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1. 发明授权

US06653068B2 Generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs 有权
标题翻译：生成与基因组DNA片段或EST编码的（多）肽结合的特异性结合配偶体
公开(公告)号：US06653068B2
公开(公告)日：2003-11-25
申请号：US09795872
申请日：2001-02-28
申请人： Christian Frisch , Titus Kretzschmar , Adolf Höss , Thomas Von Rüden
发明人： Christian Frisch , Titus Kretzschmar , Adolf Höss , Thomas Von Rüden
IPC分类号： C12Q170
CPC分类号： C40B40/02 , C07K16/1018 , C07K16/2845 , C07K2317/34 , C07K2317/622 , C07K2319/00 , C12N15/1037
摘要： The present invention relates to the generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs. The (poly)peptides are expressed as part of fusion proteins which are forming inclusion bodies on expression in host cells. The inclusion bodies are used to generate binding partners which bind specifically to said (poly)peptides. The specific binding partners, in particular immunoglobulins or fragments thereof, are useful for analysis and functional characterization of proteins encoded by nucleic acid sequences comprising the corresponding genomic DNA fragments or ESTs. The invention further relates to nucleic acid molecules, vectors and host cells to be used in the methods of the present invention. The invention further relates to the use of fusion proteins comprising the first N-terminal domain of the geneIII protein of filamentous phage as fusion partner for the expression of a (poly)peptide/protein fused to said fusion partner, and to methods for the expression of (poly)peptide/proteins.
摘要翻译：本发明涉及与由基因组DNA片段或EST编码的（多）肽结合的特异性结合配偶体的产生。（多）肽被表达为在宿主细胞中在表达上形成包涵体的融合蛋白的一部分。包涵体用于产生特异性结合所述（多）肽的结合配偶体。特异性结合配偶体，特别是免疫球蛋白或其片段，可用于由包含相应基因组DNA片段或EST的核酸序列编码的蛋白质的分析和功能表征。本发明还涉及用于本发明方法的核酸分子，载体和宿主细胞。本发明还涉及包含丝状噬菌体的基因III蛋白的第一N末端结构域的融合蛋白在与所述融合伴侣融合的（多）肽/蛋白质的表达的融合伴侣中的用途，以及表达方法的（多）肽/蛋白质。

2. 发明授权

US09133500B2 Screening strategies for the identification of binders 有权
标题翻译：用于鉴定粘合剂的筛选策略
公开(公告)号：US09133500B2
公开(公告)日：2015-09-15
申请号：US13379680
申请日：2010-08-06
申请人： Christian Frisch , Achim Knappik , Alex Y. Strongin , Sergey A. Shiryaev
发明人： Christian Frisch , Achim Knappik , Alex Y. Strongin , Sergey A. Shiryaev
IPC分类号： C12Q1/70 , C12Q1/37 , A61K39/395 , C07K14/005 , C07K16/10 , C07K16/40
CPC分类号： C12Q1/37 , C07K14/005 , C07K16/1081 , C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/33 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2770/24122 , G01N2333/185 , G01N2333/95 , G01N2500/04
摘要： The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.
摘要翻译：本发明公开了鉴定靶向酶抗原活性位点的粘合剂的新颖筛选策略。本发明还公开了结合西尼罗病毒NS2B-NS3蛋白酶的抗原结合部分，特别是与活性部位结合的结合物，从而抑制蛋白酶的酶活性。本发明的抗原结合部分具有许多治疗和诊断应用。

3. 发明申请

US20120178909A1 Novel Screening Strategies for the Identification of Binders 有权
标题翻译：用于鉴定粘结剂的新型筛选策略
公开(公告)号：US20120178909A1
公开(公告)日：2012-07-12
申请号：US13379680
申请日：2010-08-06
申请人： Christian Frisch , Achim Knappik , Alex Y. Strongin , Sergey A. Shiryaev
发明人： Christian Frisch , Achim Knappik , Alex Y. Strongin , Sergey A. Shiryaev
IPC分类号： C40B30/04 , C07K1/14 , C07K16/00
CPC分类号： C12Q1/37 , C07K14/005 , C07K16/1081 , C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/33 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2770/24122 , G01N2333/185 , G01N2333/95 , G01N2500/04
摘要： The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.
摘要翻译：本发明公开了鉴定靶向酶抗原活性位点的粘合剂的新颖筛选策略。本发明还公开了结合西尼罗病毒NS2B-NS3蛋白酶的抗原结合部分，特别是与活性部位结合的结合物，从而抑制蛋白酶的酶活性。本发明的抗原结合部分具有许多治疗和诊断应用。

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