专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4532211A Coliform bacillus having a gene for the production of staphylokinase and a process for production of staphylokinase therewith 失效
标题翻译：具有葡萄球菌激酶生产基因的大肠菌杆菌及其生产葡萄球菌激酶的方法
公开(公告)号：US4532211A
公开(公告)日：1985-07-30
申请号：US434503
申请日：1982-10-15
申请人： Tomoyuki Sako , Saeko Sawaki , Toshizo Sakurai , Masahiko Mutai , Isamu Kondo
发明人： Tomoyuki Sako , Saeko Sawaki , Toshizo Sakurai , Masahiko Mutai , Isamu Kondo
IPC分类号： C12N1/21 , C07K14/31 , C12N1/20 , C12N9/52 , C12N15/09 , C12R1/19 , C12R1/92 , C12P21/00 , C07H21/04 , C12N1/00 , C12N9/48 , C12N9/50 , C12N15/00 , C12P21/02 , C12P21/04
CPC分类号： C07K14/31
摘要： Novel coliform bacillus useful for industrial production of staphylokinase, a fibrinolytic enzyme, and process for the production of staphylokinase using said microbe are provided. The novel microbe comprises a recombinant DNA, carrying genetic information for the production of staphylokinase, said genetic information being DNA derived from a temperate phage DNA of Staphylococcus aureus.
摘要翻译：提供了可用于工业生产葡萄球菌激酶，纤维蛋白溶解酶的新型大肠杆菌，以及使用所述微生物生产葡萄球菌激酶的方法。该新型微生物包含重组DNA，携带用于产生葡萄球菌激酶的遗传信息，所述遗传信息是衍生自金黄色葡萄球菌的温带噬菌体DNA的DNA。

2. 发明授权

US06319692B1 Methods for transferring gene into chromosome 有权
标题翻译：将基因转入染色体的方法
公开(公告)号：US06319692B1
公开(公告)日：2001-11-20
申请号：US09202893
申请日：1998-12-22
申请人： Mariko Kadota , Mayumi Kiwaki , Saeko Sawaki , Yukio Shirasawa , Harue Sone , Tomoyuki Sako
发明人： Mariko Kadota , Mayumi Kiwaki , Saeko Sawaki , Yukio Shirasawa , Harue Sone , Tomoyuki Sako
IPC分类号： C12P1934
CPC分类号： C12N15/907 , C12N15/746 , C12N15/90
摘要： Methods for transferring a foreign gene into a host chromosome by integrating the foreign gene into a vector by utilizing a lysogenic phage, for the purpose of deleting unnecessary genes derived from the vector, except for the foreign gene. One method comprises (a) preparing a vector with a lysogenic phage integration site (such as an attP site) arranged between a first partial sequence of the objective foreign gene to be transferred, but lacking one terminal region thereof and a second partial sequence of the gene, but lacking the other terminal region, the second partial sequence having an overlapping region with a portion of the first partial sequence; (b) integrating the vector obtained in step (a) into the host chromosome; and (c) screening from among the recombinants obtained in step (b) a recombinant from which unnecessary genes originating in the vector have been deleted owing to the homologous recombination mechanism functioning in the overlapping region between the first and second partial sequences.
摘要翻译：通过利用溶源性噬菌体将外源基因整合到载体中，为了除去外来基因以外的来自载体的不必要的基因，将外源基因转移到宿主染色体中的方法。一种方法包括（a）制备载体，该载体具有排列在要转移的目标外源基因的第一部分序列之间，但缺少其一个末端区域和第二部分序列的溶源性噬菌体整合位点（例如attP位点）基因，但缺少另一个末端区域，第二部分序列与第一部分序列的一部分具有重叠区域; （b）将步骤（a）中获得的载体整合到宿主染色体中; 和（c）从步骤（b）中获得的重组体中筛选来自该载体的不必要的基因由于第一和第二部分序列之间的重叠区域中的同源重组机制起作用而被缺失的重组体。

