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1. 发明申请

US20060135401A1 Novel method of selecting immunosuppressant having little thrombocytopenic effect 审中-公开
标题翻译：选择具有很小血小板减少作用的免疫抑制剂的新方法
公开(公告)号：US20060135401A1
公开(公告)日：2006-06-22
申请号：US10519678
申请日：2003-07-07
申请人： Takao Fujimura , Hiroaki Mori , Katsuhiko Yoshizawa , Yoko Takata , Ichiro Aramori , Hideaki Matsuoka , Akira Unami , Takahisa Noto
发明人： Takao Fujimura , Hiroaki Mori , Katsuhiko Yoshizawa , Yoko Takata , Ichiro Aramori , Hideaki Matsuoka , Akira Unami , Takahisa Noto
IPC分类号： A61K38/17 , G01N33/567
CPC分类号： C12Q1/6897 , C12Q1/6883 , G01N33/5047 , G01N33/6869 , G01N33/6872 , G01N2333/55
摘要： The invention relates to a novel method for selecting an immunosuppressive agent with a less thrombocytopenia effect. According to the invention, a method for selecting an immunosuppressive agent which has a potent immunosuppressive activity but a lower thrombocytopenia effect, said method comprising measuring an IL-2 transcription inhibitory activity in a test cell in to which an IL-2 reporter gene has been introduced in the coexistence of an analyte, while measuring a GATA-1 transcription inhibitory activity in the test cell into which a GATA-1 reporter gene has been introduced in the coexistence of an analyte, and comparing both the transcription inhibitory activities, is provided.
摘要翻译：本发明涉及一种选择血小板减少作用较小的免疫抑制剂的新方法。根据本发明，一种选择具有有效的免疫抑制活性但较低的血小板减少症的免疫抑制剂的方法，所述方法包括测量IL-2转录抑制活性，其中IL-2报告基因已被在分析物共存的同时测量在分析物共存中引入了GATA-1报道基因的测试细胞中的GATA-1转录抑制活性，并比较两种转录抑制活性。

2. 发明申请

US20060229236A1 Cyclic tetrapeptide compound and use thereof 审中-公开
标题翻译：环状四肽化合物及其用途
公开(公告)号：US20060229236A1
公开(公告)日：2006-10-12
申请号：US10500113
申请日：2002-12-27
申请人： Shigeki Satoh , Yasuharu Urano , Kazuhiko Osoda , Mitsuru Hosaka , Kozo Sawada , Takayuki Inoue , Hiroaki Mori , Shoji Takagaki , Takao Fujimura , Hideaki Matsuoka , Katsuhiko Yoshizawa
发明人： Shigeki Satoh , Yasuharu Urano , Kazuhiko Osoda , Mitsuru Hosaka , Kozo Sawada , Takayuki Inoue , Hiroaki Mori , Shoji Takagaki , Takao Fujimura , Hideaki Matsuoka , Katsuhiko Yoshizawa
IPC分类号： A61K38/12 , C07K5/12
CPC分类号： C07K5/126 , A61K38/12
摘要： A cyclic tetrapeptide compound of the formula (I): wherein R1 is hydrogen; R2 is lower alkyl, aryl, optionally substituted ar(lower)alkyl, heterocyclic(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, lower alkylcarbamoyl(lower)alkyl or arylcarbamoyl(lower)alkyl; R3 and R4 are each independently hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic(lower)alkyl or cyclo(lower)alkyl(lower)alkyl, or R3 and R4 are linked together to form lower alkylene or condensed ring, or one of R3 and R4 is linked to the adjacent nitrogen atom to form a ring; R5 is lower alkylene or lower alkenylene, Y is [wherein RY1 is hydrogen, halogen or optionally protected hydroxy, RY2 is hydrogen, halogen, lower alkyl or phenyl, and RY3 is hydrogen or lower alkyl]; R8 is hydrogen or lower alkyl; and n is an integer of 1 or 2, or a salt thereof.
摘要翻译：式（I）的环状四肽化合物：其中R 1是氢; R 2是低级烷基，芳基，任选取代的芳（低级）烷基，杂环（低级）烷基，环（低级）烷基（低级）烷基，低级烷基氨基甲酰基（低级）烷基或芳基氨基甲酰基烷基; R 3和R 4各自独立地为氢，低级烷基，任选取代的芳（低级）烷基，任选取代的杂环（低级）烷基或环（低级）烷基（低级））烷基或R 3和R 4连接在一起形成低级亚烷基或稠环，或者R 3和R 3中的一个 > 4 与相邻的氮原子连接形成环; R 5是低级亚烷基或低级亚烯基，Y是[其中R Y1是氢，卤素或任选保护的羟基，R Y2是氢，卤素，低级烷基或苯基，R 3 Y 3是氢或低级烷基]。 R 8是氢或低级烷基; n为1或2的整数，或其盐。

