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1. 发明申请

WO2007127327A3 NANOPORE SENSOR SYSTEM 审中-公开
标题翻译： NANOPORE传感器系统
公开(公告)号：WO2007127327A3
公开(公告)日：2008-12-24
申请号：PCT/US2007010170
申请日：2007-04-25
申请人： TEXAS A & M UNIV SYS , KANG XIAOFENG , CHELEY STEPHEN , BAYLEY HAGAN P
发明人： KANG XIAOFENG , CHELEY STEPHEN , BAYLEY HAGAN P
IPC分类号： B01D69/00 , A61K38/00
CPC分类号： G01N33/48721
摘要： The invention relates to a nanopore sensor system including methods of fabrication and uses disclosed herein. In some embodiments, the invention relates to a substrate comprising a lipid membrane, preferably a phospholipid bilayer film, having a nanopore and a gel surrounding said lipid membrane. In additional embodiments, the invention relates to compositions and methods of using and making a substrate that has a lipid membrane having a single channel protein surrounded with a gel. In further embodiments, the invention relates to a method of detecting an analyte by mixing a nanopore sensor with a solution suspected of containing an analyte, measuring electrical properties, and correlating changes of electrical properties to the existence of an analyte.
摘要翻译：本发明涉及包括本文公开的制造方法和使用的纳米孔传感器系统。在一些实施方案中，本发明涉及包含脂质膜，优选磷脂双层膜的底物，其具有纳米孔和围绕所述脂质膜的凝胶。在另外的实施方案中，本发明涉及使用和制备具有由凝胶包围的单通道蛋白质的脂质膜的底物的组合物和方法。在另外的实施方案中，本发明涉及一种通过将纳米孔传感器与疑似含有分析物的溶液混合来检测分析物的方法，测量电性能，以及将电特性的变化与分析物的存在相关联。

2. 发明申请

WO2007127327A2 NANOPORE SENSOR SYSTEM 审中-公开
标题翻译： NANOPORE传感器系统
公开(公告)号：WO2007127327A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010170
申请日：2007-04-25
申请人： THE TEXAS A & M UNIVERSITY SYSTEM , KANG, Xiaofeng , CHELEY, Stephen , BAYLEY, Hagan, P.
发明人： KANG, Xiaofeng , CHELEY, Stephen , BAYLEY, Hagan, P.
IPC分类号： B01J13/02 , G01N27/00
CPC分类号： G01N33/48721
摘要： The invention relates to a nanopore sensor system including methods of fabrication and uses disclosed herein. In some embodiments, the invention relates to a substrate comprising a lipid membrane, preferably a phospholipid bilayer film, having a nanopore and a gel surrounding said lipid membrane. In additional embodiments, the invention relates to compositions and methods of using and making a substrate that has a lipid membrane having a single channel protein surrounded with a gel. In further embodiments, the invention relates to a method of detecting an analyte by mixing a nanopore sensor with a solution suspected of containing an analyte, measuring electrical properties, and correlating changes of electrical properties to the existence of an analyte.
摘要翻译：本发明涉及包括本文公开的制造方法和使用的纳米孔传感器系统。在一些实施方案中，本发明涉及包含脂质膜，优选磷脂双层膜的底物，其具有纳米孔和围绕所述脂质膜的凝胶。在另外的实施方案中，本发明涉及使用和制备具有由凝胶包围的单通道蛋白质的脂质膜的底物的组合物和方法。在另外的实施方案中，本发明涉及一种通过将纳米孔传感器与疑似含有分析物的溶液混合来检测分析物的方法，测量电性能，以及将电特性的变化与分析物的存在相关联。

3. 发明申请

WO0159453A3 Biosensor compositions and methods of use 审中-公开
标题翻译：生物传感器组合物和使用方法
公开(公告)号：WO0159453A3
公开(公告)日：2002-04-25
申请号：PCT/US0104482
申请日：2001-02-12
申请人： TEXAS A & M UNIV SYS , BAYLEY HAGAN P
发明人： HOWORKA STEFAN G , MOVILEANU LIVIU
IPC分类号： C07K14/31 , C12Q1/68 , G01N33/531 , G01N33/543 , G01N33/92 , C12Q1/00
CPC分类号： C12Q1/6837 , C07K14/31 , C12Q1/6816 , C12Q1/6834 , C12Q1/6874 , G01N33/531 , G01N33/5438 , G01N33/92 , Y10S530/825 , C12Q2565/607
摘要： Provided are pore-subunit polypeptides covalently linked to one or more sensing moieties, and uses of these modified polypeptides to detect and/or measure analytes or physical characteristics within a given sample.

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