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1. 发明专利

JP2013092437A Ic chip provided with plurality of electrodes 有权
标题翻译： IC芯片提供多种电极
公开(公告)号：JP2013092437A
公开(公告)日：2013-05-16
申请号：JP2011234459
申请日：2011-10-25
申请人： Tohoku Univ , 国立大学法人東北大学 , Japan Aviation Electronics Industry Ltd , 日本航空電子工業株式会社 , Toppan Printing Co Ltd , 凸版印刷株式会社
发明人： SUENAGA TOMOKAZU , INOUE HISAMI , MATSUDAIRA MASAAKI , ESASHI MASAKI , SUDA ATSUSHI , KIMURA TATSUO , KUNIKATA RYOTA , SHIOTANI TOSHITO , TSURUMI RYOTA
IPC分类号： G01N27/30 , G01N27/333 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide an IC chip provided with a plurality of working electrodes which can perform desired electrochemical measurement in a plurality of measurement points in a short period of time according to each of the measurement points, and cause an electrochemical reaction due to a minute electric signal by using an arbitrary working electrode out of the plurality of working electrodes or can detect a detection signal even when it is the detection signal whose movement of charges associated with the electrochemical reaction is minute.SOLUTION: In an IC chip 10, a switch group 12, an operational amplifier 13 connected to the switch group 12, and a capacitor 17 connected between one input terminal and an output terminal of the operational amplifier 13 are provided on each of working electrodes 11. The switch group 12 switches among an offset voltage measuring mode of measuring an offset voltage of the operational amplifier 13, a mode of measuring a potential of the working electrode 11, a mode of measuring an electric current passing when the working electrode 11 is set to a predetermined potential, and a mode of measuring an electric current passing through the working electrode 11 when the working electrode 11 is set to an offset potential rather than the predetermined potential.
摘要翻译：要解决的问题：提供一种设置有多个工作电极的IC芯片，其可以根据每个测量点在短时间内在多个测量点中进行所需的电化学测量，并且引起电化学即使是与电化学反应相关的电荷的运动微小的检测信号，也可以通过使用多个工作电极中的任意工作电极而产生微小电信号的反应。解决方案：在IC芯片10中，分别设置有开关组12，与开关组12连接的运算放大器13和连接在运算放大器13的一个输入端子和输出端子之间的电容器17 工作电极11.开关组12在测量运算放大器13的偏移电压的偏移电压测量模式，测量工作电极11的电位的模式，测量工作电极 11被设定为预定电位，并且当工作电极11被设定为偏移电位而不是预定电位时，测量通过工作电极11的电流的模式。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2017116517A 電気化学測定方法、電気化学測定装置及びトランスデューサ有权
公开(公告)号：JP2017116517A
公开(公告)日：2017-06-29
申请号：JP2016055283
申请日：2016-03-18
申请人：日本航空電子工業株式会社 , Japan Aviation Electronics Industry Ltd , 国立大学法人東北大学 , Tohoku Univ
发明人： KUNIKATA RYOTA , HAYASHI YASUYUKI , SUDA ATSUSHI , INO KOSUKE , INOUE HISAMI , SUENAGA TOMOKAZU
IPC分类号： G01N27/416 , C12M1/34
CPC分类号： C12M1/34 , G01N27/416
摘要：【課題】溶液中の生体サンプルで生成または消費される化学物質を電気化学的に測定する電気化学測定において、測定感度の向上を図る方法を提供する。【解決手段】化学物質と電子の授受を行なって酸化還元反応をさせる作用極の電極面の寸法と、生体サンプルの寸法とを与件に含み、生体サンプルにおいて化学物質が生成または消費される化学反応の速度と、溶液中の化学物質の濃度分布の変化と、電極面における化学物質との電子の授受の速度とに基いて作用極に流れる電流を計算するシミュレーションを、生体サンプルと電極面との電極面に対する垂直方向距離を変数として行って、電流が最大値となる点を含み電流が最大値の90%以上の大きさとなる垂直方向距離の範囲を求め、溶液中において生体サンプルを、電極面から電極面に対する垂直方向に前記範囲に属する距離だけ離間させて測定を実行する。【選択図】なし