3. 发明申请

US20070123452A1 Method of selecting novel immunosuppressant 审中-公开
标题翻译：选择新型免疫抑制剂的方法
公开(公告)号：US20070123452A1
公开(公告)日：2007-05-31
申请号：US10540546
申请日：2003-12-26
申请人： Hideaki Matsuoka , Takao Fujimura , Masako Hayashi , Ichiro Aramori
发明人： Hideaki Matsuoka , Takao Fujimura , Masako Hayashi , Ichiro Aramori
IPC分类号： A61K48/00 , A61K38/12 , A61K31/19 , C12Q1/34
CPC分类号： G01N33/573 , C12Q1/34 , G01N2500/02
摘要： The present invention provides a method of selecting an IL-2 production inhibitor and/or an immunocyte proliferation inhibitor having low GATA-1 production inhibitory activity, which comprises measuring the HDAC4 and/or HDAC8 inhibitory activity of a test substance, and a method of selecting an immunosuppressant having low thrombocytopenic activity, which comprises measuring the HDAC4 and/or HDAC8 inhibitory activity of a test HDAC inhibitor.
摘要翻译：本发明提供了选择具有低GATA-1产生抑制活性的IL-2产生抑制剂和/或免疫细胞增殖抑制剂的方法，其包括测定被检物质的HDAC4和/或HDAC8抑制活性，选择具有低血小板减少活性的免疫抑制剂，其包括测量HDAC抑制剂的HDAC4和/或HDAC8抑制活性。

4. 发明申请

US20080076138A1 Novel Pd Marker for Histone Deacetylase Inhibitor 审中-公开
标题翻译：组蛋白脱乙酰酶抑制剂的新型Pd标记
公开(公告)号：US20080076138A1
公开(公告)日：2008-03-27
申请号：US11664422
申请日：2006-02-24
申请人： Hideaki Matsuoka , Yoshinori Ishii , Kaori Matsuda , Ichiro Aramori , Hiroaki Mori
发明人： Hideaki Matsuoka , Yoshinori Ishii , Kaori Matsuda , Ichiro Aramori , Hiroaki Mori
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： C12N9/99 , C12Q1/48 , G01N33/502
摘要： It is intended to provide a method for evaluating a pharmacological effect of a histone deacetylase (HDAC) inhibitor, comprising the steps of: (a) preparing a cell expressing CPSF5 protein; (b) contacting the cell with an HDAC inhibitor; (c) measuring the acetylation level of CPSF5 protein in the cell; and (d) comparing the acetylation level measured in the step (c) with the measured acetylation level of CPSF5 protein in a control cell that has not been contacted with the HDAC inhibitor.
摘要翻译：本发明旨在提供一种评价组蛋白脱乙酰酶（HDAC）抑制剂的药理作用的方法，包括以下步骤：（a）制备表达CPSF5蛋白的细胞; （b）使细胞与HDAC抑制剂接触; （c）测量细胞中CPSF5蛋白的乙酰化水平; 和（d）将步骤（c）中测量的乙酰化水平与未与HDAC抑制剂接触的对照细胞中测量的CPSF5蛋白的乙酰化水平进行比较。

