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1. 发明申请

US20120171746A1 METHOD AND SYSTEM FOR MANIPULATION OF CELLS 审中-公开
标题翻译：用于操作细胞的方法和系统
公开(公告)号：US20120171746A1
公开(公告)日：2012-07-05
申请号：US13382314
申请日：2010-06-11
申请人： Eric Mazur , Alexander Heisterkamp , Eric Diebold
发明人： Eric Mazur , Alexander Heisterkamp , Eric Diebold
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12M35/02
摘要： The invention is directed to a method for the manipulation of at least one cell, the method comprising the steps of depositing a metal onto the surface of a substrate, placing the at least one cell at or near the surface of the substrate, and irradiating the surface of the substrate with at least one laser pulse. The inventive method is characterized by the formation of surface structures with a size of one micrometer or less on the surface of the substrate prior to depositing the metal thereon. The invention is also directed to a system for the manipulation of at least one cell, the system comprising a substrate with surface structures having a size of 1 micrometer or less, wherein a metal is deposited on the surface structures, and wherein the system further comprises a laser for irradiating the surface structures.
摘要翻译：本发明涉及一种用于操纵至少一个电池的方法，所述方法包括以下步骤：将金属沉积到衬底的表面上，将所述至少一个电池放置在衬底的表面或其附近，具有至少一个激光脉冲的衬底表面。本发明的方法的特征在于在其上沉积金属之前，在基板的表面上形成尺寸为1微米或更小的表面结构。本发明还涉及一种用于操纵至少一个电池的系统，该系统包括具有1微米或更小尺寸的表面结构的衬底，其中金属沉积在表面结构上，并且其中该系统还包括用于照射表面结构的激光。

2. 发明授权

US06787733B2 Laser machining of materials 有权
标题翻译：激光加工材料
公开(公告)号：US06787733B2
公开(公告)日：2004-09-07
申请号：US10258786
申请日：2002-10-28
申请人： Holger Lubatschowski , Alexander Heisterkamp , Gero Maatz
发明人： Holger Lubatschowski , Alexander Heisterkamp , Gero Maatz
IPC分类号： B23K2603
CPC分类号： B23K26/03 , B23K26/0624
摘要： A device for machining a material with ultrashort laser pulses is described. This device comprises: (a) a device (1) for generating a sequence of first laser pulses, where the first laser pulses each have a duration of less than 300 picoseconds and the repetition rate for the first laser pulses is in the range between 100 kHz and 1 GHz, (b) a converter (2) for converting a first set of the sequence of first laser pulses into a sequence of second laser pulses for application to and for machining of the material, where the second laser pulses each have a duration of less than 300 picoseconds and the repetition rate for the second laser pulses is in the range between 1 Hz and 1 MHz, as well as (c) a testing device (3, 5, 6, 7, 15) that is equipped to apply first laser pulses, which do not belong to the first set, to the material, to detect specific results of this application and to provide these detected results as information.
摘要翻译：描述了用于用超短激光脉冲加工材料的装置。该装置包括：（a）用于产生第一激光脉冲序列的装置（1），其中第一激光脉冲各自具有小于300皮秒的持续时间，并且第一激光脉冲的重复率在100kHz和 1GHz，（b）转换器（2），用于将第一组第一激光脉冲序列转换为第二激光脉冲序列，以供应用于和用于材料的加工，其中第二激光脉冲的持续时间较短超过300皮秒，并且第二激光脉冲的重复率在1Hz和1MHz之间的范围内，以及（c）被配备为施加第一激光脉冲的测试装置（3,5,6,7,15），不属于第一组，材料，检测此应用程序的具体结果，并将这些检测结果提供为信息。

3. 发明申请

US20140085623A1 TECHNIQUE FOR TOMOGRAPHIC IMAGE RECORDING 有权
标题翻译： TOMOGRAPHIC图像记录技术
公开(公告)号：US20140085623A1
公开(公告)日：2014-03-27
申请号：US13994589
申请日：2011-12-16
申请人： Raoul-Amadeus Lorbeer , Heiko Meyer , Marko Heidrich , Alexander Heisterkamp
发明人： Raoul-Amadeus Lorbeer , Heiko Meyer , Marko Heidrich , Alexander Heisterkamp
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01N21/4795 , G01N21/6408 , G01N21/6458 , G01N2021/1787 , G01N2201/065
摘要： The invention relates to a device (10; 210; 310; 410; 510) for tomographic image recording. The device comprises a sample retainer (14), a light source (12), and a detector unit (16). The light source (12) is designed to produce a pencil beam (38), which has a beam direction (40) and which passes through a sample volume of the sample retainer (14) provided in order to accommodate a sample, and has an optical control element (30), which is able to move the pencil beam (38) passing through the sample retainer (14) transversely to the beam direction (40) while the beam direction (40) remains substantially unchanged. The detector unit (16) is designed to detect at least a portion of scattered radiation (64; 64′) escaping from a section of the pencil beam (38) within the sample volume or the sample retainer (14) in a non-spatially-resolved manner.
摘要翻译：本发明涉及一种用于断层图像记录的装置（10; 210; 310; 410; 510）。该装置包括样品保持器（14），光源（12）和检测器单元（16）。光源（12）被设计成产生具有光束方向（40）并且穿过样本保持器（14）的样本体积以便容纳样本的笔形笔（38），并且具有光学控制元件（30），其能够横向于光束方向（40）移动通过样品保持器（14）的笔杆（38），同时光束方向（40）基本上保持不变。检测器单元（16）被设计成检测在空间上从样品体积或样品保持器（14）中的笔形束（38）的一部分逸出的散射辐射（64; 64'）的至少一部分解决方式。

