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1. 发明授权

US07725149B2 Devices, methods, and kits for non-invasive glucose measurement 失效
标题翻译：用于非侵入性葡萄糖测量的装置，方法和试剂盒
公开(公告)号：US07725149B2
公开(公告)日：2010-05-25
申请号：US11159587
申请日：2005-06-22
申请人： Thomas A. Peyser , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir
发明人： Thomas A. Peyser , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14521 , A61B5/14532 , A61B2562/0295 , G01N33/66 , G06F19/00
摘要： Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
摘要翻译：描述了用于非侵入性测量葡萄糖的装置，方法和试剂盒。通常，这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。贴剂可以包括粘合剂材料，收集层，界面层和汗液渗透膜。透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。以这种方式，不能测量不相关的皮肤表面葡萄糖。补片还可以包括诱发局部汗水反应的组件。测量装置通常包括显示器，处理器和测量机构。所述方法通常包括以下步骤：用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面，将贴片放置在皮肤表面上，以及测量在贴剂中收集的葡萄糖。还描述了包括贴剂和测量装置的试剂盒。

2. 发明申请

US20090270704A1 PATCHES, SYSTEMS, AND METHODS FOR NON-INVASIVE GLUCOSE MEASUREMENT 审中-公开
标题翻译：用于非入侵葡萄糖测量的配件，系统和方法
公开(公告)号：US20090270704A1
公开(公告)日：2009-10-29
申请号：US12435300
申请日：2009-05-04
申请人： Thomas A. PEYSER , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir , Robert N. Blair
发明人： Thomas A. PEYSER , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir , Robert N. Blair
IPC分类号： A61B5/1477
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B10/0064 , A61B2560/0412 , A61B2562/0295
摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要翻译：这里描述了用于测量葡萄糖的补丁，系统和方法。通常，贴片包括微流体收集层和检测器，并且系统包括贴片和测量装置。用于测量葡萄糖的一些方法包括清洁皮肤表面，使用微流体收集装置从皮肤表面收集汗液，以及测量收集的葡萄糖。其他方法包括清洁皮肤表面，在包含微量收集层的贴片中收集汗液，以及测量在贴片中收集的葡萄糖。还有其它方法包括清洁皮肤表面，在包括微量收集层和检测器层的贴片中从皮肤表面收集第一汗液样品，将第一汗液样品从收集层转移到检测器层，测量第一汗液样品中的葡萄糖汗液样品，并重复收集，转移和测量步骤至少一次。

3. 发明授权

US06748250B1 Method and system of monitoring a patient 失效
标题翻译：监测病人的方法和系统
公开(公告)号：US06748250B1
公开(公告)日：2004-06-08
申请号：US09844687
申请日：2001-04-27
申请人： Herbert L. Berman , Robert N. Blair , James W. Moyer
发明人： Herbert L. Berman , Robert N. Blair , James W. Moyer
IPC分类号： A61K922
CPC分类号： A61B5/002 , A61B5/0022 , A61B5/14532 , G01N21/552 , G06F19/00 , G16H40/67 , Y10S128/903 , Y10S128/92
摘要： A patient monitor system implemented by a service provider for users via recording a patient's analytes measurements by an attenuated total reflection (ATR) infrared total spectroscopy method. The system comprises an input module that provides a non-invasive method in measuring analytes in a patient, such as a measurement of the glucose level and other blood analytes. The measurement is shared among a plurality of output devices such as computers, personal digital assistants (PDAs), cellular phones, and pagers that are stationed or held by various users, such as doctors, patients, researchers, pharmacies, labs, and health insurers. In addition, behavioral attributes are recorded and correlated with the analytes measurements to generate a profile. The profile is selectively sent to output devices based on the user profile corresponding to the output device. Also, access to the profile is monitored by a security module that encrypts the profile to prevent access by un-authorized users.
摘要翻译：由用户通过衰减的全反射（ATR）红外全光谱法记录患者的分析物测量来实现由用户提供服务的患者监护系统。该系统包括输入模块，其提供测量患者中的分析物的非侵入性方法，例如葡萄糖水平和其他血液分析物的测量。诸如医生，病人，研究人员，药房，实验室和健康保险公司等各种用户所驻扎或持有的多个输出设备如计算机，个人数字助理（PDA），蜂窝电话和寻呼机共享测量。。此外，记录行为属性并与分析物测量相关联以生成轮廓。基于与输出设备相对应的用户简档，该配置文件被选择性地发送到输出设备。此外，对配置文件的访问由加密配置文件以防止未授权用户访问的安全模块来监视。

