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1. 发明授权

US5420117A 5-substituted uridine derivatives 失效
标题翻译： 5-取代的尿苷衍生物
公开(公告)号：US5420117A
公开(公告)日：1995-05-30
申请号：US963250
申请日：1992-10-19
申请人： Tadafumi Terada , Katsuhiko Fujimoto , Junichi Yamashita , Mitsugi Yasumoto , Setsuo Takeda , Junji Uchida , Konstanty Wierzba , Yuji Yamada
发明人： Tadafumi Terada , Katsuhiko Fujimoto , Junichi Yamashita , Mitsugi Yasumoto , Setsuo Takeda , Junji Uchida , Konstanty Wierzba , Yuji Yamada
IPC分类号： C07H19/06 , C07H23/00 , A61K31/505
CPC分类号： C07H23/00 , C07H19/06
摘要： This invention provides a 5-substituted uridine derivative of the formula ##STR1## wherein X is F or CF.sub.3, R.sub.1 and R.sub.2 each represent a group --OSi--(R.sub.4)(R.sub.5)(R.sub.6) (wherein R.sub.4, R.sub.5 and R.sub.6 represent C.sub.1 -C.sub.10 alkyl or the like), OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group or carboxylalkylcarbonyloxy group, R.sub.3 is a group --OSi(R.sub.4)(R.sub.5)(R.sub.6), H, OH, aminoacyloxy group wherein the amino group may be substituted with lower alkyl group, or carboxylalkylcarbonyloxy group, and at least one of R.sub.1, R.sub.2 and R.sub.3 is a group --OSi--(R.sub.4)(R.sub.5)(R.sub.6), with the proviso that when X is fluorine atom, R.sub.3 is not hydrogen, and an intermediate for the preparation thereof, preparation processes of the derivative and anti-tumor agent containing the derivative as an active ingredient.
摘要翻译：本发明提供了下式的5-取代的尿苷衍生物，其中X是F或CF 3，R 1和R 2各自表示-OSi-（R 4）（R 5）（R 6）（其中R 4，R 5和R 6表示C1 -C 10烷基等），OH，其中氨基可被低级烷基或羧基烷基羰基氧基取代的氨基酰氧基，R3是基团-OSi（R4）（R5）（R6），H，OH，氨基酰氧基，其中氨基可以被低级烷基或羧基烷基羰基氧基取代，R 1，R 2和R 3中的至少一个是-OSi-（R 4）（R 5）（R 6）基团，条件是当X是氟原子时， R3不是氢，其制备中间体，衍生物的制备方法和含有该衍生物的抗肿瘤剂作为活性成分。

2. 发明授权

US5750515A Cancer metastasis inhibitor 失效
标题翻译：癌转移抑制剂
公开(公告)号：US5750515A
公开(公告)日：1998-05-12
申请号：US737799
申请日：1996-11-26
申请人： Jiro Shibata , Konstanty Wierzba , Koji Murakami , Yuji Yamada , Koichi Shudo
发明人： Jiro Shibata , Konstanty Wierzba , Koji Murakami , Yuji Yamada , Koichi Shudo
IPC分类号： A61K31/192 , A61K31/196 , A61K31/695 , A61P35/04 , A61K31/19 , A61K31/20
CPC分类号： A61K31/695 , A61K31/192 , A61K31/196
摘要： The present invention relates to a cancer metastasis inhibitor comprising a benzoic acid derivative as an active ingredient represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each represents hydrogen atom, hydroxyl group or trimethylsilyl group, or R.sub.3 and R.sub.4 are bonded to each other to form a tetramethylene group substituted with lower alkyl group, and X represents group --COCH.dbd.C(OH)--, group --NHCO-- or group --CONH--, provided that when R.sub.3 and R.sub.4 are bonded to each other to form a tetramethylene group substituted with lower alkyl group, X is group --COCH.dbd.C(OH)-- or group --CONH--, use of the benzoic acid derivative for preparing the cancer metastasis inhibitor and method of inhibiting cancer metastasis, characterized in that an effective amount of the benzoic acid derivative is administered to a mammalian animal for inhibiting metastasis of cancer. The benzoic acid derivative represented by the above formula (I) has extremely good metastasis inhibiting properties.
摘要翻译： PCT No.PCT / JP96 / 00980 Sec。 371日期1996年11月26日 102（e）1996年11月26日PCT PCT 1996年4月10日PCT公布。第WO96 / 32101号公报日期：1996年10月17日本发明涉及包含苯甲酸衍生物作为由式（I）表示的活性成分的癌症转移抑制剂，其中R1，R2，R3和R4相同或不同，各自表示氢原子，羟基或三甲基甲硅烷基，或者R 3和R 4相互键合形成被低级烷基取代的四亚甲基，X表示-COCH = C（OH） - 基团，-NHCO-或基团 -CONH-，条件是当R 3和R 4彼此键合以形成被低级烷基取代的四亚甲基时，X是基团-COCH = C（OH） - 或基团-CONH-，使用苯甲酸衍生物制备癌转移抑制剂和抑制癌转移的方法，其特征在于向哺乳动物施用有效量的苯甲酸衍生物以抑制癌转移。上述式（I）表示的苯甲酸衍生物具有极好的转移抑制性质。

