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1. 发明专利

JP2007185135A Feed raw sausage and method for producing the same 有权
标题翻译：饲料原料及其生产方法
公开(公告)号：JP2007185135A
公开(公告)日：2007-07-26
申请号：JP2006005306
申请日：2006-01-12
申请人： Masashi Tamai , 正史玉井
发明人： TAMAI MASASHI
IPC分类号： A23K1/10 , A23K1/18
CPC分类号： Y02A40/818
摘要： PROBLEM TO BE SOLVED: To provide feed raw sausage excellent in both of resiliency and palatability: and to provide a method for producing the feed raw sausage. SOLUTION: The feed raw sausage comprises 100 pts.wt. of ground raw fish meat, 0.1-10 pts.wt. of vegetable protein, and 0.5-10 pts.wt. of transglutaminase. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供弹性和适口性优异的饲料生香肠，并提供生产原料香肠的方法。
解决方案：饲料生香肠包含100重量份地面生鱼肉，0.1-10重磅的植物蛋白，和0.5-10重量份。的转谷氨酰胺酶。版权所有（C）2007，JPO＆INPIT

2. 发明授权

US08846012B2 Melanin production inhibitor 有权
标题翻译：黑色素生成抑制剂
公开(公告)号：US08846012B2
公开(公告)日：2014-09-30
申请号：US13131827
申请日：2009-12-22
申请人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
发明人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
IPC分类号： A61K8/49 , C07D233/58 , C07D401/06 , A61K8/44 , A61K8/41 , A61K8/34 , C07D207/404 , A61Q19/02 , C07D213/38 , C07D213/30 , C07D295/03 , C07D207/12 , C07D295/096
CPC分类号： A61K8/4946 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/411 , A61K8/418 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K2800/74 , A61Q19/02 , C07D207/12 , C07D207/404 , C07D213/30 , C07D213/38 , C07D233/58 , C07D295/03 , C07D295/096 , C07D401/06
摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
摘要翻译：公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。黑色素产生抑制剂由通式（1）表示（不包括克霉唑）和/或其药理学上可接受的盐。在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基。 A1，A2和A3中的至少一个选自芳基和芳族杂环基，A1，A2和A3中所含的碳原子总数为6〜50，A1，A2和A3中的至少2个表示芳基或芳族杂环基，相邻的两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基。当R1和R2中的一个是氧代基时，另一个不存在。 R3选自氢原子和碳原子数为1〜8的烃基，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代。化合物中存在的R3的数目对应于X，并且当存在两个或更多个R 3时，R 3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且末端的R3可以结合到与A1，A2和A3结合的碳原子上，从而形成环。

3. 发明授权

US07531576B2 Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US07531576B2
公开(公告)日：2009-05-12
申请号：US10451408
申请日：2001-12-05
申请人： Takayuki Namiki , Kenichi Kishii , Masaki Mitani , Masashi Tamai , Naoki Hiyama , Makoto Kimura , Satoshi Ichinomiya
发明人： Takayuki Namiki , Kenichi Kishii , Masaki Mitani , Masashi Tamai , Naoki Hiyama , Makoto Kimura , Satoshi Ichinomiya
IPC分类号： A01N47/28 , A01N41/02 , A01N41/06 , A01N37/18 , C07C273/00 , C07C333/00 , C07C303/00 , C07C233/00
CPC分类号： C07D257/04 , C07C275/30 , C07C311/09 , C07C311/60
摘要： Biphenyl derivatives represented by the following formula (1): wherein R1 represents a C5-7 alkyl group, R2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R3 represents a tetrazolyl group, —NHCOCF3, —NHSO2CF3 or —SO2NHCONHR4 in which R4 represents a substituted or unsubstituted aromatic hydrocarbon group, and Z represents a single bond, a C1-4 alkylene group or —SO2NH—, and salts thereof; and ACAT inhibitors and medicines containing them as active ingredients. The compounds according to the present invention possess excellent ACAT inhibitory activities, and are useful as preventives and/or therapeutics for diseases cased by the enhancement of ACAT activity, for example, hypercholesterolemia, atherosclerosis and the like.
摘要翻译：由下式（1）表示的联苯衍生物：其中R1表示C5-7烷基，R2表示取代或未取代的芳族烃或环烷基，R3表示四唑基，-NHCOCF3，-NHSO2CF3或-SO2NHCONHR4，其中 R4表示取代或未取代的芳族烃基，Z表示单键，C1-4亚烷基或-SO2NH-，及其盐; 和ACAT抑制剂和含有它们作为活性成分的药物。根据本发明的化合物具有优异的ACAT抑制活性，并且可用作通过增强ACAT活性（例如高胆固醇血症，动脉粥样硬化等）而引起的疾病的预防剂和/或治疗剂。

4. 发明授权

US5942515A Pyrrolopyrazolopyrimidine compound and medicine comprising the same as active ingredient 失效
公开(公告)号：US5942515A
公开(公告)日：1999-08-24
申请号：US17223
申请日：1998-02-02
申请人： Takayuki Namiki , Masayuki Yuasa , Takako Takakuwa , Satoshi Ichinomiya , Yukio Kawazu , Kenichi Kishii , Norio Funayama , Mariko Harada , Kyoko Taneda , Naoki Hiyama , Tomoaki Yahiro , Mayumi Sugio , Masashi Tamai
发明人： Takayuki Namiki , Masayuki Yuasa , Takako Takakuwa , Satoshi Ichinomiya , Yukio Kawazu , Kenichi Kishii , Norio Funayama , Mariko Harada , Kyoko Taneda , Naoki Hiyama , Tomoaki Yahiro , Mayumi Sugio , Masashi Tamai
IPC分类号： A61K31/505 , A61P11/00 , C07D487/04 , C07D487/14 , A01N43/54 , C07D239/00
CPC分类号： C07D487/04 , C07D487/14
摘要： The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.