5. 发明申请

US20120114375A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS 有权
标题翻译：电子照相感光元件，工艺盒和电子照相设备
公开(公告)号：US20120114375A1
公开(公告)日：2012-05-10
申请号：US13384852
申请日：2010-09-03
申请人： Atsushi Fujii , Haruyuki Tsuji , Hideaki Matsuoka , Kazuhisa Shida , Nobuhiro Nakamura
发明人： Atsushi Fujii , Haruyuki Tsuji , Hideaki Matsuoka , Kazuhisa Shida , Nobuhiro Nakamura
IPC分类号： G03G15/00 , G03G21/18
CPC分类号： G03G5/08 , G03G5/104 , G03G5/142 , G03G5/144
摘要： An electrophotographic photosensitive member that can not easily cause charging lines even where it is an electrophotographic photosensitive member employing as a conductive layer a layer containing metal oxide particles is disclosed. Also disclosed are a process cartridge and an electrophotographic apparatus which have such an electrophotographic photosensitive member. The electrophotographic photosensitive member has a conductive layer which contains titanium oxide particles coated with tin oxide doped with phosphorus or tungsten.
摘要翻译：公开了即使在作为导电层使用含有金属氧化物颗粒的层的电子照相感光构件的情况下也不容易引起充电线的电子照相感光构件。还公开了具有这种电子照相感光构件的处理盒和电子照相设备。电子照相感光构件具有包含掺杂有磷或钨的氧化锡的氧化钛颗粒的导电层。

6. 发明授权

US07033721B2 Method for producing electrophotographic photosensitive member, electrophotographic photosensitive member and electrophotographic apparatus using the same 失效
标题翻译：电子照相感光构件的制造方法，电子照相感光构件和使用其的电子照相设备
公开(公告)号：US07033721B2
公开(公告)日：2006-04-25
申请号：US10630727
申请日：2003-07-31
申请人： Junichiro Hashizume , Toshiyuki Ehara , Hideaki Matsuoka , Ryuji Okamura , Koji Hitsuishi , Satoshi Kojima , Hironori Ohwaki , Kazuto Hosoi
发明人： Junichiro Hashizume , Toshiyuki Ehara , Hideaki Matsuoka , Ryuji Okamura , Koji Hitsuishi , Satoshi Kojima , Hironori Ohwaki , Kazuto Hosoi
IPC分类号： G03G5/082 , C23C16/22
CPC分类号： G03G5/08 , G03G5/08214 , G03G5/08221 , G03G5/08235 , G03G5/14704
摘要： The invention provides a method for producing an electrophotographic photosensitive member such that even if abnormal grown portions called spherical protrusions 203 exist on the surface of the photosensitive member, they do not appear on images, thus making it possible to considerably alleviate image defects. The method for producing the electrophotographic photosensitive member including layers each constituted by a non-single crystal material includes the steps of placing a substrate having a conductive surface in a film forming apparatus capable of being airtight-sealed under vacuum having evacuating means and raw material gas supplying means, and decomposing at least a raw material gas by a high frequency power to form a first layer constituted by at least a non-single crystal material on the substrate as a first step; exposing the substrate with the first layer formed thereon to a gas containing oxygen and water vapor as a second step; and decomposing at least a raw material gas by a high frequency power in the film forming apparatus to form on the first layer a second layer including an upper blocking layer constituted by a non-single crystal material as a third step.
摘要翻译：本发明提供了一种用于制造电子照相感光构件的方法，即使在感光构件的表面上存在称为球形突起203的异常生长部分，它们也不会出现在图像上，从而可以显着地减轻图像缺陷。用于制造包括由非单晶材料构成的电子照相感光构件的方法包括以下步骤：将具有导电表面的基底放置在能够在具有抽真空装置和原料气体的真空下气密密封的成膜装置中供给装置，并且通过高频功率分解至少原料气体，以形成由至少非单晶材料构成的第一层作为第一步骤; 作为第二步，将其上形成有第一层的基板暴露于含有氧和水蒸汽的气体; 并且在成膜装置中通过高频功率分解至少一种原料气体，以在第一层上形成包括由非单晶材料构成的上阻挡层的第二层作为第三步骤。