3. 发明授权

US06255314B1 Cancerous metastasis inhibitors containing uracil derivatives 失效
标题翻译：含有尿嘧啶衍生物的癌转移抑制剂
公开(公告)号：US06255314B1
公开(公告)日：2001-07-03
申请号：US09077209
申请日：1998-05-26
申请人： Kazutaka Miyadera , Tomohiro Emura , Konstanty Wierzba , Yuji Yamada
发明人： Kazutaka Miyadera , Tomohiro Emura , Konstanty Wierzba , Yuji Yamada
IPC分类号： A61K31513
CPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/55 , C07D239/553
摘要： This invention provides a drug which has inhibitory activities against thymidine phosphorylase and inhibits metastasis of a cancer. Specifically, this invention relates to a cancerous metastasis inhibitor comprising, as an active ingredient, a uracil derivative represented by the following formula (1): wherein R1 represents a chlorine, bromine or iodine atom or a cyano or lower alkyl group and R2 represents a substituted or unsubstituted 4-8 membered hetero-cyclic group having nitrogen atoms or a substituted or unsubstituted amidinothio, guanidino, (lower alkyl)amidino, amino or like group, or a salt thereof.
摘要翻译：本发明提供了对胸苷磷酸化酶具有抑制活性并抑制癌转移的药物。具体而言，本发明涉及含有作为活性成分的下述式（1）所示的尿嘧啶衍生物的癌性转移抑制剂，其中R1表示氯，溴或碘原子或氰基或低级烷基，R2表示取代或未取代的具有氮原子的4-8元杂环基或取代或未取代的脒基硫代，胍基，（低级烷基）脒基，氨基或类似基团或其盐。

4. 发明授权

US4581372A Sulfonium compounds 失效
标题翻译：锍化合物
公开(公告)号：US4581372A
公开(公告)日：1986-04-08
申请号：US541799
申请日：1983-10-14
申请人： Akihide Koda , Mikio Hori , Mitsugi Yasumoto , Ichiro Yamawaki , Yuji Yamada , Katsuo Takikawa
发明人： Akihide Koda , Mikio Hori , Mitsugi Yasumoto , Ichiro Yamawaki , Yuji Yamada , Katsuo Takikawa
IPC分类号： A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61P35/00 , A61P37/04 , C07D307/10 , C07D309/04
CPC分类号： C07D307/10 , C07D309/04
摘要： Sulfonium compounds represented by the formula ##STR1## having immunostimulant activity and useful as the active components of drugs and agricultural chemicals.
摘要翻译：由式（I）表示的具有免疫刺激活性并可用作药物和农药活性成分的锍化合物。

