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1. 发明授权

US4598070A Tripamide and cyclodextrin inclusion compound 失效
标题翻译：三酰胺和环糊精包合物
公开(公告)号：US4598070A
公开(公告)日：1986-07-01
申请号：US631997
申请日：1984-07-18
申请人： Takayuki Ohwaki , Shigeru Sakashita , Masahiro Kawahara , Aishin Shinoda , Yasuo Miyake
发明人： Takayuki Ohwaki , Shigeru Sakashita , Masahiro Kawahara , Aishin Shinoda , Yasuo Miyake
IPC分类号： C07D209/72 , A61K31/40 , A61K47/48 , C08B37/00 , A61K31/73
CPC分类号： B82Y5/00 , A61K31/40 , A61K47/48969 , C08B37/0015
摘要： An inclusion compound composed of tripamide and cyclodextrin markedly improves the solubility of tripamide which is effective for treatment of essential hypertension.
摘要翻译：由三酰胺和环糊精组成的包合物显着提高了对治疗原发性高血压有效的三酰胺的溶解度。

2. 发明授权

US4827062A Composition containing ubidecarenone with absorption promoted 失效
标题翻译：含有吸收促进的ubidecarenone的组合物
公开(公告)号：US4827062A
公开(公告)日：1989-05-02
申请号：US844025
申请日：1986-03-25
申请人： Yasuharu Saeki , Takeshi Watanabe , Takayuki Ohwaki , Masahiro Kawahara , Yasuo Miyake
发明人： Yasuharu Saeki , Takeshi Watanabe , Takayuki Ohwaki , Masahiro Kawahara , Yasuo Miyake
IPC分类号： A61K9/08 , A61K9/48 , A61K31/12 , A61K47/00 , A61K47/14 , A61K47/44
CPC分类号： A61K47/44 , A61K31/12 , A61K47/14 , Y10S514/975
摘要： A composition containing ubidecarenone, a glycerol mono-fatty acid ester and/or a propylene glycol mono-fatty acid ester, and a liquid oil. Oral administration of the composition provides a promoted absorption of ubidecarenone which is used for improving a coronary function.
摘要翻译：含有ubidecarenone，甘油单脂肪酸酯和/或丙二醇单脂肪酸酯和液体油的组合物。组合物的口服给药促进了用于改善冠状动脉功能的ubidecarenone的吸收。

3. 发明授权

US5425943A Modified tPA-containing injection composition having increased solubility 失效
标题翻译：改进的含tPA的注射组合物具有增加的溶解度
公开(公告)号：US5425943A
公开(公告)日：1995-06-20
申请号：US900796
申请日：1992-06-22
申请人： Masahiro Kawahara , Yuichiro Hayashi , Naoki Asakawa , Sumio Watanabe , Yasuo Miyake
发明人： Masahiro Kawahara , Yuichiro Hayashi , Naoki Asakawa , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K38/46 , A61K9/08 , A61K38/49 , A61K47/00 , A61K47/18 , A61K38/48 , C12N9/50 , C12N9/64
CPC分类号： A61K9/0019 , A61K38/49 , A61K47/183
摘要： An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.
摘要翻译：注射组合物包含药理学上有效量的修饰的tPA，47.5mM或更多的氨基酸或其盐，并且从稳定性和溶解性的观点来看是有改进的。

4. 发明授权

US5120719A Conjugate of prostaglandin and polysaccharide 失效
标题翻译：前列腺素和多糖的结合
公开(公告)号：US5120719A
公开(公告)日：1992-06-09
申请号：US437463
申请日：1989-11-15
申请人： Kiyoshi Iwamoto , Masahiro Kawahara , Sumio Watanabe , Yasuo Miyake , Fumio Sagami
发明人： Kiyoshi Iwamoto , Masahiro Kawahara , Sumio Watanabe , Yasuo Miyake , Fumio Sagami
IPC分类号： C08B31/04 , A61K31/557 , A61K31/715 , A61K47/48 , A61P43/00 , C07C405/00 , C08B37/00
CPC分类号： A61K47/4823 , A61K31/557
摘要： A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2.alpha., prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.

