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1. 发明申请

US20060229710A1 Vascular graft 审中-公开
标题翻译：血管移植
公开(公告)号：US20060229710A1
公开(公告)日：2006-10-12
申请号：US11386869
申请日：2006-03-23
申请人： Thomas O'Brien , Michael Walsh , Timothy McGloughlin , Pierce Grace , Siobhan O'Callaghan , Paul Devereux
发明人： Thomas O'Brien , Michael Walsh , Timothy McGloughlin , Pierce Grace , Siobhan O'Callaghan , Paul Devereux
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2002/065
摘要： A vascular graft (30) comprises a proximal inlet section (31), a first distal section (32) and a second distal section (33). The first distal section (32) and the second distal section (33) are attached to the proximal inlet section (31) at a Y-shaped bifurcation region. In use the proximal inlet section (31) is attached to a first part (34) of a host artery in an end-to-side anastomosis. A second part (35) of the host artery is cut to form a first section (36) of the host artery on a first side of the cut and a second section (37) of the host artery on a second side of the cut. The first distal section (32) is attached to the first section (36) in an end-to-end anastomosis, and the second distal section (33) is attached to the second section (37) in an end-to-end anastomosis. When implanted the graft (30) directs blood flow from the first part (34) of the host artery through the proximal inlet section (31), into the second distal section (33) and into the second section (37) of the host artery along a single flow path.
摘要翻译：血管移植物（30）包括近端入口部分（31），第一远端部分（32）和第二远端部分（33）。第一远端部分（32）和第二远端部分（33）在Y形分叉区域附接到近侧入口部分（31）。在使用中，近端入口部分（31）以端对侧吻合方式连接到宿主动脉的第一部分（34）。主动脉的第二部分（35）被切割以在切口的第一侧上形成主动脉的第一部分（36）和在切口的第二侧上的主动脉的第二部分（37）。第一远端部分（32）以端对端吻合方式附接到第一部分（36），并且第二远端部分（33）以端对端吻合方式附接到第二部分（37）。当移植物（30）植入时，将来自主动脉的第一部分（34）的血液通过近侧入口部分（31）引导到第二远端部分（33）中并进入主动脉的第二部分（37）沿着单个流动路径。

2. 发明申请

US20060116753A1 Vascular graft 有权
标题翻译：血管移植
公开(公告)号：US20060116753A1
公开(公告)日：2006-06-01
申请号：US11331275
申请日：2006-01-13
申请人： Michael Walsh , Timothy McGloughlin , Pierce Grace
发明人： Michael Walsh , Timothy McGloughlin , Pierce Grace
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2/89 , A61F2002/065 , A61F2002/068 , A61F2220/0075
摘要： A vascular graft (20) comprises a proximal section (4), integral with two branches (2, 3) which terminate in a distal end-to-end section (30). The end-to-end section (30) is attached to a host artery (5) at end-to-end anastomoses (31, 32). Flow of blood from the proximal section (4) to the host artery (5) occurs with a self-correcting flow pattern at the opposing junctions, avoiding arterial bed impingement and associated risk of restenosis.
摘要翻译：血管移植物（20）包括与两个分支（2,3）成一体的近端部分（4），其终止于远端 - 端部部分（30）。端对端部分（30）在端对端吻合（31,32）处附接到主动脉（5）。从近端部分（4）到主动脉（5）的血液流动在相对的连接点处具有自校正流动模式，避免动脉床冲击和相关的再狭窄风险。

