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1. 发明申请

US20080180188A1 Microfluidic Apparatuses with Nanochannels 有权
标题翻译：具有纳米通道的微流体装置
公开(公告)号：US20080180188A1
公开(公告)日：2008-07-31
申请号：US11669682
申请日：2007-01-31
申请人： Timothy Beerling , Karsten G. Kraiczek , Reid A. Brennen
发明人： Timothy Beerling , Karsten G. Kraiczek , Reid A. Brennen
IPC分类号： H01P5/10
CPC分类号： G01N30/6095 , B01L3/5027 , B01L2200/12 , B01L2300/0877 , B01L2300/0887 , B82Y15/00 , Y10T436/2575
摘要： In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be made in a buried silicon oxide layer by etching the buried oxide layer with a method that selectively removes silicon oxide but not silicon. Thus, one dimension of the resulting fluid channel is limited by the thickness of the buried oxide layer. It is possible to manufacture a very thin buried oxide layer with great precision, thus a nanochannel can be fabricated in a controlled manner. Moreover, in addition to buried oxide, any pairs of substances with a high etch ratio with respect to each other can be used in the same way. Further provided are the fluid channels, apparatuses, devices and systems comprising the fluid channels, and uses thereof.
摘要翻译：在本发明的一些实施例中，掩埋氧化硅技术用于制造流体通道，特别是纳米通道。例如，通过用选择性地去除氧化硅而不是硅的方法蚀刻掩埋氧化物层，可以在掩埋氧化硅层中制造流体通道。因此，所得流体通道的一个尺寸受到掩埋氧化物层的厚度的限制。可以以很高的精度制造非常薄的掩埋氧化物层，因此可以以受控的方式制造纳米通道。此外，除了掩埋氧化物之外，可以以相同的方式使用具有相对于彼此的高蚀刻比的任何物质对。进一步提供了包括流体通道的流体通道，装置，装置和系统及其用途。

2. 发明授权

US08168140B2 Microfluidic apparatuses with nanochannels 有权
标题翻译：具有纳米通道的微流控装置
公开(公告)号：US08168140B2
公开(公告)日：2012-05-01
申请号：US11669682
申请日：2007-01-31
申请人： Timothy Beerling , Karsten G. Kraiczek , Reid A. Brennen
发明人： Timothy Beerling , Karsten G. Kraiczek , Reid A. Brennen
IPC分类号： B01L3/00 , B01L3/18 , G01N1/10
CPC分类号： G01N30/6095 , B01L3/5027 , B01L2200/12 , B01L2300/0877 , B01L2300/0887 , B82Y15/00 , Y10T436/2575
摘要： In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be made in a buried silicon oxide layer by etching the buried oxide layer with a method that selectively removes silicon oxide but not silicon. Thus, one dimension of the resulting fluid channel is limited by the thickness of the buried oxide layer. It is possible to manufacture a very thin buried oxide layer with great precision, thus a nanochannel can be fabricated in a controlled manner. Moreover, in addition to buried oxide, any pairs of substances with a high etch ratio with respect to each other can be used in the same way. Further provided are the fluid channels, apparatuses, devices and systems comprising the fluid channels, and uses thereof.
摘要翻译：在本发明的一些实施例中，掩埋氧化硅技术用于制造流体通道，特别是纳米通道。例如，通过用选择性地去除氧化硅而不是硅的方法蚀刻掩埋氧化物层，可以在掩埋氧化硅层中制造流体通道。因此，所得流体通道的一个尺寸受到掩埋氧化物层的厚度的限制。可以以很高的精度制造非常薄的掩埋氧化物层，因此可以以受控的方式制造纳米通道。此外，除了掩埋氧化物之外，可以以相同的方式使用具有相对于彼此的高蚀刻比的任何物质对。进一步提供了包括流体通道的流体通道，装置，装置和系统及其用途。

