-09-14
申请号：US10505313
申请日：2003-02-20
申请人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
发明人： Michael Bardroff , Bernd Bohrmann , Manfred Brockhaus , Walter Huber , Titus Kretzschmar , Hansruedi Loetscher , Corinna Löhning , Christer Nordstedt , Christine Rothe
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译：本发明涉及能够特异性识别R-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含氨基酸酸序列VHHQKLVFFAEDVG，如SEQ ID NO：2所示或其片段。此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

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