5. 发明授权

US6057330A Pyrrolopyrazolopyrimidine compound and medicine comprising the same as active ingredient 失效
标题翻译：吡咯并吡咯并嘧啶化合物和包含与活性成分相同的药物
公开(公告)号：US6057330A
公开(公告)日：2000-05-02
申请号：US236093
申请日：1999-01-25
申请人： Takayuki Namiki , Masayuki Yuasa , Takako Takakuwa , Satoshi Ichinomiya , Yukio Kawazu , Kenichi Kishii , Norio Funayama , Mariko Harada , Kyoko Taneda , Naoki Hiyama , Tomoaki Yahiro , Mayumi Sugio , Masashi Tamai
发明人： Takayuki Namiki , Masayuki Yuasa , Takako Takakuwa , Satoshi Ichinomiya , Yukio Kawazu , Kenichi Kishii , Norio Funayama , Mariko Harada , Kyoko Taneda , Naoki Hiyama , Tomoaki Yahiro , Mayumi Sugio , Masashi Tamai
IPC分类号： A61K31/505 , A61P11/00 , C07D487/04 , C07D487/14 , A01N43/54 , C07D239/00
CPC分类号： C07D487/04 , C07D487/14
摘要： The invention relates to compounds represented by the following general formula (1): ##STR1## wherein R.sup.1 represents an alkyl group, R.sup.2 represents an amino group, alkyl group or the like, and R.sup.3 represents a nitro group, amino group, heterocyclic group, alkylsulfonylamino group or the like, or salts thereof, medicines comprising such a compound, a preparation process of the compounds, and intermediates useful for preparation thereof. The compounds (1) are useful for the prevention and treatment of a respiratory disease.
摘要翻译：本发明涉及由以下通式（1）表示的化合物：其中R1表示烷基，R2表示氨基，烷基等，R3表示硝基，氨基，杂环基，烷基磺酰基氨基或类似物或其盐，包含这种化合物的药物，该化合物的制备方法和可用于其制备的中间体。化合物（1）可用于预防和治疗呼吸系统疾病。

6. 发明申请

US20110243865A1 MELANIN PRODUCTION INHIBITOR 有权
标题翻译： MELANIN生产抑制剂
公开(公告)号：US20110243865A1
公开(公告)日：2011-10-06
申请号：US13131827
申请日：2009-12-22
申请人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
发明人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
IPC分类号： A61K8/49 , C07D233/58 , C07D401/06 , A61K8/44 , C07C229/36 , A61K8/34 , C07C43/178 , A61K8/41 , C07C215/20 , C07C43/205 , C07C43/23 , C07C211/03 , C07D207/04 , C07D211/70 , C07D213/36 , C07D207/40 , C07D265/30 , C07D241/04 , A61Q19/02
CPC分类号： A61K8/4946 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/411 , A61K8/418 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K2800/74 , A61Q19/02 , C07D207/12 , C07D207/404 , C07D213/30 , C07D213/38 , C07D233/58 , C07D295/03 , C07D295/096 , C07D401/06
摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
摘要翻译：公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。黑色素生成抑制剂包含通式（1）表示的化合物（克霉唑除外）和/或其药理学上可接受的盐。在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基，其中A1，A2和A3中的至少一个选自芳基和芳香族杂环基时，A1，A2，A3中含有的碳原子总数为6〜50，A1，A2，A3中的至少2个为芳基或芳香族杂环基时，两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基，其中当R 1和R 2之一是氧代基时，另一个不存在; 和R3选自氢原子，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代的C1-8烃基，其中存在于化合物中的R3的数目对应于 X的数目，当存在两个或更多个R3时，R3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且R 3的末端可以与碳结合与A1，A2和A3结合的原子，从而形成环。

7. 发明授权

US06329382B1 Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine remedies/preventives for respiratory diseases 失效
标题翻译：吡咯并[3,2-e]吡唑并[1,5-a]嘧啶治疗/预防呼吸系统疾病
公开(公告)号：US06329382B1
公开(公告)日：2001-12-11
申请号：US09355935
申请日：1999-08-13
申请人： Takayuki Namiki , Masayuki Yuasa , Takako Takakuwa , Satoshi Ichinomiya , Masashi Tamai , Naoki Hiyama , Yukio Kawazu , Tomoaki Yahiro , Mayumi Sugio
发明人： Takayuki Namiki , Masayuki Yuasa , Takako Takakuwa , Satoshi Ichinomiya , Masashi Tamai , Naoki Hiyama , Yukio Kawazu , Tomoaki Yahiro , Mayumi Sugio
IPC分类号： C07D48714
CPC分类号： C07D487/14 , A61K31/519
摘要： The invention relates to a therapeutic and preventive medicament for respiratory diseases, comprising, as an active ingredient, a compound represented by the general formula (1): wherein R1 represents a linear, branched or cyclic alkyl group having 1 to 10 carbon atoms; and R2 represents a hydrogen or halogen atom, a substituted alkyl group, an amino group which may be substituted, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, or an alkylcarbamoyl group, or a salt thereof. This compound has excellent tracheobronchodilative effect and inhibitory effect on airway constriction.
摘要翻译：本发明涉及用于呼吸系统疾病的治疗和预防药物，其包含作为活性成分的由通式（1）表示的化合物：其中R 1表示具有1至10个碳原子的直链，支链或环状烷基; R 2表示氢或卤原子，取代烷基，可被取代的氨基，羧基，烷氧基羰基，氨基甲酰基或烷基氨基甲酰基或其盐。该化合物对气道收缩具有优异的气管支气管扩张作用和抑制作用。

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