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1. 发明授权

EP1504114B1 STOCHASTIC SENSING THROUGH COVALENT INTERACTIONS 有权
标题翻译：通过共同相互作用的随机检测
公开(公告)号：EP1504114B1
公开(公告)日：2017-07-12
申请号：EP03738910.3
申请日：2003-05-09
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： HAGAN, Bayley , SHIN, Seong-Ho , LUCHIAN, Tudor , CHELEY, Stephen
IPC分类号： C12Q1/00 , G01N33/543 , C12M1/40 , G01N33/68 , G01N27/327
CPC分类号： G01N33/5308 , C12Q1/001 , G01N33/5438 , G01N33/6872

2. 发明公开

EP1504114A1 STOCHASTIC SENSING THROUGH COVALENT INTERACTIONS 有权
标题翻译：通过共价相互作用分析物的测定随机
公开(公告)号：EP1504114A1
公开(公告)日：2005-02-09
申请号：EP03738910.3
申请日：2003-05-09
申请人： The Texas A & M University System
发明人： HAGAN, Bayley , SHIN, Seong-Ho , LUCHIAN, Tudor , CHELEY, Stephen
IPC分类号： C12Q1/00 , G01N33/543 , C12M1/40 , G01N33/68 , G01N27/327
CPC分类号： G01N33/5308 , C12Q1/001 , G01N33/5438 , G01N33/6872
摘要： A system and method for stochastic sensing in which the analyte covalently bonds to the sensor element or an adaptor element. If such bonding is irreversible, the bond may be broken by a chemical reagent. The sensor element may be a protein, such as the engineered PSH type or αHL protein pore. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable signal. Possible signals include change in electrical current, change in force, and change in fluorescence. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may be detected.

3. 发明公开

EP1842061A2 HIGH TEMPERATURE ION CHANNELS AND PORES 审中-公开
标题翻译：高温离子通道和ION孔隙
公开(公告)号：EP1842061A2
公开(公告)日：2007-10-10
申请号：EP05858727.0
申请日：2005-12-21
申请人： The Texas A&M University System
发明人： KANG, Xiaofeng , GU, Li Qun, Andrew , CHELEY, Stephen , BAYLEY, Hagan
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N33/48721 , G01N33/54393 , G01N33/6872
摘要： The present invention includes an apparatus, system and method for stochastic sensing of an analyte to a protein pore. The protein pore may be an engineer protein pore, such as an ion channel at temperatures above 55°C and even as high as near 100°C. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable electrical current signal. Possible signals include change in electrical current. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may also be detected.

4. 发明申请

WO2007127327A2 NANOPORE SENSOR SYSTEM 审中-公开
标题翻译： NANOPORE传感器系统
公开(公告)号：WO2007127327A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010170
申请日：2007-04-25
申请人： THE TEXAS A & M UNIVERSITY SYSTEM , KANG, Xiaofeng , CHELEY, Stephen , BAYLEY, Hagan, P.
发明人： KANG, Xiaofeng , CHELEY, Stephen , BAYLEY, Hagan, P.
IPC分类号： B01J13/02 , G01N27/00
CPC分类号： G01N33/48721
摘要： The invention relates to a nanopore sensor system including methods of fabrication and uses disclosed herein. In some embodiments, the invention relates to a substrate comprising a lipid membrane, preferably a phospholipid bilayer film, having a nanopore and a gel surrounding said lipid membrane. In additional embodiments, the invention relates to compositions and methods of using and making a substrate that has a lipid membrane having a single channel protein surrounded with a gel. In further embodiments, the invention relates to a method of detecting an analyte by mixing a nanopore sensor with a solution suspected of containing an analyte, measuring electrical properties, and correlating changes of electrical properties to the existence of an analyte.
摘要翻译：本发明涉及包括本文公开的制造方法和使用的纳米孔传感器系统。在一些实施方案中，本发明涉及包含脂质膜，优选磷脂双层膜的底物，其具有纳米孔和围绕所述脂质膜的凝胶。在另外的实施方案中，本发明涉及使用和制备具有由凝胶包围的单通道蛋白质的脂质膜的底物的组合物和方法。在另外的实施方案中，本发明涉及一种通过将纳米孔传感器与疑似含有分析物的溶液混合来检测分析物的方法，测量电性能，以及将电特性的变化与分析物的存在相关联。

5. 发明申请

WO2007084103A2 HIGH TEMPERATURE ION CHANNELS AND PORES 审中-公开
标题翻译：高温离子通道和孔
公开(公告)号：WO2007084103A2
公开(公告)日：2007-07-26
申请号：PCT/US2005/046649
申请日：2005-12-21
申请人： THE TEXAS A & M UNIVERSITY SYSTEM , KANG, Xiaofeng , GU, Li Qun, Andrew , CHELEY, Stephen , BAYLEY, Hagan
发明人： KANG, Xiaofeng , GU, Li Qun, Andrew , CHELEY, Stephen , BAYLEY, Hagan
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N33/48721 , G01N33/54393 , G01N33/6872
摘要： The present invention includes an apparatus, system and method for stochastic sensing of an analyte to a protein pore. The protein pore may be an engineer protein pore, such as an ion channel at temperatures above 55°C and even as high as near 100°C. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable electrical current signal. Possible signals include change in electrical current. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may also be detected.
摘要翻译：本发明包括用于将分析物随机感测到蛋白质孔的装置，系统和方法。蛋白质孔可以是工程蛋白孔，例如在55℃以上甚至高达100℃附近的离子通道。分析物可以是任何反应性分析物，包括化学武器，环境毒素和药物。分析物共价结合到传感器元件以产生可检测的电流信号。可能的信号包括电流变化。信号的检测允许识别分析物并确定其在样品溶液中的浓度。同一解决方案中存在的多种分析物也可能被检测到。

6. 发明申请

WO2003095669A1 STOCHASTIC SENSING THROUGH COVALENT INTERACTIONS 审中-公开
标题翻译：通过物质相互作用进行机械感应
公开(公告)号：WO2003095669A1
公开(公告)日：2003-11-20
申请号：PCT/US2003/014797
申请日：2003-05-09
申请人： THE TEXAS A & M UNIVERSITY SYSTEM
发明人： HAGAN, Bayley , SHIN, Seong-Ho , LUCHIAN, Tudor , CHELEY, Stephen
IPC分类号： C12Q1/00
CPC分类号： G01N33/5308 , C12Q1/001 , G01N33/5438 , G01N33/6872
摘要： A system and method for stochastic sensing in which the analyte covalently bonds to the sensor element or an adaptor element. If such bonding is irreversible, the bond may be broken by a chemical reagent. The sensor element may be a protein, such as the engineered P SH type or αHL protein pore. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable signal. Possible signals include change in electrical current, change in force, and change in fluorescence. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may be detected.
摘要翻译：用于随机感测的系统和方法，其中分析物共价键合到传感器元件或适配器元件。如果这种键合是不可逆的，则该键可能被化学试剂破坏。传感器元件可以是蛋白质，例如工程化的PSH型或αHL蛋白质孔。分析物可以是任何反应性分析物，包括化学武器，环境毒素和药物。分析物共价键合到传感器元件以产生可检测的信号。可能的信号包括电流的变化，力的变化和荧光的变化。信号的检测允许鉴定分析物并确定其在样品溶液中的浓度。可以检测存在于相同溶液中的多种分析物。

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