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1. 发明申请

US20070204926A1 System and method for controlling fluid flow in a microfluidic circuit 审中-公开
标题翻译：用于控制微流体电路中的流体流动的系统和方法
公开(公告)号：US20070204926A1
公开(公告)日：2007-09-06
申请号：US11366197
申请日：2006-03-02
申请人： Timothy Beerling , Reid Brennen , Hongfeng Yin , Ronald Fazzio , Kevin Killeen
发明人： Timothy Beerling , Reid Brennen , Hongfeng Yin , Ronald Fazzio , Kevin Killeen
IPC分类号： F15C1/04
CPC分类号： F16K99/0019 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/143 , B01L2300/0887 , B01L2300/1827 , B01L2400/0677 , B01L2400/082 , F16K99/0001 , F16K99/0034 , F16K99/0044 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T137/2196
摘要： A system for controlling fluid flow in a microfluidic circuit includes at least one microfluidic channel, and a heating element adjacent the at least one microfluidic channel, wherein when activated, the heating element boils liquid in the at least one microfluidic channel.
摘要翻译：用于控制微流体回路中的流体流动的系统包括至少一个微流体通道和与所述至少一个微流体通道相邻的加热元件，其中当被激活时，所述加热元件在所述至少一个微流体通道中沸腾液体。

2. 发明申请

US20070234785A1 System and method for using a flexible membrane for controlling fluid flow in a microfluidic circuit 审中-公开
标题翻译：使用柔性膜来控制微流体电路中的流体流动的系统和方法
公开(公告)号：US20070234785A1
公开(公告)日：2007-10-11
申请号：US11394309
申请日：2006-03-30
申请人： Timothy Beerling , Reid Brennen , Hongfeng Yin , Ronald Fazzio , Kevin Killeen
发明人： Timothy Beerling , Reid Brennen , Hongfeng Yin , Ronald Fazzio , Kevin Killeen
IPC分类号： G01N30/38
CPC分类号： G01N30/32 , B01L3/502738 , B01L3/502746 , B01L2200/143 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0655 , B01L2400/082 , F04B43/021 , F04B43/043 , F04B43/06 , F04B43/082 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N30/6095 , G01N2030/205 , Y10T137/8593
摘要： A system for controlling fluid flow in a microfluidic circuit located in a liquid chromatograph includes at least one microfluidic channel and a flexible membrane adjacent the at least one microfluidic channel, wherein when actuated, the flexible membrane deflects into the microfluidic channel, thus impeding fluid flow in the microfluidic channel.
摘要翻译：用于控制位于液相色谱仪中的微流体回路中的流体流动的系统包括至少一个微流体通道和与所述至少一个微流体通道相邻的柔性膜，其中当致动时，柔性膜偏转到微流体通道中，从而阻碍流体流动在微流体通道中。

3. 发明申请

US20070218454A1 Optical detection cell for micro-fluidics 审中-公开
标题翻译：用于微流体学的光学检测单元
公开(公告)号：US20070218454A1
公开(公告)日：2007-09-20
申请号：US11378760
申请日：2006-03-16
申请人： Reid Brennen , Timothy Beerling , Hongfeng Yin , Kevin Killeen
发明人： Reid Brennen , Timothy Beerling , Hongfeng Yin , Kevin Killeen
IPC分类号： C12Q1/00
CPC分类号： G01N21/0303 , G01N2021/036 , G01N2201/0245
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer and a detection channel defined through the detection cell to serve as a light path for receiving light for detecting a molecule Methods of detecting molecules and making the detection cell are also disclosed
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层和通过检测单元定义的检测通道，用作接收用于检测分子的光的光路。检测方法分子和制备检测电池也被公开