3. 发明专利

JP2012141170A Electrode device for electrochemical measurement chip 有权
标题翻译：用于电化学测量芯片的电极装置
公开(公告)号：JP2012141170A
公开(公告)日：2012-07-26
申请号：JP2010292512
申请日：2010-12-28
申请人： Japan Aviation Electronics Industry Ltd , Tohoku Univ , 国立大学法人東北大学 , 日本航空電子工業株式会社
发明人： SUDA ATSUSHI , KIMURA TATSUO , KUNIKATA RYOTA , INO KOSUKE , SUENAGA TOMOKAZU
IPC分类号： G01N27/30 , G01N27/28
CPC分类号： G01N27/3272
摘要： PROBLEM TO BE SOLVED: To provide an electrode device for electrochemical measurement chip that can measure even liquid sample with high sensitivity and reliability and is suitable for simultaneous multipoint measurement and a disposable.SOLUTION: In an electrode device, a plurality of conductive electrode members 13 are held penetrating an insulation sheet 12 including an insulating property in a thickness direction thereof, a plurality of concave portions 12c for trapping a measuring object are formed in a surface 12a of the insulation sheet 12 corresponding to the plurality of electrode members 13, end parts 13a of the electrode members 13 are exposed to bottom parts of the concave portions 12c, a liquid sample S including the measuring object contacts the end parts 13a, and other ends 13b of the electrode members 13 formed protruding externally from a rear face 12b of the insulation sheet 12 contact and electrically connect to electrodes 22 of a transducer 21.
摘要翻译：要解决的问题：提供一种能够以高灵敏度和可靠性测量均匀液体样品的电化学测量芯片的电极装置，并且适用于同时多点测量和一次性测量。解决方案：在电极装置中，多个导电电极构件13被保持穿过其厚度方向具有绝缘性的绝缘片12，用于捕获测量对象的多个凹部12c形成在表面对应于多个电极构件13的绝缘片12的12a，电极构件13的端部13a暴露于凹部12c的底部，包括测量对象的液体样品S接触端部13a和其他从绝缘片12的背面12b向外突出形成的电极部件13的端部13b接触并电连接到换能器21的电极22上。（C）2012，JPO＆INPIT

4. 发明专利

JP2012141173A Electrode device for electrochemical measurement chip 有权
标题翻译：用于电化学测量芯片的电极装置
公开(公告)号：JP2012141173A
公开(公告)日：2012-07-26
申请号：JP2010292608
申请日：2010-12-28
申请人： Japan Aviation Electronics Industry Ltd , Tohoku Univ , 国立大学法人東北大学 , 日本航空電子工業株式会社
发明人： SUDA ATSUSHI , KIMURA TATSUO , KUNIKATA RYOTA , INOUE HISAMI , SUENAGA TOMOKAZU
IPC分类号： G01N27/30 , G01N27/28
CPC分类号： G01N27/307 , G01N27/403 , G01N33/487
摘要： PROBLEM TO BE SOLVED: To provide an electrode device for electrochemical measurement chip that can measure even liquid sample with high sensitivity and reliability and is suitable for simultaneous multipoint measurement and a disposable.SOLUTION: In an electrode device, a plurality of conductive electrode members 13 formed by mixture of conductive particles and an insulation material are held penetrating an insulation sheet 12 including an insulation material in a thickness direction thereof, end parts 13a of the electrode members 13 contact a liquid sample S including a measuring object, and other ends 13b of the electrode members 13 formed protruding externally from a rear face 12b of the insulation sheet 12 contact and electrically connect to electrodes 22 of a transducer 21.
摘要翻译：要解决的问题：提供一种能够以高灵敏度和可靠性测量均匀液体样品的电化学测量芯片的电极装置，并且适用于同时多点测量和一次性测量。解决方案：在电极装置中，由导电颗粒和绝缘材料的混合物形成的多个导电电极构件13贯穿其厚度方向上包括绝缘材料的绝缘片12，电极的端部13a 构件13接触包括测量对象的液体样本S，并且从绝缘片12的后表面12b向外突出形成的电极构件13的其他端部13b接触并电连接到换能器21的电极22。（C）2012，JPO＆INPIT

