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1. 发明授权

US07183415B2 Quinoline compound 失效
标题翻译：喹啉化合物
公开(公告)号：US07183415B2
公开(公告)日：2007-02-27
申请号：US10493427
申请日：2002-10-24
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
IPC分类号： C07D215/38 , C07D215/14
CPC分类号： C07D401/06 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.
摘要翻译：一种化合物，其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂，并且其由下式表示：其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同，各自为氢原子或任选具有取代基的烃基，或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基（CO除外）的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基，并且当环B还具有取代基时，取代基可以与R 1连接形成环，或其盐或其前药，被提供。

2. 发明申请

US20050209213A1 Quinoline compound 失效
标题翻译：喹啉化合物
公开(公告)号：US20050209213A1
公开(公告)日：2005-09-22
申请号：US10493427
申请日：2002-10-24
申请人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
发明人： Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
IPC分类号： A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P5/04 , A61P25/22 , A61P25/24 , A61P43/00 , C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D413/02 , C07D41/02
CPC分类号： C07D401/06 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.
摘要翻译：一种化合物，其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂，并且其由下式表示：其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同，各自为氢原子或任选具有取代基的烃基，或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基（CO除外）的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基，并且当环B还具有取代基时，取代基可以与R 1连接形成环，或其盐或其前药，被提供。

3. 发明授权

US06500820B1 Pharmaceutical composition for neurotrophic action 失效
标题翻译：用于神经营养作用的药物组合物
公开(公告)号：US06500820B1
公开(公告)日：2002-12-31
申请号：US09673057
申请日：2000-10-10
申请人： Masaomi Miyamoto , Koki Kato , Yuji Ishihara
发明人： Masaomi Miyamoto , Koki Kato , Yuji Ishihara
IPC分类号： A61K3155
CPC分类号： A61K31/445 , A61K31/55
摘要： The present invention provides a composition for neurotrophic action which comprises a compound of the formula: wherein Ar is an optionally condensed phenyl group which may be substituted; n is an integer of 1 to 10; R is a hydrogen atom or a hydrocarbon group which may be substituted; and Y is an amino group which may be substituted or a nitrogen-containing saturated heterocyclic group which may be substituted; or a salt thereof, which compounds are useful for preventing and/or treating (1) neurodegenerative diseases (e.g. senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfelt-Jakob disease, amyotrophic lateral sclerosis, diabetic neuropathy, etc.), (2) neuropathy in cerebrovascular diseases (e.g. impairment of cerebral blood flow based on cerebral infarction, cerebral hemorrhage, cerebral sclerosis, etc.), brain trauma, spinal cord injury, cerebritis sequela and cerebral palsy, (4) mental diseases (e.g. depression, panic disorder, schizophrenia, etc.), etc.
摘要翻译：本发明提供了用于神经营养作用的组合物，其包含下式化合物：其中Ar是可被取代的任选缩合的苯基; n是1至10的整数; R是氢原子或可以是取代 Y为可被取代的氨基或可被取代的含氮饱和杂环基; 或其盐，所述化合物可用于预防和/或治疗（1）神经变性疾病（例如老年性痴呆，阿尔茨海默病，唐氏综合征，帕金森病，克雅氏病，肌萎缩性侧索硬化，糖尿病性神经病变等）（2）脑血管疾病中的神经病变（如基于脑梗死，脑出血，脑硬化等）脑损伤，脑外伤，脊髓损伤，脑炎后遗症和脑瘫等脑损伤，（4）精神疾病，恐慌症，精神分裂症等）等

