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1. 发明申请

WO2009055674A1 PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：吡咯烷基炔丙基化合物及其制备方法和使用方法
公开(公告)号：WO2009055674A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081119
申请日：2008-10-24
申请人： TARGEGEN INC. , NORONHA, Glenn , CAO, Jianguo , CHOW, Chun , MAK, Chi, Ching , PALANKI, Moorthy , DNEPROVSKAIA, Elena , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , ZENG, Binqi
发明人： NORONHA, Glenn , CAO, Jianguo , CHOW, Chun , MAK, Chi, Ching , PALANKI, Moorthy , DNEPROVSKAIA, Elena , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , ZENG, Binqi
IPC分类号： C07D487/04 , A61K31/505 , A61P35/02
CPC分类号： C07D487/04
摘要： Provided herein are pyrrolopyrimide alkynyl compounds, and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.
摘要翻译：本文提供吡咯并吡啶酰亚胺炔基化合物及其制备和使用方法。这些化合物可用于炎性或骨髓增生性疾病。本公开还提供治疗癌症。

2. 发明申请

WO2006101977A3 PYRIMIDINE COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2006101977A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/009518
申请日：2006-03-15
申请人： TARGEGEN, INC. , CAO, Jianguo , SOLL, Richard, M. , NORONHA, Glenn , BARRETT, Kathy , GRITZEN, Colleen , HOOD, John , MAK, Chi, Ching , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , SPLITTGERBER, Ute , ZENG, Binqi
发明人： CAO, Jianguo , SOLL, Richard, M. , NORONHA, Glenn , BARRETT, Kathy , GRITZEN, Colleen , HOOD, John , MAK, Chi, Ching , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , SPLITTGERBER, Ute , ZENG, Binqi
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/44 , A61K31/40 , A61K31/506 , A61P19/02 , A61P29/02 , A61P37/06
摘要： The invention provides pyrimidine compounds having formula (A): The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, and various other specific receptor and non-receptor kinases.

3. 发明公开

EP1863794A2 PYRIMIDINE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：嘧啶及使用方法
公开(公告)号：EP1863794A2
公开(公告)日：2007-12-12
申请号：EP06738559.1
申请日：2006-03-15
申请人： Targegen, Inc.
发明人： CAO, Jianguo , ZENG, Binqi , RENICK, Joel , PATHAK, Ved, Prakash , MCPHERSON, Andrew , SPLITTGERBER, Ute , HOOD, John , GRITZEN, Colleen , BARRETT, Kathy , NORONHA, Glenn , SOLL, Richard, M. , MAK, Chi, Ching
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/44 , A61K31/40 , A61K31/506 , A61P19/02 , A61P29/02 , A61P37/06
CPC分类号： C07D239/48 , C07D239/49 , C07D401/12 , C07D417/12
摘要： The invention provides pyrimidine compounds having formula (A): The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, and various other specific receptor and non-receptor kinases.

4. 发明申请

WO2009049028A1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS 审中-公开
标题翻译：吡咯啉化合物及其作为JANUS KINASE调节剂的用途
公开(公告)号：WO2009049028A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079315
申请日：2008-10-09
申请人： TARGEGEN INC. , NORONHA, Glenn , CAO, Jianguo , CHOW, Chun, P. , MAK, Chi Ching , PALANKI, Moorthy, S.S. , DNEPROVSKAIA, Elena , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , ZENG, Binqi
发明人： NORONHA, Glenn , CAO, Jianguo , CHOW, Chun, P. , MAK, Chi Ching , PALANKI, Moorthy, S.S. , DNEPROVSKAIA, Elena , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , ZENG, Binqi
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519
CPC分类号： C07D487/04
摘要： Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.
摘要翻译：本文提供了式（I）的吡咯并嘧啶化合物，其中R 1是含有至少一个S原子的杂芳基，并且任选地在环碳上被一个，两个或三个取代基取代，所述取代基各自独立地选自：卤素，羟基，硝基，甲酰基，甲酰氨基，氰基，磺酰基，羧基，氨基，酰氨基，酰氨基，氨基甲酰基，氨磺酰基，烷基，烯基，CF 3，脲基，炔基，烷氧基，烷酰基，烷氧羰基，甲醛肟，N-烷基氨磺酰，N-烷基氨基甲酰基， OR13R11或-R13R11; R2是苯基或吡啶基，其中R2任选地在环碳上被一个，两个或三个取代基取代，每个独立地选自：卤素，羟基，氰基，硝基，甲酰基，甲酰氨基，羧基，磺酰基，氨基，酰氨基，-N-烷基氨基，氨基甲酰基，氨磺酰基，CF 3，脲基，烷基，烯基，炔基，烷氧基，烷酰基，烷氧基羰基，N-烷基氨磺酰基，N-烷基氨基甲酰基，-OR 11，-OR 12 R 11或-R 12 R 11; 以及制作和使用它们的方法。这些化合物可用于炎性或骨髓增生性疾病。本公开还提供治疗癌症。

5. 发明申请

WO2005096784A2 BENZOTRIAZINE INHIBITORS OF KINASES 审中-公开
标题翻译：苄基苯并噻嗪类抑制剂
公开(公告)号：WO2005096784A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/012057
申请日：2005-04-07
申请人： TARGEGEN, INC. , NORONHA, Glenn , BARRETT, Kathy , CAO, Jianguo , GRITZEN, Colleen , GONG, Xianchang , HOOD, John , MAK, Chi Ching , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , SOLL, Richard , SPLITTGERBER, Ute , WRASIDLO, Wolfgang , ZENG, Binqi , ZHAO, Ningning , DNEPROVSKAIA, Elena
发明人： NORONHA, Glenn , BARRETT, Kathy , CAO, Jianguo , GRITZEN, Colleen , GONG, Xianchang , HOOD, John , MAK, Chi Ching , MCPHERSON, Andrew , PATHAK, Ved, Prakash , RENICK, Joel , SOLL, Richard , SPLITTGERBER, Ute , WRASIDLO, Wolfgang , ZENG, Binqi , ZHAO, Ningning , DNEPROVSKAIA, Elena
IPC分类号： A61K31/53
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

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