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1. 发明申请

US20050107723A1 Methods and apparatus for determining work performed by an individual from measured physiological parameters 审中-公开
标题翻译：用于根据测量的生理参数确定个体进行的工作的方法和装置
公开(公告)号：US20050107723A1
公开(公告)日：2005-05-19
申请号：US10779149
申请日：2004-02-12
申请人： Thomas Wehman , Serjan Nikolic
发明人： Thomas Wehman , Serjan Nikolic
IPC分类号： A61B20060101 , A61B5/103 , A61B5/11 , A61B5/117
CPC分类号： A61B5/4866 , A61B5/1118 , A61B2562/0219 , G06F19/3481
摘要： Methods and apparatus for gathering and processing data sensed on an individual from portable heart monitors and accelerometers aligned along three orthogonal axes determine substantially equivalent oxygen consumption information during an individual's physical activities without requiring gas-flow or gas-analysis equipment. Such information promotes calculations of physiological energy expenditures, and analyses of the accelerometer data associated with a specific sensing location on an individual's body provide indication of the particular physical activity for selecting appropriate scaling factors and filtering requirements in analyzing the data to determine various parameters indicative of the individual's expenditure of physiological energy, and other health-oriented factors.
摘要翻译：用于收集和处理在个人身上活动的便携式心脏监测器和加速度计上检测到的数据的方法和装置在个体的身体活动期间确定基本相当的氧消耗信息，而不需要气流或气体分析设备。这样的信息促进生理能量消耗的计算，并且与个人身体上的特定感测位置相关联的加速度计数据的分析提供了用于选择合适的缩放因子的特定身体活动的指示，并且在分析数据中过滤需求以确定指示个人生理能量支出等健康导向因素。

2. 发明申请

US20050054938A1 Method and apparatus including altimeter and accelerometers for determining work performed by an individual 审中-公开
标题翻译：包括用于确定个人执行的工作的高度计和加速度计的方法和装置
公开(公告)号：US20050054938A1
公开(公告)日：2005-03-10
申请号：US10901675
申请日：2004-07-28
申请人： Thomas Wehman , Serjan Nikolic , Milos Backovic , Peter Muller , Jim Lovewell , Katie Peuvrelle
发明人： Thomas Wehman , Serjan Nikolic , Milos Backovic , Peter Muller , Jim Lovewell , Katie Peuvrelle
IPC分类号： A61B20060101 , A61B5/02 , A61B5/024 , A61B5/22 , H01R13/44
CPC分类号： A61B5/222 , A61B5/024 , A61B5/061 , A63B24/0062 , A63B2220/803 , A63B2230/06
摘要： Method and calculations determine an individual's, or several individuals' simultaneous rates of oxygen consumption, maximum rates of oxygen consumption, heart rates, calorie expenditures, and METS (multiples of metabolic resting rate) in order to determine the amounts of work that is performed by the individual's body. A heart monitor measures the heart rate, and an accelerometer measures the acceleration of the body along one or more axes. An altimeter measures change in altitude, a glucose monitor measures glucose in tissue and blood, and thermometers, thermistors, or thermocouples measure body temperature. Data including body fat and blood pressure measurements are stored locally and transferred to a processor for calculation of the rate of physiological energy expenditure. Certain cardiovascular parameters are mathematically determined. Comparison of each axis response to the individual's moment can be used to identify the type of activity performed and the information may be used to accurately calculate total energy expenditure for each physical activity. Energy expenditure may be calculated by assigning a separate proportionality coefficient to each axis and tabulating the resulting filtered dynamic acceleration over time, or by comparison with previously predetermined expenditures for each activity type. A comparison of total energy expenditure from the current activity is compared with expenditure from a previous activity, or with a baseline expenditure rate to assess the level of current expenditure. A measure of the individual's cardio-vascular health may be obtained by monitoring the heart's responses to various types of activity and to total energy expended.
摘要翻译：方法和计算确定个体或几个个体的同时氧消耗率，最大消耗氧量，心率，卡路里支出和METS（代谢静息率的倍数），以确定由个人的身体。心脏监测器测量心率，加速度计测量身体沿着一个或多个轴的加速度。高度计测量高度变化，葡萄糖监测器测量组织和血液中的葡萄糖，温度计，热敏电阻或热电偶测量体温。包括身体脂肪和血压测量的数据在本地存储并转移到处理器以计算生理能量消耗的速率。数学确定某些心血管参数。可以使用每个轴响应与个人时刻的比较来识别所执行的活动的类型，并且可以使用该信息来精确地计算每个身体活动的总能量消耗。能量消耗可以通过为每个轴分配一个比例系数来计算，并且随着时间的推移列出所得到的过滤的动态加速度，或通过与每个活动类型的先前预定的支出进行比较来计算能量消耗。将当前活动的总能源消耗与以前活动的支出进行比较，或与基准支出率进行比较，以评估当前支出水平。通过监测心脏对各种活动的反应和消耗的总能量，可以获得个体心血管健康的量度。