3. 发明申请

US20120021418A1 GENE THAT IMPARTS OXYGEN RESISTANCE AND APPLICATION THEREOF 审中-公开
标题翻译：这意味着耐氧性和应用的基因
公开(公告)号：US20120021418A1
公开(公告)日：2012-01-26
申请号：US12995296
申请日：2009-06-12
申请人： Masaki Serata , Tomoyuki Sako
发明人： Masaki Serata , Tomoyuki Sako
IPC分类号： C12Q1/68 , C12N15/74 , C12N1/21 , A23L2/52 , C07H21/04 , C40B40/08 , A23L1/29 , C12N15/53 , C12N15/63
CPC分类号： C12Y118/01002 , A23L33/135 , C12N9/0051 , C12N9/0095 , C12Y108/01009
摘要： To provide a gene useful for imparting oxygen resistance to a microorganism and use of the gene.The oxygen-resistance-imparting gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having the amino acid sequence of SEQ ID NO: 2 or 6; (b) a protein which has an amino acid sequence equivalent to the amino acid sequence of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits oxygen-resistance-imparting activity; and (c) a protein which has an amino acid sequence having an identity of 85% or higher to the amino acid sequence of (a), and which exhibits oxygen-resistance-imparting activity.
摘要翻译：提供可用于赋予微生物耐氧性和使用该基因的基因。编码选自以下蛋白质（a）〜（c）的蛋白质的耐氧性赋予基因：（a）具有SEQ ID NO：2或6的氨基酸序列的蛋白质; （b）具有与（a）的氨基酸序列相当的氨基酸序列的蛋白质，除了一至数个氨基酸残基被缺失，取代或添加，并且具有耐氧性赋予活性; 和（c）具有与（a）的氨基酸序列同一性为85％以上的氨基酸序列的蛋白质，其具有耐氧性赋予活性。

4. 发明授权

US08404823B2 Cytokine production regulator gene and use thereof 有权
标题翻译：细胞因子生产调节基因及其用途
公开(公告)号：US08404823B2
公开(公告)日：2013-03-26
申请号：US12447370
申请日：2007-10-26
申请人： Tomoyuki Sako , Emi Yasuda , Masaki Serata , Satoshi Matsumoto , Kan Shida
发明人： Tomoyuki Sako , Emi Yasuda , Masaki Serata , Satoshi Matsumoto , Kan Shida
IPC分类号： C07H21/02 , C12P1/00 , C12Q1/68 , C12N1/20 , C12N15/00 , C12N15/74 , C40B40/00
CPC分类号： C12N15/52 , A23L33/135 , A61K38/00 , C12N9/1048 , C12P19/04
摘要： The invention provides a gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having any of the amino acid sequences of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, and 108; (b) a protein which has an amino acid sequence equivalent to any of the amino acid sequences of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits cytokine production regulatory activity; and (c) a protein which has an amino acid sequence having 90% or higher identity to any of the amino acid sequences of (a), and which exhibits cytokine production regulatory activity, as well as a gene useful for regulating cytokine production and use of the gene.
摘要翻译：本发明提供了编码选自以下蛋白质（a）〜（c）的蛋白质的基因：（a）具有SEQ ID NO：2,4,6,8,10,12的任意氨基酸序列的蛋白质，14，16，82，84，86，88，90，92，94，96，98，100，102，104，106及108; （b）具有与（a）的任何氨基酸序列相同的氨基酸序列的蛋白质，除了一至数个氨基酸残基被缺失，取代或添加，并且其表现出细胞因子产生调节活性; 和（c）具有与（a）的任何氨基酸序列具有90％或更高同一性并且表现出细胞因子产生调节活性的氨基酸序列的蛋白质，以及可用于调节细胞因子产生和使用的基因的基因。

5. 发明授权

US5475089A Thrombolytic peptide, production thereof, and thrombolytic agent 失效
标题翻译：溶血肽，其制备和溶栓剂
公开(公告)号：US5475089A
公开(公告)日：1995-12-12
申请号：US75545
申请日：1993-06-14
申请人： Osamu Matsuo , Masashi Sakai , Kisaku Shimura , Hiroshi Sansawa , Tsunekazu Watanabe , Tsuneo Matsumoto , Yoshiyuki Shishido , Shusuke Hashimoto , Teruo Yokokura , Masaharu Onoue , Tomoyuki Sako
发明人： Osamu Matsuo , Masashi Sakai , Kisaku Shimura , Hiroshi Sansawa , Tsunekazu Watanabe , Tsuneo Matsumoto , Yoshiyuki Shishido , Shusuke Hashimoto , Teruo Yokokura , Masaharu Onoue , Tomoyuki Sako
IPC分类号： A61K38/46 , C07K14/31 , C12N9/52 , A61K38/43 , C07K14/00
CPC分类号： C07K14/31
摘要： A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.
摘要翻译： PCT No.PCT / JP91 / 01722 Sec。 371日期：1993年6月14日 102（e）日期1993年6月14日PCT 1991年12月17日PCT公布。出版物WO92 / 11356 日期：1992年7月9日。一种由136个氨基酸残基组成的血栓溶解肽，与葡萄球菌激酶（SAK）相比，其抗原性问题很小，仅有小剂量有效。通过使用胰蛋白酶蛋白酶切割不影响SAK活性的氨基酸或肽来获得该肽。特别地，通过在SAK的N末端切割由10个氨基酸残基构成的肽获得的SAK-11在纤维蛋白溶解，纤溶酶原激活和纤维蛋白特异性方面优于SAK。

