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1. 发明授权

US4897503A 1,1,2-triaryl-1-alkene derivatives 失效
标题翻译： 1,1,2-三芳基-1-烯烃衍生物
公开(公告)号：US4897503A
公开(公告)日：1990-01-30
申请号：US159590
申请日：1988-01-27
申请人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
发明人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
IPC分类号： C07F9/12
CPC分类号： C07F9/12
摘要： This invention provides a 1,1,2-triaryl-1-butene derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, one of R.sub.3 and R.sub.4 is a lower alkyl group and the other is a group of the formula ##STR2## (in which R.sub.5 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom or --OPO(OH).sub.2 group); or a pharmacologically acceptable salt thereof, its preparation and agents containing the derivative for treating mammary cancer and anovulatory infertility.

2. 发明授权

US5733918A Condensed-Indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩合 - 茚满衍生物及其药学上可接受的盐
公开(公告)号：US5733918A
公开(公告)日：1998-03-31
申请号：US578542
申请日：1996-01-19
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00 , A61K31/47 , C07D491/56
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR=N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
摘要翻译： PCT No.PCT / JP95 / 00944 Sec。 371日期1996年1月19日 102（e）日期1996年1月19日PCT提交1995年5月18日PCT公布。出版物WO95 / 32187 日期：1995年11月30日由式（1）表示的缩合 - 缩水甘油衍生物及其药学上可接受的盐：其中环A表示任选取代的苯环或萘环，或具有低级亚烷基二氧基基团，环B表示任选取代的苯环或具有较低亚烷基二氧基的苯环。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基，除了当R表示任意取代的含氮杂环基时; 环A和环B是没有取代基的苯环。

3. 发明授权

US5763453A Condensed indan derivatives and salts thereof 失效
标题翻译：稠合茚满衍生物及其盐
公开(公告)号：US5763453A
公开(公告)日：1998-06-09
申请号：US809602
申请日：1997-04-03
申请人： Shinji Okazaki , Tetsuji Asao , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/47 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/04 , C07D491/056
CPC分类号： C07D401/04 , C07D221/18
摘要： A condensed indan derivative represented by the formula (1) ##STR1## wherein the ring A is an optionally substituted benzene ring or a benzene ring which has lower alkylenedioxy group(s), the ring B is an optionally substituted benzene ring or a benzene ring which has lower alkylene dioxy group(s), and R is a group --NR.sub.1 R.sub.2, an optionally substituted nitrogen-containing heterocyclic group, a group --OR.sub.3 or a group --SR.sub.4 (wherein R.sub.1 and R.sub.2 are the same or different and each represent a hydrogen atom, a phenyl group, an optionally substituted nitrogen-containing heterocyclic group, or a lower alkyl group which may be substituted by optionally substituted amino group(s), lower alkoxy group(s), phenyl group(s), nitrogen-containing heterocyclic group(s) or hydroxyl group(s), and R.sub.3 and R.sub.4 each represent a lower alkyl group which may be substituted by substituted amino group(s)), provided that at least one of the rings A and B is a substituted benzene ring and R is not --NHCH.sub.3, and salts thereof, and medical use of said derivative and salts.
摘要翻译： PCT No.PCT / JP96 / 02195 Sec。 371日期1997年4月3日 102（e）日期1997年4月3日PCT提交1996年8月2日PCT公布。公开号WO97 / 06145 日本公报1997年2月20日由式（1）表示的缩合茚满衍生物（1）其中环A为任选取代的苯环或具有低亚烷基二氧基的苯环，环B为任选取代的苯环或具有低级亚烷基二氧基的苯环，R为基团-NR1R2，任选取代的含氮杂环基，-OR3基或-SR4基（其中R1和R2为相同或不同，各自表示氢原子，苯基，任选取代的含氮杂环基或可被任选取代的氨基取代的低级烷基，低级烷氧基，苯基基团，含氮杂环基或羟基，R 3和R 4各自表示可以被取代的氨基取代的低级烷基），条件是至少一个环A和B是取代的苯环，R不是-NHCH 3及其盐，以及所述衍生物和盐的医疗用途。

4. 发明授权

US5710162A Condensed-indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩水甘油衍生物及其药学上可接受的盐
公开(公告)号：US5710162A
公开(公告)日：1998-01-20
申请号：US713224
申请日：1996-09-12
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00 , C07D471/00 , A61K31/435
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted naphthalene ring, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR.dbd.N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group.
摘要翻译：由式（1）表示的缩合 - 茚满衍生物及其药学上可接受的盐：其中环A表示任选取代的萘环，环B表示任选取代的苯环或具有低级亚烷基二氧基的苯环组。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基。

