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1. 发明授权

US07193127B1 Codeinone reductase from alkaloid poppy 失效
标题翻译：来自生物碱罂粟素的苦参碱还原酶
公开(公告)号：US07193127B1
公开(公告)日：2007-03-20
申请号：US09937665
申请日：2000-03-24
申请人： Toni M. Kutchan , Meinhard H. Zenk , David G. Atkins , Anthony J. Fist
发明人： Toni M. Kutchan , Meinhard H. Zenk , David G. Atkins , Anthony J. Fist
IPC分类号： C12N15/29 , C12N15/52 , C12N15/63 , C12N15/82 , A01H1/00
CPC分类号： C12N9/0006 , C12N15/8243
摘要： The present invention concerns codeinone reductase from alkaloid poppy plants, the polynucleotides encoding the enzyme, transgenic plants transformed or transfected with polynucleotide(s) encoding codeinone reductase and to the production of alkaloids from transformed or transfected poppy plants.
摘要翻译：本发明涉及来自生物碱罂粟植物的代码依赖因子还原酶，编码该酶的多核苷酸，用编码费辛酮还原酶的多核苷酸转化或转染的转基因植物以及从转化或转化的罂粟植物生产生物碱。

2. 发明授权

US07037674B1 Cytochrome P450 reductases from poppy plants 失效
公开(公告)号：US07037674B1
公开(公告)日：2006-05-02
申请号：US09486757
申请日：1998-08-28
申请人： Toni M. Kutchan , Meinhart H. Zenk , David G. Atkins , Anthony J. Fist
发明人： Toni M. Kutchan , Meinhart H. Zenk , David G. Atkins , Anthony J. Fist
IPC分类号： C12P21/06 , C12N15/82 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12N9/0042 , C12N15/8205 , C12N15/8243
摘要： The present invention relates to production of alkaloids from poppy plants and in particular togenes encoding enzymes in the alkaloid pathway, to proteins encoded by the gens, to plants transformed or transfected with the genes and to methods of altering alkaloid content or blend of poppy plants.

3. 发明授权

US07355035B1 Catalytic molecules 失效
标题翻译：催化分子
公开(公告)号：US07355035B1
公开(公告)日：2008-04-08
申请号：US09889075
申请日：2000-01-11
申请人： David G. Atkins , Andrew R. Baker , Levon Michael Khachigian
发明人： David G. Atkins , Andrew R. Baker , Levon Michael Khachigian
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/113 , A61L31/10 , A61L33/0047 , C12N2310/12 , C12N2310/317 , C08L89/00
摘要： The present invention relates to DNAzymes which are targeted against mRNA molecules encoding EGR-1 (also known as Egr-1 and NGFI-A). The present invention also relates to compositions including these DNAzymes and to methods of treatment involving administration of the DNAzymes.
摘要翻译：本发明涉及针对编码EGR-1（也称为Egr-1和NGFI-A）的mRNA分子靶向的DNA酶。本发明还涉及包含这些DNA酶的组合物和涉及DNA酶的施用的治疗方法。

4. 发明授权

US06451603B1 Ribozyme nucleic acids and methods of use thereof for controlling viral pathogens 失效
标题翻译：核酶核酸及其用于控制病毒病原体的方法
公开(公告)号：US06451603B1
公开(公告)日：2002-09-17
申请号：US08362478
申请日：1995-03-02
申请人： David G. Atkins , Wayne L. Gerlach , Mark J. Young
发明人： David G. Atkins , Wayne L. Gerlach , Mark J. Young
IPC分类号： C07H2104
CPC分类号： C12N15/8283
摘要： The invention consists of a non-naturally occurring nucleic acid molecule capable of blocking or interfering with a replicative intermediate of a virus, a virusoid, or a viroid. The nucleic acid molecule may contain a ribozyme or a plurality of ribozymes. Alternatively, the nucleic acid molecule may be an antisense nucleic acid molecule. The ribozyme may be a hairpin ribozyme, a hammerhead ribozyme, an RNAase P ribozyme, a minizyme, or other catalytic RNA molecule. The virus may be an animal, a mammalian, a plant, a fungal, a protozoan, a yeast, a bacterial virus, or a human virus. The nucleic acid molecule may be expressed in the cell or it may be preformed and administered ex vivo. The present invention contemplates methods of controlling infection of a pathogenic infectious agent in a plant or animal.
摘要翻译：本发明由能够阻断或干扰病毒，病毒样或病毒的复制中间体的非天然存在的核酸分子组成。核酸分子可以含有核酶或多个核酶。或者，核酸分子可以是反义核酸分子。核酶可以是发夹核酶，锤头核酶，RNA酶P核酶，微型酶或其它催化RNA分子。病毒可以是动物，哺乳动物，植物，真菌，原生动物，酵母，细菌病毒或人类病毒。核酸分子可以在细胞中表达，或者其可以预先形成并且离体施用。本发明考虑了控制植物或动物中病原体感染因子感染的方法。

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