5. 发明授权

US09121334B2 Oil jet 有权
标题翻译：喷油机
公开(公告)号：US09121334B2
公开(公告)日：2015-09-01
申请号：US14343280
申请日：2013-02-22
申请人： Akihiro Honda , Motoichi Murakami , Masahiro Kawahara , Yoshitaka Yamaguchi
发明人： Akihiro Honda , Motoichi Murakami , Masahiro Kawahara , Yoshitaka Yamaguchi
IPC分类号： F01P3/08 , F01M1/08 , F01P3/06 , F01P3/00
CPC分类号： F01P3/08 , F01M1/08 , F01P3/06 , F01P2003/006
摘要： A body of an oil jet including: an oil supply port which opens into an oil passage in a cylinder block of an internal combustion engine; a cylinder one end of which is communicated with the oil supply port and the other end of which is closed; and an oil injection port which opens on a side surface of the cylinder. A piston valve is accommodated in the cylinder. The piston valve forms in the cylinder a differential pressure room which is a closed compartment. Moreover, an orifice which makes the differential pressure room being communicated with a side of the oil supply port is formed in the piston valve. The piston valve is biased toward a position at which the oil injection port is closed by a spring. Furthermore, a leak hole which allows oil to be leaked outside of the body from the differential pressure room is formed in the body.
摘要翻译：一种油喷射体，包括：向内燃机的气缸体内的油路通入的供油口; 气缸一端与供油口连通，另一端关闭; 以及在气缸的侧面开口的注油口。活塞阀容纳在气缸中。活塞阀在气缸中形成一个隔离室，它是一个封闭的隔间。此外，在活塞阀中形成有使压差室与供油口侧连通的孔口。活塞阀被弹簧偏压到注油口关闭的位置。此外，在体内形成有允许油从压差室泄漏到身体外部的泄漏孔。

6. 发明申请

US20110164840A1 SLIDING BEARING AND METHOD OF MANUFACTURING THE SAME 失效
标题翻译：滑动轴承及其制造方法
公开(公告)号：US20110164840A1
公开(公告)日：2011-07-07
申请号：US12737946
申请日：2009-09-08
申请人： Motoshi Hayashi , Masahiro Kawahara , Ken-ichirou Futamura , Toshiaki Inaguma , Makoto Shibata
发明人： Motoshi Hayashi , Masahiro Kawahara , Ken-ichirou Futamura , Toshiaki Inaguma , Makoto Shibata
IPC分类号： F16C25/02 , F16C43/02
CPC分类号： F16C33/201 , F16C17/02 , F16C23/041 , F16C33/14 , F16C2220/20 , F16C2220/82 , F16C2240/50 , Y10T29/49648 , Y10T29/49677
摘要： A cylindrical sliding bearing 1 can rotatably support a rotational shaft by a sliding surface 4 (inner circumferential surface). A crowning 5 having a sloped surface is formed at both ends of the sliding surface 4 in the axial direction. The crowning 5 includes a first crowning 3A formed of a sloped surface of a lining layer 3 and a second crowning 2A formed of a sloped surface of a back metal 2 positioned on the lower side of the first crowning. Unlike a conventional sliding bearing, the back metal 2 where the crowning 5 is positioned is provided as a sloped surface (2A). As compared with conventional bearings, the crowning 5 can be prevented from being unevenly brought into contact with the rotational shaft.
摘要翻译：圆筒形滑动轴承1可以通过滑动表面4（内圆周表面）可旋转地支撑旋转轴。在滑动面4的轴向两端形成具有倾斜面的隆起部5。隆起5包括由衬里层3的倾斜表面形成的第一隆起部3A和由位于第一冠状部的下侧的背面金属2的倾斜表面形成的第二冠状部2A。与传统的滑动轴承不同，设置凸面5的背面金属2作为倾斜表面（2A）。与传统的轴承相比，可以防止隆起部5不均匀地与旋转轴接触。

7. 发明授权

US08545102B2 Sliding bearing and method of manufacturing the same 失效
标题翻译：滑动轴承及其制造方法
公开(公告)号：US08545102B2
公开(公告)日：2013-10-01
申请号：US12737946
申请日：2009-09-08
申请人： Motoshi Hayashi , Masahiro Kawahara , Ken-ichirou Futamura , Toshiaki Inaguma , Makoto Shibata
发明人： Motoshi Hayashi , Masahiro Kawahara , Ken-ichirou Futamura , Toshiaki Inaguma , Makoto Shibata
IPC分类号： F16C23/04
CPC分类号： F16C33/201 , F16C17/02 , F16C23/041 , F16C33/14 , F16C2220/20 , F16C2220/82 , F16C2240/50 , Y10T29/49648 , Y10T29/49677
摘要： A cylindrical sliding bearing 1 can rotatably support a rotational shaft by a sliding surface 4 (inner circumferential surface). A crowning 5 having a sloped surface is formed at both ends of the sliding surface 4 in the axial direction. The crowning 5 includes a first crowning 3A formed of a sloped surface of a lining layer 3 and a second crowning 2A formed of a sloped surface of a back metal 2 positioned on the lower side of the first crowning. Unlike a conventional sliding bearing, the back metal 2 where the crowning 5 is positioned is provided as a sloped surface (2A). As compared with conventional bearings, the crowning 5 can be prevented from being unevenly brought into contact with the rotational shaft.
摘要翻译：圆筒形滑动轴承1可以通过滑动表面4（内圆周表面）可旋转地支撑旋转轴。在滑动面4的轴向两端形成具有倾斜面的隆起部5。隆起5包括由衬里层3的倾斜表面形成的第一隆起部3A和由位于第一冠状部的下侧的背面金属2的倾斜表面形成的第二冠状部2A。与传统的滑动轴承不同，设置凸面5的背面金属2作为倾斜表面（2A）。与传统的轴承相比，可以防止隆起部5不均匀地与旋转轴接触。

