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1. 发明授权

US08784872B2 Formulation for decreasing tobacco, alcohol, drug or food consumption 失效
标题翻译：减少烟草，酒精，药物或食物消费的配方
公开(公告)号：US08784872B2
公开(公告)日：2014-07-22
申请号：US11942414
申请日：2007-11-19
申请人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
IPC分类号： A61K9/00 , A61K47/00 , A61K9/68 , A61K36/00 , A61K31/4168 , A61K9/12 , A61K9/70
CPC分类号： A61K47/34 , A24B15/16 , A61K9/0056 , A61K9/08 , A61K47/02 , A61K47/32 , A61K47/36
摘要： Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking, excessive alcohol or food ingestion, drug addiction, and ingestion of caffeine or junk food providing quick “highs”. The formulations assist the smoker to become dissatisfied with smoking, until he or she willingly gives up the habit or at least cuts down on the number of cigarettes smoked per day as an initial step towards quitting in the future. The formulations can also be used in conjunction with other known formulations, such as nicotine gum or patch. The formulations contain hydrophilic polymers, for example, polyethylene glycol (PEG) alone or in combination or polyvinyl pyrrolidone (PVP) (also known as povidone or polyvidone alone or in combination.), sweeteners and/or flavorings, viscosity modifiers/binders, and pH or buffering agents.
摘要翻译：已经开发了帮助患有吸烟等成瘾的个体减少或戒除上瘾行为的制剂。代表性的行为包括吸烟，过度酒精或食物摄入，吸毒成瘾，以及摄取咖啡因或垃圾食品，提供快速“高”。这些配方有助于吸烟者对吸烟不满意，直到他或她愿意放弃习惯，或者至少减少每天吸烟的香烟数量，作为今后戒烟的最初步骤。制剂也可以与其它已知的制剂结合使用，例如尼古丁胶或贴剂。制剂含有亲水性聚合物，例如单独使用或组合使用的聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）（也称为聚维酮或聚维酮，单独或组合使用），甜味剂和/或调味剂，粘度调节剂/粘合剂和 pH或缓冲剂。

2. 发明授权

US09511016B2 Topical composition for treating pain 有权
标题翻译：用于治疗疼痛的局部组合物
公开(公告)号：US09511016B2
公开(公告)日：2016-12-06
申请号：US11851241
申请日：2007-09-06
申请人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
IPC分类号： A61K31/23 , A61K31/56 , A61L15/16 , A61P1/14 , A61P11/08 , A61P25/00 , A61K9/00 , A61K31/685 , A61K31/215 , A61K31/01 , A61K31/045 , A61K31/19
CPC分类号： A61K9/0014 , A61K9/0009 , A61K31/01 , A61K31/045 , A61K31/19 , A61K31/215 , A61K31/23 , A61K31/56 , A61K31/685
摘要： Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.
摘要翻译：已经开发了具有作为活性成分的脂质，脂肪酸酯，天然蜡，甾醇或其组合的称为“亲脂性载体”或“LV”的使用方法的局部组合物，用于改善或预防疼痛或疼痛的后遗症。组合物可以是软膏剂，霜剂，凝胶剂，洗剂，喷雾剂，泡沫剂，糊剂，贴剂，悬浮液或分散体的形式。该组合物可有效治疗急性和慢性的内脏，躯体和神经性疼痛，以及肌肉疼痛和僵硬以及关节疼痛和僵硬。

3. 发明申请

US20090117059A1 COMPOSITIONS AND METHODS OF USE THEREOF, FOR THE TREATMENT OF ORAL PAIN, COMPRISING CLOVES OR EXTRACTS THEREOF IN COMBINATION WITH A STEROID 审中-公开
标题翻译：用于治疗口腔疼痛的组合物及其使用方法，包括与其相结合的切除或提取物
公开(公告)号：US20090117059A1
公开(公告)日：2009-05-07
申请号：US12184083
申请日：2008-07-31
申请人： Bryan T. ORONSKY , Neil C. ORONSKY
发明人： Bryan T. ORONSKY , Neil C. ORONSKY
IPC分类号： A61K8/97 , A61K36/61 , A61K31/565 , A61Q11/00 , A61P29/00 , A61K8/34 , A61K31/05
CPC分类号： A61K31/05 , A61K31/573 , A61K31/58 , A61K36/61 , A61K2300/00
摘要： Provided are compositions for delivery to an individual's mouth to provide immediate as well as long-lasting pain relief, particularly after tooth extraction or other dental procedure, which include clove, a clove extract or eugenol, and optionally a steroid and other additives including an antibiotic. Kits and systems for delivery of the composition to provide sustained pain relief are also provided.
摘要翻译：提供用于递送到个人口腔的组合物，以提供即时和持久的疼痛缓解，特别是在拔牙或其他牙科手术之后，其包括丁香，丁香提取物或丁子香酚，以及任选的类固醇和其它添加剂，包括抗生素。还提供了用于递送组合物以提供持续疼痛缓解的试剂盒和系统。