3. 发明授权

US07674222B2 Cardiac device and methods of use thereof 有权
标题翻译：心脏装置及其使用方法
公开(公告)号：US07674222B2
公开(公告)日：2010-03-09
申请号：US11640469
申请日：2006-12-14
申请人： Serjan Nikolic , Alexander Khairkhahan
发明人： Serjan Nikolic , Alexander Khairkhahan
IPC分类号： A61B1/00
CPC分类号： A61N1/05 , A61B17/12122 , A61B17/12172
摘要： Devices and methods are described herein which are directed to the treatment of a patient's heart having, or one which is susceptible to heart failure, to improve diastolic function.
摘要翻译：本文描述了针对治疗患有心力衰竭或改善舒张功能的患者的心脏的装置和方法。

4. 发明申请

US20060229491A1 Method for treating myocardial rupture 审中-公开
标题翻译：治疗心肌破裂的方法
公开(公告)号：US20060229491A1
公开(公告)日：2006-10-12
申请号：US11199633
申请日：2005-08-09
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00 , A61M1/10
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/00898 , A61B2017/00942 , A61B2017/12095
摘要： A method and device for the treatment of a patient with heart disease and particularly a heart chamber having a myocardial rupture or characteristics of an incipient myocardial rupture. The heart chamber is partitioned so as to isolate a non-productive portion having a rupture or a region of an incipient rupture from a productive portion. The heart chamber is preferably partitioned with a reinforced membrane which has a pressure receiving surface that defines part of the productive portion of the heart chamber. The peripheral base of the reinforced membrane may have an eccentric configuration.
摘要翻译：用于治疗患有心脏病的患者的方法和装置，特别是具有心肌破裂或初始心肌破裂特征的心室。将心脏腔室分隔开以分离具有破裂的非生产性部分或从生产部分开始的初始区域。心室优选用加强膜分隔，该增强膜具有限定心室的生产部分的一部分的压力接收表面。增强膜的周边基底可以具有偏心构造。

5. 发明申请

US20050154252A1 Ventricular partitioning device 有权
标题翻译：心室分配装置
公开(公告)号：US20050154252A1
公开(公告)日：2005-07-14
申请号：US10754182
申请日：2004-01-09
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovanecevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovanecevic
IPC分类号： A61B17/12 , A61F2/00 , A61F2/24
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

6. 发明申请

US20080071298A1 LAMINAR VENTRICULAR PARTITIONING DEVICE 有权
标题翻译：层间静电分隔装置
公开(公告)号：US20080071298A1
公开(公告)日：2008-03-20
申请号：US11860438
申请日：2007-09-24
申请人： Alexander Khairkhahan , Serjan Nikolic
发明人： Alexander Khairkhahan , Serjan Nikolic
IPC分类号： A61B17/00
CPC分类号： A61B17/12172 , A61B17/12122 , A61B2017/00526 , A61B2017/12095
摘要： This invention is directed to a partitioning device for separating a chamber of a patient's heart into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a frame-reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber. Elements of the frame include ribs that are secured to the expandable membrane, to form an integrated structure that may be unilaminar or bilaminar in form. The proximal ends of the ribs of the frame have tissue-penetrating elements about the periphery thereof which are configured to penetrate tissue lining the heart wall at an angle approximately perpendicular to a longitudinal axis of the partitioning device. The partitioning device has a hub with a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者心脏的腔室分离为生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有框架增强的可扩张膜，其分离心室的生产性和非生产性部分。框架的元件包括固定到可膨胀膜的肋，以形成可以是单层或双层形式的整体结构。框架的肋的近端具有围绕其周边的组织穿透元件，其被构造成以大致垂直于分隔装置的纵向轴线的角度穿过围绕心脏壁的组织。分隔装置具有带有非创伤性远端的毂以接合心室壁。

