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1. 发明授权

US06835271B1 Adhesive systems 失效
标题翻译：粘合系统
公开(公告)号：US06835271B1
公开(公告)日：2004-12-28
申请号：US10048848
申请日：2002-04-05
申请人： Thomas Luchterhandt , Hendrik M Grupp , Rainer Guggenberger
发明人： Thomas Luchterhandt , Hendrik M Grupp , Rainer Guggenberger
IPC分类号： A61K600
CPC分类号： C09J4/00 , A61K6/0023 , C08F230/02 , C08F220/30 , C08L33/00 , C08L43/02
摘要： The invention relates to the use of adhesive systems which are radically polymerizable and contain 1-30 wt.-% of a reactive solvent with a pKS value less than or equal to that of acetone and are used for the attachment of materials which are only or also cationically polymerizable to hard tissue containing water. The adhesive systems contain at least one component i) which is capable of starting a radical reaction and one component ii) which contains radically polymerizable monomers which are acid-functional or contain groups which can form acids and optionally customary additives.
摘要翻译：本发明涉及使用可自由基聚合的粘合剂体系，并含有1-30重量％的pKS值小于或等于丙酮的反应性溶剂，并且用于附着仅仅是或也可阳离子聚合成含有水的硬组织。粘合剂体系含有至少一种能够开始自由基反应的组分i）和一种包含可自由基聚合的单体的组分ⅱ），该组分是酸官能团或含有可形成酸和任选的常规添加剂的基团。

2. 发明授权

US06767935B1 Adhesive systems 有权
标题翻译：粘合系统
公开(公告)号：US06767935B1
公开(公告)日：2004-07-27
申请号：US10048943
申请日：2002-06-17
申请人： Thomas Luchterhandt , Rainer Guggenberger , Hendrik M. Grupp
发明人： Thomas Luchterhandt , Rainer Guggenberger , Hendrik M. Grupp
IPC分类号： C08F246
CPC分类号： C09J163/00 , A61K6/0023 , A61K6/005 , C08G59/24 , C08G59/3254 , Y10S522/908 , C08L33/00 , C08L43/02
摘要： The invention relates to the utilization of an adhesive system containing at least one component i) which is capable of initiating cationic polymerization and is selected from unsaturated carbonic acids and their anhydrides or acid chlorides, unsaturated phosphoric acids and their esters, unsaturated phosphonic acids and their esters, unsaturated sulfonic acids and their esters, and strong inorganic acids, and at least one component, ii) that can undergo cationic polymerisation for the hardening of radical or cationic or radical and cationically curable materials on laminated fabric which contains water.
摘要翻译：本发明涉及使用含有至少一种能够引发阳离子聚合的组分i）的粘合剂体系，其选自不饱和碳酸及其酸酐或酰氯，不饱和磷酸及其酯，不饱和膦酸及其不饱和膦酸酯，不饱和磺酸及其酯和强无机酸，以及至少一种组分，ii）可经历阳离子聚合以固化含有水的层压织物上的自由基或阳离子或自由基和可阳离子固化的材料。

3. 发明授权

US07097456B1 Amalgam substitute 失效
标题翻译：汞合金替代品
公开(公告)号：US07097456B1
公开(公告)日：2006-08-29
申请号：US10110941
申请日：2000-10-20
申请人： Karsten Dede , Oliver Frey , Oswald Gasser , Rainer Guggenberger , Thomas Luchterhandt , Wolfgang Weinmann , Thomas Klettke
发明人： Karsten Dede , Oliver Frey , Oswald Gasser , Rainer Guggenberger , Thomas Luchterhandt , Wolfgang Weinmann , Thomas Klettke
IPC分类号： A61C5/00
CPC分类号： A61K6/0017 , A61K6/0023 , A61K6/083 , C08L33/00
摘要： The invention relates to filling systems containing as component i) a sealing system which is capable of bonding to the tooth hard substance, as component ii) a filling material suitable for restorative dentistry, the filling system containing in addition a component iii) in component i) and/or component ii) which reduces the curing of the respective other component by disturbance of the curing mechanism only in the boundary layer between sealant and filling material such that the bonding between components i) and ii) is less than the bonding of component i) to the tooth hard substance.
摘要翻译：本发明涉及包含作为组分的密封系统的填充系统，i）能够粘合到牙齿硬质物质上的密封系统，作为组分ii）适于修复牙科的填充材料，填充系统另外还包含组分i中的组分iii））和/或组分ii），其仅通过在密封剂和填充材料之间的边界层中的固化机理的干扰来减少相应的其它组分的固化，使得组分i）和ii）之间的键合小于组分我）到牙齿硬物质。

