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1. 发明申请

US20060229491A1 Method for treating myocardial rupture 审中-公开
标题翻译：治疗心肌破裂的方法
公开(公告)号：US20060229491A1
公开(公告)日：2006-10-12
申请号：US11199633
申请日：2005-08-09
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00 , A61M1/10
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/00898 , A61B2017/00942 , A61B2017/12095
摘要： A method and device for the treatment of a patient with heart disease and particularly a heart chamber having a myocardial rupture or characteristics of an incipient myocardial rupture. The heart chamber is partitioned so as to isolate a non-productive portion having a rupture or a region of an incipient rupture from a productive portion. The heart chamber is preferably partitioned with a reinforced membrane which has a pressure receiving surface that defines part of the productive portion of the heart chamber. The peripheral base of the reinforced membrane may have an eccentric configuration.
摘要翻译：用于治疗患有心脏病的患者的方法和装置，特别是具有心肌破裂或初始心肌破裂特征的心室。将心脏腔室分隔开以分离具有破裂的非生产性部分或从生产部分开始的初始区域。心室优选用加强膜分隔，该增强膜具有限定心室的生产部分的一部分的压力接收表面。增强膜的周边基底可以具有偏心构造。

2. 发明申请

US20060281965A1 Peripheral seal for a ventricular partitioning device 有权
标题翻译：心室分隔装置的外围密封
公开(公告)号：US20060281965A1
公开(公告)日：2006-12-14
申请号：US11151164
申请日：2005-06-10
申请人： Alexander Khairkhahan , Hugh Sharkey , Serjan Nikolic , Branislav Radovancevic
发明人： Alexander Khairkhahan , Hugh Sharkey , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/1219 , A61B2017/00243 , A61B2017/12095 , A61B2017/22061
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.
摘要翻译：本发明涉及一种用于将患者心室分离成生产部分和非生产性部分的分隔装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

3. 发明申请

US20060014998A1 Multiple partitioning devices for heart treatment 有权
标题翻译：用于心脏治疗的多重分隔装置
公开(公告)号：US20060014998A1
公开(公告)日：2006-01-19
申请号：US11151156
申请日：2005-06-10
申请人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
发明人： Hugh Sharkey , Alexander Khairkhahan , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61N1/362 , A61F2/00
CPC分类号： A61N1/3627 , A61B17/12022 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/0084 , A61B2017/12095
摘要： This invention is directed to a system and method for partitioning a patient's heart chamber into a productive portion and a non-productive portion which are particularly suitable for treating patients with congestive heart failure. The partitioning system has a plurality of partitioning devices with reinforced, expandable membranes which separate the productive and non-productive portions of the heart chamber. When deployed within the patient's heart chamber, the second partitioning device is off-set from the deployed first partitioning device to cover a region of the wall defining the patient's heart chamber which is not covered by the first partitioning device. The multiple partitioning devices may be independent from each other or may be interconnected, e.g. a tether or strand.
摘要翻译：本发明涉及一种用于将患者的心脏室分成生产部分和非生产性部分的系统和方法，其特别适用于治疗患有充血性心力衰竭的患者。分隔系统具有多个具有加强的可扩张膜的分隔装置，其分离心室的生产和非生产性部分。当部署在患者的心室内时，第二分隔装置从展开的第一分隔装置偏离，以覆盖限定不被第一分隔装置覆盖的患者心室的壁的区域。多个分割装置可以彼此独立，或者可以相互连接。系绳或股绳。

4. 发明申请

US20060030881A1 Ventricular partitioning device 审中-公开
标题翻译：心室分配装置
公开(公告)号：US20060030881A1
公开(公告)日：2006-02-09
申请号：US10913608
申请日：2004-08-05
申请人： Hugh Sharkey , Alexander Khairkhkahan , Serjan Nikolic , Branislav Radovancevic
发明人： Hugh Sharkey , Alexander Khairkhkahan , Serjan Nikolic , Branislav Radovancevic
IPC分类号： A61B17/08
CPC分类号： A61B17/12172 , A61B17/12122 , A61B2017/00526 , A61B2017/12095
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a frame-reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber. The proximal ends of the ribs of the frame have tissue penetrating elements about the periphery thereof which are configured to penetrate tissue lining the heart wall at an angle approximately perpendicular to a longitudinal axis of the partitioning device. The partitioning device has a hub with a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有框架增强的可扩张膜，其分离心室的生产性和非生产性部分。框架的肋的近端具有围绕其周边的组织穿透元件，其被构造成以大致垂直于分隔装置的纵向轴线的角度穿过围绕心脏壁的组织。分隔装置具有带有非创伤性远端的毂以接合心室壁。

