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    • 2. 发明申请
      US20090053764A1 Salutaridinol 7-0-Acetyltransferase and Derivatives Thereof 有权
    • Salutaridinol 7-0-Acetyltransferase and Derivatives Thereof
    • US20090053764A1
    • 2009-02-26
    • US12121280
    • 2008-05-15
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • C12P21/06 , C12N9/10 , C07H21/04 , C12N5/10 , C12N1/19
    • C12N9/1029 , C12N15/8243 , C12P17/188 , C12Y203/0115
    • This invention provides a protein comprising consecutive amino acids, the amino acid sequence of which is illustrated in FIG. 8 (SEQ. ID No. 14) or, a fragment thereof having at least 15 amino acids, or a variant thereof, the sequence of which has at least 70% identity with the amino acid sequence of FIG. 8 (SEQ. ID No. 14) over a length of at least 400 amino acids. This invention further provides a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase protein of at least 6 consecutive amino acids which is not present in other plant acetyltransferases as illustrated in FIG. 2 (SEQ. IDs No. 8 to 12). This invention further provides a nucleic acid molecule comprising consecutive nucleotides (i) the nucleic acid sequence of which is illustrated in FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15), or (ii) a fragment thereof having a length of at least 45 nucleotides, or (iii) a variant thereof, the sequence of which has at least 70% identity with the sequence of FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15) over a length of at least 1200 bases, or a sequence complementary to (i), (ii) or (iii), or the RNA equivalent of any of (i), (ii), or (iii). This invention further provides a nucleic acid molecule comprising a fragment of a salutaridinol 7-O-acetyltransferase gene, at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene and being chosen from the 5′ or 3′ untranslated regions of the sequence illustrated in FIG. 9 (SEQ. ID No. 13), or a sequence which is complementary thereto. This invention further provides a method for producing pentacyclic morphinan alkaloids comprising (i) introducing a nucleic acid molecule encoding salutaridinol 7-O-acetyltransferase into a plant cell capable of expressing salutaridinol and/or salutaridine and/or (R)-reticuline, (ii) propagating said plant cell to produce a multiplicity of morphinan-producing cells, and (iii) recovering said morphinan(s) from said multiplicity of cells. This invention further provides a method for the production of thebaine comprising the steps of (i) contacting in vitro a protein having salutaridinol 7-O-acetyltransferase activity with salutaridinol and acetyl co-enzyme A at pH 8 to 9, and (ii) recovering the thebaine thus produced.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 3. 发明授权
      US07390642B2 Salutaridinol 7-O-acetyltransferase and derivatives thereof 失效
    • Salutaridinol 7-O-acetyltransferase and derivatives thereof
    • salutaridinol 7-O-乙酰转移酶及其衍生物
    • US07390642B2
    • 2008-06-24
    • US10167603
    • 2002-06-11
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • Toni M. Kutchan , Meinhart H. Zenk , Torsten Grothe
    • C12N15/54 , C12N9/10
    • C12N9/1029 , C12N15/8243 , C12P17/188 , C12Y203/0115
    • This invention provides: (A) a protein the sequence of which is in FIG. 8 (SEQ. ID n° 14), or a fragment thereof having at least 15 amino acids, or a variant thereof, having at least 70% identity with FIG. 8 (SEQ. ID n° 14) over a length of at least 400 amino acids; (B) a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase of at least 6 consecutive amino acids not present in other plant acetyltransferases as in FIG. 2 (SEQ. IDs n° 8 to 12); (C) a nucleic acid (i) the sequence of which is in FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15), or (ii) a fragment thereof of at least 45 nucleotides, or (iii) a variant thereof, having at least 70% identity with FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15) over a length of at least 1200 bases, or (iv) a sequence complementary to (i), (ii) or (iii); or (v) the RNA equivalent of any of (i), (ii), or (iii); (D) a nucleic acid comprising a fragment of a salutaridinol 7-O-acetyltransferase gene of at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene from the 5′ or 3′ untranslated regions in FIG. 9 (SEQ. ID n° 13), or a sequence complementary thereto. This invention also provides methods for producing pentacyclic morphinan alkaloids and thebaine.