4. 发明申请

US20120107245A1 DENTAL COMPOSITION FOR DETECTION OF CARIOUS TISSUE, DETECTION METHOD 审中-公开
标题翻译：用于检测重症组织的牙齿组合物，检测方法
公开(公告)号：US20120107245A1
公开(公告)日：2012-05-03
申请号：US13348310
申请日：2012-01-11
申请人： Rainer Guggenberger , Thomas Luchterhandt , Ingo R. Haeberlein , Oliver Kappler , Miriam Hansen
发明人： Rainer Guggenberger , Thomas Luchterhandt , Ingo R. Haeberlein , Oliver Kappler , Miriam Hansen
IPC分类号： A61K49/00 , A61P1/02
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/466 , A61K8/49 , A61K49/006 , A61K49/0071 , A61K2800/45
摘要： A dental composition and method for detecting carious tissue on the surface of a tooth, and the use of the dental composition to manufacture a remedy for detection of carious tissue. The dental composition can comprise an aqueous solution of 1) at least one acidic compound, 2) at least one salt of said acidic compound, 3) at least one indicator that generates a detectable signal when said solution reaches a particular pH value that is less than 5.5; wherein 1) and 2) are selected such that the aqueous solution has a pH of less than that particular pH value where the indicator generates the signal. The method can comprise the steps of 1) providing the above mentioned dental composition, 2) applying said composition to the surface of said tooth, and 3) measuring the amount of time required for the composition to change color.
摘要翻译：用于检测牙齿表面上的龋齿组织的牙科用组合物和方法，以及牙科组合物用于制造用于检测龋齿组织的补救剂的用途。牙科用组合物可以包含1）至少一种酸性化合物的水溶液，2）所述酸性化合物的至少一种盐，3）当所述溶液达到特定pH值较小时产生可检测信号的至少一种指示剂超过5.5; 其中选择1）和2）使得水溶液的pH值小于指示剂产生信号的特定pH值。该方法可以包括以下步骤：1）提供上述牙齿组合物，2）将所述组合物施用到所述牙齿的表面，以及3）测量所述组合物改变颜色所需的时间量。

5. 发明申请

US20080241800A1 Dental Composition For Detection of Carious Tissue, Detection Method 审中-公开
标题翻译：用于检测龋齿组织的牙科组合，检测方法
公开(公告)号：US20080241800A1
公开(公告)日：2008-10-02
申请号：US11914990
申请日：2006-05-24
申请人： Rainer Guggenberger , Thomas Luchterhandt , Ingo R. Haeberlein , Miriam Hansen
发明人： Rainer Guggenberger , Thomas Luchterhandt , Ingo R. Haeberlein , Miriam Hansen
IPC分类号： C09K3/00 , A61K6/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/466 , A61K8/49 , A61K49/006 , A61K49/0071 , A61K2800/45
摘要： The present invention relates to a dental composition comprising an aqueous solution of 1) at least one acidic compound, 2) at least one salt of said acidic compound, 3) at least one indicator that generates a detectable signal when said solution reaches a particular pH value that is less than 5.5 wherein 1) and 2) are selected such that the aqueous solution has a pH of less than that particular pH value where the indicator generates the signal. It further relates to a method for detection of carious tissue on the surface of a tooth, comprising the steps of 1) providing the above mentioned dental composition, 2) applying said composition to the surface of said tooth, and 3) measuring the amount of time required for the composition to change color.It further relates to the use of said dental composition to manufacture a remedy for detection of carious tissue.
摘要翻译：本发明涉及一种牙科用组合物，其包含1）至少一种酸性化合物的水溶液，2）所述酸性化合物的至少一种盐，3）当所述溶液达到特定pH时产生可检测信号的至少一种指示剂选择小于5.5的值，其中1）和2）被选择为使得水溶液的pH值小于指示剂产生信号的特定pH值。它还涉及一种用于检测牙齿表面上的龋齿组织的方法，包括以下步骤：1）提供上述牙科组合物，2）将所述组合物施用到所述牙齿的表面，以及3）组合物改变颜色所需的时间。它还涉及所述牙科用组合物的用途来制造用于检测龋齿组织的补救措施。

