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1. 发明申请

US20090093761A1 Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities 审中-公开
标题翻译：具有改善的光学对比度的医疗手术辅助装置和方法，以及新的从业者 - 安全性，装置固定，电极和磁疗以及管腔扩张能力
公开(公告)号：US20090093761A1
公开(公告)日：2009-04-09
申请号：US11973052
申请日：2007-10-05
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
IPC分类号： A61M5/32
CPC分类号： A61M5/427 , A61B17/3403 , A61B90/30 , A61B2090/309 , A61B2090/373 , A61N1/0452 , A61N1/0456 , A61N1/325 , A61N1/36021
摘要： Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.
摘要翻译：许多医疗程序，例如针刺，可以从辅助装置中获益，该辅助装置改善外部目标特征和驻留在皮肤和/或暴露的器官组织下方的感兴趣的流明的光学对比度。本发明的廉价的装置和方法可用于这样的外部目标特征和流明，同时还保护从业者并且如果需要释放他/她的双手，从而消除从业者自身的问题。本装置提供良好的光学对比度，并且还提供针对艾滋病毒，肝炎和其他血源性疾病的飞溅防护。本发明的装置方法和装置还可以包括振动皮下电神经刺激（TENS），基于药物的或加热处理能力，用于减少与装置引导的过程相关的疼痛，感觉和真实疼痛。最后，还发现减轻疼痛的机制可用于管腔扩张。

2. 发明申请

US20100233021A1 Systems and methods to deal with health-relevant fouling or plugging depositions and growths 审中-公开
标题翻译：处理与健康有关的结垢或堵塞沉积和生长的系统和方法
公开(公告)号：US20100233021A1
公开(公告)日：2010-09-16
申请号：US12381423
申请日：2009-03-11
申请人： John W. Sliwa , George W. Keilman , Bryan T. Oronsky , Carol A. Tosaya , Herbert L. Berman
发明人： John W. Sliwa , George W. Keilman , Bryan T. Oronsky , Carol A. Tosaya , Herbert L. Berman
IPC分类号： A61L2/10 , A61L2/03 , A61L2/025 , A61N1/32
CPC分类号： A61M25/0017 , A61B90/70 , A61M27/00 , A61M37/00 , A61M2025/0019 , A61N1/205 , A61N1/32 , A61N1/40
摘要： Disclosed are methods of inhibiting, avoiding or destroying existing, potential or incipient biodeposits, biofilms or pathogens any of (a) in or on a living body including in or on a medical device or implement placed, inserted or insertable in the body, (b) in, on or in contact with an ex vivo bodily tissue or fluid, or (c) in, on or in contact with a medium or matter to be consumed, ingested by or exposed to a living being or entity. Also disclosed are medical devices, implements, and prostheses that can be kept in a safe defouled, pathogen-free or pathogen-reduced condition with the help of an electric field(s). Also disclosed are medical or industrial devices, implements, equipment-articles and storage/handling-entities that can be kept in a safely defouled, pathogen-free or pathogen-reduced condition with the help of a membrane or orifice that has one or more of the antifouling or antipathogenic attributes.
摘要翻译：公开了抑制，避免或破坏现有的，潜在的或初期的生物沉积物，生物膜或病原体（a）在生物体内或之上的生物体，包括在放置，插入或插入体内的医疗装置或器具中或之上，（b））在离体身体组织或流体接触或接触时，或（c）在要消费的介质或物质中或与其接触或摄入或暴露于活体或实体时。还公开了医疗装置，器具和假体，其可以在电场的帮助下保持在安全的防污染，无病原体或病原体减少的状态。还公开了医疗或工业装置，器具，设备制品和储存/处理实体，其可以在具有一个或多个以下的膜或孔的帮助下保持在安全脱钩，无病原体或病原体减少的状态防污或抗病原性。