3. 发明授权

US08647590B2 Optical detection cell with micro-fluidic chip 有权
标题翻译：具有微流体芯片的光学检测单元
公开(公告)号：US08647590B2
公开(公告)日：2014-02-11
申请号：US11384149
申请日：2006-03-16
申请人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
发明人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N2021/0346
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer, a micro-fluidic chip having a fluidic port and a detection channel defined through the detection cell and being in fluid communication with the fluidic port of the chip, the detection channel serving as a light path for receiving light for detecting a molecule. Methods of detecting molecules and making the detection cell are also disclosed.
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层，具有流体端口的微流体芯片和通过检测单元限定的检测通道，并与芯片的流体端口，检测通道用作用于接收用于检测分子的光的光路。还公开了检测分子和制备检测细胞的方法。

4. 发明申请

US20080031782A1 Microfluidic device with valve and method 审中-公开
公开(公告)号：US20080031782A1
公开(公告)日：2008-02-07
申请号：US11500234
申请日：2006-08-07
申请人： Timothy Beerling , Reid A. Brennen
发明人： Timothy Beerling , Reid A. Brennen
IPC分类号： B01L11/00 , B01L3/00
CPC分类号： F16K99/0032 , B01L3/502707 , B01L3/502738 , B01L2300/1805 , B01L2300/1827 , B01L2400/0677 , F16K99/0001 , F16K99/0036 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084
摘要： The invention provides a microfluidic system, including an optional separation system for separating and preparing an analyte solution, a microfluidic device downstream from the separation system for dispensing and analyte solution, comprising a substrate having a channel defining a portion of a microfluidic channel; a polymeric substrate having a channel for contacting the substrate to define the second portion of the microfluidic channel; a cooling element associated with the substrate and channel for cooling an analyte solution in the microfluidic channel; and a heating element adjacent to the microfluidic channel for heating the analyte solution, wherein the cooling element operates to maintain the channel in a closed state by cooling the analyte solution in the channel and wherein the heating element may be activated to place the channel in an open state by heating the analyte solution in the channel; and a detector for detecting the dispensed analyte solutionThe invention also provides a microfluidic device and/or valve, including a substrate having a micro fluidic channel for carrying an analyte solution; a cooling element associated with the substrate and micro fluidic channel for cooling the analyte solution in the channel; and a heating element adjacent to the channel for heating the analyte solution in the channel wherein the cooling element operates to maintain the channel in a closed state by cooling the analyte solution in the channel and wherein the heating element may be activated to place the channel in an open state by heating the cooled analyte solution in the channel.The invention also provides a method of valve control in a microfluidic device, including maintaining a cooling element in an active state to freeze an analyte solution in a microfluidic channel and close the microfluidic channel; and engaging a heating element to thaw the analyte solution in the microfluidic channel and open the microfluidic channel to allow fluid flow through the channel.

5. 发明授权

US08774944B2 Tools, systems, and methods for inserting an electrode array portion of a lead into a bodily orifice 有权
标题翻译：用于将铅的电极阵列部分插入身体孔口的工具，系统和方法
公开(公告)号：US08774944B2
公开(公告)日：2014-07-08
申请号：US12824122
申请日：2010-06-25
申请人： Chuladatta Thenuwara , Rosa Gallegos , Timothy Beerling
发明人： Chuladatta Thenuwara , Rosa Gallegos , Timothy Beerling
IPC分类号： A61N1/00 , A61B17/34
CPC分类号： A61B17/3468 , A61B2017/00787 , A61N1/0541
摘要： Exemplary insertion tools, systems, and methods for inserting an electrode array portion of a lead into a bodily orifice are described herein. An exemplary insertion tool includes a handle assembly, a retractor assembly disposed at least partially within the handle assembly, and a slider assembly disposed at least partially within the handle assembly. The retractor assembly may include a stiffening member configured to be inserted into an electrode array portion and a spring-loaded retractor member coupled to the stiffening member and configured to move from a distal position to a proximal position to at least partially retract the stiffening member from the electrode array portion. The slider assembly may be configured to selectively retain the spring-loaded retractor member and further configured to release the spring-loaded retractor member to move from the distal position to the proximal position in response to actuation by a user of the slider assembly.
摘要翻译：本文描述了用于将铅的电极阵列部分插入身体孔的示例性插入工具，系统和方法。示例性插入工具包括手柄组件，至少部分地设置在手柄组件内的牵开器组件，以及至少部分地设置在手柄组件内的滑块组件。牵开器组件可以包括构造成插入到电极阵列部分中的加强构件和联接到加强构件的弹簧加载的牵开器构件，并且构造成从远侧位置移动到近侧位置以至少部分地将加强构件从电极阵列部分。滑动器组件可以被配置为选择性地保持弹簧加载的牵开器构件，并进一步构造成响应于使用者的滑动器组件的致动而释放弹簧加载的牵开器构件以从远侧位置移动到近侧位置。