3. 发明申请

US20060229709A1 Vascular graft 审中-公开
标题翻译：血管移植
公开(公告)号：US20060229709A1
公开(公告)日：2006-10-12
申请号：US11391474
申请日：2006-03-29
申请人： Liam Morris , Timothy McGloughlin , Patrick Delassus , Michael Walsh , Thomas O'Brien , John Callanan
发明人： Liam Morris , Timothy McGloughlin , Patrick Delassus , Michael Walsh , Thomas O'Brien , John Callanan
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2/90 , A61F2002/065 , A61F2002/068 , A61F2002/075
摘要： A vascular graft comprising a proximal section, iliac distal legs and a bifurcation blending section (7) between the proximal section and the distal legs. The cross-sectional area of the proximal section at the bifurcation point is less than or equal to the sum of the two cross sectional areas of both iliac legs. The blending section (7) generates a smooth transition from the proximal section to both iliac legs which minimizes wave reflections by ensuring that the area ratio at the bifurcated junction (7) is as close to unity or greater than unity as possible. The blending section (7) defines a first lumen for fluid flow from the proximal section into the first distal leg, and a separate second lumen for fluid flow from the proximal section into the second distal leg. The two lumen are separated by means of a gradual flow which separates the fluid flow from the proximal section into each lumen. The distal legs are connected to the blending section (7) at the bifurcation region to form a substantially “Y”-shaped graft.
摘要翻译：一种血管移植物，包括近端部分，髂骨远端腿部和近端部分和远端腿部之间的分叉混合部分（7）。在分叉点处的近端部分的横截面面积小于或等于两个髂腿的两个横截面面积的总和。混合部分（7）产生从近端部分到两个髂骨腿的平滑过渡，其通过确保分叉连接点（7）处的面积比尽可能接近于一致或大于单位而使波反射最小化。混合部分（7）限定用于从近端部分进入第一远端腿部的流体流动的第一腔，以及用于从近端部分流入第二远端腿部的流体的单独的第二腔。通过将流体从近端部分分离成每个管腔的逐渐流动来分离两个内腔。远端腿在分叉区域连接到混合部分（7）以形成基本上“Y”形的移植物。

4. 发明申请

US20110137331A1 Perfusion device 审中-公开
标题翻译：灌注装置
公开(公告)号：US20110137331A1
公开(公告)日：2011-06-09
申请号：US12926704
申请日：2010-12-06
申请人： Michael Walsh , Barry O'Connell , Timothy McGloughlin , Michael V. Lawlor , Michael O'Donnell
发明人： Michael Walsh , Barry O'Connell , Timothy McGloughlin , Michael V. Lawlor , Michael O'Donnell
IPC分类号： A61M29/02
CPC分类号： A61F2/013 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61F2230/0093
摘要： A vascular filter device (1) has a perfusion balloon (3) with a through-hole for blood flow. There is a distal filter (4) for trapping emboli, and the filter (4) is configured to filter an annular cross-sectional area extending from a vessel wall, while leaving an un-filtered central passageway. The filter (4) may be substantially frusto-conical in shape when deployed, and have a proximal tubular part (41) which is attached to the perfusion balloon or a support for the perfusion balloon. The filter has a retainer (5) to retain an end of the filter in an in-use position abutting a vessel wall. The retainer may comprise wires (5) or an inflated ring (8). The device may have an internal support (2, 12, 22, 96, 112) for the perfusion balloon (3, 11, 21, 95, 111). The balloon inflates and expands the inner arterial wall, and the filter captures emboli released during the procedure while leaving a channel that allows blood to flow to tissues distal to the blockage, maintaining antegrade flow. This may prevent the onset of an ischemic stroke or other perioperative neurological events.
摘要翻译：血管过滤器装置（1）具有带有用于血流的通孔的灌注球囊（3）。存在用于捕获栓塞的远端过滤器（4），并且过滤器（4）构造成过滤从容器壁延伸的环形横截面区域，同时留下未过滤的中心通道。过滤器（4）在展开时可以基本上为截头圆锥形，并且具有附接到灌注球囊的近端管状部分（41）或用于灌注球囊的支撑件。过滤器具有保持器（5），以将过滤器的端部保持在与容器壁相邻的使用中的位置。保持器可以包括电线（5）或充气环（8）。该装置可以具有用于灌注球囊（3,11,21,91,111）的内部支撑件（2,12,22,96,112）。气囊膨胀并膨胀内动脉壁，并且过滤器捕获在手术期间释放的栓塞，同时留下允许血液流动到远离阻塞的组织的通道，保持顺行流动。这可能会阻止缺血性卒中或其他围手术期神经系统事件的发生。