6. 发明授权

US08379640B2 Internetwork device 有权
标题翻译：网络设备
公开(公告)号：US08379640B2
公开(公告)日：2013-02-19
申请号：US12816501
申请日：2010-06-16
申请人： Masataka Ichihashi , Shinji Katsume , Tomoyuki Sako
发明人： Masataka Ichihashi , Shinji Katsume , Tomoyuki Sako
IPC分类号： H04L12/28
CPC分类号： H04L47/10 , H04L29/12367 , H04L45/00 , H04L61/2514
摘要： An internetwork device comprises a receiving module, an inter-device packet transfer interface, an inter-device packet transfer controller, an address translation module, and a transmission module. The receiving module receives a packet from a first network. The inter-device packet transfer interface carries out inter-device packet transfer involving transfer of a packet to or from another internetwork device. The inter-device packet transfer controller controls the inter-device packet transfers such that multiple fragmented packets created from a same original packet are collected by the same internetwork device, the fragmented packets being packets created by dividing a single original packet into multiple parts. The address translation module translates between a local address used within a specific network and a global address used across multiple networks, for at least one of a source address and a destination address of a packet. The transmission module transmits an address-translated packet to a second network.
摘要翻译：互联网络设备包括接收模块，设备间分组传输接口，设备间分组传输控制器，地址转换模块和传输模块。接收模块从第一网络接收分组。设备间分组传送接口执行涉及将数据包传送到另一个互联网络设备的设备之间的传输。设备间分组传送控制器控制设备间分组传输，使得由同一原始分组创建的多个分片分组被相同的网络设备收集，分片分组是通过将单个原始分组划分成多个部分而创建的分组。地址转换模块在特定网络中使用的本地地址和跨多个网络使用的全局地址之间进行翻译，用于分组的源地址和目的地地址中的至少一个。传输模块将地址转换的分组发送到第二网络。

7. 发明申请

US20120329059A1 METHOD FOR CONSTRUCTING NOVEL BACTERIUM BELONGING TO THE GENUS BIFIDOBACTERIUM 有权
标题翻译：用于将新生细菌与乙型肝炎病毒相结合的方法
公开(公告)号：US20120329059A1
公开(公告)日：2012-12-27
申请号：US13577511
申请日：2011-02-21
申请人： Tomoyuki Sako , Mika Miura , Yasuhisa Shimakawa , Koji Miyazaki , Junji Fujimoto , Koichi Watanabe
发明人： Tomoyuki Sako , Mika Miura , Yasuhisa Shimakawa , Koji Miyazaki , Junji Fujimoto , Koichi Watanabe
IPC分类号： C12N1/20 , A23C9/12 , A23L1/30 , A23L2/52 , C07H21/04 , C12Q1/68
CPC分类号： C12R1/01 , A23C9/1234 , A23C9/1236 , A23L2/52 , A23L33/135 , A23Y2220/03 , A23Y2240/41 , A23Y2300/00 , A23Y2300/25 , A23Y2300/29 , C12N1/36 , C12Q1/689
摘要： A method for producing bacteria belonging to the genus Bifidobacterium having excellent viability even under various conditions with different environmental factors, novel bacteria belonging to the genus Bifidobacterium obtained by the method, and a method for detecting the bacteria are provided. By subculturing and storing bacteria belonging to the genus Bifidobacterium alternately in systems under conditions with different environmental factors, the bacteria belonging to the genus Bifidobacterium exhibiting excellent viability under all the conditions used for the alternate subculturing and storing can be produced.
摘要翻译：本发明提供了即使在不同环境因素的各种条件下也具有优异生存能力的双歧杆菌属细菌的生产方法，通过该方法获得的属于双歧杆菌属的新细菌，以及检测细菌的方法。通过在具有不同环境因素的条件下在系统中传代培养和存储属于双歧杆菌属的细菌，可以制备在用于替代传代培养和储存的所有条件下表现出优异活力的属于双歧杆菌属的细菌。

