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1. 发明授权

US4272482A Metering apparatus 失效
标题翻译：计量装置
公开(公告)号：US4272482A
公开(公告)日：1981-06-09
申请号：US54060
申请日：1979-07-02
申请人： Thomas C. Jessop , Jeffrey L. Helfer
发明人： Thomas C. Jessop , Jeffrey L. Helfer
IPC分类号： G01N35/00 , G01N35/04 , G01N35/06
CPC分类号： G01N35/00029 , G01N2035/00039
摘要： Apparatus is disclosed which is adapted to repeatedly and accurately dispense predetermined amounts of fluid, especially biological fluids, onto generally planar test elements. The apparatus comprises a movable carriage for supporting and locating a dispensing device at a plurality of metering stations in an analyzer. A pair of locating means are operable in sequence to precisely locate the dispensing device relative to a test element in each of the stations.
摘要翻译：公开了适用于将大量平面的测试元件重复且准确地分配预定量的流体，特别是生物流体的设备。该装置包括用于在分析器中的多个计量站处支撑和定位分配装置的可移动滑架。一对定位装置可以顺序操作以相对于每个站中的测试元件精确地定位分配装置。

2. 发明申请

US20080286278A1 Process for in vivo treatment of specific biological targets in bodily fluids 失效
标题翻译：体内治疗体液中特定生物靶标的方法
公开(公告)号：US20080286278A1
公开(公告)日：2008-11-20
申请号：US12219139
申请日：2008-07-16
申请人： Patrick R. Connelly , Jeffrey L. Helfer , Andrew W. Custer , Michael B. Kim
发明人： Patrick R. Connelly , Jeffrey L. Helfer , Andrew W. Custer , Michael B. Kim
IPC分类号： G01N33/53 , A61F2/00 , C12Q1/00
CPC分类号： C07K16/00
摘要： A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
摘要翻译：一种用于处理生物体的流体中的生物靶的方法，包括将包含生物靶的流体引入到包括连接到接收流体的入口和连接以使来自组件的流体的出口的组件，其中组件包括用于输送流体流的流动室和包含靶特异性结合剂的捕获区，其中在流体流过流动室期间，生物靶沿着靶特异性结合剂经受焊剂滚动。

3. 发明授权

US07389137B2 Optical MRI catheter system 失效
标题翻译：光学MRI导管系统
公开(公告)号：US07389137B2
公开(公告)日：2008-06-17
申请号：US11119677
申请日：2005-05-02
申请人： Jeffrey L. Helfer , Stuart G. MacDonald , Robert W. Gray , Christopher Thomas
发明人： Jeffrey L. Helfer , Stuart G. MacDonald , Robert W. Gray , Christopher Thomas
IPC分类号： A61B5/05 , A61B6/00 , G01V3/00
CPC分类号： A61B5/055 , G01R33/285 , G01R33/34084 , G01R33/3692
摘要： An assembly for delivering optical signals comprising a nuclear magnetic resonance system comprised of magnets, an NMR programmable logic unit, a signal input channel, and a command output channel; an optical interface assembly electrically connected to the nuclear magnetic resonance system, the optical interface assembly comprising a first laser modulated so as to produce laser optical signals, an interface optical to electrical signal convertor; and a catheter assembly connected to said optical interface assembly, the catheter assembly comprising a proximal end, a distal end, a fiber optic cable assembly, an electronics assembly disposed at the distal end comprised of a catheter electrical to optical signal convertor and a catheter optical to electrical signal convertor, and a first receiving coil disposed at the distal end.
摘要翻译：一种用于传送光信号的组件，包括由磁体组成的核磁共振系统，NMR可编程逻辑单元，信号输入通道和命令输出通道; 光学接口组件，其电连接到所述核磁共振系统，所述光学接口组件包括被调制以产生激光光信号的第一激光器，光信号到电信号转换器的接口; 以及连接到所述光学接口组件的导管组件，所述导管组件包括近端，远端，光纤电缆组件，设置在远端处的电子组件，所述电子组件包括电导向光信号转换器的导管和导管光学到电信号转换器，以及设置在远端的第一接收线圈。

4. 发明授权

US06765144B1 Magnetic resonance imaging coated assembly 失效
标题翻译：磁共振成像涂层组件
公开(公告)号：US06765144B1
公开(公告)日：2004-07-20
申请号：US10384288
申请日：2003-03-07
申请人： Xingwu Wang , Howard J. Greenwald , Jeffrey L. Helfer , Robert W. Gray , Michael L. Weiner
发明人： Xingwu Wang , Howard J. Greenwald , Jeffrey L. Helfer , Robert W. Gray , Michael L. Weiner
IPC分类号： H01B1106
CPC分类号： B82Y25/00 , A61N1/16 , H01B11/10 , H01B11/1083 , H01F1/0063 , H01F10/007 , H01F10/324
摘要： An assembly for shielding an implanted medical device from the effects of high-frequency radiation and for emitting magnetic resonance signals during magnetic resonance imaging. The assembly includes an implanted medical device and a magnetic shield comprised of nanomagnetic material disposed between the medical device and the high-frequency radiation. In one embodiment, the magnetic resonance signals are detected by a receiver, which is thus able to locate the implanted medical device within a biological organism.
摘要翻译：一种用于屏蔽植入式医疗装置免受高频辐射影响并在磁共振成像期间发射磁共振信号的组件。该组件包括植入医疗装置和由设置在医疗装置与高频辐射之间的纳米磁性材料构成的磁屏蔽。在一个实施例中，磁共振信号由接收器检测，接收器因此能够将植入的医疗装置定位在生物体内。