4. 发明授权

US07487163B2 Apparatus and method for business process tracking and business process tracking program, and recording medium thereof 有权
标题翻译：业务流程跟踪和业务流程跟踪程序的设备和方法及其记录介质
公开(公告)号：US07487163B2
公开(公告)日：2009-02-03
申请号：US10823562
申请日：2004-04-14
申请人： Yoshihide Nomura , Koki Kato , Hirotaka Hara , Mimiko Hayashi , Hiroshi Kobayashi , Osamu Kimura
发明人： Yoshihide Nomura , Koki Kato , Hirotaka Hara , Mimiko Hayashi , Hiroshi Kobayashi , Osamu Kimura
IPC分类号： G06F17/00 , G06Q30/00
CPC分类号： G06F17/30368 , G06Q10/103 , G06Q30/06 , H04L67/10 , Y10S707/99945
摘要： An event management apparatus collects event data which an event extraction unit of each business system extracts on the basis of event extraction definition, and performs queuing to an event queue. An event relation unit makes groups of event data in units of business data, and performs the relative processing of business data to store the event data in an event management DB. When retrieval conditions are inputted from a user terminal, the output unit retrieves the event management DB according to the retrieval conditions, and outputs and displays relation between business data on the user terminal in a tree form.
摘要翻译：事件管理装置基于事件提取定义来收集每个业务系统的事件提取单元提取的事件数据，并且对事件队列进行排队。事件关系单元以业务数据为单位生成事件数据组，并且执行业务数据的相关处理以将事件数据存储在事件管理DB中。当从用户终端输入检索条件时，输出单元根据检索条件检索事件管理DB，并以树形式输出并显示用户终端上的业务数据之间的关系。

5. 发明授权

US5909268A Alignment detecting apparatus 失效
标题翻译：对准检测装置
公开(公告)号：US5909268A
公开(公告)日：1999-06-01
申请号：US958158
申请日：1997-10-27
申请人： Naoki Isogai , Koki Kato , Nobuharu Kobayashi , Mitsuhiro Gono , Noriyuki Ishihara
发明人： Naoki Isogai , Koki Kato , Nobuharu Kobayashi , Mitsuhiro Gono , Noriyuki Ishihara
IPC分类号： A61B3/10 , A61B3/103 , A61B3/107 , A61B3/15 , A61B3/14
CPC分类号： A61B3/152 , A61B3/103 , A61B3/107
摘要： An alignment detecting apparatus for detecting an alignment condition between an eye to be examined having approximately spherical surface or approximately toric surface and a device having a standard axial lines the apparatus comprising a target projecting optical system which includes a first target projecting optical system for projecting a first target with a predetermined angle relative to the standard axial line, and a second target projecting optical system for projecting a second target with a different angle compared with the angle of the first target projecting optical system relative to the standard axial lines of which at least one between the first and second targets is a target of a finite distances a detecting optical system for detecting positions of images of the first and second targets which are projected onto the eye by the first and second target projecting optical systems, and a judging device for judging the alignment condition based on results detected by the detecting optical system.
摘要翻译：一种对准检测装置，用于检测具有大致球形表面或近似复曲面的待检查眼睛之间的对准状态和具有标准轴线的装置，该装置包括目标投影光学系统，该目标投影光学系统包括：第一目标投影光学系统，第一目标相对于标准轴线具有预定角度;以及第二目标投影光学系统，用于与第一目标投影光学系统相对于至少在第一目标投影光学系统的标准轴线的角度具有不同的角度投影第二目标第一和第二目标之间的一个是具有有限距离的目标，用于检测由第一和第二目标投影光学系统投射到眼睛上的第一和第二目标的图像的位置的检测光学系统，以及用于根据de检测到的结果判断对准条件光学系统。

