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1. 发明授权

US06858404B2 Genes for the biosynthesis of epothilones 失效
标题翻译：埃博霉素生物合成基因
公开(公告)号：US06858404B2
公开(公告)日：2005-02-22
申请号：US10014717
申请日：2001-11-13
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
IPC分类号： C07K14/195 , C12N1/21 , C12P17/18 , C12P1/00
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.
摘要翻译：核酸分子从编码为埃坡霉素生物合成所必需的多肽的纤维索兰分离。披露了用本发明的基因转化的重组宿主中埃坡霉素生产的方法。以这种方式，埃坡霉素可以以足够大的量生产，以使其能够在诸如用于治疗癌症的药物制剂中进行纯化和使用。

2. 发明授权

US06656711B2 Fermentative preparation process for and crystal forms of cytostatics 失效
公开(公告)号：US06656711B2
公开(公告)日：2003-12-02
申请号：US10059587
申请日：2002-01-29
申请人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Küsters , Michael Mutz
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Küsters , Michael Mutz
IPC分类号： C07D4900
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

3. 发明授权

US5693774A DNA sequences involved in soraphen biosynthesis by myxobacteria 失效
标题翻译：涉及索拉帕生物合成的DNA序列
公开(公告)号：US5693774A
公开(公告)日：1997-12-02
申请号：US392731
申请日：1995-02-24
申请人： Thomas Schupp , Snezana Neff , James M. Ligon
发明人： Thomas Schupp , Snezana Neff , James M. Ligon
IPC分类号： C12N15/09 , C07K14/195 , C07K14/21 , C12N1/21 , C12N15/52 , C12N15/78 , C12N15/82 , C12P21/02 , C12Q1/68 , C12R1/01 , C07H21/04
CPC分类号： C12N15/52 , C07K14/195 , C07K14/21 , C12N15/78 , C12N15/8282
摘要： The present invention relates to a DNA molecule isolated from the genome of Sorangium cellulosum that encodes a polypeptide required for soraphen biosynthesis and to methods for the preparation of said DNA fragment. The present invention further relates to plasmids, vectors, and host cells that comprise the DNA molecule of the invention.
摘要翻译： PCT No.PCT / US93 / 07954 371日期：1995年2月24日 102（e）1995年2月24日PCT PCT 1993年8月24日PCT公布。公开号WO94 / 05793 日期：1994年3月17日本发明涉及从编码索拉帕生物合成所需的多肽的纤维索朗丝酵母基因组分离的DNA分子及其制备方法。本发明还涉及包含本发明的DNA分子的质粒，载体和宿主细胞。

4. 发明申请

US20050053927A1 Rifamycin biosynthesis gene cluster 失效
标题翻译：利福霉素生物合成基因簇
公开(公告)号：US20050053927A1
公开(公告)日：2005-03-10
申请号：US10042665
申请日：2002-01-09
申请人： Thomas Schupp , Christiane Toupet , Nathalie Engel
发明人： Thomas Schupp , Christiane Toupet , Nathalie Engel
IPC分类号： C12N1/21 , C12N9/00 , C12N15/52 , C12N15/70 , C12P17/10 , C12P17/18 , C12Q1/68 , C07H21/04 , C12N5/06 , C12P21/02 , G01N33/53
CPC分类号： C12N9/93 , C12N15/52 , C12P17/10 , C12P17/189
摘要： The present invention primarily relates to a DNA fragment which is obtainable from the gene cluster responsible for rifamycin biosynthesis within the genome of Amycolatopsis mediterranei, and comprises at least one gene or a part of a gene which codes for a polypeptide which is directly or indirectly involved in the biosynthesis of rifamycin, and to a method for preparing said DNA fragment. The present invention furthermore relates to recombinant DNA molecules which comprise one of the DNA fragments according to the invention, and to the plasmids and vectors derived therefrom. Host organisms transformed with said plasmid or vector DNA are likewise embraced.
摘要翻译：本发明主要涉及一种可从位于无性赖链霉菌属基因组的基因组中负责利福霉素生物合成的基因簇获得的DNA片段，并且包含编码直接或间接涉及的多肽的至少一个基因或一部分基因在利福霉素的生物合成中，以及制备所述DNA片段的方法。本发明还涉及包含根据本发明的DNA片段之一的重组DNA分子以及由其衍生的质粒和载体。用所述质粒或载体DNA转化的宿主生物体同样被包围。

5. 发明授权

US06383787B1 Genes for the biosynthesis of epothilones 失效
公开(公告)号：US06383787B1
公开(公告)日：2002-05-07
申请号：US09567899
申请日：2000-05-10
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
IPC分类号： C12N900
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

