专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20170219510A1 ELECTRODE ARRANGEMENTS FOR ELECTROCHEMICAL TEST ELEMENTS 审中-公开
公开(公告)号：US20170219510A1
公开(公告)日：2017-08-03
申请号：US15488574
申请日：2017-04-17
申请人： Terry Beaty , Harvey Buck , Eric Diebold , Martin Gerber
发明人： Terry Beaty , Harvey Buck , Eric Diebold , Martin Gerber
IPC分类号： G01N27/327 , G01N33/49
摘要： Electrode arrangements for test elements, test elements and methods of determining sample sufficiency, monitoring fill time, establishing fill directions and/or confirming electrode coverage by a sample for test elements are disclosed. The test elements have an electrode-support substrate including a spacer having an edge defining a boundary of a capillary channel. The electrode-support substrate also includes a first electrode pair and a second electrode pair, wherein the first electrode pair is positioned between the second electrode pair. The method includes dosing the test sensor with the fluid sample; applying a signal to the first electrode pair and the second electrode pair, detecting a first response to the signal from the first electrode pair, and detecting a second response to the signal from the second electrode pair; determining a time period between the first response and the second response and then applying a measurement test sequence for an analyte of interest on the fluid sample if the time period is less than a first predetermined threshold.

2. 发明申请

US20050023137A1 Biosensor with multiple electrical functionalities 有权
标题翻译：具有多种电气功能的生物传感器
公开(公告)号：US20050023137A1
公开(公告)日：2005-02-03
申请号：US10871843
申请日：2004-06-18
申请人： Raghbir Bhullar , Harvey Buck , Brian Hill , Paul Walling , Terry Beaty , David Burke , Eric Diebold
发明人： Raghbir Bhullar , Harvey Buck , Brian Hill , Paul Walling , Terry Beaty , David Burke , Eric Diebold
IPC分类号： B01L3/02 , C12Q1/00 , G01N1/00 , G01N27/00 , G01N27/30 , G01N33/487
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
摘要翻译：具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。

3. 发明申请

US20110186428A1 ELECTRODE ARRANGEMENTS FOR BIOSENSORS 审中-公开
标题翻译：生物传感器的电极装置
公开(公告)号：US20110186428A1
公开(公告)日：2011-08-04
申请号：US12696316
申请日：2010-01-29
申请人： Terry Beaty , Henning Groll , Harvey Buck , Eric Diebold , Abner Joseph , Randy Riggles
发明人： Terry Beaty , Henning Groll , Harvey Buck , Eric Diebold , Abner Joseph , Randy Riggles
IPC分类号： G01N33/50
CPC分类号： G01N27/327 , G01N27/3272
摘要： The present invention relates to a biosensor. The biosensor includes a support substrate, electrodes positioned on the support substrate, a spacer substrate positioned on the support substrate, and a cover positioned on the spacer substrate. The cover cooperates with the support substrate to define a capillary channel. The electrodes include at least one working electrode defining a working electrode area in the capillary channel. The working electrode is configured to minimize variation in the working electrode area in the capillary channel due to variations in the spacer substrate placement relative to the working electrode.
摘要翻译：本发明涉及生物传感器。生物传感器包括支撑基板，位于支撑基板上的电极，位于支撑基板上的间隔基板和位于间隔基板上的盖。盖与支撑基板配合以限定毛细通道。电极包括限定毛细通道中的工作电极区域的至少一个工作电极。工作电极被配置为使得由于间隔基板相对于工作电极的位置的变化而使毛细通道中的工作电极面积的变化最小化。

4. 发明授权

US08439201B2 Nanoparticle separation using coherent anti-stokes Raman scattering 有权
标题翻译：使用相干反斯托克斯拉曼散射的纳米粒子分离
公开(公告)号：US08439201B2
公开(公告)日：2013-05-14
申请号：US12989833
申请日：2009-05-21
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： B03B1/00
CPC分类号： B82B3/0071
摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.
摘要翻译：本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

5. 发明授权

US08294891B2 Non-invasive optical analysis using surface enhanced raman spectroscopy 有权
标题翻译：使用表面增强拉曼光谱的无创光学分析
公开(公告)号：US08294891B2
公开(公告)日：2012-10-23
申请号：US12523567
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： G01N21/03 , G01J3/44
CPC分类号： G01N21/658 , B65D79/02 , B65D2203/02 , G01N33/02
摘要： In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface thereof is accessible via an environment external to the package. The system further includes a radiation source adapted to direct radiation to the substrate's back surface such that the radiation would interact with one or more molecular species of the product that are in contact with the substrate's sensing surface. The system also includes a detector that is adapted to detect radiation returning from the substrate in response to its illumination by the radiation source. The front surface of the sensing substrate can comprise a plurality of micron-sized or submicron-sized ridges having a discontinuous or continuous metal coating, e.g., a metallic layer with a thickness in a range of about 10 nm to about 1000 nm (and preferably in a range of about 50 nm to about 120 nm), disposed thereon.
摘要翻译：在一个方面，公开了一种用于产品包装的系统，其包括耦合到包装的聚合物感测衬底，使得其前感测表面与存储在包装中的产品（例如，可替代产品）的一部分接触并且其后表面可通过包装外部的环境访问。该系统还包括适于将辐射引导到衬底的背表面的辐射源，使得辐射将与与衬底的感测表面接触的产品的一种或多种分子种类相互作用。该系统还包括检测器，其适于检测响应于其由辐射源照射的从衬底返回的辐射。感测基板的前表面可以包括具有不连续或连续金属涂层的多个微米尺寸或亚微米尺寸的脊，例如厚度在约10nm至约1000nm范围内的金属层（优选地，在约50nm至约120nm的范围内）。

