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    • 3. 发明授权
      US07390642B2 Salutaridinol 7-O-acetyltransferase and derivatives thereof 失效
    • Salutaridinol 7-O-acetyltransferase and derivatives thereof
    • salutaridinol 7-O-乙酰转移酶及其衍生物
    • US07390642B2
    • 2008-06-24
    • US10167603
    • 2002-06-11
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • C12N15/54 , C12N9/10
    • C12N9/1029 , C12N15/8243 , C12P17/188 , C12Y203/0115
    • This invention provides: (A) a protein the sequence of which is in FIG. 8 (SEQ. ID n° 14), or a fragment thereof having at least 15 amino acids, or a variant thereof, having at least 70% identity with FIG. 8 (SEQ. ID n° 14) over a length of at least 400 amino acids; (B) a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase of at least 6 consecutive amino acids not present in other plant acetyltransferases as in FIG. 2 (SEQ. IDs n° 8 to 12); (C) a nucleic acid (i) the sequence of which is in FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15), or (ii) a fragment thereof of at least 45 nucleotides, or (iii) a variant thereof, having at least 70% identity with FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15) over a length of at least 1200 bases, or (iv) a sequence complementary to (i), (ii) or (iii); or (v) the RNA equivalent of any of (i), (ii), or (iii); (D) a nucleic acid comprising a fragment of a salutaridinol 7-O-acetyltransferase gene of at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene from the 5′ or 3′ untranslated regions in FIG. 9 (SEQ. ID n° 13), or a sequence complementary thereto. This invention also provides methods for producing pentacyclic morphinan alkaloids and thebaine.
    • 本发明提供：（A）其序列在图1中的蛋白质。 8（SEQ ID NO 14）或其具有至少15个氨基酸的片段，或其变体与图1至少具有70％的同一性。 8（SEQ ID NO：14），长度至少为400个氨基酸; （B）包含不存在于如图1所示的其它植物乙酰转移酶中的至少6个连续氨基酸的salutaridinol 7-O-乙酰转移酶片段的肽。 2（SEQ ID NO 8至12）; （C）核酸（i）其序列在图1中。 9（SEQ ID NO：13）或图9。 10（SEQ ID NO：15），或（ii）至少45个核苷酸的片段，或（iii）其变体与图1至少具有70％的同一性。 9（SEQ ID NO：13）或图9。 10（SEQ ID NO：15），长度至少为1200个碱基，或（iv）与（i），（ii）或（iii）互补的序列; 或（v）（i），（ii）或（iii）中任何一种的RNA当量; （D）包含图5中5'或3'非翻译区的salutaridinol 7-O-乙酰转移酶基因独特的至少18个连续核苷酸的salutaridinol 7-O-乙酰转移酶基因片段的核酸。 9（SEQ ID NO：13）或其互补序列。 本发明还提供了生产五环吗啡生物碱和蒂巴因的方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 5. 发明申请
      US20090053764A1 Salutaridinol 7-0-Acetyltransferase and Derivatives Thereof 有权
    • Salutaridinol 7-0-Acetyltransferase and Derivatives Thereof
    • US20090053764A1
    • 2009-02-26
    • US12121280
    • 2008-05-15
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • C12P21/06 , C12N9/10 , C07H21/04 , C12N5/10 , C12N1/19
    • C12N9/1029 , C12N15/8243 , C12P17/188 , C12Y203/0115
    • This invention provides a protein comprising consecutive amino acids, the amino acid sequence of which is illustrated in FIG. 8 (SEQ. ID No. 14) or, a fragment thereof having at least 15 amino acids, or a variant thereof, the sequence of which has at least 70% identity with the amino acid sequence of FIG. 8 (SEQ. ID No. 14) over a length of at least 400 amino acids. This invention further provides a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase protein of at least 6 consecutive amino acids which is not present in other plant acetyltransferases as illustrated in FIG. 2 (SEQ. IDs No. 8 to 12). This invention further provides a nucleic acid molecule comprising consecutive nucleotides (i) the nucleic acid sequence of which is illustrated in FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15), or (ii) a fragment thereof having a length of at least 45 nucleotides, or (iii) a variant thereof, the sequence of which has at least 70% identity with the sequence of FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15) over a length of at least 1200 bases, or a sequence complementary to (i), (ii) or (iii), or the RNA equivalent of any of (i), (ii), or (iii). This invention further provides a nucleic acid molecule comprising a fragment of a salutaridinol 7-O-acetyltransferase gene, at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene and being chosen from the 5′ or 3′ untranslated regions of the sequence illustrated in FIG. 9 (SEQ. ID No. 13), or a sequence which is complementary thereto. This invention further provides a method for producing pentacyclic morphinan alkaloids comprising (i) introducing a nucleic acid molecule encoding salutaridinol 7-O-acetyltransferase into a plant cell capable of expressing salutaridinol and/or salutaridine and/or (R)-reticuline, (ii) propagating said plant cell to produce a multiplicity of morphinan-producing cells, and (iii) recovering said morphinan(s) from said multiplicity of cells. This invention further provides a method for the production of thebaine comprising the steps of (i) contacting in vitro a protein having salutaridinol 7-O-acetyltransferase activity with salutaridinol and acetyl co-enzyme A at pH 8 to 9, and (ii) recovering the thebaine thus produced.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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