5. 发明授权

US06300331B1 Naphthalimidobenzamide derivatives 失效
标题翻译：萘酰亚胺酰胺衍生物
公开(公告)号：US06300331B1
公开(公告)日：2001-10-09
申请号：US09508044
申请日：2000-03-03
申请人： Kazuharu Noguchi , Motoji Wakida , Kenji Suzuki , Yuji Yamada , Tetsuji Asao
发明人： Kazuharu Noguchi , Motoji Wakida , Kenji Suzuki , Yuji Yamada , Tetsuji Asao
IPC分类号： A61K31473
CPC分类号： C07D221/14 , C07D401/14 , C07D471/04
摘要： The present invention relates to a naphthalimidobenzamide derivative represented by the following formula (1): (wherein, R1 represents a hydrogen atom, etc., Y represents a hydrogen atom or —CON(R4)—A2—X2, R2 and R4 are the same or different and each independently represents a hydrogen atom, etc., A1 and A2 are the same or different and each independently represents an alkylene group which may be interrupted at least once by —N(R3)— (R3 representing a hydrogen atom, etc.) and X1 and X2 are the same or different and each independently represents a (hetero)aryl group which may have a substituent, etc.) or salt thereof; and a pharmaceutical comprising it as an effective ingredient. The compound is useful as an antitumor agent and the like.
摘要翻译：本发明涉及由下式（1）表示的萘二甲酰亚胺酰胺衍生物:(其中，R1表示氢原子等，Y表示氢原子或-CON（R4）-A2-X2，R2和R4表示相同或不同，各自独立地表示氢原子等，A1和A2相同或不同，并且各自独立地表示可以被-N（R3） - （R3表示氢原子，等等），X 1和X 2相同或不同，并且各自独立地表示可以具有取代基的（杂）芳基等）或其盐; 和包含它作为有效成分的药物。该化合物可用作抗肿瘤剂等。

6. 发明授权

US6028079A Condensed-indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩水甘油衍生物及其药学上可接受的盐
公开(公告)号：US6028079A
公开(公告)日：2000-02-22
申请号：US909934
申请日：1997-08-12
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR.dbd.N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
摘要翻译：由式（1）表示的缩合 - 茚满衍生物及其药学上可接受的盐：其中环A表示任选取代的苯环或萘环，或具有低亚烷基二氧基的苯环，环B表示任选取代的苯环或具有低亚烷基二氧基的苯环。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基，除了当R表示任意取代的含氮杂环基时; 环A和环B是没有取代基的苯环。

7. 发明授权

US5420117A 5-substituted uridine derivatives 失效
标题翻译： 5-取代的尿苷衍生物
公开(公告)号：US5420117A
公开(公告)日：1995-05-30
申请号：US963250
申请日：1992-10-19
申请人： Tadafumi Terada , Katsuhiko Fujimoto , Junichi Yamashita , Mitsugi Yasumoto , Setsuo Takeda , Junji Uchida , Konstanty Wierzba , Yuji Yamada
发明人： Tadafumi Terada , Katsuhiko Fujimoto , Junichi Yamashita , Mitsugi Yasumoto , Setsuo Takeda , Junji Uchida , Konstanty Wierzba , Yuji Yamada
IPC分类号： C07H19/06 , C07H23/00 , A61K31/505
CPC分类号： C07H23/00 , C07H19/06
摘要： This invention provides a 5-substituted uridine derivative of the formula ##STR1## wherein X is F or CF.sub.3, R.sub.1 and R.sub.2 each represent a group --OSi--(R.sub.4)(R.sub.5)(R.sub.6) (wherein R.sub.4, R.sub.5 and R.sub.6 represent C.sub.1 -C.sub.10 alkyl or the like), OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group or carboxylalkylcarbonyloxy group, R.sub.3 is a group --OSi(R.sub.4)(R.sub.5)(R.sub.6), H, OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group, or carboxylalkylcarbonyloxy group, and at least one of R.sub.1, R.sub.2 and R.sub.3 is a group --OSi--(R.sub.4)(R.sub.5)(R.sub.6), with the proviso that when X is fluorine atom, R.sub.3 is not hydrogen, and an intermediate for the preparation thereof, preparation processes of the derivative and anti-tumor agent containing the derivative as an active ingredient.
摘要翻译：本发明提供了下式的5-取代的尿苷衍生物，其中X是F或CF 3，R 1和R 2各自表示-OSi-（R 4）（R 5）（R 6）（其中R 4，R 5和R 6表示C1 -C 10烷基等），OH，其中氨基可被低级烷基或羧基烷基羰基氧基取代的氨基酰氧基，R3是基团-OSi（R4）（R5）（R6），H，OH，氨基酰氧基，其中氨基可以被低级烷基或羧基烷基羰基氧基取代，R 1，R 2和R 3中的至少一个是-OSi-（R 4）（R 5）（R 6）基团，条件是当X是氟原子时， R3不是氢，其制备中间体，衍生物的制备方法和含有该衍生物的抗肿瘤剂作为活性成分。

