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1. 发明授权

US09050332B2 Enzyme containing composition, process of producing said composition and its use 有权
标题翻译：含酶组合物，所述组合物的制备方法及其用途
公开(公告)号：US09050332B2
公开(公告)日：2015-06-09
申请号：US12122027
申请日：2008-05-16
申请人： Ingo Häberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Häberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K38/47 , A61K38/48
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产这种酶的方法，其包含组合物和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

2. 发明申请

US20080213196A1 ENZYME CONTAINING COMPOSITION, PROCESS OF PRODUCING SAID COMPOSITION AND ITS USE 有权
标题翻译：含酶组合物，生产组合物的方法及其用途
公开(公告)号：US20080213196A1
公开(公告)日：2008-09-04
申请号：US12122027
申请日：2008-05-16
申请人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K8/96 , A61K38/47 , A61Q11/00
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产这种酶的方法，其包含组合物和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

3. 发明申请

US20060115436A1 Enzyme containing composition, process of producing said composition and its use 审中-公开
标题翻译：含酶组合物，所述组合物的制备方法及其用途
公开(公告)号：US20060115436A1
公开(公告)日：2006-06-01
申请号：US10525294
申请日：2003-05-16
申请人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K8/96
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such an enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产包含组合物的酶的方法和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

4. 发明授权

US07435558B2 Ascertaining the patient related risk of caries 有权
标题翻译：确定与患者相关的龋齿风险
公开(公告)号：US07435558B2
公开(公告)日：2008-10-14
申请号：US10468958
申请日：2002-02-22
申请人： Ingo Häberlein , Ingo Wagner , Rainer Guggenberger , Thomas Bökenkamp , Christian Steinbeiss , Michaela Bader-Danziger
发明人： Ingo Häberlein , Ingo Wagner , Rainer Guggenberger , Thomas Bökenkamp , Christian Steinbeiss , Michaela Bader-Danziger
IPC分类号： C12Q1/26
CPC分类号： C12Q1/32 , G01N2333/904
摘要： The invention relates to a method for the determination of the patient-related risk of caries by determination of lactic acid and/or lactate in saliva and to a method for the location-specific determination of the patient-related risk of caries.
摘要翻译：本发明涉及通过测定唾液中的乳酸和/或乳酸来确定龋齿患者相关风险的方法以及用于特定位置确定与患者相关的龋齿风险的方法。

5. 发明授权

US07175430B1 Support materials and imaging method for intraoral diagnostic purposes 有权
标题翻译：支持材料和成像方法进行口内诊断
公开(公告)号：US07175430B1
公开(公告)日：2007-02-13
申请号：US10009603
申请日：2000-06-13
申请人： Oswald Gasser , Rainer Guggenberger , Bernd Gangnus , Ingo Häberlein
发明人： Oswald Gasser , Rainer Guggenberger , Bernd Gangnus , Ingo Häberlein
IPC分类号： A61C9/00 , A61K49/00 , C12Q1/14
CPC分类号： A61K49/0041 , A61K6/10 , A61K49/006 , C12Q1/04
摘要： The invention relates to deformable, curable or film-forming support materials which contain diagnostically useful additives for locus- and substance-specific intraoral diagnostics, and processes for the preparation of images for intraoral locus- and substance-specific diagnostic purposes, in which diagnostically useful additives are applied to deformable, curable or film-forming support materials containing no diagnostically useful additives, in such a quantity that a diagnostic signal can be observed, the diagnostic result being obtained without a cultivation step.
摘要翻译：本发明涉及可变形的，可固化的或成膜的载体材料，其包含用于基因座和物质特异性口内诊断的诊断上有用的添加剂，以及用于制备用于口内位点和物质特异性诊断目的的图像的方法，其中诊断上有用将添加剂应用于不含诊断上有用的添加剂的可变形，可固化或成膜载体材料，其量可以观察到诊断信号，而无需培养步骤获得诊断结果。