7. 发明申请

US20050254046A1 Single cell operation supporting robot 审中-公开
标题翻译：单电池操作支持机器人
公开(公告)号：US20050254046A1
公开(公告)日：2005-11-17
申请号：US10523637
申请日：2002-08-08
申请人： Hideaki Matsuoka , Mikako Saito
发明人： Hideaki Matsuoka , Mikako Saito
IPC分类号： C12M3/00 , G02B21/32 , G02B27/32
CPC分类号： C12M23/12 , C12M23/50 , C12M35/00 , C12M41/48 , G02B21/32
摘要： A single-cell operation supporting robot for supporting a single-cell operation work with multi-purposes by carrying out a work which an operator himself/herself carries out difficultly, according to the indication of the operator. The robot is equipped with a microscope 1, multi-micro well 4 for storing cells and a single-cell stimulating device 5 which are respectively provided on the stage 1a of the microscope 1, a sample injection transportation means 7 which transports a glass capillary 6 for injecting a sample into the single-cell relatively to and from the multi-microwell 4 and an automatic stage 2, a cell transportation device 9 which transports a glass capillary 8 for holding the single-cell relatively to and from each well of the multi-microwell 4, the single-cell stimulating device 5 and the glass capillary 6, a microscopic spectral measurement device 10 which is combined with the microscope 1, computers 11 and 12 which automatically control an actuation of at least one among the microscope 1, the sample injection transportation device 7, the cell transportation device 9, the automatic stage 2, the single-cell stimulating device 5 and the microscopic spectral measurement device 10, and a manual operation device 17 which inputs signals to the computers 11 and 12 based on an operation by an operator and actuates the microscope and the like.
摘要翻译：根据操作者的指示，通过执行操作者自身执行的工作，支持机器人的单电池操作支持多单元操作工作。机器人装备有显微镜1，用于存储细胞的多微孔4和分别设置在显微镜1的台1a上的单细胞刺激装置5，输送玻璃毛细管的样品注射输送装置7 6，用于将样品相对于多微孔4和自动载物台2注入单细胞;细胞运送装置9，其输送用于保持单细胞的玻璃毛细管8相对于和/ 多微孔4，单细胞刺激装置5和玻璃毛细管6，与显微镜1组合的微观光谱测量装置10，计算机11和12，其自动控制显微镜1中的至少一个的致动，样品注射输送装置7，细胞运送装置9，自动载物台2，单细胞刺激装置5和微观光谱测定装置10，根据操作者的操作将信号输入到计算机11和12的手动装置17，并驱动显微镜等。

8. 发明授权

US06335281B1 Deposited film forming process 有权
标题翻译：沉积成膜工艺
公开(公告)号：US06335281B1
公开(公告)日：2002-01-01
申请号：US09334176
申请日：1999-06-16
申请人： Yoshio Segi , Hideaki Matsuoka , Hiroyuki Katagiri , Yasuyoshi Takai
发明人： Yoshio Segi , Hideaki Matsuoka , Hiroyuki Katagiri , Yasuyoshi Takai
IPC分类号： H01L2144
CPC分类号： C23C16/54 , C23C16/4581 , C23C16/46
摘要： In a deposited film forming process or apparatus, a deposited film is formed on a film-forming substrate by reduced-pressure vapor phase growth. The film-forming substrate is set on an auxiliary substrate and an auxiliary-substrate cap member is set at the upper part thereof. A maximum temperature difference between temperature at the upper end of the film-forming substrate and the temperature at the lower end of the auxiliary-substrate cap member provided on the film-forming substrate at its upper part is so controlled as to be not greater than a prescribed value so that a film deposited on the auxiliary-substrate cap member is improved in adhesion. Any deposits of films on the part other than the film-forming substrate can be prevented from coming off and scattering on the film-forming substrate so that deposited films having uniform film thickness and film quality can steadily be formed and also faulty images can occur less frequently. It is also possible to achieve improvements of various properties of films formed, film forming rate, reproducibility, and productivity so that yield can dramatically be improved in mass production.
摘要翻译：在沉积膜形成工艺或装置中，通过减压气相生长在成膜基板上形成沉积膜。成膜基板设置在辅助基板上，辅助基板盖部件设置在其上部。成膜基板的上端的温度与设置在成膜基板上部的辅助基板盖部件的下端的温度之间的最大温度差被控制为不大于规定值，使得沉积在辅助基板盖构件上的膜提高了粘附性。可以防止膜形成基板以外的部分的沉积物在成膜基板上脱落并散射，从而可以稳定地形成膜厚度和膜质量均匀的沉积膜，并且可以发生较少的图像经常。也可以实现成膜的各种性能，成膜速度，再现性和生产率的改善，从而大量提高产量。

