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1. 发明授权

US5716849A Genes for the biosynthesis of soraphen 失效
标题翻译：索拉帕生物合成基因
公开(公告)号：US5716849A
公开(公告)日：1998-02-10
申请号：US764233
申请日：1996-12-14
申请人： James M. Ligon , Thomas Schupp , James J. Beck , Dwight S. Hill , Snezana Neff , John A. Ryals
发明人： James M. Ligon , Thomas Schupp , James J. Beck , Dwight S. Hill , Snezana Neff , John A. Ryals
IPC分类号： C12N15/52 , C12N1/20
CPC分类号： C12N15/52
摘要： The present invention is directed to the production of a polyketide antibiotic such as soraphen in a host via recombinant expression of the polypeptides needed to biologically synthesize the polyketide antibiotic. Polyketide synthase (PKS) genes encoding polypeptides necessary to synthesize soraphen are provided, along with methods for identifying and isolating the PKS genes needed to recombinantly biosynthesize any desired polyketide antibiotic. The cloned PKS genes may be transformed and expressed in a desired host organisms to produce soraphen for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of soraphen.
摘要翻译：本发明涉及通过重组表达生物合成聚酮化合物抗生素所需的多肽来在宿主中生产聚酮化合物抗生素例如索帕洛芬。提供了编码合成索拉非所需的多肽的聚酮化合物合酶（PKS）基因，以及用于鉴定和分离重组生物合成任何所需聚酮化合物抗生素所需的PKS基因的方法。克隆的PKS基因可以在所需的宿主生物体中转化和表达，以产生多种目的的索拉帕，包括保护宿主免受病原体的侵袭，将宿主作为生物防治剂开发，并产生大量均匀量的索拉帕芬。

2. 发明授权

US5693774A DNA sequences involved in soraphen biosynthesis by myxobacteria 失效
标题翻译：涉及索拉帕生物合成的DNA序列
公开(公告)号：US5693774A
公开(公告)日：1997-12-02
申请号：US392731
申请日：1995-02-24
申请人： Thomas Schupp , Snezana Neff , James M. Ligon
发明人： Thomas Schupp , Snezana Neff , James M. Ligon
IPC分类号： C12N15/09 , C07K14/195 , C07K14/21 , C12N1/21 , C12N15/52 , C12N15/78 , C12N15/82 , C12P21/02 , C12Q1/68 , C12R1/01 , C07H21/04
CPC分类号： C12N15/52 , C07K14/195 , C07K14/21 , C12N15/78 , C12N15/8282
摘要： The present invention relates to a DNA molecule isolated from the genome of Sorangium cellulosum that encodes a polypeptide required for soraphen biosynthesis and to methods for the preparation of said DNA fragment. The present invention further relates to plasmids, vectors, and host cells that comprise the DNA molecule of the invention.
摘要翻译： PCT No.PCT / US93 / 07954 371日期：1995年2月24日 102（e）1995年2月24日PCT PCT 1993年8月24日PCT公布。公开号WO94 / 05793 日期：1994年3月17日本发明涉及从编码索拉帕生物合成所需的多肽的纤维索朗丝酵母基因组分离的DNA分子及其制备方法。本发明还涉及包含本发明的DNA分子的质粒，载体和宿主细胞。

3. 发明授权

US5686295A Process for the genetic manipulation of myxobacteria 失效
标题翻译：嗜酸性粒细胞的遗传操作过程
公开(公告)号：US5686295A
公开(公告)日：1997-11-11
申请号：US276752
申请日：1994-07-18
申请人： Samir Jaoua , Thomas Schupp , Snezana Neff
发明人： Samir Jaoua , Thomas Schupp , Snezana Neff
IPC分类号： C12N1/21 , C12N15/09 , C12N15/74 , C12R1/01 , C12N15/63
CPC分类号： C12N15/74
摘要： The present invention relates to a novel process for the genetic manipulation of myxobacteria, preferably of myxobacteria of the Sorangium/Polyangium group, which makes it possible for the first time specifically to apply recombinant DNA techniques to this group of organisms. The technical implementation of this process is based primarily on the preparation of recombinant DNA molecules which, by reason of their specific construction, are able to integrate genes or DNA sequences which code, where appropriate, for novel and desirable properties, with the aid of homologous recombination at sites, which are accurately defined by reason of the homologies present, within the bacterial genome, and on the insertion thereof into the myxobacterial cell.
摘要翻译：本发明涉及一种用于神经细菌的遗传操作的新方法，优选地是Sorangium / Polyangium组的粘液细菌，这使得它可以首次将这些重组DNA技术应用于该组生物体。该方法的技术实施主要基于重组DNA分子的制备，由于其特异性构建，能够整合在合适的情况下编码适合的新颖和所需性质的基因或DNA序列，借助于同源物在细菌基因组内，以及在其插入到粘液细菌细胞中的位点处的重组，其被精确地定义为存在的同源物。