6. 发明授权

US08712554B2 Integrated wire carrier for electrode array 有权
标题翻译：电极阵列集成线载体
公开(公告)号：US08712554B2
公开(公告)日：2014-04-29
申请号：US12506964
申请日：2009-07-21
申请人： Timothy Beerling , Chuladatta Thenuwara
发明人： Timothy Beerling , Chuladatta Thenuwara
IPC分类号： A61N1/00
CPC分类号： A61N1/0541 , A61F11/004 , Y10T29/49185
摘要： A cochlear lead includes a plurality electrodes forming an electrode array configured to stimulate an auditory nerve from within a cochlea; a lead body connected to the electrode array; a plurality of wires passing through the lead body and connecting to the plurality of electrodes; an integrated wire carrier extending between an exit of the wires from the lead body and a first electrode in the electrode array, the integrated wire carrier comprising a cavity along its longitudinal axis configured to contain the plurality of wires and shape the plurality of wires into a wire bundle in which the plurality of wires passing through the integrated wire carrier are substantially parallel to the longitudinal axis of the integrated wire carrier; and a flexible body encapsulating the integrated wire carrier and the wires.
摘要翻译：耳蜗引线包括形成电极阵列的多个电极，其构造成从耳蜗内刺激听觉神经; 连接到电极阵列的引线体; 穿过所述引线体并连接到所述多个电极的多条电线; 在导体本体的导线出口和电极阵列中的第一电极之间延伸的集成导线载体，所述集成导线架包括沿其纵向轴线的空腔，所述腔体构造为容纳所述多根导线并将所述多根导线成形为电线束，其中穿过集成线载体的多条电线基本上平行于集成线载体的纵向轴线; 以及封装集成线载体和电线的柔性体。

7. 发明申请

US20110319908A1 TOOLS, SYSTEMS, AND METHODS FOR INSERTING A PRE-CURVED ELECTRODE ARRAY PORTION OF A LEAD INTO A BODILY ORIFICE 有权
标题翻译：工具，系统和方法将前导电极阵列的导线插入一个体系中
公开(公告)号：US20110319908A1
公开(公告)日：2011-12-29
申请号：US12824119
申请日：2010-06-25
申请人： Chuladatta Thenuwara , Timothy Beerling , Mark Downing , Paul Hoffman , William Orinski
发明人： Chuladatta Thenuwara , Timothy Beerling , Mark Downing , Paul Hoffman , William Orinski
IPC分类号： A61F11/04 , A61N1/05 , A61B17/00
CPC分类号： A61B17/00 , A61B17/3468 , A61F11/04 , A61N1/05 , A61N1/0541
摘要： Exemplary insertion tools, systems, and methods for inserting a pre-curved electrode array portion of a lead into a bodily orifice are described herein. An exemplary insertion tool includes a handle assembly, a slider assembly, an insertion assembly coupled to the handle assembly, and a retractor assembly disposed at least partially within the handle assembly and configured to selectively couple to a straightening member inserted into the pre-curved electrode array portion and at least partially retract the straightening member from the pre-curved electrode array portion in response to actuation by a user of the slider assembly. The retractor assembly may comprise a spring-loaded retractor member configured to move from a distal position to a proximal position in response to actuation by the user of the slider assembly to at least partially retract the straightening member from the pre-curved electrode array portion. Corresponding insertion tools, systems, and methods are also described.
摘要翻译：本文描述了用于将引线的预弯曲电极阵列部分插入身体孔口的示例性插入工具，系统和方法。示例性的插入工具包括手柄组件，滑块组件，联接到手柄组件的插入组件和至少部分地设置在手柄组件内并被配置为选择性地联接到插入到预弯曲电极中的矫正构件的牵开器组件并且响应于滑块组件的使用者的致动，至少部分地将矫正构件从预弯曲的电极阵列部分缩回。牵开器组件可以包括弹簧加载的牵开器构件，其构造成响应于滑块组件的使用者的致动而从远侧位置移动到近侧位置，以使矫正构件至少部分地从预弯曲电极阵列部分缩回。还描述了相应的插入工具，系统和方法。