4. 发明申请

US20120225418A1 APPARATUS AND METHOD FOR SELECTING PARTICLES 有权
标题翻译：选择颗粒的装置和方法
公开(公告)号：US20120225418A1
公开(公告)日：2012-09-06
申请号：US13379944
申请日：2010-06-24
申请人： Heiko Meyer , Alexander Heisterkamp , Raoul Amadeus Lorbeer , Detlef Rath
发明人： Heiko Meyer , Alexander Heisterkamp , Raoul Amadeus Lorbeer , Detlef Rath
IPC分类号： A01N1/02 , B01D43/00
CPC分类号： G01N15/1459 , G01N2015/149
摘要： The invention provides a device and a method for flow cytometric fractionation of particles contained in a fluid stream, wherein sections of the fluid stream, especially droplets if the fluid stream is a droplet stream, are irradiated with a laser. The laser disposed for the irradiation of the sections of the fluid stream can have a wavelength which is absorbed by the fluid and can have a sufficient radiation duration and radiation intensity to deflect sections of the fluid stream.
摘要翻译：本发明提供了流体流中所含颗粒的流式细胞分级分离装置和方法，其中如果流体流是液滴流，则流体流的部分，尤其是液滴流中的液滴被激光照射。设置用于照射流体流的部分的激光器可以具有被流体吸收的波长，并且可以具有足够的辐射持续时间和辐射强度以偏转流体流的部分。

5. 发明授权

US09250061B2 Technique for tomographic image recording 有权
标题翻译：断层图像记录技术
公开(公告)号：US09250061B2
公开(公告)日：2016-02-02
申请号：US13994589
申请日：2011-12-16
申请人： Raoul-Amadeus Lorbeer , Heiko Meyer , Marko Heidrich , Alexander Heisterkamp
发明人： Raoul-Amadeus Lorbeer , Heiko Meyer , Marko Heidrich , Alexander Heisterkamp
IPC分类号： G01N21/00 , G01B9/02 , G01N21/47 , G01N21/64 , G01N21/17
CPC分类号： G01B9/02091 , G01N21/4795 , G01N21/6408 , G01N21/6458 , G01N2021/1787 , G01N2201/065
摘要： The invention relates to a device (10; 210; 310; 410; 510) for tomographic image recording. The device comprises a sample retainer (14), a light source (12), and a detector unit (16). The light source (12) is designed to produce a pencil beam (38), which has a beam direction (40) and which passes through a sample volume of the sample retainer (14) provided in order to accommodate a sample, and has an optical control element (30), which is able to move the pencil beam (38) passing through the sample retainer (14) transversely to the beam direction (40) while the beam direction (40) remains substantially unchanged. The detector unit (16) is designed to detect at least a portion of scattered radiation (64; 64′) escaping from a section of the pencil beam (38) within the sample volume or the sample retainer (14) in a non-spatially-resolved manner.
摘要翻译：本发明涉及一种用于断层图像记录的装置（10; 210; 310; 410; 510）。该装置包括样品保持器（14），光源（12）和检测器单元（16）。光源（12）被设计成产生具有光束方向（40）并且穿过样本保持器（14）的样本体积以便容纳样本的笔形笔（38），并且具有光学控制元件（30），其能够横向于光束方向（40）移动通过样品保持器（14）的笔杆（38），同时光束方向（40）基本上保持不变。检测器单元（16）被设计成检测在空间上从样品体积或样品保持器（14）中的笔形束（38）的一部分逸出的散射辐射（64; 64'）的至少一部分解决方式。

6. 发明授权

US09034260B2 Apparatus and method for selecting particles 有权
标题翻译：用于选择颗粒的装置和方法
公开(公告)号：US09034260B2
公开(公告)日：2015-05-19
申请号：US13379944
申请日：2010-06-24
申请人： Heiko Meyer , Raoul Amadeus Lorbeer , Alexander Heisterkamp , Detlef Rath
发明人： Heiko Meyer , Raoul Amadeus Lorbeer , Alexander Heisterkamp , Detlef Rath
IPC分类号： G01N33/00 , B41J2/135 , B41J2/02 , G01N15/14
CPC分类号： G01N15/1459 , G01N2015/149
摘要： The invention provides a device and a method for flow cytometric fractionation of particles contained in a fluid stream, wherein sections of the fluid stream, especially droplets if the fluid stream is a droplet stream, are irradiated with a laser. The laser disposed for the irradiation of the sections of the fluid stream can have a wavelength which is absorbed by the fluid and can have a sufficient radiation duration and radiation intensity to deflect sections of the fluid stream.
摘要翻译：本发明提供了流体流中所含颗粒的流式细胞分级分离装置和方法，其中如果流体流是液滴流，则流体流的部分，尤其是液滴流中的液滴被激光照射。设置用于照射流体流的部分的激光器可以具有被流体吸收的波长，并且可以具有足够的辐射持续时间和辐射强度以偏转流体流的部分。

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