7. 发明申请

US20070213815A1 System for improving cardiac function 有权
公开(公告)号：US20070213815A1
公开(公告)日：2007-09-13
申请号：US11801075
申请日：2007-05-07
申请人： Alexander Khairkhahan , Hugh Sharkey , Serjan Nikolic
发明人： Alexander Khairkhahan , Hugh Sharkey , Serjan Nikolic
IPC分类号： A61M1/10
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.

8. 发明申请

US20100121132A1 CARDIAC DEVICE AND METHODS OF USE THEREOF 有权
标题翻译：心脏装置及其使用方法
公开(公告)号：US20100121132A1
公开(公告)日：2010-05-13
申请号：US12691587
申请日：2010-01-21
申请人： Serjan Nikolic , Alexander Khairkhahan
发明人： Serjan Nikolic , Alexander Khairkhahan
IPC分类号： A61M1/12
CPC分类号： A61N1/05 , A61B17/12122 , A61B17/12172
摘要： Devices and methods are described herein which are directed to the treatment of a patient's heart having, or one which is susceptible to heart failure, to improve diastolic function.
摘要翻译：本文描述了针对治疗患有心力衰竭或改善舒张功能的患者的心脏的装置和方法。

9. 发明申请

US20070161846A1 Cardiac device and methods of use thereof 有权
标题翻译：心脏装置及其使用方法
公开(公告)号：US20070161846A1
公开(公告)日：2007-07-12
申请号：US11640469
申请日：2006-12-14
申请人： Serjan Nikolic , Alexander Khairkhahan
发明人： Serjan Nikolic , Alexander Khairkhahan
IPC分类号： A61N1/362
CPC分类号： A61N1/05 , A61B17/12122 , A61B17/12172
摘要： Devices and methods are described herein which are directed to the treatment of a patient's heart having, or one which is susceptible to heart failure, to improve diastolic function.
摘要翻译：本文描述了针对治疗患有心力衰竭或改善舒张功能的患者的心脏的装置和方法。

10. 发明申请

US20060014998A1 Multiple partitioning devices for heart treatment 有权
标题翻译：用于心脏治疗的多重分隔装置
公开(公告)号：US20060014998A1
公开(公告)日：2006-01-19
申请号：US11151156
申请日：2005-06-10
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61N1/362 , A61F2/00
CPC分类号： A61N1/3627 , A61B17/12022 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/0084 , A61B2017/12095
摘要： This invention is directed to a system and method for partitioning a patient's heart chamber into a productive portion and a non-productive portion which are particularly suitable for treating patients with congestive heart failure. The partitioning system has a plurality of partitioning devices with reinforced, expandable membranes which separate the productive and non-productive portions of the heart chamber. When deployed within the patient's heart chamber, the second partitioning device is off-set from the deployed first partitioning device to cover a region of the wall defining the patient's heart chamber which is not covered by the first partitioning device. The multiple partitioning devices may be independent from each other or may be interconnected, e.g. a tether or strand.
摘要翻译：本发明涉及一种用于将患者的心脏室分成生产部分和非生产性部分的系统和方法，其特别适用于治疗患有充血性心力衰竭的患者。分隔系统具有多个具有加强的可扩张膜的分隔装置，其分离心室的生产和非生产性部分。当部署在患者的心室内时，第二分隔装置从展开的第一分隔装置偏离，以覆盖限定不被第一分隔装置覆盖的患者心室的壁的区域。多个分割装置可以彼此独立，或者可以相互连接。系绳或股绳。

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