6. 发明授权

US5520922A Formable composition and its use as filling material for dental root canals 失效
标题翻译：成型组合物及其作为牙根管填充材料的用途
公开(公告)号：US5520922A
公开(公告)日：1996-05-28
申请号：US323708
申请日：1994-10-18
申请人： Oswald Gasser , Rainer Guggenberger
发明人： Oswald Gasser , Rainer Guggenberger
IPC分类号： A61K6/027 , A61K6/00 , A61K6/06 , A61K6/083 , C04B28/28 , C08K3/16 , C08K3/22 , C08K3/40
CPC分类号： A61K6/0038 , A61K6/0032 , A61K6/0276 , C04B28/28 , C08K3/16 , C08K3/22 , C08K3/40 , C04B2103/0004 , C04B2111/00836
摘要： There are provided formable compositions which comprise:(A) 25 to 80% by weight of a glass ionomer cement, containing (a) an aluminum fluorosilicate glass, (b) at least one polymeric polyacid with an average molecular weight >500, (c) water and (d) optionally a chelating agent;(B) and 20 to 75% by weight of a fluoride and/or oxide and/or mixed fluoride and/or mixed oxide of heavy metal elements which are essentially insoluble at ambient temperatures in an aqueous solution containing the polymeric polyacid and/or an aqueous solution containing the chelating agent.The compositions are especially well suited as filling materials for dental root canals.
摘要翻译：提供了可成型组合物，其包含：（A）25至80重量％的玻璃离聚物粘合剂，其包含（a）氟硅酸铝玻璃，（b）至少一种平均分子量> 500的聚合多元酸（c ）水和（d）任选的螯合剂; （B）和20至75重量％的氟化物和/或氧化物和/或混合的氟化物和/或重金属元素的混合氧化物，其在环境温度下基本上不溶于含有聚合多元酸的水溶液和/或含有螯合剂的水溶液。该组合物特别适用于牙根管的填充材料。

7. 发明授权

US5086148A Polyether-impression material and method for its preparation and use 失效
标题翻译：聚酯材料及其制备和使用方法
公开(公告)号：US5086148A
公开(公告)日：1992-02-04
申请号：US435994
申请日：1989-11-14
申请人： Peter Jochum , Oswald Gasser , Wolf-Dietrich Zahler , Gunther Lechner , Rainer Guggenberger , Klaus Ellrich
发明人： Peter Jochum , Oswald Gasser , Wolf-Dietrich Zahler , Gunther Lechner , Rainer Guggenberger , Klaus Ellrich
IPC分类号： A61K6/10 , C08G77/46 , C08K5/549 , C08L71/00 , C08L71/02
CPC分类号： A61K6/10
摘要： A polyether-impression material comprising components(a) a polyether, which has at least two optionally substituted vinyl- and/or allyl-end groups,(b) an SiH component,(c) a platinum catalyst, and optionally(d) the usual additivescharacterized in that the SiH-component (b) can be obtained by the reaction of at least a bi- functional, or polyfunctional, e.g., trifunctional, allyl- or vinyl-hydrocarbon compound, the hydrocarbon radical of which, without taking account of the allyl- or vinyl-groups and the optionally present alkylene ether groups, has 6 to 30 C-atom and contains at least one aromatically unsaturated, heterocyclic, or cycloaliphatic ring, with at least one mole per vinyl- or allyl-group of at least a bifunctional, or polyfunctional, e.g., trifunctional, SiH compound of the formula: ##STR1## in which e=0 to 8,g=0 to 8,h=0 to 4 andR.sup.4 and R.sup.10 are the same or different, and are each H, methyl or ethyl, with the proviso that at least 1 and at the most 5 of R.sup.4 to R.sup.10 are H, wherein g and h cannot simultaneously be O, and wherein at least the components (b) and (c) lie spatially separated from each other.
摘要翻译：一种聚醚压印材料，其包含组分（a）聚醚，其具有至少两个任选取代的乙烯基和/或烯丙基端基，（b）SiH组分，（c）铂催化剂和任选地（d）通常的添加剂，其特征在于SiH组分（b）可以通过至少二官能或多官能的，例如三官能的烯丙基或乙烯基烃化合物，其烃基，而不考虑的烯丙基或乙烯基和任选存在的亚烷基醚基具有6至30个C原子并且含有至少一个芳族不饱和的，杂环的或脂环族的环，每个乙烯基或烯丙基具有至少一个摩尔至少一种双官能或多官能的例如三官能的下式的化合物：其中e = 0至8，g = 0至8，h = 0至4，R4和R10为相同或不同，并且各自为H，甲基或乙基，条件是R 4的至少1和最多5个至R 10为H，其中g和h不能同时为O，并且其中至少组分（b）和（c）在空间上彼此分离。