5. 发明专利

JP2012141169A Electrode device for electrochemical measurement chip 有权
标题翻译：用于电化学测量芯片的电极装置
公开(公告)号：JP2012141169A
公开(公告)日：2012-07-26
申请号：JP2010292497
申请日：2010-12-28
申请人： Japan Aviation Electronics Industry Ltd , Tohoku Univ , 国立大学法人東北大学 , 日本航空電子工業株式会社
发明人： SUDA ATSUSHI , KIMURA TATSUO , KUNIKATA RYOTA , SUENAGA TOMOKAZU
IPC分类号： G01N27/30 , G01N27/28
CPC分类号： G01N27/307 , G01N27/403 , G01N33/487
摘要： PROBLEM TO BE SOLVED: To provide an electrode device for electrochemical measurement chip that can measure even liquid sample with high sensitivity and reliability and is suitable for simultaneous multipoint measurement and a disposable.SOLUTION: In an electrode device, a plurality of conductive electrode members 13 are held penetrating an insulation sheet 12 including an insulating property in a thickness direction thereof, end parts 13a of the electrode members 13 contact a liquid sample S including a measuring object, and other ends 13b of the electrode members 13 formed protruding externally from a rear face 12b of the insulation sheet 12 contact and electrically connect to electrodes 22 of a transducer 21.
摘要翻译：要解决的问题：提供一种能够以高灵敏度和可靠性测量均匀液体样品的电化学测量芯片的电极装置，并且适用于同时多点测量和一次性测量。解决方案：在电极装置中，多个导电电极构件13被保持穿过其厚度方向具有绝缘性的绝缘片12，电极构件13的端部13a接触包括测量的液体样品S 物体和从绝缘片12的后表面12b向外突出形成的电极部件13的其他端部13b接触并电连接到换能器21的电极22.（C）2012，JPO＆INPIT