4. 发明申请

US20120231092A1 Combination Therapy for Bipolar Disorder 审中-公开
标题翻译：双相障碍联合治疗
公开(公告)号：US20120231092A1
公开(公告)日：2012-09-13
申请号：US13420025
申请日：2012-03-14
申请人： Bryan T. Oronsky , Neil C. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky
IPC分类号： A61K31/485 , A61K31/496 , A61P25/18 , A61K31/519 , A61K31/554 , A61K33/00 , A61K31/5513
CPC分类号： A61K31/485 , A61K45/06 , A61K2300/00
摘要： Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.
摘要翻译：描述了包括施用丁丙诺啡的情绪障碍的治疗方案，单独给药或与额外的药理学组合。具体地，描述了减轻与双相障碍相关的赛车思想的治疗方案，以及用于其中的药物组合物和试剂盒。还描述了用于治疗与阿片样物质戒断相关的躁狂症的给药方案，组合物和试剂盒，包括丁丙诺啡。

5. 发明申请

US20100042137A1 ACUPUNCTURE AND ACUPRESSURE THERAPIES 审中-公开
标题翻译：治疗和预防治疗
公开(公告)号：US20100042137A1
公开(公告)日：2010-02-18
申请号：US12389248
申请日：2009-02-19
申请人： Bryan T. ORONSKY , Neil C. Oronsky , Arnold L. Oronsky
发明人： Bryan T. ORONSKY , Neil C. Oronsky , Arnold L. Oronsky
IPC分类号： A61B17/00 , A61M37/00 , A61M5/00 , A61M31/00
CPC分类号： A61H39/086 , A61H23/0245 , A61H39/002 , A61H39/007 , A61H39/083 , A61H2039/005 , A61H2201/0207 , A61H2201/105 , A61M5/28 , A61M5/329 , A61M37/0015 , A61M37/0092 , A61M2005/3201 , A61M2037/0023 , A61M2037/0046
摘要： Described here are devices, methods, and kits for acupuncture or acupressure therapy. The devices may include a tissue-piercing member and a reservoir containing an agent. The devices and agents may be packaged as kits useful for relieving pain and/or treating various medical conditions. The devices, methods, and kits may enable less skilled practitioners to administer acupuncture or acupressure therapy, and may extend the duration of pain relief or other symptom relief.
摘要翻译：这里描述的是用于针灸或指压治疗的装置，方法和试剂盒。装置可以包括组织刺穿构件和包含试剂的储存器。装置和试剂可以包装成用于缓解疼痛和/或治疗各种医疗状况的试剂盒。装置，方法和试剂盒可以使较不熟练的从业者执行针灸或指压治疗，并且可以延长疼痛缓解或其它症状缓解的持续时间。

6. 发明申请

US20090311347A1 COMBINATION THERAPY FOR BIPOLAR DISORDER 有权
标题翻译：双极性疾病的组合治疗
公开(公告)号：US20090311347A1
公开(公告)日：2009-12-17
申请号：US12422156
申请日：2009-04-10
申请人： Bryan T. Oronsky , Neil C. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky
IPC分类号： A61K31/485 , A61K31/554 , A61K31/496 , A61K31/53 , A61K33/00 , A61P25/00
CPC分类号： A61K31/485 , A61K45/06 , A61K2300/00
摘要： Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.
摘要翻译：描述了包括施用丁丙诺啡的情绪障碍的治疗方案，单独给药或与额外的药理学组合。具体地说，描述了减轻与双相障碍相关的赛车思想的治疗方案，以及用于其中的药物组合物和试剂盒。还描述了用于治疗与阿片样物质戒断相关的躁狂症的给药方案，组合物和试剂盒，包括丁丙诺啡。

7. 发明申请

US20090266290A1 Buoyant-capable beverage and food content-sensor 审中-公开
标题翻译：具有浮力的饮料和食物含量传感器
公开(公告)号：US20090266290A1
公开(公告)日：2009-10-29
申请号：US12150505
申请日：2008-04-28
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky
IPC分类号： G01N33/00
CPC分类号： G01N33/14 , G01N21/78 , G01N33/02
摘要： A buoyant-capable sensor system device is disclosed for use alone or on an apparatus such as a straw, stirrer, mixer, stick or utensil which detects the presence or absence of one or more substances in a beverage or liquid food such as soup comprising a sensing element(s) which is either in direct or indirect contact with the beverage or food and a buoyant sensor body to assure user-visibility of the sensing element(s).
摘要翻译：公开了一种可浮动的传感器系统装置，用于单独使用或在诸如秸秆，搅拌器，混合器，棒或器具的装置上使用，该装置检测饮料或液体食物如汤中是否存在一种或多种物质，与饮料或食物直接或间接接触的感测元件和浮力传感器体，以确保感测元件的用户可视性。