4. 发明申请

US20060217402A1 Biocidal compounds and their preparation 审中-公开
标题翻译：杀菌剂及其制备方法
公开(公告)号：US20060217402A1
公开(公告)日：2006-09-28
申请号：US11324647
申请日：2006-01-03
申请人： Jill Benner , Bettina Gertrud Boehlendorf , Martin Kipps , Nicolas Eugene Lambert , Riet Luck , Louis-Pierre Molleyres , Snezana Neff , Traugott Schuez , Paul Stanley
发明人： Jill Benner , Bettina Gertrud Boehlendorf , Martin Kipps , Nicolas Eugene Lambert , Riet Luck , Louis-Pierre Molleyres , Snezana Neff , Traugott Schuez , Paul Stanley
IPC分类号： A61K31/513 , C07D493/02 , C12N1/21 , C12P17/00 , A01N43/54
CPC分类号： C07D493/04
摘要： This invention concerns new biocidal compounds of formula (I) wherein R is H or CH3. Of particular interest are two isomers that are named malayamycin A and desmethylmalayamycin A. These isomers, which may be prepared by growing under controlled conditions a previously unknown strain of micro-organism from the species Streptomyces malaysiensis, are characterised by nmr and mass spectroscopic data. They have biocidal activity, including anti-fungal, anti-viral and anti-cancer activity, and are of special interest for use in agriculture, horticulture, animal and human health.
摘要翻译：本发明涉及式（I）的新的杀生物化合物，其中R是H或CH 3。特别令人感兴趣的是称为马来霉素A和去甲基马来霉素A的两种异构体。这些异构体可以通过在受控条件下生长，从马来西亚马链霉菌种的以前未知的微生物菌株生长，其特征在于nmr和质谱数据。它们具有杀菌活性，包括抗真菌，抗病毒和抗癌活性，对于农业，园艺，动物和人类健康尤为重要。

5. 发明授权

US07026270B2 Biocidal compounds and their preparation 失效
公开(公告)号：US07026270B2
公开(公告)日：2006-04-11
申请号：US10501816
申请日：2003-01-10
申请人： Jill Patricia Benner , Bettina Gertrud Henriette Boehlendorf , Martin Richard Kipps , Nicolas Eugene Paul Lambert , Riet Luck , Louis-Pierre Molleyres , Snezana Neff , Traugott Christoph Schuez , Paul David Stanley
发明人： Jill Patricia Benner , Bettina Gertrud Henriette Boehlendorf , Martin Richard Kipps , Nicolas Eugene Paul Lambert , Riet Luck , Louis-Pierre Molleyres , Snezana Neff , Traugott Christoph Schuez , Paul David Stanley
IPC分类号： A01N25/00 , A01N43/00 , A01N43/60 , A01N239/02 , A01N401/00
CPC分类号： C07D493/04
摘要： This invention concerns new biocidal compounds of formula (I) wherein R is H or CH3. Of particular interest are two isomers that are named malayamycin A and desmethylmalayamycin A. These isomers, which may be prepared by growing under controlled conditions a previously unknown strain of micro-organism from the species Streptomyces malaysiensis, are characterised by nmr and mass spectroscopic data. They have biocidal activity, including anti-fungal, anti-viral and anti-cancer activity, and are of special interest for use in agriculture, horticulture, animal and human health.

6. 发明申请

US20050096229A1 Biocidal compounds and their preparation 失效
标题翻译：杀菌剂及其制备方法
公开(公告)号：US20050096229A1
公开(公告)日：2005-05-05
申请号：US10501816
申请日：2003-01-10
申请人： Jill Benner , Bettina Boehlendorf , Martin Kipps , Nicolas Lambert , Riet Luck , Louis-Pierre Molleyres , Snezana Neff , Traugott Schuez , Paul Stanley
发明人： Jill Benner , Bettina Boehlendorf , Martin Kipps , Nicolas Lambert , Riet Luck , Louis-Pierre Molleyres , Snezana Neff , Traugott Schuez , Paul Stanley
IPC分类号： C12P17/16 , A01N47/36 , A61K31/513 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , C07D20060101 , C07D493/04 , C12N1/20 , C12N1/21 , C12R1/465 , A01N43/54 , C07D493/02
CPC分类号： C07D493/04
摘要： This invention concerns new biocidal compounds of formula (I) wherein R is H or CH3. Of particular interest are two isomers that are named malayamycin A and desmethylmalayamycin A. These isomers, which may be prepared by growing under controlled conditions a previously unknown strain of micro-organism from the species Streptomyces malaysiensis, are characterised by nmr and mass spectroscopic data. They have biocidal activity, including anti-fungal, anti-viral and anti-cancer activity, and are of special interest for use in agriculture, horticulture, animal and human health.
摘要翻译：本发明涉及式（I）的新的杀生物化合物，其中R是H或CH 3。特别令人感兴趣的是称为马来霉素A和去甲基马来霉素A的两种异构体。这些异构体可以通过在受控条件下生长，从马来西亚马链霉菌种的以前未知的微生物菌株生长，其特征在于nmr和质谱数据。它们具有杀菌活性，包括抗真菌，抗病毒和抗癌活性，对于农业，园艺，动物和人类健康尤为重要。

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