6. 发明专利

JP2012127695A Method for detecting concentration of endotoxin and electrode chip for detecting endotoxin 有权
标题翻译：检测内毒素浓度的方法和用于检测内毒素的电极芯片
公开(公告)号：JP2012127695A
公开(公告)日：2012-07-05
申请号：JP2010277329
申请日：2010-12-13
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： SUENAGA TOMOKAZU , INOUE HISAMI , INO KOSUKE , SHUKU HITOSHI
IPC分类号： G01N27/48 , G01N33/579
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting a concentration of endotoxin by which endotoxin may be determined with merely a small amount of a reagent even in a specimen including a slight amount of endotoxin, and an electrode chip usable in the method.SOLUTION: In a method for detecting a concentration of endotoxin, a specimen including endotoxin is brought into contact with a reagent including factor C, factor B, a coagulase precursor and a peptide linked to a pigment, so as to cause a cascade reaction for successively producing activated factor C from the factor C, activated factor B from the factor B and activated coagulase from the coagulase precursor, and a reaction to free the pigment from the peptide is caused by the activated coagulase. A resultant mixture of the specimen and the reagent obtained after the freeing reaction is subjected to differential pulse voltammetry, so as to determine endotoxin on the basis of the thus measured current value.
摘要翻译：要解决的问题：提供一种检测内毒素浓度的方法，即使在含有少量内毒素的试样中也可以仅使用少量试剂来测定内毒素的浓度，以及可用于方法。解决方案：在检测内毒素浓度的方法中，将包含内毒素的样品与包括因子C，因子B，凝固酶前体和与颜料连接的肽的试剂接触，以引起级联从因子C连续产生活化因子C的反应，来自因子B的活化因子B和来自凝固酶前体的活化凝固酶，并且由活化凝固酶引起色素游离的反应。将释放反应后获得的试样和试剂的混合物进行差示脉冲伏安法，以便根据这样测量的电流值来确定内毒素。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2008014791A Liquid mixing device, liquid mixing method, and measuring method of very small amount of specimen 审中-公开
标题翻译：液体混合装置，液体混合方法和非常小量样品的测量方法
公开(公告)号：JP2008014791A
公开(公告)日：2008-01-24
申请号：JP2006186109
申请日：2006-07-05
申请人： Nipro Corp , Tohoku Univ , ニプロ株式会社 , 国立大学法人東北大学
发明人： YASUKAWA TOMOYUKI , INOUE HISAMI , SHUKU HITOSHI , SUENAGA TOMOKAZU , YOSHIDA HIROSHI , SUETAKE TOSHINORI
IPC分类号： G01N1/28 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive liquid mixing device.
SOLUTION: The liquid mixing device is a device constituted so as to mix two kinds of liquids and equipped with a crossing unit. The crossing unit includes a first refraction flow channel, which is refracted twice, and a second refraction flow channel which is refracted twice and has a structure wherein the undersurface of the flow channel after the first refraction communicates with the top surface of the flow channel after the first refraction of the first refraction flow channel. This device preferably includes the crossing units. Further preferably, the device includes a collection flow channel for collecting the liquids flowing out of a plurality of the crossing units to one. Especially preferably, the device includes the first vortex flow channel connected to the collection flow channel and converged into a vortex state toward its center and the second vortex flow channel connected to the end part of the first vortex flow channel and outward diverged in a vortex state.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供廉价的液体混合装置。液体混合装置是混合两种液体并装有交叉装置的装置。交叉单元包括被折射两次的第一折射流动通道和折射两次的第二折射流动通道，并且具有其中在第一折射之后的流动通道的下表面与流动通道的顶表面连通的结构，第一折射流道的第一折射。该装置优选地包括交叉单元。更优选地，该装置包括用于将从多个交叉单元流出的液体收集到一个的收集流动通道。特别优选地，该装置包括连接到收集流动通道并且朝向其中心汇聚成涡流状态的第一涡流流动通道和连接到第一涡流流动通道的端部并且向外以涡流状态分散的第二涡流通道。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2012063287A Well unit and electrochemical analysis method 有权
标题翻译：井单元和电化学分析方法
公开(公告)号：JP2012063287A
公开(公告)日：2012-03-29
申请号：JP2010208817
申请日：2010-09-17
申请人： Hokuto Denko Kk , Tohoku Univ , Yasojima Proceed Co Ltd , 八十島プロシード株式会社 , 北斗電工株式会社 , 国立大学法人東北大学
发明人： AOYAGI SHIGEO , UTSUMI YOSUKE , SUENAGA TOMOKAZU , SHUKU HITOSHI , ABE HIROYUKI , KONO HIROYUKI , KASHIWAZAKI TOSHINOBU , HOSHI HIROYOSHI , HOSHI TSUBASA
IPC分类号： G01N27/28 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To perform electrochemical evaluation of a sample introduced to a well with sufficient workability.SOLUTION: In a well unit 1, a well 2 is formed, and the well unit 1 includes an electrode 3 on the surface of the well 2. Metal wire 4 is embedded in the well unit 1, cutting work is performed to the well unit 1 so as to cut the metal wire 4 to form the well 2 in the well unit 1. Then, a cross section of the cut metal wire 4 is used as the electrode 3. The sample is introduced to the well 2, potential of the electrode 3 is controlled so that the potential of the electrode 3 becomes oxidation-reduction potential to be measured, and a value of current which flows to the electrode 3 is measured. Then, the electrochemical evaluation of the sample to be measured and evaluation of electrode catalytic activity are performed based on the value of the current. As the sample to be measured, a biological material such as fertilized eggs of mammals and an inorganic ion, etc. are exemplified.
