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1. 发明授权

US08822699B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08822699B2
公开(公告)日：2014-09-02
申请号：US13223455
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： A61K31/42 , C07D263/30 , C07D413/02
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

2. 发明申请

US20120059030A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20120059030A1
公开(公告)日：2012-03-08
申请号：US13223455
申请日：2011-09-01
申请人： Tatsuki KOIKE , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki KOIKE , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： A61K31/437 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

3. 发明申请

US20130178497A1 FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT 有权
标题翻译：用于治疗或预防小儿认知功能障碍的三叉神经痛
公开(公告)号：US20130178497A1
公开(公告)日：2013-07-11
申请号：US13819239
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异的淀粉样蛋白β产生抑制活性和/或优异的γ-分泌酶调节活性的杂环衍生物及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

4. 发明授权

US08901309B2 Fused triazoles for the treatment or prophylaxis of mild cognitive impairment 有权
标题翻译：融合三唑用于治疗或预防轻度认知障碍
公开(公告)号：US08901309B2
公开(公告)日：2014-12-02
申请号：US13819239
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Takafumi Takai , Yuichi Kajita , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Takafumi Takai , Yuichi Kajita , Makoto Kamata
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

5. 发明申请

US20060128690A1 Amine derivative 失效
标题翻译：胺衍生物
公开(公告)号：US20060128690A1
公开(公告)日：2006-06-15
申请号：US10545120
申请日：2004-02-12
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa
IPC分类号： A61K31/55 , A61K31/401 , A61K31/445
CPC分类号： C07D211/16 , A61K31/55 , C07C233/73 , C07C235/42 , C07D207/09 , C07D207/12 , C07D211/14 , C07D213/82 , C07D233/24 , C07D295/135
摘要： The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s) or a pyridyl optionally having substituent(s); Ra1, Ra2, Ra3 and Ra4 are the same or different and each is a hydrogen atom, an optionally halogenated C1-6 alkyl or the like; Ar is a monocyclic aromatic ring optionally having substituent(s); Y is an optionally halogenated alkylene group; and R1 and R2 are (1) the same or different and each is a hydrogen atom or a C1-6 alkyl, (2) R1 and R2 form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, or (3) R1 and Y form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, and R2 is a hydrogen atom or a C1-6 alkyl; provided that when the nitrogen-containing heterocycle formed by R1 and R2 together with the adjacent nitrogen atom is a piperazine, or when R is a C1-4 alkyl, Ar1 is a cyclic group having substituent(s), or a salt thereof, having a melanin-concentrating hormone antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like.
摘要翻译：本发明提供由下式表示的化合物：其中Ar 1是任选具有取代基的环状基团; R是氢原子，任选卤代的C 1-6烷基，任选具有取代基的苯基或任选具有取代基的吡啶基; Ra 1，R 2，R 3，R 3和R 4相同或不同，各自为氢原子，任选卤代的C 1-6烷基等; Ar是任选具有取代基的单环芳环; Y是任选卤代的亚烷基; 且R 1和R 2均为（1）相同或不同，并且各自为氢原子或C 1-6烷基，（ 2）R 1和R 2 2形成任选具有取代基的氮杂环与相邻的氮原子，或（3）R 1， Y和Y形成任选具有取代基的氮杂环与相邻的氮原子一起形成，R 2是氢原子或C 1-6 烷基; 条件是当由R 1和R 2与相邻氮原子一起形成的含氮杂环是哌嗪时，或当R是C 1〜 4个烷基，Ar 1是具有取代基的环状基团或其盐，其具有黑色素浓缩激素拮抗作用并且可用作预防或治疗的药剂肥胖等。

6. 发明申请

US20050209213A1 Quinoline compound 失效
标题翻译：喹啉化合物
公开(公告)号：US20050209213A1
公开(公告)日：2005-09-22
申请号：US10493427
申请日：2002-10-24
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
IPC分类号： A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P5/04 , A61P25/22 , A61P25/24 , A61P43/00 , C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D413/02 , C07D41/02
CPC分类号： C07D401/06 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.
摘要翻译：一种化合物，其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂，并且其由下式表示：其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同，各自为氢原子或任选具有取代基的烃基，或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基（CO除外）的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基，并且当环B还具有取代基时，取代基可以与R 1连接形成环，或其盐或其前药，被提供。

