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1. 发明申请

WO2003095669A1 STOCHASTIC SENSING THROUGH COVALENT INTERACTIONS 审中-公开
标题翻译：通过物质相互作用进行机械感应
公开(公告)号：WO2003095669A1
公开(公告)日：2003-11-20
申请号：PCT/US2003/014797
申请日：2003-05-09
申请人： THE TEXAS A & M UNIVERSITY SYSTEM
发明人： HAGAN, Bayley , SHIN, Seong-Ho , LUCHIAN, Tudor , CHELEY, Stephen
IPC分类号： C12Q1/00
CPC分类号： G01N33/5308 , C12Q1/001 , G01N33/5438 , G01N33/6872
摘要： A system and method for stochastic sensing in which the analyte covalently bonds to the sensor element or an adaptor element. If such bonding is irreversible, the bond may be broken by a chemical reagent. The sensor element may be a protein, such as the engineered P SH type or αHL protein pore. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable signal. Possible signals include change in electrical current, change in force, and change in fluorescence. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may be detected.
摘要翻译：用于随机感测的系统和方法，其中分析物共价键合到传感器元件或适配器元件。如果这种键合是不可逆的，则该键可能被化学试剂破坏。传感器元件可以是蛋白质，例如工程化的PSH型或αHL蛋白质孔。分析物可以是任何反应性分析物，包括化学武器，环境毒素和药物。分析物共价键合到传感器元件以产生可检测的信号。可能的信号包括电流的变化，力的变化和荧光的变化。信号的检测允许鉴定分析物并确定其在样品溶液中的浓度。可以检测存在于相同溶液中的多种分析物。

2. 发明授权

EP1504114B1 STOCHASTIC SENSING THROUGH COVALENT INTERACTIONS 有权
标题翻译：通过共同相互作用的随机检测
公开(公告)号：EP1504114B1
公开(公告)日：2017-07-12
申请号：EP03738910.3
申请日：2003-05-09
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： HAGAN, Bayley , SHIN, Seong-Ho , LUCHIAN, Tudor , CHELEY, Stephen
IPC分类号： C12Q1/00 , G01N33/543 , C12M1/40 , G01N33/68 , G01N27/327
CPC分类号： G01N33/5308 , C12Q1/001 , G01N33/5438 , G01N33/6872

3. 发明公开

EP1504114A1 STOCHASTIC SENSING THROUGH COVALENT INTERACTIONS 有权
标题翻译：通过共价相互作用分析物的测定随机
公开(公告)号：EP1504114A1
公开(公告)日：2005-02-09
申请号：EP03738910.3
申请日：2003-05-09
申请人： The Texas A & M University System
发明人： HAGAN, Bayley , SHIN, Seong-Ho , LUCHIAN, Tudor , CHELEY, Stephen
IPC分类号： C12Q1/00 , G01N33/543 , C12M1/40 , G01N33/68 , G01N27/327
CPC分类号： G01N33/5308 , C12Q1/001 , G01N33/5438 , G01N33/6872
摘要： A system and method for stochastic sensing in which the analyte covalently bonds to the sensor element or an adaptor element. If such bonding is irreversible, the bond may be broken by a chemical reagent. The sensor element may be a protein, such as the engineered PSH type or αHL protein pore. The analyte may be any reactive analyte, including chemical weapons, environmental toxins and pharmaceuticals. The analyte covalently bonds to the sensor element to produce a detectable signal. Possible signals include change in electrical current, change in force, and change in fluorescence. Detection of the signal allows identification of the analyte and determination of its concentration in a sample solution. Multiple analytes present in the same solution may be detected.

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