4. 发明授权

US06362144B1 Cleaning system for infrared ATR glucose measurement system (II) 失效
标题翻译：红外ATR葡萄糖测定系统清洗系统（二）
公开(公告)号：US06362144B1
公开(公告)日：2002-03-26
申请号：US09665391
申请日：2000-09-20
申请人： Herbert L. Berman , Jeffrey N. Roe
发明人： Herbert L. Berman , Jeffrey N. Roe
IPC分类号： C11D344
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/245 , G01N21/552
摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。该装置使用衰减全反射（ATR）红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

5. 发明授权

US4372690A Thermal radiation measuring arrangement 失效
标题翻译：热辐射测量装置
公开(公告)号：US4372690A
公开(公告)日：1983-02-08
申请号：US241467
申请日：1981-03-06
申请人： Herbert L. Berman , James C. Sprout
发明人： Herbert L. Berman , James C. Sprout
IPC分类号： G01J5/00
CPC分类号： G01K17/00 , G01J5/02 , G01J5/0265 , G01J5/0295 , G01J5/08 , G01J5/0806 , G01J5/16 , G01J5/522 , G01J2005/068
摘要： In a thermal radiation measuring arrangement, a thermal radiation detector is located at the focal point of a collecting mirror, upon which incident thermal radiation from a surface, such as a building wall, is directed. The thermal radiation detector may be, for example, a thermopile, and provides an output signal having a magnitude proportional to the amount of thermal radiation which it receives. The temperature detection means detects the temperature of the thermal radiation detector and, for example, may detect the cold junction of the thermopile. In a first operating condition, a signal summing means receives the output signal from the thermal radiation detector and the temperature detection means and provides a third output signal proportional to the sum of these first and second output signals. In a second operating condition, a signal biasing means is connected into the signal summing means. The signal biasing means provides a signal to the signal summing means to cause the third output signal to become zero when radiation is received from a reference surface. When the arrangement is in the second operating condition and directed to receive thermal radiation from a second surface different from the reference surface, the signal biasing means maintains the same level of bias to the signal summing means as it did when detecting the radiation from the reference surface.
摘要翻译：在热辐射测量装置中，热辐射检测器位于收集反射镜的焦点处，来自诸如建筑物墙壁的表面的入射热辐射被引导到其上。热辐射检测器可以是例如热电堆，并且提供具有与其接收的热辐射量成比例的大小的输出信号。温度检测装置检测热辐射检测器的温度，例如可以检测热电堆的冷接点。在第一操作条件下，信号求和装置接收来自热辐射检测器和温度检测装置的输出信号，并提供与这些第一和第二输出信号的和成比例的第三输出信号。在第二操作条件下，信号偏置装置连接到信号求和装置中。当从参考表面接收辐射时，信号偏置装置向信号求和装置提供信号以使第三输出信号变为零。当该装置处于第二操作状态并且被指导为接收不同于参考表面的第二表面的热辐射时，信号偏置装置保持与信号求和装置相同的偏置水平，就像在检测来自参考的辐射时一样表面。

6. 发明申请

US20090093761A1 Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities 审中-公开
标题翻译：具有改善的光学对比度的医疗手术辅助装置和方法，以及新的从业者 - 安全性，装置固定，电极和磁疗以及管腔扩张能力
公开(公告)号：US20090093761A1
公开(公告)日：2009-04-09
申请号：US11973052
申请日：2007-10-05
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
IPC分类号： A61M5/32
CPC分类号： A61M5/427 , A61B17/3403 , A61B90/30 , A61B2090/309 , A61B2090/373 , A61N1/0452 , A61N1/0456 , A61N1/325 , A61N1/36021
摘要： Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.
摘要翻译：许多医疗程序，例如针刺，可以从辅助装置中获益，该辅助装置改善外部目标特征和驻留在皮肤和/或暴露的器官组织下方的感兴趣的流明的光学对比度。本发明的廉价的装置和方法可用于这样的外部目标特征和流明，同时还保护从业者并且如果需要释放他/她的双手，从而消除从业者自身的问题。本装置提供良好的光学对比度，并且还提供针对艾滋病毒，肝炎和其他血源性疾病的飞溅防护。本发明的装置方法和装置还可以包括振动皮下电神经刺激（TENS），基于药物的或加热处理能力，用于减少与装置引导的过程相关的疼痛，感觉和真实疼痛。最后，还发现减轻疼痛的机制可用于管腔扩张。