5. 发明授权

US06725092B2 Electromagnetic radiation immune medical assist device adapter 失效
标题翻译：电磁辐射免疫医疗辅助装置适配器
公开(公告)号：US06725092B2
公开(公告)日：2004-04-20
申请号：US10132457
申请日：2002-04-25
申请人： Stuart G. MacDonald , Jeffrey L. Helfer , Michael L. Weiner
发明人： Stuart G. MacDonald , Jeffrey L. Helfer , Michael L. Weiner
IPC分类号： A61N100
CPC分类号： A61N1/3752 , A61N1/086 , A61N1/3625 , A61N1/3718 , A61N1/3925
摘要： An electromagnetic radiation immune medical assist system includes a medical assist device; a photonic lead having a proximal end and a distal end; and an adapter to operatively connect the medical assist device with the photonic catheter. The adapter includes a housing, an interface to provide an operative communication connection between the adapter and the medical assist device, a transducer to convert information from the medical assist device into optical energy, and an optical interface to provide an operative connection between the adapter and the photonic catheter.
摘要翻译：电磁辐射免疫医疗辅助系统包括医疗辅助装置; 具有近端和远端的光子引线; 以及用于将医疗辅助装置与光导管可操作地连接的适配器。适配器包括壳体，用于在适配器和医疗辅助装置之间提供可操作的通信连接的接口，用于将来自医疗辅助装置的信息转换为光能的换能器，以及光学接口，以提供适配器和光子导管。

6. 发明授权

US5172153A Processing apparatus 失效
标题翻译：处理装置
公开(公告)号：US5172153A
公开(公告)日：1992-12-15
申请号：US633521
申请日：1990-12-28
申请人： Lee F. Frank , Jeffrey L. Helfer , Haribhajan S. Kocher , Paul W. Wagner
发明人： Lee F. Frank , Jeffrey L. Helfer , Haribhajan S. Kocher , Paul W. Wagner
IPC分类号： G03D5/04 , G03D15/02
CPC分类号： G03D5/04 , G03D15/022
摘要： A web treatment apparatus comprises a means defining a channel through which the web is transported. Treatment fluid is injected into the channel on opposite sides of the web at spaced injection sites and evacuated from the channel on opposite sides of the web at spaced evacuation sites. The injection sites and evacuation sites alternate so that injected fluid is evacuated from adjacent evacuation sites. The streams of evacuated fluid are combined such that streams varying in flow path length and chemical depletion are sequentially mixed together in an ordered sequence prior to reinjection into the chemicals. In one embodiment means are also provided for sequentially dividing the fluid flow from a recirculation pump into fluid streams that are supplied to the injection sites.
摘要翻译：纸幅处理装置包括限定纸幅通过其传送的通道的装置。处理液在间隔开的注射部位被注入到幅材的相对侧上的通道中，并且在间隔的排出部位从纤维网的相对侧从通道排出。注射部位和疏散部位相互交替，使注入的液体从相邻的排泄部位排出。将排出的流体流合并，使得在流路长度和化学耗尽中变化的流在再次注入化学品之前以有序的顺序依次混合在一起。在一个实施例中，还提供了用于将来自再循环泵的流体流顺序地分成供给到注射部位的流体流的装置。

7. 发明授权

US4810653A Cuvette with non-flexing thermally conductive wall 失效
标题翻译：比色杯带有不弯曲的导热壁
公开(公告)号：US4810653A
公开(公告)日：1989-03-07
申请号：US123752
申请日：1987-11-23
申请人： Jeffrey L. Helfer , Johannes J. Porte , David H. Middleton
发明人： Jeffrey L. Helfer , Johannes J. Porte , David H. Middleton
IPC分类号： B01L3/00 , C12M1/02
CPC分类号： B01L3/502
摘要： There is disclosed a cuvette constructed with an improved sample fluid thermal time constant, featuring a flexible heat transfer wall. To prevent such wall from deforming under pressure generated at high processing temperatures, thereby reducing heat transfer efficiency, the opposite wall is constructed to have a flexural strength that is sufficiently less than that of the heat transfer wall. This causes flexing to occur in the opposite wall, under pressure, rather than the heat transfer wall.
摘要翻译：公开了一种具有改进的样品流体热时间常数的比色皿，其特征在于柔性传热壁。为了防止这种壁在高加工温度下产生的压力下变形，从而降低传热效率，相对的壁被构造成具有足够小于传热壁的弯曲强度。这导致在相对的壁中在压力下而不是传热壁发生弯曲。