5. 发明授权

US4340543A Sulfonium compounds 失效
标题翻译：锍化合物
公开(公告)号：US4340543A
公开(公告)日：1982-07-20
申请号：US231126
申请日：1981-02-03
申请人： Akihide Koda , Mikio Hori , Mitsugi Yasumoto , Ichiro Yamawaki , Yuji Yamada , Katsuo Takikawa
发明人： Akihide Koda , Mikio Hori , Mitsugi Yasumoto , Ichiro Yamawaki , Yuji Yamada , Katsuo Takikawa
IPC分类号： A61K31/34 , A61K31/341 , A61K31/35 , A61K31/351 , A61P35/00 , A61P37/04 , C07D307/10 , C07D309/04
CPC分类号： C07D307/10 , C07D309/04 , Y10S514/96 , Y10S514/962 , Y10S514/966
摘要： Sulfonium compounds represented by the formula ##STR1## have anticancer activity, immunostimulant activity and the like, and useful as the active components of drugs and agricultural chemicals.
摘要翻译：由式（I）表示的锍化合物具有抗癌活性，免疫刺激活性等，可用作药物和农药的活性成分。

6. 发明授权

US4897503A 1,1,2-triaryl-1-alkene derivatives 失效
标题翻译： 1,1,2-三芳基-1-烯烃衍生物
公开(公告)号：US4897503A
公开(公告)日：1990-01-30
申请号：US159590
申请日：1988-01-27
申请人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
发明人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
IPC分类号： C07F9/12
CPC分类号： C07F9/12
摘要： This invention provides a 1,1,2-triaryl-1-butene derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, one of R.sub.3 and R.sub.4 is a lower alkyl group and the other is a group of the formula ##STR2## (in which R.sub.5 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom or --OPO(OH).sub.2 group); or a pharmacologically acceptable salt thereof, its preparation and agents containing the derivative for treating mammary cancer and anovulatory infertility.

7. 外观设计

USD987848S1 Massage appliance 有权
公开(公告)号：USD987848S1
公开(公告)日：2023-05-30
申请号：US35513659
申请日：2021-08-13
申请人： Yuji Yamada
设计人： Yuji Yamada
摘要： The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
1. Massage Appliance
2. Massage Appliance
Fig. 1.1 is a front perspective view of the first embodiment of the massage appliance;
Fig. 1.2 is a front view thereof;
Fig. 1.3 is a back view thereof;
Fig. 1.4 is a top view thereof;
Fig. 1.5 is a bottom view thereof;
Fig. 1.6 is a left view thereof;
Fig. 1.7 is a right view thereof;
Fig. 2.1 is a front perspective view of the second embodiment of the massage appliance;
Fig. 2.2 is a front view thereof;
Fig. 2.3 is a back view thereof;
Fig. 2.4 is a top view thereof;
Fig. 2.5 is a bottom view thereof;
Fig. 2.6 is a left view thereof; and
Fig. 2.7 is a right view thereof.

8. 发明授权

US08644531B2 Information processing system and information processing method 有权
标题翻译：信息处理系统和信息处理方法
公开(公告)号：US08644531B2
公开(公告)日：2014-02-04
申请号：US12634999
申请日：2009-12-10
申请人： Homare Kon , Yuji Yamada
发明人： Homare Kon , Yuji Yamada
IPC分类号： H04R5/02
CPC分类号： H04S7/304 , H04S2400/01
摘要： An information processing system includes a display, a display sensor that detects a movement or a rotation of the display, a transducer unit as an earphone unit or a headphone unit, a sound processing part that processes an audio signal so as to localize a sound image in a position outside a head of a listener wearing the transducer unit and listening to sound, and an operation controller that computes an output from the display sensor to obtain a moving direction and a moving distance, or a rotation direction and a rotation angle of the display, and controls sound processing performed by the sound processing part in accordance with a result of the computation so that a positional relation between the display and the head of the listener is mapped as a positional relation between an image display surface and the head of the listener in a virtual viewing space.
摘要翻译：信息处理系统包括显示器，检测显示器的移动或旋转的显示传感器，作为耳机单元或耳机单元的换能器单元，处理音频信号以便将声音图像定位的声音处理部件在佩戴换能器单元并收听声音的听众的头部外的位置，以及操作控制器，其计算来自显示传感器的输出以获得移动方向和移动距离，或者旋转方向和旋转角度根据计算结果显示和控制由声音处理部分执行的声音处理，使得显示器和听众的头部之间的位置关系被映射为图像显示表面和图像显示面的头部之间的位置关系监听器在虚拟观看空间中。