7. 发明授权

US08501804B2 Bicyclic compound 失效
标题翻译：双环化合物
公开(公告)号：US08501804B2
公开(公告)日：2013-08-06
申请号：US13126103
申请日：2009-10-26
申请人： Makoto Kamata , Tohru Yamashita , Asato Kina , Michiko Amano
发明人： Makoto Kamata , Tohru Yamashita , Asato Kina , Michiko Amano
IPC分类号： A61K31/343 , C07D307/83
CPC分类号： C07D235/14 , C07D261/20 , C07D263/56 , C07D277/64 , C07D307/81 , C07D333/58 , C07D405/06 , C07D405/12 , C07D407/06 , C07D407/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D491/048
摘要： The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供具有ACC抑制作用的化合物，其可用作预防或治疗肥胖症，糖尿病，高血压，高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症，癌症等的药剂，并且具有优越的疗效。本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

8. 发明申请

US20130172328A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS 有权
标题翻译：熔融杂环化合物作为磷酸二氢钾（PDES）抑制剂
公开(公告)号：US20130172328A1
公开(公告)日：2013-07-04
申请号：US13806352
申请日：2011-06-22
申请人： Takahiko Taniguchi , Masato Yoshikawa , Kasei Miura , Tomoaki Hasui , Eiji Honda , Keisuke Imamura , Makoto Kamata , Haruhi Kamisaki , John F. Quinn , Joseph Raker , Fatoumata Camara , Yi Wang
发明人： Takahiko Taniguchi , Masato Yoshikawa , Kasei Miura , Tomoaki Hasui , Eiji Honda , Keisuke Imamura , Makoto Kamata , Haruhi Kamisaki , John F. Quinn , Joseph Raker , Fatoumata Camara , Yi Wang
IPC分类号： C07D471/04 , C07D498/04 , C07D473/00 , C07D519/00
CPC分类号： A61K31/4353 , A61K31/4355 , A61K31/437 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/551 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/28 , C07D487/04 , C07D495/04 , C07D498/04 , C07D498/08 , C07D519/00 , C07F7/10
摘要： The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (I):
摘要翻译：本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗由式（I）表示的精神分裂症等的药剂：

9. 发明申请

US20100093777A1 SPIRO-RING COMPOUND 审中-公开
标题翻译：螺环化合物
公开(公告)号：US20100093777A1
公开(公告)日：2010-04-15
申请号：US12449084
申请日：2008-01-24
申请人： Kohji Fukatsu , Makoto Kamata , Tohru Yamashita
发明人： Kohji Fukatsu , Makoto Kamata , Tohru Yamashita
IPC分类号： A61K31/4545 , C07D471/10 , C07D498/10 , C07D513/10 , A61P3/04 , A61P3/10 , A61P9/00 , A61P35/00
CPC分类号： C07D519/00 , C07D495/04 , C07D498/10 , C07F7/1804
摘要： The present invention aims to provide a compound having an acetyl-CoA carboxylase (ACC) inhibitory action, which is useful for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention provides a compound represented by the formula (I): wherein R1 is a hydrogen atom or a substituent; ring P is an optionally substituted 6-membered nitrogen-containing aromatic heterocycle; ring Q is an optionally further substituted 5- to 7-membered nitrogen-containing non-aromatic heterocycle; and ring R is an optionally fused 5- to 7-membered non-aromatic ring, which is further optionally substituted, or a salt thereof.
摘要翻译：本发明旨在提供一种具有乙酰-CoA羧化酶（ACC）抑制作用的化合物，其可用于预防或治疗肥胖，糖尿病，高血压，高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症，癌症和并具有优越的疗效。本发明提供由式（I）表示的化合物：其中R1是氢原子或取代基; 环P是任选取代的6元含氮芳族杂环; 环Q是任选进一步取代的5-至7-元含氮非芳族杂环; 并且环R是任选稠合的5至7元非芳族环，其进一步任选被取代，或其盐。

10. 发明申请

US20060130516A1 Outdoor unit of air conditioner 失效
标题翻译：室外空调机组
公开(公告)号：US20060130516A1
公开(公告)日：2006-06-22
申请号：US11220914
申请日：2005-09-08
申请人： Shinji Sugiyama , Akihiko Nojima , Ryohei Kondo , Makoto Kamata , Ritsushi Taira
发明人： Shinji Sugiyama , Akihiko Nojima , Ryohei Kondo , Makoto Kamata , Ritsushi Taira
IPC分类号： F25B39/04 , F25D19/00
CPC分类号： F24F1/56 , F24F1/46
摘要： A front panel constituted by a synthetic resin molded product is used with respect to a base panel, side panels, and a top panel which are formed of a metal, first retaining means for the side panels and second retaining means for the top panel are provided on the front panel to effect fixation.
摘要翻译：使用由合成树脂模制产品构成的前面板相对于由金属形成的基板，侧板和顶板，提供用于侧板的第一保持装置和用于顶板的第二保持装置在前面板进行固定。

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