    • 本发明提供：（A）其序列在图1中的蛋白质。 8（SEQ ID NO 14）或其具有至少15个氨基酸的片段，或其变体与图1至少具有70％的同一性。 8（SEQ ID NO：14），长度至少为400个氨基酸; （B）包含不存在于如图1所示的其它植物乙酰转移酶中的至少6个连续氨基酸的salutaridinol 7-O-乙酰转移酶片段的肽。 2（SEQ ID NO 8至12）; （C）核酸（i）其序列在图1中。 9（SEQ ID NO：13）或图9。 10（SEQ ID NO：15），或（ii）至少45个核苷酸的片段，或（iii）其变体与图1至少具有70％的同一性。 9（SEQ ID NO：13）或图9。 10（SEQ ID NO：15），长度至少为1200个碱基，或（iv）与（i），（ii）或（iii）互补的序列; 或（v）（i），（ii）或（iii）中任何一种的RNA当量; （D）包含图5中5'或3'非翻译区的salutaridinol 7-O-乙酰转移酶基因独特的至少18个连续核苷酸的salutaridinol 7-O-乙酰转移酶基因片段的核酸。 9（SEQ ID NO：13）或其互补序列。 本发明还提供了生产五环吗啡生物碱和蒂巴因的方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 6. 发明申请
      US20130338219A1 Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them 有权
    • Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them
    • 萜类螺旋酮化合物与LXR激动剂的活性，它们的用途和配方
    • US20130338219A1
    • 2013-12-19
    • US13994447
    • 2011-12-08
    • Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
    • Torsten Grothe , Marc Stadler , Bärbel Köpcke , Ernst Roemer , Jens Bitzer , Philipp Wabnitz , Thomas Küper
    • C07D471/10
    • C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
    • The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.
    • 本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。 使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。 治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。 本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。 它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。 它们也可以用于非治疗性的，例如， 化妆品，用途。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 7. 发明申请
      US20110213026A1 EXTRACTS WITH LIVER-X-RECEPTOR MODULATORS, COMPOUNDS AND THEIR USE ESPECIALLY IN WEIGHT CONTROL 审中-公开
    • EXTRACTS WITH LIVER-X-RECEPTOR MODULATORS, COMPOUNDS AND THEIR USE ESPECIALLY IN WEIGHT CONTROL
    • 与肝脏受体调节剂，化合物及其在体重控制中特别有用的提取物
    • US20110213026A1
    • 2011-09-01
    • US12673655
    • 2008-07-29
    • Torsten Grothe , Ernst Roemer , Thomas Henkel
    • Torsten Grothe , Ernst Roemer , Thomas Henkel
    • A61K31/36 , A61K31/09 , C07C43/23 , C07D317/70 , C07D493/04 , A61P3/04
    • A61K31/36 , A61K31/085 , A61K31/09 , A61K31/215 , A61K31/222 , A61K31/343 , A61K36/57 , A61K36/79
    • The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra, Illicium, Kadsura, Steganotaenia and Magnolia, alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament for the treatment of obesity, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in the regulation of body weight and/or fat loss and/or for the management of obesity.
    • 本发明涉及分别使用来自植物或植物部分的提取物和/或一种或多种天然化合物的用途或方法（特别是关于动物，特别是人类） ，选自五味子，Illicium，Kadsura，Steganotaenia和Magnolia的属，单独或作为补充作为活性成分，用于调节体重和/或脂肪减少和/或用于肥胖的管理， 人或动物使用所述提取物和/或天然化合物或混合物来制造用于调节体重和/或脂肪损失的药物或营养制剂，和/或用于肥胖的管理 在人类或动物中。 上述提取物和/或化合物还可用于减少受试者中的一种或多种不利代谢参数。 本发明还涉及用于治疗或制备用于治疗肥胖症的药物及其制备的所述提取物和/或化合物。 它还涉及包含可用于调节体重和/或脂肪减少和/或用于肥胖的管理的所述提取物和/或天然化合物的药物或营养制剂。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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