9. 发明申请

US20120106763A1 AUDIO SIGNAL PROCESSING DEVICE, AUDIO SIGNAL PROCESSING METHOD, AND PROGRAM 有权
标题翻译：音频信号处理设备，音频信号处理方法和程序
公开(公告)号：US20120106763A1
公开(公告)日：2012-05-03
申请号：US13278644
申请日：2011-10-21
申请人： Koyuru OKIMOTO , Yuji Yamada
发明人： Koyuru OKIMOTO , Yuji Yamada
IPC分类号： H04R1/02
CPC分类号： H04S7/301 , H04R2499/13 , H04R2499/15 , H04S7/302 , H04S7/305
摘要： An audio signal processing device includes two audio signal processing units that serially perform a processing with respect to an input audio signal, and obtain an output audio signal for driving a speaker. One audio signal processing unit of the two audio signal processing units performs, with respect to the input audio signal, a correction process through a filter that realizes a reverse characteristic of an impulse response measured at a first measurement position that is a front position of the speaker. The other audio signal processing unit performs, with respect to the input audio signal, a correction process through a filter that realizes a reverse characteristic of an impulse response measured at a second measurement position different from the first measurement position that is a front position of the speaker.
摘要翻译：音频信号处理装置包括对输入音频信号进行串行处理的两个音频信号处理单元，并获得用于驱动扬声器的输出音频信号。两个音频信号处理单元的一个音频信号处理单元相对于输入音频信号执行通过滤波器的校正处理，该滤波器实现在作为第一测量位置的第一测量位置处测量的脉冲响应的反向特性扬声器。另一个音频信号处理单元相对于输入音频信号执行通过滤波器的校正处理，该滤波器实现在与作为第一测量位置的第一测量位置不同的第二测量位置处测量的脉冲响应的反向特性扬声器。

10. 发明授权

US08122584B2 Method of producing honeycomb structure molding die 有权
标题翻译：生产蜂窝结构成型模具的方法
公开(公告)号：US08122584B2
公开(公告)日：2012-02-28
申请号：US12003417
申请日：2007-12-26
申请人： Toshiji Kondou , Yuji Yamada , Kunitsugu Mototani
发明人： Toshiji Kondou , Yuji Yamada , Kunitsugu Mototani
IPC分类号： B23P13/04
CPC分类号： B23P15/243 , B28B2003/203 , B29C47/0028 , B29C47/12 , B29L2031/60 , Y10T29/49002 , Y10T29/49169 , Y10T29/49172 , Y10T29/49995 , Y10T29/49996
摘要： In a method of producing a honeycomb structure molding die composed of feed holes through which molding material is fed and slit grooves communicated with the feed holes for the use of molding a honeycomb structure body, the slit grooves are formed on one surface of a metal material in a lattice arrangement by repeatedly moving a thin circular grindstone blade which is rotating in a straight-line direction or a line direction approximating a straight line in order to cut the surface of the metal material. In particular, the method removes fine metal powder, generated by cutting the surface of the metal material, using polishing grooves formed in a dressing grindstone disposed in front of the metal material every cutting of the metal material during the slit groove formation.
摘要翻译：在制造蜂窝结构体成型模具的方法中，所述蜂窝结构体成形模具由供给成形材料的供给孔和与用于成形蜂窝结构体的进给孔连通的狭缝槽构成，所述狭缝槽形成在金属材料的一个面上通过重复移动沿着直线方向或近似直线的线方向旋转的细圆形磨石刀片以切割金属材料的表面，以格子布置。特别地，该方法通过在切槽形成期间每次切割金属材料时，使用在金属材料前方设置的修整磨石中形成的抛光槽来除去金属材料的表面产生的细金属粉末。

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