摘要翻译：要解决的问题：对具有足够可加工性的引入井的样品进行电化学评价。解决方案：在井单元1中，形成井2，井单元1在井2的表面上包括电极3.金属丝4嵌入井单元1中，进行切削加工井单元1切割金属丝4以在井单元1中形成井2。然后，使用切割金属丝4的横截面作为电极3.将样品引入井2，控制电极3的电位，使得电极3的电位成为要测量的氧化还原电位，并且测量流向电极3的电流值。然后，基于电流值进行待测量的样品的电化学评价和电极催化活性的评价。作为被测定样品，可举出哺乳动物受精卵，无机离子等生物体。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2010162673A Method for arranging nanostructure, method for preparing nanodevice, and substrate for nanodevice preparation 审中-公开
标题翻译：安装纳米结构的方法，制备纳米器件的方法和用于纳米器件制备的衬底
公开(公告)号：JP2010162673A
公开(公告)日：2010-07-29
申请号：JP2009009404
申请日：2009-01-19
申请人： Tohoku Univ , 国立大学法人東北大学
发明人： SUENAGA TOMOKAZU , LEE SANG HYUN , LEE HYUN JUNG , SHUKU HITOSHI , YAO TAKAFUMI
IPC分类号： B82B3/00 , B82B1/00 , C01G9/02
摘要： PROBLEM TO BE SOLVED: To provide a method for arranging nanostructures which can achieve reliable arrangement of nanostructures in a gap between electrodes and to provide a method for preparing a nanodevice using the method and a substrate for nanodevice preparation.
SOLUTION: While forming an alternating electric field between a first electrode 11 and a second electrode 12 provided on an identical line while providing a space therebetween, a dispersion in which a plurality of nanostructures are mixed is allowed to flow in a flow path defined along the direction of arrangement of the first electrode 11 and the second electrode 12, whereby the nanostructures in the dispersion are arranged so as to astride the first electrode 11 and the second electrode 12.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于布置纳米结构的方法，其可以在电极之间的间隙中实现纳米结构的可靠布置，并提供使用该方法制备纳米器件的方法和用于纳米器件制备的衬底。解决方案：在设置在同一线上的第一电极11和第二电极12之间形成交替电场同时在其间提供空间的同时，允许混合多个纳米结构的分散体在流路沿着第一电极11和第二电极12的布置方向限定，由此分散体中的纳米结构被布置成跨越第一电极11和第二电极12.版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2010261923A Scanning-type electrochemistry ion conductance microscope measuring method, scanning-type electrochemistry ion conductance microscope, probe for the same, and probe manufacturing method 有权
标题翻译：扫描型电化学离子导管显微镜测量方法，扫描型电化学离子导电显微镜，相同的探针和探针制造方法
公开(公告)号：JP2010261923A
公开(公告)日：2010-11-18
申请号：JP2009140602
申请日：2009-06-11
申请人： Imperial Innovations Ltd , Tohoku Univ , インペリアルイノベーションズリミテッド , 国立大学法人東北大学
发明人： TAKAHASHI YASUSHI , SUENAGA TOMOKAZU , SHUKU HITOSHI , MURAKAMI ARIYOSHI , NAGAMINE KUNIAKI , SHEVCHUK ANDREW , KORCHEV YURI
IPC分类号： G01Q60/60 , G01Q60/22
摘要： PROBLEM TO BE SOLVED: To provide a scanning-type electrochemistry ion conductance microscope measuring method, scanning type electrochemistry ion conductance microscope, probe of the same, and probe measuring method, capable of attaining shape imaging and electrochemistry imaging by performing scanning, in such a mode that the distance between one probe and a sample is constant, using the probe.
SOLUTION: A SECM electrode 26A for measuring a Faraday current is attached onto an end surface formed by sharpening one end of a hollow base material to take it as one end 25b and cutting the end. A probe 21, having a SICM electrode 27 for measuring an ion current corresponding to an outflow amount from an opening 25c
1 in the end surface of electrolyte charged into a hollow portion 25a
1 , is used in the hollow portion 25a
1 of the hollow base material. The probe 21 is scanned relatively along a sample surface, in such a way that the distance between the probe and the sample is constant. Electrochemical imaging of the sample surface is performed with the SECM electrode 26A, while the ion current to be measured with the SICM electrode 27 is used in a distance-control feedback signal, and form imaging of the sample surface is performed with the SICM electrode 27.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了提供扫描型电化学离子电导显微镜测量方法，扫描型电化学离子电导显微镜，其探针和探针测量方法，能够通过进行扫描获得形状成像和电化学成像，以这样的模式，使用探针使得一个探针和样品之间的距离恒定。解决方案：用于测量法拉第电流的SECM电极26A附着在通过磨削中空基材的一端而形成的端面上，以将其作为一端25b并切割端部。具有SICM电极27的探针21，该SICM电极27用于测量与填充到中空部25a中的电解质的端部表面中的开口25c <1S / s>相当的流出量的离子电流。 >，用于中空基材的中空部25a <1> 。探针21沿着样品表面被相对扫描，使得探针和样品之间的距离是恒定的。使用SECM电极26A进行样品表面的电化学成像，而在距离控制反馈信号中使用要用SICM电极27测量的离子电流，并且利用SICM电极27进行样品表面的成像版权所有（C）2011，JPO＆INPIT

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