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1. 发明授权

US06034234A Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient 失效
标题翻译：含有与活性成分相同的双链寡核苷酸和抗癌剂
公开(公告)号：US06034234A
公开(公告)日：2000-03-07
申请号：US676241
申请日：1996-07-17
申请人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
发明人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13
摘要： This invention provides a double-stranded oligonucleotide or a derivative thereof which comprises 15 to 40 base pairs, wherein at least one side of the strands contains at least one nucleotide sequence represented by 5'-TTTSSCGS-3' (S is G or C). Also, since the compound of the present invention can inhibit expression of growth-related genes which are regulated by E2F, through its function to undergo sequence-specific competitive inhibition of the binding of E2F protein to the transcription region at a low concentration, a pharmaceutical composition containing the inventive compound as its active ingredient is useful as a drug having low side effects for use in the prevention and treatment of cancers.
摘要翻译： PCT No.PCT / JP95 / 02348 Sec。 371日期：1996年7月17日 102（e）日期1996年7月17日PCT提交1995年11月16日PCT公布。公开号WO96 / 16074 日期：1996年5月30日本发明提供了包含15〜40个碱基对的双链寡核苷酸或其衍生物，其中链的至少一侧含有至少一个由5'-TTTSSCGS-3'表示的核苷酸序列（S为 G或C）。此外，由于本发明的化合物可以抑制由E2F调节的生长相关基因的表达，通过其以低浓度进行E2F蛋白与转录区域的结合的序列特异性竞争性抑制的功能，药物含有本发明化合物作为其活性成分的组合物可用作用于预防和治疗癌症的副作用低的药物。

2. 发明授权

US6028079A Condensed-indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩水甘油衍生物及其药学上可接受的盐
公开(公告)号：US6028079A
公开(公告)日：2000-02-22
申请号：US909934
申请日：1997-08-12
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR.dbd.N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
摘要翻译：由式（1）表示的缩合 - 茚满衍生物及其药学上可接受的盐：其中环A表示任选取代的苯环或萘环，或具有低亚烷基二氧基的苯环，环B表示任选取代的苯环或具有低亚烷基二氧基的苯环。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基，除了当R表示任意取代的含氮杂环基时; 环A和环B是没有取代基的苯环。

3. 发明授权

US5733918A Condensed-Indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩合 - 茚满衍生物及其药学上可接受的盐
公开(公告)号：US5733918A
公开(公告)日：1998-03-31
申请号：US578542
申请日：1996-01-19
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00 , A61K31/47 , C07D491/56
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR=N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
摘要翻译： PCT No.PCT / JP95 / 00944 Sec。 371日期1996年1月19日 102（e）日期1996年1月19日PCT提交1995年5月18日PCT公布。出版物WO95 / 32187 日期：1995年11月30日由式（1）表示的缩合 - 缩水甘油衍生物及其药学上可接受的盐：其中环A表示任选取代的苯环或萘环，或具有低级亚烷基二氧基基团，环B表示任选取代的苯环或具有较低亚烷基二氧基的苯环。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基，除了当R表示任意取代的含氮杂环基时; 环A和环B是没有取代基的苯环。

4. 发明授权

US5710162A Condensed-indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩水甘油衍生物及其药学上可接受的盐
公开(公告)号：US5710162A
公开(公告)日：1998-01-20
申请号：US713224
申请日：1996-09-12
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00 , C07D471/00 , A61K31/435
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted naphthalene ring, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR.dbd.N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group.
摘要翻译：由式（1）表示的缩合 - 茚满衍生物及其药学上可接受的盐：其中环A表示任选取代的萘环，环B表示任选取代的苯环或具有低级亚烷基二氧基的苯环组。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基。

5. 发明授权

US08667670B2 Electronic component mounting apparatus 有权
标题翻译：电子元件安装装置
公开(公告)号：US08667670B2
公开(公告)日：2014-03-11
申请号：US13430277
申请日：2012-03-26
申请人： Keisuke Ishida
发明人： Keisuke Ishida
IPC分类号： B23P19/00
CPC分类号： H05K13/0452 , H05K13/041 , Y10T29/49124 , Y10T29/4913 , Y10T29/49133 , Y10T29/53039 , Y10T29/53174 , Y10T29/53178 , Y10T29/53183
摘要： A mounting apparatus includes a first placing unit and a second placing unit each configured to thrust an electronic component that is held toward a substrate, place the electronic component on the substrate, and leave the substrate, and a controller configured to set an inhibit period during which, while one placing unit of the first placing unit and the second placing unit thrusts the electronic component or leaves the substrate, at least one of a thrusting operation of the electronic component and an operation of leaving the substrate by another placing unit is inhibited so that the other placing unit does not execute the at least one of the thrusting operation and the operation of leaving the substrate.
摘要翻译：安装装置包括第一放置单元和第二放置单元，每个第一放置单元和第二放置单元均构造成推动保持在基板上的电子部件，将电子部件放置在基板上并离开基板;以及控制器，其被配置为在当第一放置单元和第二放置单元的一个放置单元推动电子部件或离开基板时，电子部件的推进操作和由另一个放置单元离开基板的操作中的至少一个被抑制，另一个放置单元不执行推出操作和离开基板的操作中的至少一个。

6. 发明申请

US20120246928A1 MOUNTING APPARATUS, ELECTRONIC COMPONENT PLACEMENT METHOD, AND SUBSTRATE MANUFACTURING METHOD 有权
标题翻译：安装设备，电子部件放置方法和基板制造方法
公开(公告)号：US20120246928A1
公开(公告)日：2012-10-04
申请号：US13430277
申请日：2012-03-26
申请人： Keisuke Ishida
发明人： Keisuke Ishida
IPC分类号： H05K3/30 , H05K3/00
CPC分类号： H05K13/0452 , H05K13/041 , Y10T29/49124 , Y10T29/4913 , Y10T29/49133 , Y10T29/53039 , Y10T29/53174 , Y10T29/53178 , Y10T29/53183
摘要： A mounting apparatus includes a first placing unit and a second placing unit each configured to thrust an electronic component that is held toward a substrate, place the electronic component on the substrate, and leave the substrate, and a controller configured to set an inhibit period during which, while one placing unit of the first placing unit and the second placing unit thrusts the electronic component or leaves the substrate, at least one of a thrusting operation of the electronic component and an operation of leaving the substrate by another placing unit is inhibited so that the other placing unit does not execute the at least one of the thrusting operation and the operation of leaving the substrate.
摘要翻译：安装装置包括第一放置单元和第二放置单元，每个第一放置单元和第二放置单元均构造成推动保持在基板上的电子部件，将电子部件放置在基板上并离开基板;以及控制器，其被配置为在当第一放置单元和第二放置单元的一个放置单元推动电子部件或离开基板时，电子部件的推进操作和由另一个放置单元离开基板的操作中的至少一个被抑制，另一个放置单元不执行推出操作和离开基板的操作中的至少一个。

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