8. 发明授权

US09050332B2 Enzyme containing composition, process of producing said composition and its use 有权
标题翻译：含酶组合物，所述组合物的制备方法及其用途
公开(公告)号：US09050332B2
公开(公告)日：2015-06-09
申请号：US12122027
申请日：2008-05-16
申请人： Ingo Häberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Häberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K38/47 , A61K38/48
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产这种酶的方法，其包含组合物和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

9. 发明授权

US5968998A Dental compositions comprising bifunctional or polyfunctional acrylic-acid esters or methacrylic-acid esters 失效
标题翻译：包含双官能或多官能丙烯酸酯或甲基丙烯酸酯的牙科组合物
公开(公告)号：US5968998A
公开(公告)日：1999-10-19
申请号：US47381
申请日：1993-04-16
申请人： Peter Jochum , Rainer Guggenberger , Gunther Lechner , Klaus Ellrich
发明人： Peter Jochum , Rainer Guggenberger , Gunther Lechner , Klaus Ellrich
IPC分类号： A61K6/083 , A61K6/08
CPC分类号： A61K6/083
摘要： Dental compositions based on an bifunctional or polyfunctional acrylic-acid and/or methacrylic-acid esters, which contain an initiator system for radical polymerization and which additionally contain a compound of the general formula ##STR1## in which: Ar represents aryl or substituted aryl,R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, aryl or substituted aryl, straight-chain or branched chain C.sub.1-18 -alkyl, C.sub.1-18 -alkoxyl or C.sub.1-17 -alkoxycarbonyl, in which alkyl and alkoxyl can be substituted by halogen or aryl,in which, R.sup.1 or R.sup.2, when represented by aryl or substituted aryl, C.sub.1-18 -alkyl or C.sub.1-18 -alkoxyl, can be linked with Ar by a single-bond andin which, Ar, when represented by phenyl, C.sub.1-18 -alkylphenyl, C.sub.1-18 -alkoxylphenyl, carboxyl-C.sub.1-17 -alkylphenyl or halogenphenyl, R.sup.2 can be represented by --O--, which is linked with the phenyl or phenyl moiety of Ar to a benzofuran, andin which at least one of R.sup.1 to R.sup.3 represents H, and at least one of R.sup.1 to R.sup.3 represents aryl or aryl substituted by a straight-chain or branched-chain C.sub.1-18 -alkyl, C.sub.1-18 -alkoxyl, carboxyl-C.sub.1-17 -alkyl or halogen.As a result of the content of a compound (I) the setting phase of the dental compositions is lengthened.
摘要翻译：基于双官能或多官能丙烯酸和/或甲基丙烯酸酯的牙科组合物，其含有用于自由基聚合的引发剂体系，并且还含有下列通式的化合物：其中：Ar表示芳基或取代的芳基，R 1，R 2 并且R 3表示氢，芳基或取代的芳基，直链或支链C 1-18 - 烷基，C 1-18 - 烷氧基或C 1-17 - 烷氧基羰基，其中烷基和烷氧基可被卤素或芳基取代，其中，当由芳基或取代的芳基，C 1-18 - 烷基或C 1-18 - 烷氧基表示时，R 1或R 2可以通过单键与Ar连接，并且其中当Ar表示苯基时，C 1-18烷基苯基，C 1-18烷氧基苯基，羧基-C 1-7 - 烷基苯基或卤素苯基，R 2可以由-O-表示，它与Ar的苯基或苯基部分连接至苯并呋喃，其中R1至 R 3表示H，R 1至R 3中的至少一个表示被直链取代的芳基或芳基或支链C 1-18 - 烷基，C 1-18烷氧基，羧基-C 1-17 - 烷基或卤素。作为化合物（I）的含量的结果，牙科组合物的凝固阶段被延长。