6. 发明授权

US6030081A Eye refractive power measurement apparatus 有权
$Eye refractive power measurement apparatus$
标题翻译：眼屈光力测量仪
公开(公告)号：US6030081A
公开(公告)日：2000-02-29
申请号：US141347
申请日：1998-08-27
申请人： Koki Kato
发明人： Koki Kato
IPC分类号： A61B3/10 , A61B3/103
CPC分类号： A61B3/103
摘要： An eye refractive power measurement apparatus for measuring a refractive power of an eye to be examined, the apparatus comprising a projecting optical system for scanning and projecting a slit light bundle onto a fundus of the eye to be examined, a photo-receiving optical system provided with a photo-detector arranged at a conjugate position with a cornea of the eye so as to have a predetermined position with respect to a scanning direction of the slit light bundle and an open diaphragm, can be arranged at different predetermined positions, for reducing the slit light bundle, a selecting device for selecting the position of the open diaphragm so as to change a range in which the photo-receiving optical system can detect an eye refractive power and an eye refractive power calculating device to calculate a refractive power of the eye based on an output signal from the photo-detector receiving the slit light bundle reflected from the fundus of the eye through the open diaphragm and the position of the open diaphragm.
摘要翻译：一种用于测量待检眼睛的屈光力的眼屈光力测量装置，该装置包括用于扫描并将狭缝光束投射到待检眼睛的眼底上的投影光学系统，设置的光接收光学系统利用布置在与眼睛的角膜的共轭位置处的光检测器，以便相对于狭缝光束和开口膜片的扫描方向具有预定位置，可以布置在不同的预定位置，以减少狭缝光束，选择装置，用于选择开放光阑的位置，以便改变光接收光学系统可以检测眼睛屈光度的范围和眼睛屈光度计算装置，以计算眼睛的屈光度基于来自光电检测器的输出信号，其接收从眼睛的眼底通过开放的隔膜反射的狭缝光束和po 打开隔膜的位置。

7. 发明授权

US5713021A Multimedia data search system that searches for a portion of multimedia data using objects corresponding to the portion of multimedia data 失效
标题翻译：多媒体数据搜索系统，使用与该多媒体数据的一部分相对应的对象来搜索一部分多媒体数据
公开(公告)号：US5713021A
公开(公告)日：1998-01-27
申请号：US528041
申请日：1995-09-14
申请人： Akiko Kondo , Koki Kato , Hiroshi Ishikawa
发明人： Akiko Kondo , Koki Kato , Hiroshi Ishikawa
IPC分类号： G06F12/00 , G06F17/30
CPC分类号： G06F17/30817 , G06F17/30044 , G06F17/3084 , Y10S707/99944 , Y10S707/99945
摘要： A multimedia data search system, includes a storage unit for storing features of a portion of data and data identifying the portion of data, a search unit for searching view objects stored in the storage unit according to a feature of the portion of data, and a display/reproduction unit for displaying and reproducing a portion of data corresponding to a searched view object, or multimedia data including the portion of the data. The system implemented with this invention facilitates searching for a portion of sequential data, and displays neighboring data depending on a requirement when displaying the portion of data.
摘要翻译：一种多媒体数据搜索系统，包括：存储单元，用于存储识别数据部分的一部分数据和数据;搜索单元，用于根据数据部分的特征搜索存储在存储单元中的查看对象;以及用于显示和再现与搜索到的查看对象相对应的数据的一部分的显示/再现单元，或包括该部分数据的多媒体数据。利用本发明实现的系统有助于搜索一部分顺序数据，并且在显示数据部分时根据需要显示相邻数据。

8. 发明申请

US20050142065A1 Screening method 审中-公开
标题翻译：筛选方法
公开(公告)号：US20050142065A1
公开(公告)日：2005-06-30
申请号：US10512237
申请日：2003-04-24
申请人： Koki Kato , Yasutaka Nagisa , Hiroyuki Odaka
发明人： Koki Kato , Yasutaka Nagisa , Hiroyuki Odaka
IPC分类号： A61P3/10 , A61P43/00 , G01N33/50 , G01N33/72 , A61K49/00 , A01K67/027
CPC分类号： G01N33/723 , G01N33/5088 , G01N2800/042
摘要： The present invention provides a method of screening for an agent for the treatment of human diabetes mellitus, which comprises administering a test compound to a diabetes mellitus model non-human mammal, and selecting a compound that causes a decrease of not less than 0.5% in a glycated hemoglobin value after administration.
摘要翻译：本发明提供一种筛选人类糖尿病治疗药物的方法，该方法包括将试验化合物给予非人类哺乳动物糖尿病模型，并选择引起不少于0.5％的化合物给药后糖化血红蛋白值。

