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1. 发明申请

US20080188813A1 Injection Device with a Processor for Collecting Ejection Information 审中-公开
标题翻译：具有用于收集喷射信息的处理器的注射装置
公开(公告)号：US20080188813A1
公开(公告)日：2008-08-07
申请号：US11665623
申请日：2005-10-20
申请人： Thomas Miller , Christian Peter Enggaard , Preben Nielsen , Bodo von Munchow
发明人： Thomas Miller , Christian Peter Enggaard , Preben Nielsen , Bodo von Munchow
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/14566 , A61M5/20 , A61M5/24 , A61M5/31525 , A61M5/31553 , A61M5/3202 , A61M2005/3125 , A61M2005/3126 , A61M2205/3317 , A61M2205/3389 , A61M2205/50 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587 , A61M2209/086 , G01D5/2451 , G01D21/00 , G01F11/029
摘要： A medication delivery device comprises an injection device having a reservoir comprising a medicament to be ejected, and a sensor arranged to detect an ejection of the medicament from the injection device, the sensor being arranged to output a signal comprising ejecting information, and a processor for collecting and storing the ejection information.
摘要翻译：药物输送装置包括具有包括待喷射的药物的储存器的注射装置和布置成检测来自注射装置的药物的喷射的传感器，所述传感器被布置成输出包括喷射信息的信号，以及处理器收集和存储弹出信息。

2. 发明授权

US10383996B2 Injection device with a processor for collecting ejection information 有权
公开(公告)号：US10383996B2
公开(公告)日：2019-08-20
申请号：US11665623
申请日：2005-10-20
申请人： Thomas Miller , Christian Peter Enggaard , Preben Nielsen , Bodo von Münchow
发明人： Thomas Miller , Christian Peter Enggaard , Preben Nielsen , Bodo von Münchow
IPC分类号： A61M5/20 , A61M5/24 , A61M5/31 , A61M5/32 , A61M5/145 , A61M5/315 , G01D21/00 , G01D5/245 , G01F11/02
摘要： A medication delivery device comprises an injection device having a reservoir comprising a medicament to be ejected, and a sensor arranged to detect an ejection of the medicament from the injection device, the sensor being arranged to output a signal comprising ejecting information, and a processor for collecting and storing the ejection information.

3. 发明授权

US09901828B2 Method for an augmented reality character to maintain and exhibit awareness of an observer 有权
公开(公告)号：US09901828B2
公开(公告)日：2018-02-27
申请号：US12963585
申请日：2010-12-08
申请人： Thomas Miller , George Weising
发明人： Thomas Miller , George Weising
IPC分类号： G09G5/00 , A63F13/655 , A63F13/5255 , A63F13/213 , A63F13/211 , A63F13/92 , G06T19/00
CPC分类号： A63F13/655 , A63F13/211 , A63F13/213 , A63F13/5255 , A63F13/92 , A63F2300/105 , A63F2300/1093 , A63F2300/204 , A63F2300/6607 , A63F2300/6676 , A63F2300/69 , G06F3/011 , G06F3/013 , G06F3/017 , G06F3/0304 , G06T19/006 , G09G2340/12 , G09G2340/125 , G09G2340/14 , G09G2354/00
摘要： Methods and systems for enabling an augmented reality character to maintain and exhibit awareness of an observer are provided. A portable device held by a user is utilized to capture an image stream of a real environment, and generate an augmented reality image stream which includes a virtual character. The augmented reality image stream is displayed on the portable device to the user. As the user maneuvers the portable device, its position and movement are continuously tracked. The virtual character is configured to demonstrate awareness of the user by, for example, adjusting its gaze so as to look in the direction of the portable device.

4. 发明授权

US08367990B2 Modular commercial microwave oven 有权
标题翻译：模块化商用微波炉
公开(公告)号：US08367990B2
公开(公告)日：2013-02-05
申请号：US12783938
申请日：2010-05-20
申请人： Thomas Miller , Robert A. Schulte , Kami Poppen , Deborah Parenza
发明人： Thomas Miller , Robert A. Schulte , Kami Poppen , Deborah Parenza
IPC分类号： H05B6/80
CPC分类号： H05B6/6426
摘要： A microwave oven cabinet is ergonomic designed to provide for both stacking and jigsaw-type back-to-back interlining of multiple units of the microwave ovens. In particular, the cabinet configuration advantageously establishes a reduced footprint, ergonomically designed microwave oven which can be effectively employed in various fields, including fast food chains wherein multiple such ovens may need to be functionally positioned in a limited area, while still being easily accessible.
摘要翻译：微波炉柜符合人体工程学设计，可提供多台微波炉的堆叠和拼图型背对背衬布。特别地，橱柜配置有利地建立了减少的占地面积，符合人体工程学设计的微波炉，其可以有效地用于各种领域，包括快餐食品链，其中多个这样的烤箱可能需要在有限的区域中功能地定位，同时仍然易于接近。