6. 发明申请

US20120107245A1 DENTAL COMPOSITION FOR DETECTION OF CARIOUS TISSUE, DETECTION METHOD 审中-公开
标题翻译：用于检测重症组织的牙齿组合物，检测方法
公开(公告)号：US20120107245A1
公开(公告)日：2012-05-03
申请号：US13348310
申请日：2012-01-11
申请人： Rainer Guggenberger , Thomas Luchterhandt , Ingo R. Haeberlein , Oliver Kappler , Miriam Hansen
发明人： Rainer Guggenberger , Thomas Luchterhandt , Ingo R. Haeberlein , Oliver Kappler , Miriam Hansen
IPC分类号： A61K49/00 , A61P1/02
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/466 , A61K8/49 , A61K49/006 , A61K49/0071 , A61K2800/45
摘要： A dental composition and method for detecting carious tissue on the surface of a tooth, and the use of the dental composition to manufacture a remedy for detection of carious tissue. The dental composition can comprise an aqueous solution of 1) at least one acidic compound, 2) at least one salt of said acidic compound, 3) at least one indicator that generates a detectable signal when said solution reaches a particular pH value that is less than 5.5; wherein 1) and 2) are selected such that the aqueous solution has a pH of less than that particular pH value where the indicator generates the signal. The method can comprise the steps of 1) providing the above mentioned dental composition, 2) applying said composition to the surface of said tooth, and 3) measuring the amount of time required for the composition to change color.
摘要翻译：用于检测牙齿表面上的龋齿组织的牙科用组合物和方法，以及牙科组合物用于制造用于检测龋齿组织的补救剂的用途。牙科用组合物可以包含1）至少一种酸性化合物的水溶液，2）所述酸性化合物的至少一种盐，3）当所述溶液达到特定pH值较小时产生可检测信号的至少一种指示剂超过5.5; 其中选择1）和2）使得水溶液的pH值小于指示剂产生信号的特定pH值。该方法可以包括以下步骤：1）提供上述牙齿组合物，2）将所述组合物施用到所述牙齿的表面，以及3）测量所述组合物改变颜色所需的时间量。

7. 发明授权

US07097456B1 Amalgam substitute 失效
标题翻译：汞合金替代品
公开(公告)号：US07097456B1
公开(公告)日：2006-08-29
申请号：US10110941
申请日：2000-10-20
申请人： Karsten Dede , Oliver Frey , Oswald Gasser , Rainer Guggenberger , Thomas Luchterhandt , Wolfgang Weinmann , Thomas Klettke
发明人： Karsten Dede , Oliver Frey , Oswald Gasser , Rainer Guggenberger , Thomas Luchterhandt , Wolfgang Weinmann , Thomas Klettke
IPC分类号： A61C5/00
CPC分类号： A61K6/0017 , A61K6/0023 , A61K6/083 , C08L33/00
摘要： The invention relates to filling systems containing as component i) a sealing system which is capable of bonding to the tooth hard substance, as component ii) a filling material suitable for restorative dentistry, the filling system containing in addition a component iii) in component i) and/or component ii) which reduces the curing of the respective other component by disturbance of the curing mechanism only in the boundary layer between sealant and filling material such that the bonding between components i) and ii) is less than the bonding of component i) to the tooth hard substance.
摘要翻译：本发明涉及包含作为组分的密封系统的填充系统，i）能够粘合到牙齿硬质物质上的密封系统，作为组分ii）适于修复牙科的填充材料，填充系统另外还包含组分i中的组分iii））和/或组分ii），其仅通过在密封剂和填充材料之间的边界层中的固化机理的干扰来减少相应的其它组分的固化，使得组分i）和ii）之间的键合小于组分我）到牙齿硬物质。

8. 发明授权

US06908953B2 Polymerizable compositions based on epoxides 失效
标题翻译：基于环氧化物的可聚合组合物
公开(公告)号：US06908953B2
公开(公告)日：2005-06-21
申请号：US10389814
申请日：2003-03-18
申请人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
发明人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
IPC分类号： A61K6/087 , C07F7/08 , C07F7/21 , C08G59/20 , C08G59/22 , C08G59/24 , C08G59/30 , C08G59/32 , C08K3/00 , C08L63/00 , G03F7/038 , A61K6/093
CPC分类号： A61K6/0023 , A61K6/0017 , A61K6/087 , A61K6/09 , A61K6/093 , C07F7/0838 , C07F7/21 , C08G59/22 , C08G59/24 , C08G59/306 , C08G59/3218 , C08G59/3254 , C08L63/00 , G03F7/038 , C08L83/10 , C08L83/12
摘要： The present invention is directed to polymerizable dental compositions containing (a) 3 to 80 wt. % of cycloaliphatic epoxides; b) 0 to 80 wt. % of an epoxide or a mixture of epoxides which are different from a); c) 3 to 85 wt. % of a filler material; d) 0.01 to 25 wt. % of initiators, inhibitors and/or accelerators; e) 0 to 25 wt. % of auxiliary agents, the individual percentages of which are in relation to the total weight. The new polymerizable agents are particularly suited as dental material.
摘要翻译：本发明涉及可聚合牙科用组合物，其含有（a）3-80重量％％脂环族环氧化物; b）0至80wt。％的不同于a）的环氧化物或环氧化物的混合物; c）3-85重量％％的填料; d）0.01〜25重量％％的引发剂，抑制剂和/或促进剂; e）0-25重量％辅助剂的百分比，其各自的百分比与总重量有关。新的可聚合剂特别适用于牙科材料。