7. 发明授权

US06424848B1 Method for preparing skin surface and determining glucose levels from that surface 失效
标题翻译：制备皮肤表面并测定该表面葡萄糖水平的方法
公开(公告)号：US06424848B1
公开(公告)日：2002-07-23
申请号：US09668685
申请日：2000-09-22
申请人： Herbert L. Berman , Jeffrey N. Roe
发明人： Herbert L. Berman , Jeffrey N. Roe
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/245 , G01N21/552
摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。该装置使用衰减全反射（ATR）红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

8. 发明授权

US06421548B1 Infrared ATR glucose measurement system having an ATR with mirrored ends 失效
标题翻译：红外线ATR葡萄糖测量系统具有镜像端的ATR
公开(公告)号：US06421548B1
公开(公告)日：2002-07-16
申请号：US09668207
申请日：2000-09-22
申请人： Herbert L. Berman , Jeffrey N. Roe
发明人： Herbert L. Berman , Jeffrey N. Roe
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/245 , G01N21/552
摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。该装置使用衰减全反射（ATR）红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

9. 发明授权

US4823291A Radiometric measurement of wafer temperatures during deposition 失效
标题翻译：沉积期间晶圆温度的辐射测量
公开(公告)号：US4823291A
公开(公告)日：1989-04-18
申请号：US95378
申请日：1987-09-10
申请人： Herbert L. Berman
发明人： Herbert L. Berman
IPC分类号： C23C14/54 , C23C16/52 , G01J5/58 , G01J5/10 , G01K1/02
CPC分类号： C23C16/52 , C23C14/541 , G01J5/58
摘要： An infrared heat source is directed through a chopper or modulator and beam splitter to the surface of the water. A pair of radiometers are provided, one located behind the back surface of the wafer to measure transmittance, the other adjacent to the beam splitter to measure wafer reflectance. The wafer temperature may then be calculated using an experimentally determined relationship between wafer radiance W.sub.W and wafer temperature, with wafer radiance being provided by the relationship ##EQU1## where r.sub.BS is the reflectance of the beam splitter, W.sub.W is the blackbody radiance of the wafer, W.sub.a is the blackbody radiance equivalent to ambient temperature, and e.sub.W is the wafer emittance. Alternatively, rather than locate a radiometer behind the wafer to measure wafer transmittance, a mirror may be located behind the wafer to reflect the transmitted energy back through the wafer on a periodic basis for a short part of each duty cycle. A single radiometer can then measure both the reflected and transmitted energy.
摘要翻译：红外热源通过斩光器或调制器和分束器引导到水面。提供一对辐射计，一个位于晶片背面后面以测量透射率，另一个靠近分束器测量晶片的反射率。然后可以使用晶片辐射WW和晶片温度之间的实验确定的关系来计算晶片温度，其中晶片辐射度由关系提供，其中rBS是分束器的反射率，WW是晶片的黑体辐射度， Wa是相当于环境温度的黑体辐射，eW是晶片发射率。或者，不是将晶片后面的辐射计定位以测量晶片透射率，所以可以在晶片的后面位于反射镜的周围，以便在每个占空比的短时间内将透射的能量反射回晶片。单个辐射计可以测量反射和透射的能量。

10. 发明申请

US20090266290A1 Buoyant-capable beverage and food content-sensor 审中-公开
标题翻译：具有浮力的饮料和食物含量传感器
公开(公告)号：US20090266290A1
公开(公告)日：2009-10-29
申请号：US12150505
申请日：2008-04-28
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky
IPC分类号： G01N33/00
CPC分类号： G01N33/14 , G01N21/78 , G01N33/02
摘要： A buoyant-capable sensor system device is disclosed for use alone or on an apparatus such as a straw, stirrer, mixer, stick or utensil which detects the presence or absence of one or more substances in a beverage or liquid food such as soup comprising a sensing element(s) which is either in direct or indirect contact with the beverage or food and a buoyant sensor body to assure user-visibility of the sensing element(s).
摘要翻译：公开了一种可浮动的传感器系统装置，用于单独使用或在诸如秸秆，搅拌器，混合器，棒或器具的装置上使用，该装置检测饮料或液体食物如汤中是否存在一种或多种物质，与饮料或食物直接或间接接触的感测元件和浮力传感器体，以确保感测元件的用户可视性。

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