9. 发明授权

US08986656B2 Method for evaluating specific incorporation of D-glucose into cells 有权
标题翻译： D-葡萄糖特异性掺入细胞的方法
公开(公告)号：US08986656B2
公开(公告)日：2015-03-24
申请号：US13058061
申请日：2009-08-07
申请人： Katsuya Yamada , Hideaki Matsuoka , Tadashi Teshima , Toshihiro Yamamoto
发明人： Katsuya Yamada , Hideaki Matsuoka , Tadashi Teshima , Toshihiro Yamamoto
IPC分类号： G01N33/58 , G01N33/50 , C12Q1/54 , C12Q1/02 , G01N33/533
CPC分类号： G01N33/582 , C09B51/00 , C09B57/00 , C12Q1/02 , C12Q1/54 , G01N33/5005 , G01N33/533
摘要： An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.
摘要翻译：本发明的目的是提供一种用于精确评估D-葡萄糖在细胞中的特异性掺入的方法。作为实现该目的的手段的本发明的特征在于，使分子中具有荧光发色团的D-葡萄糖衍生物与细胞特异性结合，并且在分子中具有荧光发色团的L-葡萄糖衍生物不同分别将待分析的具有荧光发色团的D-葡萄糖衍生物发射的荧光发射到具有荧光的L-葡萄糖衍生物发射的荧光的细胞中进行评价的细胞，并且通过取两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖的细胞特异性掺入细胞。

10. 发明申请

US20110189708A1 METHOD FOR EVALUATING SPECIFIC INCORPORATION OF D-GLUCOSE INTO CELLS 有权
标题翻译：评估D-葡萄糖进入细胞的具体方法
公开(公告)号：US20110189708A1
公开(公告)日：2011-08-04
申请号：US13058061
申请日：2009-08-07
申请人： Katsuya Yamada , Hideaki Matsuoka , Tadashi Teshima , Toshihiro Yamamoto
发明人： Katsuya Yamada , Hideaki Matsuoka , Tadashi Teshima , Toshihiro Yamamoto
IPC分类号： C12Q1/54 , C07H15/26 , C07H15/18 , C07H1/00 , C07H5/06
CPC分类号： G01N33/582 , C09B51/00 , C09B57/00 , C12Q1/02 , C12Q1/54 , G01N33/5005 , G01N33/533
摘要： An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.
摘要翻译：本发明的目的是提供一种用于精确评估D-葡萄糖在细胞中的特异性掺入的方法。作为实现该目的的手段的本发明的特征在于，使分子中具有荧光发色团的D-葡萄糖衍生物与细胞特异性结合，并且在分子中具有荧光发色团的L-葡萄糖衍生物不同分别将待分析的具有荧光发色团的D-葡萄糖衍生物发射的荧光发射到具有荧光的L-葡萄糖衍生物发射的荧光的细胞中进行评价的细胞，并且通过取两种荧光强度之间的差异来评估D-葡萄糖相对于L-葡萄糖的细胞特异性掺入细胞。

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