8. 发明授权

US5254545A Injectable preparations containing cephalosporin medicament 失效
标题翻译：含有头孢菌素药物的注射剂
公开(公告)号：US5254545A
公开(公告)日：1993-10-19
申请号：US589922
申请日：1990-09-28
申请人： Yasuo Ishibashi , Isamu Hasegawa , Masanori Kayano , Ryoichi Machida , Masahiro Kawahara , Sumio Watanabe
发明人： Yasuo Ishibashi , Isamu Hasegawa , Masanori Kayano , Ryoichi Machida , Masahiro Kawahara , Sumio Watanabe
IPC分类号： A61K9/08 , A61K9/00 , A61K31/545 , A61K31/546 , A61K47/00 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： A61K9/0019 , A61K31/545
摘要： A preparation containing a cephalosporin medicament is disclosed. The preparation comprises a cephalosporin derivative represented by the following formula: ##STR1## namely, 7.beta.-{2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2-fluoromethoxyiminoacetamido}-3-{(E)-3-(carbamoylmethylethylmethylammonio) -1-propen-1-yl}-3-cephem-4-carboxylate or a pharmaceutically acceptable salt thereof salt, lactose, citric acid or a sodium salt thereof, and arginine or a hydrochloride thereof; or the cephalosporin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof, lactose, citric acid or a sodium salt thereof, and sodium chloride.

9. 发明授权

US06271259B1 Method for improving the brain function, inhibiting glutamate excitotoxicity and rescuing from neuronal death 失效
标题翻译：改善脑功能，抑制谷氨酸兴奋毒性和拯救神经元死亡的方法
公开(公告)号：US06271259B1
公开(公告)日：2001-08-07
申请号：US08646066
申请日：1996-05-07
申请人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
发明人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
IPC分类号： A01H3712
CPC分类号： A61K31/198 , A23L33/10 , A23V2002/00 , A23V2250/641 , A23V2250/708 , A23V2250/704 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/7052 , A23V2250/0644
摘要： This invention is characterized by a brain function improving preparation containing theanine not less than 50 &mgr;M. It was confirmed that theanine could increase intracellular Ca2+ concentration by acting on NMDA receptors even at a low dose of about 50 &mgr;M. Thus, the brain function improving preparation of this invention was shown to be capable of causing plastic change in neurons or neural circuit. Since theanine has been approved as a food additive and being consumed daily, its safety has no problem. Moreover, theanine passes the blood-brain barrier relatively easily and, thus, it is effective as an oral preparation.
摘要翻译：本发明的特征在于包含茶氨酸的脑功能改善制剂不低于50μM。证实茶氨酸可以通过作用于NMDA受体而增加细胞内Ca2 +浓度，即使在约50μM的低剂量下。因此，改善本发明制剂的脑功能被证明能够引起神经元或神经回路中的塑性变化。由于茶氨酸已被批准为食品添加剂并被日常消费，因此其安全性没有问题。此外，茶氨酸相对容易地通过血脑屏障，因此作为口服制剂是有效的。

10. 发明授权

US4736700A Small watercraft with movable wing 失效
标题翻译：小型船只与活动翼
公开(公告)号：US4736700A
公开(公告)日：1988-04-12
申请号：US867518
申请日：1986-05-27
申请人： Tsutomu Ishimatsu , Hiroshi Nishida , Masahiro Kawahara
发明人： Tsutomu Ishimatsu , Hiroshi Nishida , Masahiro Kawahara
IPC分类号： B63B1/32 , B63B35/73 , B63B35/00
CPC分类号： B63B35/731 , B63B1/322 , Y02T70/12
摘要： This disclosure relates to a small craft comprising a hull, a control handle supported on the hull adjacent its bow for pivotal movement in a substantially vertical plane that includes the center line of the hull. The handle extends rearwardly over the hull and is adapted to be manually operated. A wing is connected to the handle so as to have an angle of attack which changes as the handle is pivoted.
摘要翻译：本公开涉及一种小型船舶，其包括船体，支撑在船体上的控制手柄，邻近其船弓，用于在包括船体的中心线的基本垂直的平面中枢转运动。手柄向后延伸到船身上并适于手动操作。机翼连接到手柄，以便具有随手柄枢转而改变的迎角。

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