9. 发明申请

US20050076059A1 Apparatus and method for business process tracking and business process tracking program, and recording medium thereof 有权
标题翻译：业务流程跟踪和业务流程跟踪程序的设备和方法及其记录介质
公开(公告)号：US20050076059A1
公开(公告)日：2005-04-07
申请号：US10823562
申请日：2004-04-14
申请人： Yoshihide Nomura , Koki Kato , Hirotaka Hara , Mimiko Hayashi , Hiroshi Kobayashi , Osamu Kimura
发明人： Yoshihide Nomura , Koki Kato , Hirotaka Hara , Mimiko Hayashi , Hiroshi Kobayashi , Osamu Kimura
IPC分类号： G06Q10/06 , G06F17/30 , G06Q10/00 , G06Q50/00 , H04L29/08 , G06F7/00
CPC分类号： G06F17/30368 , G06Q10/103 , G06Q30/06 , H04L67/10 , Y10S707/99945
摘要： An event management apparatus collects event data which an event extraction unit of each business system extracts on the basis of event extraction definition, and performs queuing to an event queue. An event relation unit makes groups of event data in units of business data, and performs the relative processing of business data to store the event data in an event management DB. When retrieval conditions are inputted from a user terminal, the output unit retrieves the event management DB according to the retrieval conditions, and outputs and displays relation between business data on the user terminal in a tree form.
摘要翻译：事件管理装置基于事件提取定义来收集每个业务系统的事件提取单元提取的事件数据，并且对事件队列进行排队。事件关系单元以业务数据为单位生成事件数据组，并且执行业务数据的相关处理以将事件数据存储在事件管理DB中。当从用户终端输入检索条件时，输出单元根据检索条件检索事件管理DB，并以树形式输出并显示用户终端上的业务数据之间的关系。

10. 发明授权

US06340704B1 Cell differentiation inducing amide derivatives, their production and use 失效
标题翻译：细胞分化诱导酰胺衍生物，其生产和使用
公开(公告)号：US06340704B1
公开(公告)日：2002-01-22
申请号：US09341803
申请日：1999-07-19
申请人： Shogo Marui , Masatoshi Hazama , Kohei Notoya , Koki Kato
发明人： Shogo Marui , Masatoshi Hazama , Kohei Notoya , Koki Kato
IPC分类号： A61K31357
CPC分类号： C07D491/04 , A61K31/166 , A61K31/36 , A61K31/47 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/5377 , C07D215/48 , C07D317/70 , C07D401/04 , C07D405/04
摘要： The present invention provides a compound represented by the formula: wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which may be substituted or N(O)m (m is 0 or 1); a ring A is a homo- or hetero-cycle which is substituted by a halogen atom, lower alkyl, lower alkoxy or lower alkylenedioxy; and a ring B is a homo- or hetero-cycle which may be substituted; or a salt thereof, which exhibits excellent cell differentiation-inducing action and cell differentiation-inducing factor action-enhancing action, and is useful in the treatment and prevention of various nerve diseases or bone/joint diseases.
摘要翻译：本发明提供由下式表示的化合物：其中R1是可被取代的氨基; R2是氢原子或可被取代的低级烷基; X是可以被取代的甲炔基或N（O）m（m是0或1）; 环A是被卤素原子，低级烷基，低级烷氧基或低级亚烷基二氧基取代的同 - 或异 - 循环; 并且环B是可被取代的同 - 或异 - 循环; 或其盐，其表现出优异的细胞分化诱导作用和细胞分化诱导因子作用增强作用，并且可用于治疗和预防各种神经疾病或骨/关节疾病。

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