3. 发明申请

US20080213904A1 Monitoring drug compliance, food-intake or toxin-intake using non-invasively-read labels 审中-公开
标题翻译：使用非侵入式阅读标签监测药物依从性，食物摄入量或毒素摄入量
公开(公告)号：US20080213904A1
公开(公告)日：2008-09-04
申请号：US11895400
申请日：2007-08-23
申请人： John W. Sliwa , Herbert L. Berman , Bryan T. Oronsky , Carol A. Tosaya
发明人： John W. Sliwa , Herbert L. Berman , Bryan T. Oronsky , Carol A. Tosaya
IPC分类号： G01N33/00 , G01N37/00 , G01N21/64 , F21K2/00
CPC分类号： G01N21/6428 , A61B5/0059 , A61B5/117 , A61B5/1171 , A61B5/411 , G01N21/71 , Y10T436/13
摘要： A system is disclosed for monitoring a property of an ingested or in-taken drug, food, drink or toxic substance, non-invasively or minimally invasively, which can also identify the subject person being monitored, if desired. The system comprises: a means of labeling the substance with a labeling media to have a useful signature indicative of, or bearing a relation to the property; a means to allow the signature to be read non-invasively or minimally invasively; and a means to identify, in any manner, who is being monitored.
摘要翻译：公开了一种系统，用于非侵入式或最低侵入性地监测摄入或摄入的药物，食物，饮料或有毒物质的性质，如果需要，还可以识别被监测的受试者。该系统包括：用标签介质标记物质的手段，以便具有指示或与该财产有关系的有用签名; 允许非侵入性或最小程度地侵入签名的手段; 并且以任何方式识别谁正在被监视的手段。

4. 发明申请

US20080140026A1 Acoustically-Aided and/or gel-aided delivery of beneficial gaseous, ionic, unstable, metastable, short-lived or reactive species for medical purposes 审中-公开
标题翻译：用于医疗目的的有利气体，离子，不稳定，亚稳态，短寿命或反应性物质的辅助和/或凝胶辅助递送
公开(公告)号：US20080140026A1
公开(公告)日：2008-06-12
申请号：US12001701
申请日：2007-12-11
申请人： John W. Sliwa , Herbert L. Berman , Bryan T. Oronsky , Carol A. Tosaya
发明人： John W. Sliwa , Herbert L. Berman , Bryan T. Oronsky , Carol A. Tosaya
IPC分类号： A61M35/00
CPC分类号： A61M37/0092 , A61M35/00
摘要： An apparatus and method are provided for delivering to a patient's first bodily site and allowing bodily transport therefrom to one or more second bodily sites of a medically, physiologically, neurologically or other health-beneficial species, the at least one species or species precursor which would normally be one or more of volatile, gaseous, vaporous, sublimating, reactive, unacceptably degradable, toxic, hazardous, metastable or unstable if stored in unprotected ambient atmospheric conditions
摘要翻译：提供了一种装置和方法，用于递送给患者的第一身体部位，并允许从身体转运到医疗，生理学，神经学或其他健康有益物种的一个或多个第二身体部位，所述至少一种物种或物质前体将通常是一种或多种挥发性，气态，气态，升华，反应性，不可接受的降解，有毒，危险，亚稳或不稳定，如果储存在无保护的环境大气条件

5. 发明申请

US20090266290A1 Buoyant-capable beverage and food content-sensor 审中-公开
标题翻译：具有浮力的饮料和食物含量传感器
公开(公告)号：US20090266290A1
公开(公告)日：2009-10-29
申请号：US12150505
申请日：2008-04-28
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky
IPC分类号： G01N33/00
CPC分类号： G01N33/14 , G01N21/78 , G01N33/02
摘要： A buoyant-capable sensor system device is disclosed for use alone or on an apparatus such as a straw, stirrer, mixer, stick or utensil which detects the presence or absence of one or more substances in a beverage or liquid food such as soup comprising a sensing element(s) which is either in direct or indirect contact with the beverage or food and a buoyant sensor body to assure user-visibility of the sensing element(s).
摘要翻译：公开了一种可浮动的传感器系统装置，用于单独使用或在诸如秸秆，搅拌器，混合器，棒或器具的装置上使用，该装置检测饮料或液体食物如汤中是否存在一种或多种物质，与饮料或食物直接或间接接触的感测元件和浮力传感器体，以确保感测元件的用户可视性。

