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1. 发明专利

JP2005124996A Biomaterial 审中-公开
标题翻译：生物材料
公开(公告)号：JP2005124996A
公开(公告)日：2005-05-19
申请号：JP2003366452
申请日：2003-10-27
申请人： Celagix:Kk , Toshio Nikaido , 敏雄二階堂 , 有限会社セラジックス
发明人： NIKAIDO TOSHIO , AMANO JUN , KUBO KEISHI , IWAMA MASAMICHI , ISHIHARA YOSHIHISA
IPC分类号： A61L27/00 , A61F2/04 , A61F2/06
摘要： PROBLEM TO BE SOLVED: To provide a new biomaterial which promotes tissue formation and suppresses stenosis due to the hyperplasia of connective tissue. SOLUTION: The biomaterial consists of: an amnion or amniotic cells; and a porous support body. It is preferable that the porous support body is reinforced by a reinforcing body. The reinforcing body may be of a ring shape or a spiral shape. The material for the porous support body is preferably segmented polyurethane, more preferably, aliphatic segmented polyurethane. It is preferable that the amnion or the amniotic cells to be used is the amnion or the amniotic cells originating from a human. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供促进组织形成并抑制由于结缔组织增生引起的狭窄的新生物材料。
解决方案：生物材料包括：羊膜或羊膜细胞; 和多孔支撑体。优选地，多孔支撑体被增强体增强。加强体可以是环状或螺旋状。用于多孔支撑体的材料优选为分段聚氨酯，更优选为脂肪族分段聚氨酯。优选使用的羊膜或羊膜细胞是来源于人的羊膜或羊膜细胞。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2005139067A Human amnion-originated cell-containing medicine composition for treating cardiac disease 审中-公开
标题翻译：用于治疗心脏病的人乳腺癌细胞含有药物组合物
公开(公告)号：JP2005139067A
公开(公告)日：2005-06-02
申请号：JP2002262265
申请日：2002-09-09
申请人： Toshio Nikaido , Sankyo Co Ltd , 三共株式会社 , 敏雄二階堂
发明人： NIKAIDO TOSHIO
IPC分类号： A61K35/50 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10
摘要： PROBLEM TO BE SOLVED: To provide a cardiac disease-treating agent containing human amnion-originated mesenchymal cells as an active ingredient.
SOLUTION: It was found that undifferentiated human amnion-originated mesenchymal cells could be differentiated into cardiac muscle cells. Thereby, a medicine composition containing the cells as an active ingredient and used for treating cardiac diseases can be provided.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供含有人类羊膜起始的间充质细胞作为活性成分的心脏疾病治疗剂。解决方案：发现未分化的人类羊膜起源的间充质细胞可以分化成心肌细胞。因此，可以提供含有细胞作为活性成分并用于治疗心脏病的药物组合物。版权所有（C）2005，JPO＆NCIPI

3. 发明授权

US08414929B2 Medical substitute membrane, use thereof, and method for repair of membrane tissue in living body 有权
标题翻译：医用替代膜，其用途，以及修复活体内膜组织的方法
公开(公告)号：US08414929B2
公开(公告)日：2013-04-09
申请号：US12528103
申请日：2008-02-21
申请人： Toshio Nikaido , Motonori Okabe , Toshiko Yoshida , Shunro Endo , Nakamasa Hayashi , Shigeru Saito
发明人： Toshio Nikaido , Motonori Okabe , Toshiko Yoshida , Shunro Endo , Nakamasa Hayashi , Shigeru Saito
IPC分类号： A61F2/00 , A61K35/12 , A61K35/54 , A01N63/00 , A01N65/00
CPC分类号： A61L27/3604
摘要： The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.
摘要翻译：干燥的羊膜通过干燥包裹人的动物的胚胎的新鲜的羊膜来制造，可以用作生物体中的膜组织的替代膜; 将干燥的羊膜脱水干燥，使干燥的羊膜能够以无菌状态储存在干燥空气中; 当通过浸入水或缓冲溶液中再次水合时，羊膜仍具有构成新鲜羊膜的上皮细胞，基底膜和结缔组织。干燥的羊膜可用作诸如硬脑膜，meninx，心包膜，胸膜和腹膜的活体中的膜组织的医用替代膜。

