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    • 10. 发明申请
    • MEDICAL SUBSTITUTE MEMBRANE, USE THEREOF, AND METHOD FOR REPAIR OF MEMBRANE TISSUE IN LIVING BODY
    • 医用替代膜,其使用方法和生活体内膜组织修复方法
    • US20100098743A1
    • 2010-04-22
    • US12528103
    • 2008-02-21
    • Toshio NikaidoMotonori OkabeToshiko YoshidaShunro EndoNakamasa HayashiShigeru Saito
    • Toshio NikaidoMotonori OkabeToshiko YoshidaShunro EndoNakamasa HayashiShigeru Saito
    • A61K9/00A61K45/00A61P43/00
    • A61L27/3604
    • An object is to overcome the disadvantages of a conventional lyophilized amniotic membrane or the like which causes damages in a cell membrane or an amniotic membrane tissue and is therefore not suitable for use as a substitute membrane for a membrane tissue in a living body, and to provide a novel medical substitute membrane composed of a dried amniotic membrane, which can be used as a substitute membrane for a membrane tissue in a living body. The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.
    • 本发明的目的在于克服在细胞膜或羊膜组织中引起损伤的常规冻干羊膜等的缺点,因此不适合用作生物体中的膜组织的替代膜, 提供由干燥羊膜构成的新型医用替代膜,其可以用作活体中的膜组织的替代膜。 干燥的羊膜通过干燥包裹人的动物的胚胎的新鲜的羊膜来制造,可以用作生物体中的膜组织的替代膜; 将干燥的羊膜脱水干燥,使干燥的羊膜能够以无菌状态储存在干燥空气中; 当通过浸入水或缓冲溶液中再次水合时,羊膜仍具有构成新鲜羊膜的上皮细胞,基底膜和结缔组织。 干燥的羊膜可用作诸如硬脑膜,meninx,心包膜,胸膜和腹膜的活体中的膜组织的医用替代膜。