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1. 发明申请

US20100208237A1 POLYMERIC SUBSTRATES FOR RAMAN SPECTROSCOPY 审中-公开
标题翻译：用于拉曼光谱的聚合物基板
公开(公告)号：US20100208237A1
公开(公告)日：2010-08-19
申请号：US12094719
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold , Tommaso Baldacchini
发明人： Eric Mazur , Eric Diebold , Tommaso Baldacchini
IPC分类号： G01J3/44 , B05D3/06 , G01J3/00 , B32B3/00
CPC分类号： G01N21/658 , B23K26/0006 , B23K26/352 , B23K2101/34 , B23K2103/42 , B23K2103/50 , B29C33/3878 , B29C33/40 , Y10T428/24355
摘要： The present invention generally provides substrates for use in a variety of analytical and/or diagnostic applications as well as optical systems that employ them, in particular systems based on surface enhanced Raman spectroscopy (SERS). In one aspect, the invention provides polymeric substrates having conductive surfaces that exhibit micron-sized, and preferably submicron-sized, structures. In other aspects, methods for fabricating such substrates are disclosed, including a step of irradiating a mold surface with a plurality of short laser pulses to form micron-sized or submicron-sized structures and the mold surface and generating the polymeric substrate by replication from the mold surface.
摘要翻译：本发明通常提供用于各种分析和/或诊断应用的基板以及采用它们的光学系统，特别是基于表面增强拉曼光谱（SERS）的系统。在一个方面，本发明提供具有导电表面的聚合物基材，其具有微米尺寸，优选亚微米尺寸的结构。在其它方面，公开了用于制造这种基底的方法，包括用多个短激光脉冲照射模具表面以形成微米级或亚微米尺寸的结构和模具表面并通过从模具表面。

2. 发明授权

US08439201B2 Nanoparticle separation using coherent anti-stokes Raman scattering 有权
标题翻译：使用相干反斯托克斯拉曼散射的纳米粒子分离
公开(公告)号：US08439201B2
公开(公告)日：2013-05-14
申请号：US12989833
申请日：2009-05-21
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： B03B1/00
CPC分类号： B82B3/0071
摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.
摘要翻译：本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

3. 发明授权

US08294891B2 Non-invasive optical analysis using surface enhanced raman spectroscopy 有权
标题翻译：使用表面增强拉曼光谱的无创光学分析
公开(公告)号：US08294891B2
公开(公告)日：2012-10-23
申请号：US12523567
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： G01N21/03 , G01J3/44
CPC分类号： G01N21/658 , B65D79/02 , B65D2203/02 , G01N33/02
摘要： In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface thereof is accessible via an environment external to the package. The system further includes a radiation source adapted to direct radiation to the substrate's back surface such that the radiation would interact with one or more molecular species of the product that are in contact with the substrate's sensing surface. The system also includes a detector that is adapted to detect radiation returning from the substrate in response to its illumination by the radiation source. The front surface of the sensing substrate can comprise a plurality of micron-sized or submicron-sized ridges having a discontinuous or continuous metal coating, e.g., a metallic layer with a thickness in a range of about 10 nm to about 1000 nm (and preferably in a range of about 50 nm to about 120 nm), disposed thereon.
摘要翻译：在一个方面，公开了一种用于产品包装的系统，其包括耦合到包装的聚合物感测衬底，使得其前感测表面与存储在包装中的产品（例如，可替代产品）的一部分接触并且其后表面可通过包装外部的环境访问。该系统还包括适于将辐射引导到衬底的背表面的辐射源，使得辐射将与与衬底的感测表面接触的产品的一种或多种分子种类相互作用。该系统还包括检测器，其适于检测响应于其由辐射源照射的从衬底返回的辐射。感测基板的前表面可以包括具有不连续或连续金属涂层的多个微米尺寸或亚微米尺寸的脊，例如厚度在约10nm至约1000nm范围内的金属层（优选地，在约50nm至约120nm的范围内）。

4. 发明申请

US20090046283A1 METALIZED SEMICONDUCTOR SUBSTRATES FOR RAMAN SPECTROSCOPY 有权
标题翻译：用于拉曼光谱的金属化半导体衬底
公开(公告)号：US20090046283A1
公开(公告)日：2009-02-19
申请号：US12017720
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold , Steven M. Ebstein
发明人： Eric Mazur , Eric Diebold , Steven M. Ebstein
IPC分类号： G01J3/44 , H01L21/00
CPC分类号： B81B1/006 , B01L3/5023 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/165 , B81C1/00206 , B82Y15/00 , B82Y30/00 , G01N21/658
摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.
摘要翻译：一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