4. 发明申请

US20070217953A1 Optical detection cell with micro-fluidic chip 有权
标题翻译：具有微流体芯片的光学检测单元
公开(公告)号：US20070217953A1
公开(公告)日：2007-09-20
申请号：US11384149
申请日：2006-03-16
申请人： Reid Brennen , Timothy Beerling , Hongfeng Yin , Kevin Killeen
发明人： Reid Brennen , Timothy Beerling , Hongfeng Yin , Kevin Killeen
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N2021/0346
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer, a micro-fluidic chip having a fluidic port and a detection channel defined through the detection cell and being in fluid communication with the fluidic port of the chip, the detection channel serving as a light path for receiving light for detecting a molecule. Methods of detecting molecules and making the detection cell are also disclosed.
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层，具有流体端口的微流体芯片和通过检测单元限定的检测通道，并与芯片的流体端口，检测通道用作用于接收用于检测分子的光的光路。还公开了检测分子和制备检测细胞的方法。

5. 发明授权

US08647590B2 Optical detection cell with micro-fluidic chip 有权
标题翻译：具有微流体芯片的光学检测单元
公开(公告)号：US08647590B2
公开(公告)日：2014-02-11
申请号：US11384149
申请日：2006-03-16
申请人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
发明人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N2021/0346
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer, a micro-fluidic chip having a fluidic port and a detection channel defined through the detection cell and being in fluid communication with the fluidic port of the chip, the detection channel serving as a light path for receiving light for detecting a molecule. Methods of detecting molecules and making the detection cell are also disclosed.
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层，具有流体端口的微流体芯片和通过检测单元限定的检测通道，并与芯片的流体端口，检测通道用作用于接收用于检测分子的光的光路。还公开了检测分子和制备检测细胞的方法。

6. 发明申请

US20080142479A1 MICROMACHINED TITANIUM FOR HIGH PRESSURE MICROFLUIDIC APPLICATIONS 有权
标题翻译：用于高压微流控应用的微孔板
公开(公告)号：US20080142479A1
公开(公告)日：2008-06-19
申请号：US11554537
申请日：2006-10-30
申请人： Timothy Beerling , Hongfeng Yin
发明人： Timothy Beerling , Hongfeng Yin
IPC分类号： C03C25/68 , C23F1/00 , B44C1/22
CPC分类号： B81C1/00063 , B01L3/5027 , B81B2201/058 , B81C2201/0132 , G01N30/6095
摘要： In accordance with the invention, a method for making microfluidic structures in bulk titanium is disclosed. Specific microfluidic structures include HPLC structures.
摘要翻译：根据本发明，公开了一种在体积钛中制造微流体结构的方法。特定的微流体结构包括HPLC结构。

7. 发明申请

US20070000762A1 Architecture and method of fabrication for a liquid metal microswitch (LIMMS) 失效
标题翻译：液态金属微动开关（LIMMS）的结构和制造方法
公开(公告)号：US20070000762A1
公开(公告)日：2007-01-04
申请号：US11171610
申请日：2005-06-30
申请人： Timothy Beerling , Steven Rosenau , Benjamin Law , Ronald Fazzio , Marco Aimi
发明人： Timothy Beerling , Steven Rosenau , Benjamin Law , Ronald Fazzio , Marco Aimi
IPC分类号： H01H29/00
CPC分类号： H01H1/0036 , H01H2029/008
摘要： A switch comprises a first wafer having a thin-film structure defined thereon, a second wafer having a plurality of features defined therein, and a seal between the first wafer and the second wafer forming a two-wafer structure having a liquid metal microswitch defined therebetween.
摘要翻译：开关包括具有限定在其上的薄膜结构的第一晶片，具有限定在其中的多个特征的第二晶片，以及在第一晶片和第二晶片之间的密封，形成两晶片结构，其具有限定在其间的液态金属微动开关。

8. 发明授权

US08501029B2 Micromachined titanium for high pressure microfluidic applications 有权
标题翻译：微加工钛用于高压微流体应用
公开(公告)号：US08501029B2
公开(公告)日：2013-08-06
申请号：US11554537
申请日：2006-10-30
申请人： Timothy Beerling , Hongfeng Yin
发明人： Timothy Beerling , Hongfeng Yin
IPC分类号： C23F1/00
CPC分类号： B81C1/00063 , B01L3/5027 , B81B2201/058 , B81C2201/0132 , G01N30/6095
摘要： In accordance with the invention, a method for making microfluidic structures in bulk titanium is disclosed. Specific microfluidic structures include HPLC structures.
摘要翻译：根据本发明，公开了一种在体积钛中制造微流体结构的方法。特定的微流体结构包括HPLC结构。