8. 发明授权

US07473843B2 Magnetic resonance imaging coated assembly 失效
标题翻译：磁共振成像涂层组件
公开(公告)号：US07473843B2
公开(公告)日：2009-01-06
申请号：US11331928
申请日：2006-01-13
申请人： Xingwu Wang , Howard J. Greenwald , Jeffrey L. Helfer , Robert W. Gray , Michael L. Weiner
发明人： Xingwu Wang , Howard J. Greenwald , Jeffrey L. Helfer , Robert W. Gray , Michael L. Weiner
IPC分类号： H01B11/06
CPC分类号： G01R33/286 , A61K49/1818 , A61N1/16 , B82Y5/00 , B82Y25/00 , H01B11/10 , H01B11/1083 , H01F10/007 , H01F10/324
摘要： An assembly for shielding an implanted medical device from the effects of high-frequency radiation and for emitting magnetic resonance signals during magnetic resonance imaging. The assembly includes an implanted medical device and a magnetic shield comprised of nanomagnetic material disposed between the medical device and the high-frequency radiation. In one embodiment, the magnetic resonance signals are detected by a receiver, which is thus able to locate the implanted medical device within a biological organism.
摘要翻译：一种用于屏蔽植入式医疗装置免受高频辐射影响并在磁共振成像期间发射磁共振信号的组件。该组件包括植入医疗装置和由设置在医疗装置与高频辐射之间的纳米磁性材料构成的磁屏蔽。在一个实施例中，磁共振信号由接收器检测，接收器因此能够将植入的医疗装置定位在生物体内。

9. 发明授权

US07091412B2 Magnetically shielded assembly 失效
标题翻译：磁屏蔽组装
公开(公告)号：US07091412B2
公开(公告)日：2006-08-15
申请号：US10780045
申请日：2004-02-17
申请人： Xingwu Wang , Howard J. Greenwald , Ronald E. Miller , Jeffrey L. Helfer , Robert Gray
发明人： Xingwu Wang , Howard J. Greenwald , Ronald E. Miller , Jeffrey L. Helfer , Robert Gray
IPC分类号： H05K9/00
CPC分类号： A61M25/0045 , A61M25/005 , A61M2025/0004 , A61M2025/0039 , A61M2025/004 , A61N1/3718 , A61N1/375 , B82Y25/00 , H01F10/007
摘要： A shielded medical device implanted in a biological organism. The device has a magnetic shield, and the magnetic shield contains a layer of nanomagnetic material; such layer has a morphological density of at least 98 percent. The nanomagnetic material in such layer has a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, a a relative magnetic permeability of from about 1 to about 500,000, and an average particle size of less than about 100 nanometers.
摘要翻译：植入生物体内的屏蔽医疗器械。该器件具有磁屏蔽，磁屏蔽包含一层纳米磁性材料; 该层的形态密度至少为98％。该层中的纳米磁性材料具有约1至约36,000高斯的饱和磁化强度，约0.01至约5,000奥斯特的矫顽力，约1至约500,000的相对导磁率，平均粒径较小比约100纳米。

10. 发明授权

US06980865B1 Implantable shielded medical device 失效
标题翻译：可植入屏蔽医疗器械
公开(公告)号：US06980865B1
公开(公告)日：2005-12-27
申请号：US10313847
申请日：2002-12-07
申请人： Xingwu Wang , Jeffrey L. Helfer , Howard J. Greenwald
发明人： Xingwu Wang , Jeffrey L. Helfer , Howard J. Greenwald
IPC分类号： A61N1/05 , A61N1/16 , H01B7/04 , H01B7/18
CPC分类号： A61N1/16 , H01B7/1805 , H01F1/0063
摘要： An implantable device that contains a power source, a device for producing electrical signals, and a conductor assembly for communicating the electrical signals to biological matter. The conductor assembly contains of a conductor that is capable of being flexed at least about 15 degrees and that has a resistivity at 20 degrees Centigrade of from about 1 to about 100 micro ohm-centimeters. The conductor assembly also contains a magnetic shield located above the flexible conductor; the magnetic shield contains an antithrombogenic composition. The magnetic shield also contains a magnetic shielding material that has a magnetic shielding factor of at least about 0.5.
摘要翻译：一种包含电源的可植入装置，用于产生电信号的装置，以及用于将电信号传送到生物物质的导体组件。导体组件包括能够弯曲至少约15度并且具有约1至约100微欧厘米的20摄氏度的电阻率的导体。导体组件还包含位于柔性导体上方的磁屏蔽; 磁屏蔽包含抗血栓形成组合物。磁屏蔽还包含具有至少约0.5的磁屏蔽因子的磁屏蔽材料。

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