5. 发明授权

US07862500B2 Multiple partitioning devices for heart treatment 有权
标题翻译：用于心脏治疗的多重分隔装置
公开(公告)号：US07862500B2
公开(公告)日：2011-01-04
申请号：US11151156
申请日：2005-06-10
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B17/12022 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/0084 , A61B2017/12095
摘要： This invention is directed to a system and method for partitioning a patient's heart chamber into a productive portion and a non-productive portion which are particularly suitable for treating patients with congestive heart failure. The partitioning system has a plurality of partitioning devices with reinforced, expandable membranes which separate the productive and non-productive portions of the heart chamber. When deployed within the patient's heart chamber, the second partitioning device is off-set from the deployed first partitioning device to cover a region of the wall defining the patient's heart chamber which is not covered by the first partitioning device. The multiple partitioning devices may be independent from each other or may be interconnected, e.g. a tether or strand.
摘要翻译：本发明涉及一种用于将患者的心脏室分成生产部分和非生产性部分的系统和方法，其特别适用于治疗患有充血性心力衰竭的患者。分隔系统具有多个具有加强的可扩张膜的分隔装置，其分离心室的生产和非生产性部分。当部署在患者的心室内时，第二分隔装置从展开的第一分隔装置偏离，以覆盖限定不被第一分隔装置覆盖的患者心室的壁的区域。多个分割装置可以彼此独立，或者可以相互连接。系绳或股绳。

6. 发明授权

US07582051B2 Peripheral seal for a ventricular partitioning device 有权
标题翻译：心室分隔装置的外围密封
公开(公告)号：US07582051B2
公开(公告)日：2009-09-01
申请号：US11151164
申请日：2005-06-10
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/1219 , A61B2017/00243 , A61B2017/12095 , A61B2017/22061
摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.
摘要翻译：一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

7. 发明申请

US20080228205A1 VENTRICULAR PARTITIONING DEVICE 审中-公开
标题翻译：静脉分隔装置
公开(公告)号：US20080228205A1
公开(公告)日：2008-09-18
申请号：US12125015
申请日：2008-05-21
申请人： Hugh R. Sharkey , Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic
发明人： Hugh R. Sharkey , Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61B17/08 , A61M29/00 , A61B19/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

8. 发明申请

US20090287040A1 PERIPHERAL SEAL FOR A VENTRICULAR PARTITIONING DEVICE 有权
标题翻译：用于静脉分隔装置的外周密封
公开(公告)号：US20090287040A1
公开(公告)日：2009-11-19
申请号：US12509289
申请日：2009-07-24
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61F2/02
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/12095 , A61B2017/22061
摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.
摘要翻译：一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

9. 发明授权

US07399271B2 Ventricular partitioning device 有权
标题翻译：心室分配装置
公开(公告)号：US07399271B2
公开(公告)日：2008-07-15
申请号：US10754182
申请日：2004-01-09
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

10. 发明申请

US20070106315A1 Ventricular pump coupling 有权
标题翻译：心室泵联轴器
公开(公告)号：US20070106315A1
公开(公告)日：2007-05-10
申请号：US11582721
申请日：2006-10-17
申请人： Igor Gregoric , Branislav Radovancevic , Alex Hsia
发明人： Igor Gregoric , Branislav Radovancevic , Alex Hsia
IPC分类号： A61B17/08
CPC分类号： A61B17/11 , A61B17/0057 , A61B2017/00247 , A61B2018/00392 , A61M1/1008 , A61M1/12 , A61M1/122
摘要： A device and method for creating a connection with the left ventricle of a heart are provided. A seal member capable of moving between a folded position and an open position is attached to the end of a conduit. An introducer capable of moving between a first and second position allows for the expansion of the seal member into an open position. A clamp component is positioned outside of the heart to provide an axial clamping force with the wall of the heart so that a seal is created between the seal member and the wall of the heart.
摘要翻译：提供了用于创建与心脏左心室的连接的装置和方法。能够在折叠位置和打开位置之间移动的密封件附接到导管的端部。能够在第一位置和第二位置之间移动的引导器允许密封构件膨胀到打开位置。夹紧部件位于心脏外部，以提供与心脏壁的轴向夹紧力，从而在密封构件和心脏壁之间产生密封。

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