10. 发明授权

US5583164A Dental compositions comprising bifunctional or polyfunctional acrylic-acid esters or methacrylic-acid esters 失效
标题翻译：包含双官能或多官能丙烯酸酯或甲基丙烯酸酯的牙科组合物
公开(公告)号：US5583164A
公开(公告)日：1996-12-10
申请号：US451050
申请日：1995-05-25
申请人： Peter Jochum , Rainer Guggenberger , Gunther Lechner , Klaus Ellrich
发明人： Peter Jochum , Rainer Guggenberger , Gunther Lechner , Klaus Ellrich
IPC分类号： A61K6/083 , A61F2/00 , A61C5/00 , C08F22/26
CPC分类号： A61K6/083
摘要： Dental compositions based on an at least bifunctional or polyfunctional acrylic-acid and/or methacrylic-acid esters, which contain an initiator system for radical polymerization and which additionally contain a compound of the general formula ##STR1## in which: Ar represents aryl or substituted aryl,R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, aryl or substituted aryl, straight-chain or branched chain C.sub.1-18 -alkyl, C.sub.1-18 -alkoxyl or C.sub.1-17 -alkoxycarbonyl, in which alkyl and alkoxyl can be substituted by halogen or aryl,in which, R.sup.1 or R.sup.2, when represented by aryl or substituted aryl, C.sub.1-18 -alkyl or C.sub.1-18 -alkoxyl, can be linked with Ar by a single-bond andin which, Ar, when represented by phenyl, C.sub.1-18 -alkylphenyl, C.sub.1-18 -alkoxylphenyl, carboxyl-C.sub.1-17 -alkylphenyl or halogenphenyl, R.sup.2 can be represented by --O--, which is linked with the phenyl or phenyl moiety of Ar to a benzofuran, andin which at least one of R.sup.1 to R.sup.3 represents H, and at least one of R.sup.1 to R.sup.3 represents aryl or aryl substituted by a straight-chain or branched-chain C.sub.1-18 -alkyl, C.sub.1-18 -alkoxyl, carboxyl-C.sub.1-17 -alkyl or halogen.As a result of the content of a compound (I) the setting phase of the dental compositions is lengthened.
摘要翻译：基于至少双功能或多官能丙烯酸和/或甲基丙烯酸酯的牙科组合物，其含有用于自由基聚合的引发剂体系，并且还含有通式为I的化合物，其中：Ar表示芳基或取代的芳基，R 1，R 2和R 3表示氢，芳基或取代的芳基，直链或支链C 1-18 - 烷基，C 1-18 - 烷氧基或C 1-17 - 烷氧基羰基，其中烷基和烷氧基可被卤素或芳基，其中当由芳基或取代的芳基，C 1-18 - 烷基或C 1-18 - 烷氧基表示时，R 1或R 2可以通过单键与Ar连接，并且其中Ar，当被苯基，C 1-18烷基苯基，C 1-18烷氧基苯基，羧基-C 1-17 - 烷基苯基或卤代苯基，R 2可以由-O-表示，它与Ar的苯基或苯基部分连接至苯并呋喃，其中 R 1至R 3中的至少一个表示H，并且R 1至R 3中的至少一个表示芳基或芳基取代的b 直链或支链C 1-18 - 烷基，C 1-18烷氧基，羧基-C 1-17 - 烷基或卤素。作为化合物（I）的含量的结果，牙科组合物的凝固阶段被延长。

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