8. 发明授权

US08889120B2 Method for constructing novel bacterium belonging to the genus Bifidobacterium 有权
标题翻译：构建属于双歧杆菌属的新型细菌的方法
公开(公告)号：US08889120B2
公开(公告)日：2014-11-18
申请号：US13577511
申请日：2011-02-21
申请人： Tomoyuki Sako , Mika Miura , Yasuhisa Shimakawa , Koji Miyazaki , Junji Fujimoto , Koichi Watanabe
发明人： Tomoyuki Sako , Mika Miura , Yasuhisa Shimakawa , Koji Miyazaki , Junji Fujimoto , Koichi Watanabe
IPC分类号： C12R1/01 , A23L2/52 , C12N1/36 , A23L1/30 , A23C9/123 , C12Q1/68
CPC分类号： C12R1/01 , A23C9/1234 , A23C9/1236 , A23L2/52 , A23L33/135 , A23Y2220/03 , A23Y2240/41 , A23Y2300/00 , A23Y2300/25 , A23Y2300/29 , C12N1/36 , C12Q1/689
摘要： A method for producing bacteria belonging to the genus Bifidobacterium having excellent viability even under various conditions with different environmental factors, novel bacteria belonging to the genus Bifidobacterium obtained by the method, and a method for detecting the bacteria are provided. By subculturing and storing bacteria belonging to the genus Bifidobacterium alternately in systems under conditions with different environmental factors, the bacteria belonging to the genus Bifidobacterium exhibiting excellent viability under all the conditions used for the alternate subculturing and storing can be produced.
摘要翻译：本发明提供了即使在不同环境因素的各种条件下也具有优异生存能力的双歧杆菌属细菌的生产方法，通过该方法获得的属于双歧杆菌属的新细菌，以及检测细菌的方法。通过在具有不同环境因素的条件下在系统中传代培养和存储属于双歧杆菌属的细菌，可以制备在用于替代传代培养和储存的所有条件下表现出优异活力的属于双歧杆菌属的细菌。

9. 发明申请

US20100322247A1 INTERNETWORK DEVICE 有权
标题翻译：互联网设备
公开(公告)号：US20100322247A1
公开(公告)日：2010-12-23
申请号：US12816501
申请日：2010-06-16
申请人： Masataka ICHIHASHI , Shinji Katsume , Tomoyuki Sako
发明人： Masataka ICHIHASHI , Shinji Katsume , Tomoyuki Sako
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L29/12367 , H04L45/00 , H04L61/2514
摘要： An internetwork device comprises a receiving module, an inter-device packet transfer interface, an inter-device packet transfer controller, an address translation module, and a transmission module. The receiving module receives a packet from a first network. The inter-device packet transfer interface carries out inter-device packet transfer involving transfer of a packet to or from another internetwork device. The inter-device packet transfer controller controls the inter-device packet transfers such that multiple fragmented packets created from a same original packet are collected by the same internetwork device, the fragmented packets being packets created by dividing a single original packet into multiple parts. The address translation module translates between a local address used within a specific network and a global address used across multiple networks, for at least one of a source address and a destination address of a packet. The transmission module transmits an address-translated packet to a second network.
摘要翻译：互联网络设备包括接收模块，设备间分组传输接口，设备间分组传输控制器，地址转换模块和传输模块。接收模块从第一网络接收分组。设备间分组传送接口执行涉及将数据包传送到另一个互联网络设备的设备之间的传输。设备间分组传送控制器控制设备间分组传输，使得由同一原始分组创建的多个分片分组被相同的网络设备收集，分片分组是通过将单个原始分组划分成多个部分而创建的分组。地址转换模块在特定网络中使用的本地地址和跨多个网络使用的全局地址之间进行翻译，用于分组的源地址和目的地地址中的至少一个。传输模块将地址转换的分组发送到第二网络。

10. 发明申请

US20100144551A1 CYTOKINE PRODUCTION REGULATOR GENE AND USE THEREOF 有权
标题翻译：细胞因子生产调节因子基因及其用途
公开(公告)号：US20100144551A1
公开(公告)日：2010-06-10
申请号：US12447370
申请日：2007-10-26
申请人： Tomoyuki Sako , Emi Yasuda , Masaki Serata , Satoshi Matsumoto , Kan Shida
发明人： Tomoyuki Sako , Emi Yasuda , Masaki Serata , Satoshi Matsumoto , Kan Shida
IPC分类号： C40B40/08 , C07H21/00 , C12N15/74 , C12N1/00 , C12N1/21 , C12Q1/68 , C12N15/63
CPC分类号： C12N15/52 , A23L33/135 , A61K38/00 , C12N9/1048 , C12P19/04
摘要： The invention provides a gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having any of the amino acid sequences of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, and 108; (b) a protein which has an amino acid sequence equivalent to any of the amino acid sequences of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits cytokine production regulatory activity; and (c) a protein which has an amino acid sequence having 90% or higher identity to any of the amino acid sequences of (a), and which exhibits cytokine production regulatory activity, as well as a gene useful for regulating cytokine production and use of the gene.
摘要翻译：本发明提供了编码选自以下蛋白质（a）〜（c）的蛋白质的基因：（a）具有SEQ ID NO：2,4,6,8,10,12的任意氨基酸序列的蛋白质，14，16，82，84，86，88，90，92，94，96，98，100，102，104，106及108; （b）具有与（a）的任何氨基酸序列相同的氨基酸序列的蛋白质，除了一至数个氨基酸残基被缺失，取代或添加，并且其表现出细胞因子产生调节活性; 和（c）具有与（a）的任何氨基酸序列具有90％或更高同一性并且表现出细胞因子产生调节活性的氨基酸序列的蛋白质，以及可用于调节细胞因子产生和使用的基因的基因。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式