6. 发明授权

US5968992A Reduction of the amine content of recycled polyols 失效
标题翻译：回收多元醇的胺含量的降低
公开(公告)号：US5968992A
公开(公告)日：1999-10-19
申请号：US136224
申请日：1998-08-19
申请人： Bernhard Naber , Michael Gassan , Thomas Schupp , Sarbananda Chakrabarti
发明人： Bernhard Naber , Michael Gassan , Thomas Schupp , Sarbananda Chakrabarti
IPC分类号： C07C29/88 , C07C31/18 , C07C31/20 , C08G18/32 , C08G18/76 , C08G18/83 , C08J11/24
CPC分类号： C08J11/24 , C08G18/765 , C08G18/831 , C08J2375/04 , Y02W30/706
摘要： In a process for reducing the primary amine content of a composition comprising at least one polyol, in which a composition comprising at least one polyol is admixed with at least one isocyanate which contains only secondary and/or tertiary, aliphatically bound isocyanate groups, isocyanate is added in an amount of up to 5% by weight, based on the total composition, and a polyol preparation is obtained.
摘要翻译：在降低包含至少一种多元醇的组合物的伯胺含量的方法中，其中包含至少一种多元醇的组合物与至少一种仅含有二级和/或三级脂族结合的异氰酸酯基团的异氰酸酯混合，异氰酸酯是基于总组合物添加至多5重量％的量，并获得多元醇制剂。

7. 发明授权

US4411896A Rifamycins, their compositions and use as antibiotics 失效
标题翻译：利福霉素，其组合物和用作抗生素
公开(公告)号：US4411896A
公开(公告)日：1983-10-25
申请号：US397379
申请日：1982-07-12
申请人： Thomas Schupp , Peter Traxler , Jakob Nuesch
发明人： Thomas Schupp , Peter Traxler , Jakob Nuesch
IPC分类号： C07D498/08 , C07D498/18 , C12P17/18 , A61K31/395 , C07D491/08
CPC分类号： C07D498/08 , C07D498/18 , C12P17/189 , C12R1/365 , Y10S435/872 , Y10S435/886
摘要： New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X=>C.dbd.O; R.sup.1 =OH; R.sup.2 =H), 3,31-dihydroxy-rifamycin S (formula A: X=>C.dbd.O; R.sup.1 =R.sup.2 =OH) and 1-desoxy-1-oxarifamycin S (formula A: X=--O--; R.sup.1 =R.sup.2 =H) ##STR1## are formed by cultivating, under aerobic conditions, a strain of Nocardia mediterranei which is derived from Streptomyces mediterranei ATCC 13 685 as the parent strain and is characterized by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia mediterranei DSM 1415 has proved suitable. The mentioned rifamycin S analogues have analogous antibiotic properties to this but have a wider range of action, especially against gram-negative bacteria.
摘要翻译：具有利福霉素S的基本结构的新的抗生素活性化合物即3-羟基喜树碱S（式A：X => C = O; R1 = OH; R2 = H），3,31-二羟基利福霉素S（式A：X （A = X = -O-; R 1 = R 2 = H）通过在有氧下培养形成（A），（C = O; R1 = R2 = OH）和1-脱氧-1-氧硫霉素S 条件，来自地衣链霉菌（Streptomyces mediterranei）ATCC13685作为亲本菌株的诺卡氏菌（Nocardia mediterranei）菌株，其特征在于产生至少一种所述化合物的能力。重组菌诺卡氏菌DSM 1415已证明是合适的。所提到的利福霉素S类似物具有类似的抗生素特性，但具有更广泛的作用范围，特别是针对革兰氏阴性细菌。

8. 发明申请

US20070197611A1 Fermentative preparation process for and crystal forms of cytostatics 审中-公开
标题翻译：发酵制备过程和晶体形式的细胞抑制剂
公开(公告)号：US20070197611A1
公开(公告)日：2007-08-23
申请号：US11671357
申请日：2007-02-05
申请人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
IPC分类号： A61K31/427 , C12P17/18 , C12N1/21 , C07D417/02
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto, New crystal forms of epothilone B are also described,
摘要翻译：本发明涉及用于将埃坡霉素浓缩在培养基中的新方法，用于生产埃坡霉素的新方法，用于分离埃坡霉素A和B的新方法和通过诱变获得的用于产生埃坡霉素的新菌株，以及相关方面也描述了埃坡霉素B的新晶体形式，

9. 发明授权

US07101702B2 Fermentative preparation process for and crystal forms of cytostatics 失效
公开(公告)号：US07101702B2
公开(公告)日：2006-09-05
申请号：US10459762
申请日：2003-06-12
申请人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
发明人： Hans Hofmann , Marion Mahnke , Klaus Memmert , Frank Petersen , Thomas Schupp , Ernst Kusters , Michael Mutz
IPC分类号： C12N1/20
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

10. 发明授权

US06358719B1 Genes for the biosynthesis of epothilones 失效
公开(公告)号：US06358719B1
公开(公告)日：2002-03-19
申请号：US09568472
申请日：2000-05-10
申请人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
发明人： Thomas Schupp , James Madison Ligon , Istvan Molnar , Ross Zirkle , Devon Dawn Cyr , Jörn Görlach
IPC分类号： C12N902
CPC分类号： C07K14/195 , C12P17/181
摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

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