6. 发明授权

US08289274B2 Microdroplet-based 3-D volumetric displays utilizing emitted and moving droplet projection screens 有权
标题翻译：基于微滴的3-D体积显示器利用发射和移动的液滴投影屏幕
公开(公告)号：US08289274B2
公开(公告)日：2012-10-16
申请号：US12082064
申请日：2008-04-08
申请人： John W. Sliwa , Carol A. Tosaya
发明人： John W. Sliwa , Carol A. Tosaya
IPC分类号： G09G3/34
CPC分类号： G09G3/34 , G02B27/2271 , G03B21/562 , G03B21/608 , G03B25/00 , H04N13/393
摘要： Volumetric three-dimensional (3-D) graphical or computer displays are disclosed herein that are capable of presenting objects, data, scenes or other visual information in a realistic or solid-like manner, allowing for an unaided observer to observe such static or moving objects from multiple perspectives with natural depth-cues and superior image quality. We utilize in this refined approach moving-screens formed from particulate-arrays and we preferably optically project multiple image sub-slices on each such flying-screen as it passes through the image-volume thereby minimizing particulate mass-flow since only once screen per image-volume is needed to present the several or many necessary slices of each volumetric frame.
摘要翻译：本文公开了体积三维（3-D）图形或计算机显示器，其能够以逼真或实体的方式呈现对象，数据，场景或其他视觉信息，允许无人看管者观察这样的静态或移动具有自然深度线索和卓越图像质量的多个视角的物体。我们利用这种精致的方法，从颗粒阵列形成的移动屏幕，我们优选在每个这样的飞行屏幕上通过图像体积光学投影多个图像子切片，从而最小化颗粒质量流量，因为每个图像只有一次屏幕 - 需要体积来呈现每个体积框架的几个或许多必要的切片。

7. 发明申请

US20100321478A1 Microdroplet-based 3-D volumetric displays utilizing emitted and moving droplet projection screens 有权
标题翻译：基于微滴的3-D体积显示器利用发射和移动的液滴投影屏幕
公开(公告)号：US20100321478A1
公开(公告)日：2010-12-23
申请号：US12082064
申请日：2008-04-08
申请人： John W. Sliwa , Carol A. Tosaya
发明人： John W. Sliwa , Carol A. Tosaya
IPC分类号： H04N13/04
CPC分类号： G09G3/34 , G02B27/2271 , G03B21/562 , G03B21/608 , G03B25/00 , H04N13/393
摘要： Volumetric three-dimensional (3-D) graphical or computer displays are disclosed herein that are capable of presenting objects, data, scenes or other visual information in a realistic or solid-like manner, allowing for an unaided observer to observe such static or moving objects from multiple perspectives with natural depth-cues and superior image quality. We utilize in this refined approach moving-screens formed from particulate-arrays and we preferably optically project multiple image sub-slices on each such flying-screen as it passes through the image-volume thereby minimizing particulate mass-flow since only once screen per image-volume is needed to present the several or many necessary slices of each volumetric frame.
摘要翻译：本文公开了体积三维（3-D）图形或计算机显示器，其能够以逼真或实体的方式呈现对象，数据，场景或其他视觉信息，允许无人看管者观察这样的静态或移动具有自然深度线索和卓越图像质量的多个视角的物体。我们利用这种精致的方法，从颗粒阵列形成的移动屏幕，我们优选在每个这样的飞行屏幕上通过图像体积光学投影多个图像子切片，从而最小化颗粒质量流量，因为每个图像只有一次屏幕 - 需要体积来呈现每个体积框架的几个或许多必要的切片。