5. 发明授权

US10127813B2 Systems and methods for alerting drivers of approaching emergency vehicles 有权
公开(公告)号：US10127813B2
公开(公告)日：2018-11-13
申请号：US14600925
申请日：2015-01-20
申请人： Michael Walsh , Virginia E. Foster , Ryan McNeely
发明人： Michael Walsh , Virginia E. Foster , Ryan McNeely
IPC分类号： G08G1/0965
摘要： A computer-implemented method for alerting passenger vehicles of approaching emergency vehicles is implemented by an alert management computing device. The method includes receiving an emergency vehicle alert request message from an emergency vehicle transmitter, receiving passenger vehicle location data from a plurality of passenger vehicle user computing devices located in a plurality of passenger vehicles, wherein the passenger vehicle location data includes a present passenger vehicle location and a present passenger vehicle trajectory, identifying an alert zone for the emergency vehicle based on the present emergency vehicle location and the present emergency vehicle trajectory, identifying a vehicle zone for each of the plurality of passenger vehicles, identifying a subset of the passenger vehicles within the alert zone by comparing each vehicle zone to the alert zone, and transmitting a warning to the subset of passenger vehicles via the passenger vehicle user computing devices.

6. 发明授权

US08165078B2 System and method for controlling use of a network resource 有权
标题翻译：控制网络资源使用的系统和方法
公开(公告)号：US08165078B2
公开(公告)日：2012-04-24
申请号：US12274348
申请日：2008-11-19
申请人： Michael Walsh , Ravi Keswani , Manicka Babu , Nahrin Reihaneh , Bingwu Li
发明人： Michael Walsh , Ravi Keswani , Manicka Babu , Nahrin Reihaneh , Bingwu Li
IPC分类号： G06Q30/00
CPC分类号： H04L63/10 , G06Q30/02 , G06Q30/0225 , H04L63/123
摘要： A system includes a control source that is provided on a server and control logic that executes on a terminal. The control logic executes on a terminal to (i) identify a plurality of attributes on the terminal, the attributes including an identifier for each of a plurality of terminal assets that include one or more of a hardware fixture, firmware, or operating system; and (ii) generate signature data from the plurality of attributes. The control source is configured to make a determination from the signature data as to whether the terminal is known or unknown.
摘要翻译：系统包括提供在服务器上的控制源和在终端上执行的控制逻辑。控制逻辑在终端上执行以（i）识别终端上的多个属性，所述属性包括包括硬件固定装置，固件或操作系统中的一个或多个的多个终端资产中的每一个的标识符; 和（ii）从多个属性生成签名数据。控制源被配置为从签名数据确定终端是已知的还是未知的。

7. 发明申请

US20090285385A1 Queuing Systems for Contact Centers 审中-公开
标题翻译：联络中心排队系统
公开(公告)号：US20090285385A1
公开(公告)日：2009-11-19
申请号：US12119711
申请日：2008-05-13
申请人： Christopher Dunbar , Thomas Morris , Michael Walsh
发明人： Christopher Dunbar , Thomas Morris , Michael Walsh
IPC分类号： H04M3/00
CPC分类号： H04M3/523 , H04M3/48
摘要： Customers queuing in the contact center are provided with the option to request a ticket number. Upon a ticket number being generated for the customer, the customer may disconnect or hang up, and an absentee contact is maintained in a queuing system. This allows the customer to reconnect within a predefined period and regain a place in a queue, possibly at a more advantageous position or at the top of the queue. Alternatively, the customer may reconnect at a less favorable position, but without having to re-enter all customer details in order to be allocated to an appropriate queue.
摘要翻译：在联络中心排队的客户可以选择要求机票号码。在为客户生成机票号码时，客户可能会断开连接或挂断，并且在排队系统中维护缺席者联系人。这允许客户在预定义的时间段内重新连接并且重新获得队列中的位置，可能在更有利的位置或队列的顶部。或者，客户可以在不太有利的位置重新连接，而不必重新输入所有客户细节，以便分配给适当的队列。