4. 发明授权

US08932641B2 Dried amnion and method for drying treatment of amnion 有权
标题翻译：干羊草干燥处理方法
公开(公告)号：US08932641B2
公开(公告)日：2015-01-13
申请号：US11990904
申请日：2006-08-18
申请人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
发明人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
IPC分类号： A61K35/50 , A61L27/36 , A01N1/02 , C12N5/00
CPC分类号： A61L27/3641 , A01N1/02 , A01N1/0205 , A01N1/0231 , A01N1/0289 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L2430/40 , C12N5/0068 , C12N2533/92
摘要： The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.
摘要翻译：本发明提供一种干燥的羊膜，其干燥并保持生羊膜的组织，并且可以容易地长时间储存。通过重复进行减压操作和压力恢复操作多次，可以通过重复进行多次的生产羊膜的维持细胞和组织而干燥的羊膜，减压操作包括：将放置在处理容器中的原料羊膜连续加热设置在处理容器中的远红外加热器，并且降低处理容器内部的压力，以及压力恢复操作，包括通过从微波照射的微波加热羊膜来回收处理容器内部的减压加热装置设置在处理容器的外部，羊膜的特征在于保留作为原料羊膜成分的基底膜和结缔组织。

5. 发明申请

US20100098743A1 MEDICAL SUBSTITUTE MEMBRANE, USE THEREOF, AND METHOD FOR REPAIR OF MEMBRANE TISSUE IN LIVING BODY 有权
标题翻译：医用替代膜，其使用方法和生活体内膜组织修复方法
公开(公告)号：US20100098743A1
公开(公告)日：2010-04-22
申请号：US12528103
申请日：2008-02-21
申请人： Toshio Nikaido , Motonori Okabe , Toshiko Yoshida , Shunro Endo , Nakamasa Hayashi , Shigeru Saito
发明人： Toshio Nikaido , Motonori Okabe , Toshiko Yoshida , Shunro Endo , Nakamasa Hayashi , Shigeru Saito
IPC分类号： A61K9/00 , A61K45/00 , A61P43/00
CPC分类号： A61L27/3604
摘要： An object is to overcome the disadvantages of a conventional lyophilized amniotic membrane or the like which causes damages in a cell membrane or an amniotic membrane tissue and is therefore not suitable for use as a substitute membrane for a membrane tissue in a living body, and to provide a novel medical substitute membrane composed of a dried amniotic membrane, which can be used as a substitute membrane for a membrane tissue in a living body. The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.
摘要翻译：本发明的目的在于克服在细胞膜或羊膜组织中引起损伤的常规冻干羊膜等的缺点，因此不适合用作生物体中的膜组织的替代膜，提供由干燥羊膜构成的新型医用替代膜，其可以用作活体中的膜组织的替代膜。干燥的羊膜通过干燥包裹人的动物的胚胎的新鲜的羊膜来制造，可以用作生物体中的膜组织的替代膜; 将干燥的羊膜脱水干燥，使干燥的羊膜能够以无菌状态储存在干燥空气中; 当通过浸入水或缓冲溶液中再次水合时，羊膜仍具有构成新鲜羊膜的上皮细胞，基底膜和结缔组织。干燥的羊膜可用作诸如硬脑膜，meninx，心包膜，胸膜和腹膜的活体中的膜组织的医用替代膜。

6. 发明申请

US20090258082A1 Dried amnion and method for drying teatment of amnion 有权
标题翻译：干羊毛干燥法和羊膜干燥法
公开(公告)号：US20090258082A1
公开(公告)日：2009-10-15
申请号：US11990904
申请日：2006-08-18
申请人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
发明人： Toshio Nikaido , Toshiko Yoshida , Motonori Okabe , Ayaka Toda , Kiyotaka Kitagawa , Masahiko Arakawa
IPC分类号： A61K35/54 , A61P27/02
CPC分类号： A61L27/3641 , A01N1/02 , A01N1/0205 , A01N1/0231 , A01N1/0289 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L2430/40 , C12N5/0068 , C12N2533/92
摘要： The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.
摘要翻译：本发明提供一种干燥的羊膜，其干燥并保持生羊膜的组织，并且可以容易地长时间储存。通过重复进行减压操作和压力恢复操作多次，可以通过重复进行多次的生产羊膜的维持细胞和组织而干燥的羊膜，减压操作包括：将放置在处理容器中的原料羊膜连续加热设置在处理容器中的远红外加热器，并且降低处理容器内部的压力，以及压力恢复操作，包括通过从微波照射的微波加热羊膜来回收处理容器内部的减压加热装置设置在处理容器的外部，羊膜的特征在于保留作为原料羊膜成分的基底膜和结缔组织。

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