9. 发明授权

US06566413B1 Polymerisable materials which are based on hardenable siloxane compounds 有权
公开(公告)号：US06566413B1
公开(公告)日：2003-05-20
申请号：US09868525
申请日：2001-09-19
申请人： Wolfgang Weinmann , Joachim Zech , Oswald Gasser , Rainer Guggenberger , Gunther Eckhardt , Peter Bissinger , Wolfgang Soglowek
发明人： Wolfgang Weinmann , Joachim Zech , Oswald Gasser , Rainer Guggenberger , Gunther Eckhardt , Peter Bissinger , Wolfgang Soglowek
IPC分类号： C08F246
CPC分类号： A61K6/083 , C07F7/21 , C08L51/085
摘要： The invention relates to novel cyclic siloxane compounds of the following general formula (I): in which: n=0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 preferably 1, 2, 3, 4, 5; A=H or C1-C15 alk(en)yl, C3-C15 cycloalk(en)yl, C6-C12 aryl, C8-C18 alkaryl, where, in the said radicals, in each case one or more C atoms can be replaced by O, C═O, O(C═O), SiR2 and/or NR, R being an aliphatic radical with 1 to 7 C atoms, in which one or more C atoms can be replaced by O, C═O, and/or O(C═O); B=E or a linear, branched or polycyclic aliphatic- or aromatic-groups-containing hydrocarbon radical which links 2 to 10 of the cyclosiloxane radicals defined above, less B, to one another and contains 2 to 50 C atoms and additionally 0 to 30 other atoms from the group O, N, S, P, Si, Cl, F, Br, I and from which correspondingly 1 to 9, preferably 1 to 4 of the above defined cyclosiloxane radicals, less B, are pending; E=A or a polymerizable group G—Q—L, where on average up to 50% or less of the groups E correspond to representatives of A; G=C1-10 alk(en)ylene; Q=O, N—A or a di- or polyvalent linear, branched or cyclic alcohol, amine or aminoalcohol radical with 2 to 10 C atoms; L=an organic radical, containing a C═C double bond, with 2 to 10 C atoms; and with the proviso that no annelated siloxane ring systems can occur in (I), and also dental compositions which contain the compounds of formula (I) and/or compounds of formula (II): in which: T=independently of each other H or C1-C10 alk(en)yl, C3-C10 cycloalk(en)yl, C6-C12 aryl or C8-C8 alkaryl; N=a polymerizable group R1—R2—R3; b=0 to 500, where the proportion b may be at most 50% of the repeat units (b+c); c=1 to 1000; R1=C1-C10 alk(en)ylene; R2=O, N—T or a di- or polyvalent linear, branched or cyclic alcohol, amine or aminoalcohol radical with 2 to 10 C atoms; R3=an organic radical, containing a C═C double bond, with 3 to 10 C atoms; V=SiMe2T, SiEt2T, SiMePhT, SiPh2T.

10. 发明授权

US06245828B1 Polymerizable compositions based on epoxides 有权
标题翻译：基于环氧化物的可聚合组合物
公开(公告)号：US06245828B1
公开(公告)日：2001-06-12
申请号：US09101867
申请日：1998-09-21
申请人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
发明人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
IPC分类号： A61K6087
CPC分类号： A61K6/0023 , A61K6/0017 , A61K6/087 , A61K6/09 , A61K6/093 , C07F7/0838 , C07F7/21 , C08G59/22 , C08G59/24 , C08G59/306 , C08G59/3218 , C08G59/3254 , C08L63/00 , G03F7/038 , C08L83/10 , C08L83/12
摘要： The present invention is directed to polymerizable dental compositions containing a) 3 to 80 wt. % of cycloaliphatic epoxides; b) 0 to 80 wt. % of an epoxide or a mixture of epoxides which are different from a); c) 3 to 85 wt. % of a filer material; d) 0.01 to 25 wt. % of initiators, inhibitors and/or accelerators; e) 0 to 25 wt. % of auxiliary agents, the individual percentages of which are in relation to the total weight. The new polymerizable agents are particularly suited as dental material.
摘要翻译：本发明涉及可聚合牙科组合物，其含有a）3-80wt。％脂环族环氧化物; b）0至80wt。％的不同于a）的环氧化物或环氧化物的混合物; c）3-85重量％％的档案资料; d）0.01〜25重量％％的引发剂，抑制剂和/或促进剂; e）0-25重量％辅助剂的百分比，其各自的百分比与总重量有关。新的可聚合剂特别适用于牙科材料。

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