5. 发明申请

US20120171746A1 METHOD AND SYSTEM FOR MANIPULATION OF CELLS 审中-公开
标题翻译：用于操作细胞的方法和系统
公开(公告)号：US20120171746A1
公开(公告)日：2012-07-05
申请号：US13382314
申请日：2010-06-11
申请人： Eric Mazur , Alexander Heisterkamp , Eric Diebold
发明人： Eric Mazur , Alexander Heisterkamp , Eric Diebold
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12M35/02
摘要： The invention is directed to a method for the manipulation of at least one cell, the method comprising the steps of depositing a metal onto the surface of a substrate, placing the at least one cell at or near the surface of the substrate, and irradiating the surface of the substrate with at least one laser pulse. The inventive method is characterized by the formation of surface structures with a size of one micrometer or less on the surface of the substrate prior to depositing the metal thereon. The invention is also directed to a system for the manipulation of at least one cell, the system comprising a substrate with surface structures having a size of 1 micrometer or less, wherein a metal is deposited on the surface structures, and wherein the system further comprises a laser for irradiating the surface structures.
摘要翻译：本发明涉及一种用于操纵至少一个电池的方法，所述方法包括以下步骤：将金属沉积到衬底的表面上，将所述至少一个电池放置在衬底的表面或其附近，具有至少一个激光脉冲的衬底表面。本发明的方法的特征在于在其上沉积金属之前，在基板的表面上形成尺寸为1微米或更小的表面结构。本发明还涉及一种用于操纵至少一个电池的系统，该系统包括具有1微米或更小尺寸的表面结构的衬底，其中金属沉积在表面结构上，并且其中该系统还包括用于照射表面结构的激光。

6. 发明授权

US07864312B2 Substrates for Raman spectroscopy having discontinuous metal coatings 有权
标题翻译：具有不连续金属涂层的拉曼光谱用基板
公开(公告)号：US07864312B2
公开(公告)日：2011-01-04
申请号：US12017698
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , Y10T428/249978
摘要： In one aspect, the present invention provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with discontinuous metal coating characterized by one or more metalized surface region and a plurality of surface gaps.
摘要翻译：一方面，本发明提供用于制造用于各种分析和/或诊断应用的基底的方法。可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。然后可以用不连续金属涂层涂覆结构化表面，其特征在于一个或多个金属化表面区域和多个表面间隙。

7. 发明申请

US20100171949A1 NON-INVASIVE OPTICAL ANALYSIS USING SURFACE ENHANCED RAMAN SPECTROSCOPY 有权
标题翻译：使用表面增强拉曼光谱的非入射光学分析
公开(公告)号：US20100171949A1
公开(公告)日：2010-07-08
申请号：US12523567
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： G01J3/44 , G01N21/84 , G01N21/65 , G01N21/17
CPC分类号： G01N21/658 , B65D79/02 , B65D2203/02 , G01N33/02
摘要： In one aspect, a system for use in product packaging is disclosed that includes a polymeric sensing substrate coupled to a package such that a front sensing surface thereof is in contact with a portion of a product, e.g., a fungible product, stored in the package and a back surface thereof is accessible via an environment external to the package. The system further includes a radiation source adapted to direct radiation to the substrate's back surface such that the radiation would interact with one or more molecular species of the product that are in contact with the substrate's sensing surface. The system also includes a detector that is adapted to detect radiation returning from the substrate in response to its illumination by the radiation source. The front surface of the sensing substrate can comprise a plurality of micron-sized or submicron-sized ridges having a discontinuous or continuous metal coating, e.g., a metallic layer with a thickness in a range of about 10 nm to about 1000 nm (and preferably in a range of about 50 nm to about 120 nm), disposed thereon.
摘要翻译：在一个方面，公开了一种用于产品包装的系统，其包括耦合到包装的聚合物感测衬底，使得其前感测表面与存储在包装中的产品（例如，可替代产品）的一部分接触并且其后表面可通过包装外部的环境访问。该系统还包括适于将辐射引导到衬底的背表面的辐射源，使得辐射将与与衬底的感测表面接触的产品的一种或多种分子种类相互作用。该系统还包括检测器，其适于检测响应于其由辐射源照射的从衬底返回的辐射。感测基板的前表面可以包括具有不连续或连续金属涂层的多个微米级或亚微米尺寸的脊，例如厚度在约10nm至约1000nm范围内的金属层（优选地，在约50nm至约120nm的范围内）。