8. 发明授权

US06034234A Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient 失效
标题翻译：含有与活性成分相同的双链寡核苷酸和抗癌剂
公开(公告)号：US06034234A
公开(公告)日：2000-03-07
申请号：US676241
申请日：1996-07-17
申请人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
发明人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13
摘要： This invention provides a double-stranded oligonucleotide or a derivative thereof which comprises 15 to 40 base pairs, wherein at least one side of the strands contains at least one nucleotide sequence represented by 5'-TTTSSCGS-3' (S is G or C). Also, since the compound of the present invention can inhibit expression of growth-related genes which are regulated by E2F, through its function to undergo sequence-specific competitive inhibition of the binding of E2F protein to the transcription region at a low concentration, a pharmaceutical composition containing the inventive compound as its active ingredient is useful as a drug having low side effects for use in the prevention and treatment of cancers.
摘要翻译： PCT No.PCT / JP95 / 02348 Sec。 371日期：1996年7月17日 102（e）日期1996年7月17日PCT提交1995年11月16日PCT公布。公开号WO96 / 16074 日期：1996年5月30日本发明提供了包含15〜40个碱基对的双链寡核苷酸或其衍生物，其中链的至少一侧含有至少一个由5'-TTTSSCGS-3'表示的核苷酸序列（S为 G或C）。此外，由于本发明的化合物可以抑制由E2F调节的生长相关基因的表达，通过其以低浓度进行E2F蛋白与转录区域的结合的序列特异性竞争性抑制的功能，药物含有本发明化合物作为其活性成分的组合物可用作用于预防和治疗癌症的副作用低的药物。

9. 发明授权

US5869246A Triplex Oligonucleotides targeted to p120 失效
标题翻译：靶向p120的三重寡核苷酸
公开(公告)号：US5869246A
公开(公告)日：1999-02-09
申请号：US666420
申请日：1996-06-12
申请人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Norio Masuko , Yuji Yamada
发明人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Norio Masuko , Yuji Yamada
IPC分类号： C07H21/04 , A61K31/70 , A61K38/00 , A61P35/00 , C07H21/02 , C12N15/113 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/113 , C07H21/02 , A61K38/00 , C12N2310/15
摘要： This invention provides a method for inhibiting transcription of a p120 gene, which comprises using an oligonucleotide capable of forming a triple-stranded chain in a homopurine/homopyrimidine region of the p120 gene, as well as an oligonucleotide capable of forming a triple-stranded chain, or a derivative thereof, which has the following nucleotide sequence GAAWGGAGGAGGAGAAA or a complementary sequence thereof, and a pharmaceutical composition which contains the oligonucleotide as its active ingredient and is useful as an agent for the prevention and treatment of cancers with less side effects.
摘要翻译： PCT No.PCT / JP95 / 02113 Sec。 371日期：1996年6月12日 102（e）日期1996年6月12日PCT提交1995年10月13日PCT公布。公开号WO96 / 11938 日期：1996年04月25日本发明提供了抑制p120基因转录的方法，该方法包括使用能够在p120基因的均嘌呤/同型嘧啶区域中形成三链链的寡核苷酸，以及能够形成具有以下核苷酸序列GAAWGGAGGAGGAGAAA或其互补序列的三链链或其衍生物，以及含有该寡核苷酸作为其活性成分并可用作预防和治疗癌症的药物的药物组合物，少副作用。

10. 外观设计

USD987848S1 Massage appliance 有权
公开(公告)号：USD987848S1
公开(公告)日：2023-05-30
申请号：US35513659
申请日：2021-08-13
申请人： Yuji Yamada
设计人： Yuji Yamada
摘要： The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
1. Massage Appliance
2. Massage Appliance
Fig. 1.1 is a front perspective view of the first embodiment of the massage appliance;
Fig. 1.2 is a front view thereof;
Fig. 1.3 is a back view thereof;
Fig. 1.4 is a top view thereof;
Fig. 1.5 is a bottom view thereof;
Fig. 1.6 is a left view thereof;
Fig. 1.7 is a right view thereof;
Fig. 2.1 is a front perspective view of the second embodiment of the massage appliance;
Fig. 2.2 is a front view thereof;
Fig. 2.3 is a back view thereof;
Fig. 2.4 is a top view thereof;
Fig. 2.5 is a bottom view thereof;
Fig. 2.6 is a left view thereof; and
Fig. 2.7 is a right view thereof.

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