6. 发明申请

US20090046283A1 METALIZED SEMICONDUCTOR SUBSTRATES FOR RAMAN SPECTROSCOPY 有权
标题翻译：用于拉曼光谱的金属化半导体衬底
公开(公告)号：US20090046283A1
公开(公告)日：2009-02-19
申请号：US12017720
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold , Steven M. Ebstein
发明人： Eric Mazur , Eric Diebold , Steven M. Ebstein
IPC分类号： G01J3/44 , H01L21/00
CPC分类号： B81B1/006 , B01L3/5023 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/165 , B81C1/00206 , B82Y15/00 , B82Y30/00 , G01N21/658
摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.
摘要翻译：一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

7. 发明申请

US20120171746A1 METHOD AND SYSTEM FOR MANIPULATION OF CELLS 审中-公开
标题翻译：用于操作细胞的方法和系统
公开(公告)号：US20120171746A1
公开(公告)日：2012-07-05
申请号：US13382314
申请日：2010-06-11
申请人： Eric Mazur , Alexander Heisterkamp , Eric Diebold
发明人： Eric Mazur , Alexander Heisterkamp , Eric Diebold
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12M35/02
摘要： The invention is directed to a method for the manipulation of at least one cell, the method comprising the steps of depositing a metal onto the surface of a substrate, placing the at least one cell at or near the surface of the substrate, and irradiating the surface of the substrate with at least one laser pulse. The inventive method is characterized by the formation of surface structures with a size of one micrometer or less on the surface of the substrate prior to depositing the metal thereon. The invention is also directed to a system for the manipulation of at least one cell, the system comprising a substrate with surface structures having a size of 1 micrometer or less, wherein a metal is deposited on the surface structures, and wherein the system further comprises a laser for irradiating the surface structures.
摘要翻译：本发明涉及一种用于操纵至少一个电池的方法，所述方法包括以下步骤：将金属沉积到衬底的表面上，将所述至少一个电池放置在衬底的表面或其附近，具有至少一个激光脉冲的衬底表面。本发明的方法的特征在于在其上沉积金属之前，在基板的表面上形成尺寸为1微米或更小的表面结构。本发明还涉及一种用于操纵至少一个电池的系统，该系统包括具有1微米或更小尺寸的表面结构的衬底，其中金属沉积在表面结构上，并且其中该系统还包括用于照射表面结构的激光。

8. 发明申请

US20100208237A1 POLYMERIC SUBSTRATES FOR RAMAN SPECTROSCOPY 审中-公开
标题翻译：用于拉曼光谱的聚合物基板
公开(公告)号：US20100208237A1
公开(公告)日：2010-08-19
申请号：US12094719
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold , Tommaso Baldacchini
发明人： Eric Mazur , Eric Diebold , Tommaso Baldacchini
IPC分类号： G01J3/44 , B05D3/06 , G01J3/00 , B32B3/00
CPC分类号： G01N21/658 , B23K26/0006 , B23K26/352 , B23K2101/34 , B23K2103/42 , B23K2103/50 , B29C33/3878 , B29C33/40 , Y10T428/24355
摘要： The present invention generally provides substrates for use in a variety of analytical and/or diagnostic applications as well as optical systems that employ them, in particular systems based on surface enhanced Raman spectroscopy (SERS). In one aspect, the invention provides polymeric substrates having conductive surfaces that exhibit micron-sized, and preferably submicron-sized, structures. In other aspects, methods for fabricating such substrates are disclosed, including a step of irradiating a mold surface with a plurality of short laser pulses to form micron-sized or submicron-sized structures and the mold surface and generating the polymeric substrate by replication from the mold surface.
摘要翻译：本发明通常提供用于各种分析和/或诊断应用的基板以及采用它们的光学系统，特别是基于表面增强拉曼光谱（SERS）的系统。在一个方面，本发明提供具有导电表面的聚合物基材，其具有微米尺寸，优选亚微米尺寸的结构。在其它方面，公开了用于制造这种基底的方法，包括用多个短激光脉冲照射模具表面以形成微米级或亚微米尺寸的结构和模具表面并通过从模具表面。

9. 发明申请

US20060200981A1 Method of making a biosensor 审中-公开
标题翻译：制作生物传感器的方法
公开(公告)号：US20060200981A1
公开(公告)日：2006-09-14
申请号：US11416491
申请日：2006-05-01
申请人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , P. Walling
发明人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , P. Walling
IPC分类号： H05K3/02 , B23K26/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm
摘要翻译：提供制造生物传感器的方法。生物传感器包括在基底上的导电材料和形成在基底上的电极图案，图案具有不同的特征尺寸。使用宽场激光烧蚀部分地从基底去除导电材料，使得小于90％的导电材料保留在基底上，并且电极图案具有在两个点之间延伸的边缘。边缘与两点之间延伸的线的标准偏差小于约6um

10. 发明申请

US20050103624A1 Biosensor and method of making 审中-公开
标题翻译：生物传感器和制作方法
公开(公告)号：US20050103624A1
公开(公告)日：2005-05-19
申请号：US10871937
申请日：2004-06-18
申请人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , Paul Walling
发明人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , Paul Walling
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/403 , G01N33/487 , G01N33/49 , G01N33/543 , H05K1/00 , H05K3/02 , G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译：具有电极元件的电化学生物传感器具有光滑，高质量的边缘。这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量形成它们

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式