5. 发明授权

US08272325B2 Detonator free laser initiated blasting system 有权
标题翻译：雷管自由激光发射爆破系统
公开(公告)号：US08272325B2
公开(公告)日：2012-09-25
申请号：US12450137
申请日：2008-03-14
申请人： Richard John Goodridge , Rodney Wayne Appleby , David Olaf Johnson , Thomas Miller
发明人： Richard John Goodridge , Rodney Wayne Appleby , David Olaf Johnson , Thomas Miller
IPC分类号： F42B3/113
CPC分类号： F42D1/043 , F42B3/113
摘要： A detonator free blasting system, which comprises: a bulk explosive; a confined explosive; a fiber optic adapted to deliver laser light to the confined explosive, wherein the confined explosive is provided relative to the bulk explosive such that detonation of the confined explosive causes initiation of the bulk explosive.
摘要翻译：爆炸器自由爆破系统，包括：爆炸物; 限制爆炸物适用于向受限制的炸药传送激光的光纤，其中所述密封的爆炸物相对于大量爆炸物提供，使得限制的爆炸物的爆炸引起爆炸物的爆发。

6. 发明申请

US20120225793A1 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS 审中-公开
标题翻译：鉴别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US20120225793A1
公开(公告)日：2012-09-06
申请号：US13409416
申请日：2012-03-01
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C40B30/04
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

7. 发明授权

US08131475B2 Methods for identifying, diagnosing, and predicting survival of lymphomas 有权
标题翻译：识别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US08131475B2
公开(公告)日：2012-03-06
申请号：US11493387
申请日：2006-07-25
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

8. 发明申请

US20110230834A1 SYSTEMS AND METHODS ALLOWING FOR RESERVOIR AIR BUBBLE MANAGEMENT 有权
标题翻译：用于储存空气泡沫管理的系统和方法
公开(公告)号：US20110230834A1
公开(公告)日：2011-09-22
申请号：US13118358
申请日：2011-05-27
申请人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
发明人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
IPC分类号： A61M5/142 , B23P17/00 , A61M5/14
CPC分类号： A61M5/36 , A61J1/201 , A61J1/2075 , A61J1/2096 , A61M5/1413 , A61M5/14248 , A61M5/165 , A61M5/38 , A61M2005/14268 , A61M2005/341 , A61M2209/045 , Y10T29/494
摘要： Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.
摘要翻译：本发明的各种实施方案涉及限制储存器中流体介质中气泡的存在。空气通道可允许空气从储存器中的流体介质中逸出。在流体介质进入储存器之前，膜可以允许在流体介质中捕获气泡。膜可以允许空气从包含流体介质的第一储存器流动到第二储存器，而每个储存器内的柱塞头在储存器内移动。具有膜的内部储存器可以在外部储存器内移动以允许空气从外部储存器移动到内部储存器。含有加压气体的内部容器可允许将流体介质转移到外部储存器。

9. 发明授权

US07959715B2 Systems and methods allowing for reservoir air bubble management 有权
标题翻译：允许储层气泡管理的系统和方法
公开(公告)号：US07959715B2
公开(公告)日：2011-06-14
申请号：US12111815
申请日：2008-04-29
申请人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
发明人： Julian D. Kavazov , Rafael Bikovsky , Arsen Ibranyan , David Hezzell , Christopher G. Griffin , Mike Lee , Truong Gia Luan , Benjamin X. Shen , Thomas Miller
IPC分类号： B01D53/22 , B01D19/00
CPC分类号： A61M5/36 , A61J1/201 , A61J1/2075 , A61J1/2096 , A61M5/1413 , A61M5/14248 , A61M5/165 , A61M5/38 , A61M2005/14268 , A61M2005/341 , A61M2209/045 , Y10T29/494
摘要： Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.
摘要翻译：本发明的各种实施方案涉及限制储存器中流体介质中气泡的存在。空气通道可允许空气从储存器中的流体介质中逸出。在流体介质进入储存器之前，膜可以允许在流体介质中捕获气泡。膜可以允许空气从包含流体介质的第一储存器流动到第二储存器，而每个储存器内的柱塞头在储存器内移动。具有膜的内部储存器可以在外部储存器内移动以允许空气从外部储存器移动到内部储存器。含有加压气体的内部容器可允许将流体介质转移到外部储存器。

10. 发明授权

US07772238B2 Benzothiophene hydroxamic acid derivatives 有权
标题翻译：苯并噻吩异羟肟酸衍生物
公开(公告)号：US07772238B2
公开(公告)日：2010-08-10
申请号：US11918912
申请日：2006-04-14
申请人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
发明人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
IPC分类号： A61K31/496 , A61K31/381 , C07D405/04 , C07D333/56
CPC分类号： C07D333/70 , A61K31/38 , A61K31/381 , A61K31/41
摘要： The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
摘要翻译：本发明涉及一类新型异羟肟酸衍生物。异羟肟酸化合物可用于治疗癌症。异羟肟酸化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经变性疾病本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。

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