8. 发明申请

US20090093761A1 Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities 审中-公开
标题翻译：具有改善的光学对比度的医疗手术辅助装置和方法，以及新的从业者 - 安全性，装置固定，电极和磁疗以及管腔扩张能力
公开(公告)号：US20090093761A1
公开(公告)日：2009-04-09
申请号：US11973052
申请日：2007-10-05
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
IPC分类号： A61M5/32
CPC分类号： A61M5/427 , A61B17/3403 , A61B90/30 , A61B2090/309 , A61B2090/373 , A61N1/0452 , A61N1/0456 , A61N1/325 , A61N1/36021
摘要： Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.
摘要翻译：许多医疗程序，例如针刺，可以从辅助装置中获益，该辅助装置改善外部目标特征和驻留在皮肤和/或暴露的器官组织下方的感兴趣的流明的光学对比度。本发明的廉价的装置和方法可用于这样的外部目标特征和流明，同时还保护从业者并且如果需要释放他/她的双手，从而消除从业者自身的问题。本装置提供良好的光学对比度，并且还提供针对艾滋病毒，肝炎和其他血源性疾病的飞溅防护。本发明的装置方法和装置还可以包括振动皮下电神经刺激（TENS），基于药物的或加热处理能力，用于减少与装置引导的过程相关的疼痛，感觉和真实疼痛。最后，还发现减轻疼痛的机制可用于管腔扩张。

9. 发明授权

US08138169B2 Combination therapy for bipolar disorder 有权
标题翻译：双相障碍联合治疗
公开(公告)号：US08138169B2
公开(公告)日：2012-03-20
申请号：US12422156
申请日：2009-04-10
申请人： Bryan T. Oronsky , Neil C. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky
IPC分类号： A61K31/485 , A61K31/496 , A61K31/53 , A61K31/554
CPC分类号： A61K31/485 , A61K45/06 , A61K2300/00
摘要： Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.
摘要翻译：描述了包括施用丁丙诺啡的情绪障碍的治疗方案，单独给药或与额外的药理学组合。具体地，描述了减轻与双相障碍相关的赛车思想的治疗方案，以及用于其中的药物组合物和试剂盒。还描述了用于治疗与阿片样物质戒断相关的躁狂症的给药方案，组合物和试剂盒，包括丁丙诺啡。

10. 发明申请

US20090130178A1 FORMULATION FOR DECREASING TOBACCO, ALCOHOL, DRUG OR FOOD CONSUMPTION 失效
标题翻译：减少烟草，酒类，药物或食品消费的配方
公开(公告)号：US20090130178A1
公开(公告)日：2009-05-21
申请号：US11942414
申请日：2007-11-19
申请人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
IPC分类号： A61K9/00 , A61K47/00 , A61K9/68 , A61K36/00 , A61K31/4168 , A61P43/00 , A61K33/38 , A61K9/12 , A61K9/70
CPC分类号： A61K47/34 , A24B15/16 , A61K9/0056 , A61K9/08 , A61K47/02 , A61K47/32 , A61K47/36
摘要： Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking, excessive alcohol or food ingestion, drug addiction, and ingestion of caffeine or junk food providing quick “highs”. The formulations assist the smoker to become dissatisfied with smoking, until he or she willingly gives up the habit or at least cuts down on the number of cigarettes smoked per day as an initial step towards quitting in the future. The formulations can also be used in conjunction with other known formulations, such as nicotine gum or patch. The formulations contain hydrophilic polymers, for example, polyethylene glycol (PEG) alone or in combination or polyvinyl pyrrolidone (PVP) (also known as povidone or polyvidone alone or in combination.), sweeteners and/or flavorings, viscosity modifiers/binders, and pH or buffering agents.
摘要翻译：已经开发了帮助患有吸烟等成瘾的个体减少或戒除上瘾行为的制剂。代表性的行为包括吸烟，过度酒精或食物摄入，吸毒成瘾，以及摄取咖啡因或垃圾食品，提供快速“高”。这些配方有助于吸烟者对吸烟不满意，直到他或她愿意放弃习惯，或者至少减少每天吸烟的香烟数量，作为今后戒烟的最初步骤。制剂也可以与其它已知的制剂结合使用，例如尼古丁胶或贴剂。制剂含有亲水性聚合物，例如单独使用或组合使用的聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）（也称为聚维酮或聚维酮，单独或组合使用），甜味剂和/或调味剂，粘度调节剂/粘合剂和 pH或缓冲剂。

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