8. 发明申请

US20090197268A1 METHODS FOR OPTIMIZING CLINICAL RESPONSIVENESS TO METHOTREXATE THERAPY USING METABOLITE PROFILING AND PHARMACOGENETICS 审中-公开
公开(公告)号：US20090197268A1
公开(公告)日：2009-08-06
申请号：US12191290
申请日：2008-08-13
申请人： Thierry Dervieux , Michael Walsh
发明人： Thierry Dervieux , Michael Walsh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N33/574 , Y10T436/24
摘要： The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the individual. The present invention also provides methods for generating a pharmacogenetic index for predicting clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. In addition, the present invention provides methods for optimizing therapeutic efficacy of chemotherapy in an individual by calculating the level of at least one long-chain MTXPG in a sample obtained from the individual.

9. 发明申请

US20090197267A1 METHODS FOR OPTIMIZING CLINICAL RESPONSIVENESS TO METHOTREXATE THERAPY USING METABOLITE PROFILING AND PHARMACOGENETICS 审中-公开
标题翻译：使用代谢物分析和药代动力学优化甲基化疗法临床应答的方法
公开(公告)号：US20090197267A1
公开(公告)日：2009-08-06
申请号：US12191287
申请日：2008-08-13
申请人： Thierry Dervieux , Michael Walsh
发明人： Thierry Dervieux , Michael Walsh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N33/574 , Y10T436/24
摘要： The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the individual. The present invention also provides methods for generating a pharmacogenetic index for predicting clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. In addition, the present invention provides methods for optimizing therapeutic efficacy of chemotherapy in an individual by calculating the level of at least one long-chain MTXPG in a sample obtained from the individual.
摘要翻译：本发明提供了通过至少一种基因中的多态性的基因型分析优化个体化疗的临床应答性的方法。本发明的方法还可以包括确定从个体获得的样品中至少一种长链甲氨蝶呤聚谷氨酸（MTXPG）的水平。本发明还提供了通过至少一种基因中的多态性的基因分析来产生用于预测个体对化疗的临床反应性的药代动力学指标的方法。此外，本发明提供了通过计算从个体获得的样品中的至少一种长链MTXPG的水平来优化个体化疗的治疗功效的方法。

10. 发明申请

US20090083176A1 METHODS FOR ALLOCATING RISKS OF FUTURE MAJOR DEVELOPMENTS 审中-公开
标题翻译：分配未来主要发展风险的方法
公开(公告)号：US20090083176A1
公开(公告)日：2009-03-26
申请号：US12263050
申请日：2008-10-31
申请人： Richard SANDOR , Michael Walsh
发明人： Richard SANDOR , Michael Walsh
IPC分类号： G06Q40/00
CPC分类号： G06Q40/06 , G06Q40/04 , G06Q40/08 , G06Q50/26
摘要： Computer-implemented methods for allocating risks from major developments are described. The methods include identifying one or more future major developments with economic impact; identifying a parameter to indicate that each of the developments has or has not occurred; creating a contractual instrument that is based on the occurrence or non-occurrence of the one or more major developments; and trading the instrument. A contractual instrument based upon on an occurrence or non-occurrence of one or more major developments in electronic form and tradable in the methods is also described.
摘要翻译：描述了计算机实施的主要发展风险分配方法。这些方法包括确定一个或多个以后的经济影响的重大发展; 确定一个参数，以表明每个发展已经或没有发生; 创建一个基于发生或不发生一个或多个主要发展的合同文书; 并交易仪器。还描述了基于在电子形式的一个或多个主要发展的发生或不发生的方法中可交易的合同工具。

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