专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120059030A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20120059030A1
公开(公告)日：2012-03-08
申请号：US13223455
申请日：2011-09-01
申请人： Tatsuki KOIKE , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki KOIKE , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： A61K31/437 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

2. 发明申请

US20110196003A1 TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：三氯化合物及其药物用途
公开(公告)号：US20110196003A1
公开(公告)日：2011-08-11
申请号：US13047363
申请日：2011-03-14
申请人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , C07D277/62 , A61P25/00
CPC分类号： A61K31/428 , A61K31/423 , C07D263/52 , C07D277/60 , C07D277/62 , C07D413/06
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.
摘要翻译：本发明提供下式表示的化合物，其可用作预防或治疗与褪黑激素或其盐等有关的疾病的药剂。

3. 发明授权

US08822699B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08822699B2
公开(公告)日：2014-09-02
申请号：US13223455
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： A61K31/42 , C07D263/30 , C07D413/02
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

4. 发明授权

US08785460B2 Tricyclic compounds and use thereof 失效
标题翻译：三环化合物及其用途
公开(公告)号：US08785460B2
公开(公告)日：2014-07-22
申请号：US12357158
申请日：2009-01-21
申请人： Kazuyoshi Aso , Katsumi Kobayashi , Takafumi Takai , Takuto Kojima , Kazuyuki Tokumaru , Michiyo Mochizuki , Yasutaka Hoashi
发明人： Kazuyoshi Aso , Katsumi Kobayashi , Takafumi Takai , Takuto Kojima , Kazuyuki Tokumaru , Michiyo Mochizuki , Yasutaka Hoashi
IPC分类号： A61K31/519 , C07D487/04 , C07D239/70 , A61K31/4188
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/519 , C07D239/70 , C07D498/04
摘要： There is provided a compound of the formula (I′): wherein x is a nitrogen or CRx, Rx is a hydrogen, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted hydrocarbon group, etc., ring A is 5- to 8-membered heterocyclic ring, etc., and each of Y1, Y2 and Y3 is an optionally substituted carbon or a nitrogen, etc.; or a salt thereof or a prodrug thereof, which have CRF receptor antagonistic activity and use thereof.
摘要翻译：提供式（I'）的化合物：其中x是氮或CR x，Rx是氢等，R 1是任选取代的烃基等，R 2是任选取代的烃基等。环A为5〜8元杂环等，Y 1，Y 2，Y 3为任意取代的碳或氮等。或其盐或其前药，其具有CRF受体拮抗活性及其用途。

5. 发明授权

US08349879B2 Tricyclic compound and pharmaceutical use thereof 有权
公开(公告)号：US08349879B2
公开(公告)日：2013-01-08
申请号：US13047363
申请日：2011-03-14
申请人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , C07D277/60
CPC分类号： A61K31/428 , A61K31/423 , C07D263/52 , C07D277/60 , C07D277/62 , C07D413/06
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

6. 发明授权

US08318784B2 Tricyclic compound and pharmaceutical use thereof 有权
公开(公告)号：US08318784B2
公开(公告)日：2012-11-27
申请号：US13047363
申请日：2011-03-14
申请人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , C07D277/60
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

7. 发明授权

US08273761B2 Tricyclic compound and medical use thereof 有权
标题翻译：三环化合物及其医疗用途
公开(公告)号：US08273761B2
公开(公告)日：2012-09-25
申请号：US12448094
申请日：2007-12-07
申请人： Osamu Uchikawa , Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
发明人： Osamu Uchikawa , Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
IPC分类号： C07D491/048 , A61K31/4355
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
摘要翻译：本发明提供由下式表示的化合物，其中R 1是任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基，R2是氢原子或任选具有取代基的烃基，R 3是氢原子，卤素原子，任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的巯基，取代基，Xa〜Xe各自为碳原子或氮原子，m为0〜2，环A〜环C各自为任选具有取代基的环，或其盐，可用作试剂用于预防或治疗与褪黑素的作用相关的疾病等。

8. 发明申请

US20100298287A1 TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
标题翻译：具有胆红素释放因子拮抗活性的三环化合物和含有它们的药物组合物
公开(公告)号：US20100298287A1
公开(公告)日：2010-11-25
申请号：US12863851
申请日：2009-01-21
申请人： Kazuyoshi Aso , Katsumi Kobayashi , Takafumi Takai , Takuto Kojima , Kazuyuki Tokumaru , Michiyo Mochizuki , Yasutaka Hoashi
发明人： Kazuyoshi Aso , Katsumi Kobayashi , Takafumi Takai , Takuto Kojima , Kazuyuki Tokumaru , Michiyo Mochizuki , Yasutaka Hoashi
IPC分类号： A61K31/4188 , C07D487/04 , A61K31/4439 , A61K31/519 , A61K31/551 , A61K31/5377 , C07D498/04 , A61K31/553 , A61K31/5383 , C07D471/04 , A61K31/437 , A61K31/4985 , A61P25/00 , A61P25/22 , A61P25/24
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/519 , C07D239/70 , C07D498/04
摘要： There is provided a compound of the formula (I′): wherein X is a nitrogen or CRx, Rx is a hydrogen, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted hydrocarbon group, etc., ring A is 5- to -8-membered heterocyclic ring, etc., and each of Y1, Y2 and Y3 is an optionally substituted carbon or a nitrogen, etc.; or ‘a salt thereof or a prodrug thereof, which have CRF receptor antagonistic activity and use thereof.
摘要翻译：提供式（I'）的化合物：其中X是氮或CR x，Rx是氢等，R 1是任选取代的烃基等，R 2是任选取代的烃基等。环A为5〜8元杂环等，Y 1，Y 2，Y 3为任意取代的碳或氮等。或其盐或其前药，其具有CRF受体拮抗活性及其用途。

9. 发明申请

US20130178497A1 FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT 有权
标题翻译：用于治疗或预防小儿认知功能障碍的三叉神经痛
公开(公告)号：US20130178497A1
公开(公告)日：2013-07-11
申请号：US13819239
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异的淀粉样蛋白β产生抑制活性和/或优异的γ-分泌酶调节活性的杂环衍生物及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

10. 发明授权

US08247429B2 Tricyclic compound and pharmaceutical use thereof 有权
标题翻译：三环化合物及其药物用途
公开(公告)号：US08247429B2
公开(公告)日：2012-08-21
申请号：US12448366
申请日：2007-12-27
申请人： Osamu Uchikawa , Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
发明人： Osamu Uchikawa , Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
IPC分类号： A61K31/437 , A61K31/416 , C07D235/02
CPC分类号： C07D471/04 , C07D213/72 , C07D231/54 , C07D231/56 , C07D235/02
摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa, Xb, Xc and Xd are each a carbon atom or a nitrogen atom, provided that any one or two of Xa, Xb, Xc and Xd is/are nitrogen atom(s), m is 0 to 2, and rings A to C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
摘要翻译：本发明提供由下式表示的化合物，其中R 1是任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基，R2是氢原子或任选具有取代基的烃基，R 3是氢原子，卤素原子，任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的巯基，取代基Xa，Xb，Xc和Xd各自为碳原子或氮原子，条件是Xa，Xb，Xc和Xd中的任何一个或两个为氮原子，m为0至2，并且环A至C各自为任选具有取代基的环或其盐，其可用作预防或治疗与褪黑素的作用有关的疾病等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式