9. 发明申请

US20060260919A1 Methods and apparatus for filling a microswitch with liquid metal 审中-公开
标题翻译：用液态金属填充微动开关的方法和装置
公开(公告)号：US20060260919A1
公开(公告)日：2006-11-23
申请号：US11130846
申请日：2005-05-17
申请人： Marco Aimi , Timothy Beerling , Kevin Killeen
发明人： Marco Aimi , Timothy Beerling , Kevin Killeen
IPC分类号： H01H35/34 , H01H11/00
CPC分类号： H01H11/02 , H01H2029/008 , Y10T29/49105
摘要： Enclosed (or at least substantially enclosed) microswitch cavities can be constructed with suitable channels, and in some instances vents, to allow for the transport of fluidic microswitch components to the cavities. This generally allows for fluid transport to cavities that are largely completed. Various techniques, including formation of pressure gradients and electrowetting, can be used to transport fluid along the channels. Additionally, structures and techniques for providing fluid to multiple microswitches and for providing fluid in desired amounts to microswitches are disclosed.
摘要翻译：封闭的（或至少基本上封闭的）微动开关腔可以用适当的通道构造，并且在一些情况下可以构造为通气口，以允许将流体微动开关部件输送到空腔。这通常允许流体输送到大部分完成的空腔。可以使用各种技术，包括形成压力梯度和电润湿，以沿着通道输送流体。另外，公开了用于向多个微型开关提供流体并用于将流体以所需量提供给微型开关的结构和技术。

10. 发明授权

US08774944B2 Tools, systems, and methods for inserting an electrode array portion of a lead into a bodily orifice 有权
标题翻译：用于将铅的电极阵列部分插入身体孔口的工具，系统和方法
公开(公告)号：US08774944B2
公开(公告)日：2014-07-08
申请号：US12824122
申请日：2010-06-25
申请人： Chuladatta Thenuwara , Rosa Gallegos , Timothy Beerling
发明人： Chuladatta Thenuwara , Rosa Gallegos , Timothy Beerling
IPC分类号： A61N1/00 , A61B17/34
CPC分类号： A61B17/3468 , A61B2017/00787 , A61N1/0541
摘要： Exemplary insertion tools, systems, and methods for inserting an electrode array portion of a lead into a bodily orifice are described herein. An exemplary insertion tool includes a handle assembly, a retractor assembly disposed at least partially within the handle assembly, and a slider assembly disposed at least partially within the handle assembly. The retractor assembly may include a stiffening member configured to be inserted into an electrode array portion and a spring-loaded retractor member coupled to the stiffening member and configured to move from a distal position to a proximal position to at least partially retract the stiffening member from the electrode array portion. The slider assembly may be configured to selectively retain the spring-loaded retractor member and further configured to release the spring-loaded retractor member to move from the distal position to the proximal position in response to actuation by a user of the slider assembly.
摘要翻译：本文描述了用于将铅的电极阵列部分插入身体孔的示例性插入工具，系统和方法。示例性插入工具包括手柄组件，至少部分地设置在手柄组件内的牵开器组件，以及至少部分地设置在手柄组件内的滑块组件。牵开器组件可以包括构造成插入到电极阵列部分中的加强构件和联接到加强构件的弹簧加载的牵开器构件，并且构造成从远侧位置移动到近侧位置以至少部分地将加强构件从电极阵列部分。滑动器组件可以被配置为选择性地保持弹簧加载的牵开器构件，并进一步构造成响应于使用者的滑动器组件的致动而释放弹簧加载的牵开器构件以从远侧位置移动到近侧位置。

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