8. 发明申请

US20070235303A1 Architecture for multi-throw micro-fluidic devices 审中-公开
标题翻译：多级微流体装置的架构
公开(公告)号：US20070235303A1
公开(公告)日：2007-10-11
申请号：US11399644
申请日：2006-04-06
申请人： Timothy Beerling
发明人： Timothy Beerling
IPC分类号： H01H29/00
CPC分类号： H01H29/04 , H01H2029/008
摘要： In accordance with the invention, a multiple throw switching device can be achieved on a single substrate by organizing a micro-fluidic switch into spokes radiating outward from the center of a wafer such that each spoke (switch throw) controls a switched output and each switch throw, in turn, is controlled by an individual stimulus.
摘要翻译：根据本发明，通过将微流体开关组织成从晶片的中心向外辐射的辐条，可以在单个基板上实现多重切换装置，使得每个辐条（开关投掷）控制开关输出，并且每个开关反过来，由个人刺激控制。

9. 发明申请

US20070217953A1 Optical detection cell with micro-fluidic chip 有权
标题翻译：具有微流体芯片的光学检测单元
公开(公告)号：US20070217953A1
公开(公告)日：2007-09-20
申请号：US11384149
申请日：2006-03-16
申请人： Reid Brennen , Timothy Beerling , Hongfeng Yin , Kevin Killeen
发明人： Reid Brennen , Timothy Beerling , Hongfeng Yin , Kevin Killeen
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N2021/0346
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer, a micro-fluidic chip having a fluidic port and a detection channel defined through the detection cell and being in fluid communication with the fluidic port of the chip, the detection channel serving as a light path for receiving light for detecting a molecule. Methods of detecting molecules and making the detection cell are also disclosed.
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层，具有流体端口的微流体芯片和通过检测单元限定的检测通道，并与芯片的流体端口，检测通道用作用于接收用于检测分子的光的光路。还公开了检测分子和制备检测细胞的方法。

10. 发明申请

US20070204926A1 System and method for controlling fluid flow in a microfluidic circuit 审中-公开
标题翻译：用于控制微流体电路中的流体流动的系统和方法
公开(公告)号：US20070204926A1
公开(公告)日：2007-09-06
申请号：US11366197
申请日：2006-03-02
申请人： Timothy Beerling , Reid Brennen , Hongfeng Yin , Ronald Fazzio , Kevin Killeen
发明人： Timothy Beerling , Reid Brennen , Hongfeng Yin , Ronald Fazzio , Kevin Killeen
IPC分类号： F15C1/04
CPC分类号： F16K99/0019 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/143 , B01L2300/0887 , B01L2300/1827 , B01L2400/0677 , B01L2400/082 , F16K99/0001 , F16K99/0034 , F16K99/0044 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T137/2196
摘要： A system for controlling fluid flow in a microfluidic circuit includes at least one microfluidic channel, and a heating element adjacent the at least one microfluidic channel, wherein when activated, the heating element boils liquid in the at least one microfluidic channel.
摘要翻译：用于控制微流体回路中的流体流动的系统包括至少一个微流体通道和与所述至少一个微流体通道相邻的加热元件，其中当被激活时，所述加热元件在所述至少一个微流体通道中沸腾液体。

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