8. 发明授权

US07715003B2 Metalized semiconductor substrates for raman spectroscopy 有权
标题翻译：用于拉曼光谱的金属化半导体衬底
公开(公告)号：US07715003B2
公开(公告)日：2010-05-11
申请号：US12017720
申请日：2008-01-22
申请人： Eric Mazur , Eric Diebold , Steven Ebstein
发明人： Eric Mazur , Eric Diebold , Steven Ebstein
IPC分类号： G01J3/44
CPC分类号： B81B1/006 , B01L3/5023 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/165 , B81C1/00206 , B82Y15/00 , B82Y30/00 , G01N21/658
摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.
摘要翻译：一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

9. 发明申请

US20110155649A1 NANOPARTICLE SEPARATION USING COHERENT ANTI-STOKES RAMAN SCATTERING 有权
标题翻译：使用相似的反坦克拉曼散射的纳米分离
公开(公告)号：US20110155649A1
公开(公告)日：2011-06-30
申请号：US12989833
申请日：2009-05-21
申请人： Eric Mazur , Eric Diebold
发明人： Eric Mazur , Eric Diebold
IPC分类号： B82B3/00 , B07B13/00 , B82Y40/00
CPC分类号： B82B3/0071
摘要： The invention provides methods and systems for separating particles that exhibit different Raman characteristics. The method can include introducing nanoparticles, on which Raman-active molecules are adsorbed, into a photopolymerizable resin and exposing to excite Raman active vibrational modes of the molecules to generate Raman-shifted radiation suitable for polymerizing the resin such that the Raman-shifted radiation causes selective polymerization of a resin surrounding nanoparticles if the nanoparticles provide a Raman enhancement factor greater than a threshold. In addition, methods for electrically isolating nanoparticles, or selectively removing one type of nanoparticles from collections, are disclosed. These methods rely on generation of blue-shifted anti-Stokes photons to selectively expose portions of a photoresist covering the nanoparticles to those photons. Such exposure can cause a change in the exposed portions (e.g., polymerize or increase solubility to a developing agent), which can be employed to achieve isolation of the nanoparticles or their selective removal.
摘要翻译：本发明提供了分离显示不同拉曼特性的颗粒的方法和系统。该方法可以包括将其上吸附有拉曼活性分子的纳米颗粒引入可光聚合的树脂中并暴露于分子的激发拉曼活性振动模式以产生适于聚合树脂的拉曼偏移辐射，使得拉曼位移辐射导致如果纳米颗粒提供大于阈值的拉曼增强因子，则围绕纳米颗粒的树脂的选择性聚合。此外，公开了用于电绝缘纳米颗粒或从集合中选择性地除去一种类型的纳米颗粒的方法。这些方法依赖于产生蓝移的反斯托克斯光子，以选择性地将覆盖纳米颗粒的光刻胶的部分暴露于那些光子。这种暴露可导致暴露部分的变化（例如，聚合或增加对显影剂的溶解度），其可用于实现纳米颗粒的分离或其选择性去除。

10. 发明申请

US20100171948A1 METALIZED SEMICONDUCTOR SUBSTRATES FOR RAMAN SPECTROSCOPY 审中-公开
标题翻译：用于拉曼光谱的金属化半导体衬底
公开(公告)号：US20100171948A1
公开(公告)日：2010-07-08
申请号：US12481973
申请日：2009-06-10
申请人： Eric Mazur , Eric Diebold , Steven Ebstein
发明人： Eric Mazur , Eric Diebold , Steven Ebstein
IPC分类号： G01J3/44
CPC分类号： B82Y30/00 , B01L3/5023 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/165 , B81B1/006 , B81C1/00206 , B82Y15/00 , G01N21/658
摘要： In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm.
摘要翻译：一方面，本发明通常提供用于制造用于各种分析和/或诊断应用的基底的方法。可以通过将半导体表面（例如，硅表面）暴露于多个短激光脉冲以在表面上产生微米尺寸且优选亚微米尺寸的结构来产生这种基板。然后可以用薄金属层涂覆结构化表面，例如具有在约10nm至约1000nm范围内的厚度的金属层。

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