8. 发明授权

US08864757B2 System and method for measuring force and torque applied to a catheter electrode tip 有权
标题翻译：用于测量施加到导管电极尖端的力和扭矩的系统和方法
公开(公告)号：US08864757B2
公开(公告)日：2014-10-21
申请号：US12347607
申请日：2008-12-31
申请人： Gleb V. Klimovitch , John W. Sliwa
发明人： Gleb V. Klimovitch , John W. Sliwa
IPC分类号： A61B18/18 , A61B18/04 , A61B17/42 , A61B17/46 , A61D1/10 , A61B8/00 , A61B5/04 , A61B18/14 , A61B5/00 , A61B5/042 , A61B18/02 , A61B19/00 , A61N7/02 , A61B18/24
CPC分类号： A61B5/6885 , A61B5/042 , A61B8/12 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B2090/065 , A61B2218/002 , A61N1/05 , A61N7/022
摘要： A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including insulation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.
摘要翻译：一种接触检测组件，包括导管，其包括具有邻近导管主体的头部安装的基部的电极。传感器邻近基部设置，用于测量施加到电极末端部分的压缩或拉伸力，并且包括预定的灵敏度。基部和头部包括预定的刚度，使得施加到电极末端部分的力可以根据灵敏度和传感器输出来确定。接触检测组件还包括可操作地连接到导管主体的用于与导管主体一起移动和弯曲的电极管，以及设置在电极管中并包括绝缘体的电极线。在导管弯曲期间由电极线向电极管的移动或电极线与电极管的接触的电容变化与施加于导管的力相关。

9. 发明授权

US07877854B2 Method of manufacturing an ultrasound transducer 有权
标题翻译：制造超声波换能器的方法
公开(公告)号：US07877854B2
公开(公告)日：2011-02-01
申请号：US11958862
申请日：2007-12-18
申请人： John W. Sliwa , John P. Goetz , Zhenyi Ma
发明人： John W. Sliwa , John P. Goetz , Zhenyi Ma
IPC分类号： H04R31/00
CPC分类号： G10K11/30 , Y10T29/49005 , Y10T29/49007 , Y10T29/4908 , Y10T29/49172 , Y10T29/49194
摘要： A focused ultrasound transducer includes a first ultrasonic emitter and at least one metallic ultrasonic lens acoustically coupled thereto. The emitter generates ultrasonic energy that propagates along a beam path projecting therefrom. The at least one metallic ultrasonic lens is positioned at least partially in the beam path so that it can direct (e.g., focus, defocus, and/or collimate) in at least one direction (or along at least one plane) at least some of the ultrasonic energy propagating from the emitter. The metallic lens may be formed by extrusion, by molding (e.g., diecast molding or thermoforming), or by sintering (e.g., powder metallurgy). The metallic lens also advantageously functions as a heat sink, improving thermal performance of the ultrasound transducer.
摘要翻译：聚焦超声波换能器包括第一超声波发射器和声耦合到其上的至少一个金属超声波透镜。发射器产生沿着从其突出的光束路径传播的超声波能量。至少一个金属超声波透镜至少部分地定位在光束路径中，使得其可以在至少一个方向（或沿着至少一个平面）上引导（例如，聚焦，散焦和/或准直）至少一个超声能量从发射器传播。金属透镜可以通过挤出，模制（例如，压铸模塑或热成型）或通过烧结（例如粉末冶金）形成。金属透镜还有利地用作散热器，从而改善超声换能器的热性能。

10. 发明申请

US20100168620A1 SYSTEM AND METHOD FOR MEASURING FORCE AND TORQUE APPLIED TO A CATHETER ELECTRODE TIP 有权
标题翻译：用于测量导体电极尖端的力和扭矩的系统和方法
公开(公告)号：US20100168620A1
公开(公告)日：2010-07-01
申请号：US12347607
申请日：2008-12-31
申请人： Gleb V. Klimovitch , John W. Sliwa
发明人： Gleb V. Klimovitch , John W. Sliwa
IPC分类号： A61B5/00
CPC分类号： A61B5/6885 , A61B5/042 , A61B8/12 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B2090/065 , A61B2218/002 , A61N1/05 , A61N7/022
摘要： A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including isolation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.
摘要翻译：一种接触检测组件，包括导管，其包括具有邻近导管主体的头部安装的基部的电极。传感器邻近基部设置，用于测量施加到电极末端部分的压缩或拉伸力，并且包括预定的灵敏度。基部和头部包括预定的刚度，使得施加到电极尖端部分的力可以作为灵敏度和传感器输出的函数来确定。接触检测组件还包括可操作地连接到导管主体的电极管，用于与导管主体一起移动和弯曲，以及设置在电极管中并包括隔离的电极线。在导管弯曲期间由电极线向电极管的移动或电极线与电极管的接触的电容变化与施加于导管的力相关。

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