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1. 发明申请

US20100228045A1 BIOCOMPATIBLE SUSPENSION STABILIZER FOR DISPERSING INORGANIC NANOPARTICLES INTO AQUEOUS SOLUTION 审中-公开
标题翻译：用于将无机纳米颗粒分解成水溶液的生物可溶性悬浮稳定剂
公开(公告)号：US20100228045A1
公开(公告)日：2010-09-09
申请号：US12682955
申请日：2008-10-15
申请人： Taeghwan Hyeon , Sang-Wook Kim , Hyon-Bin Na
发明人： Taeghwan Hyeon , Sang-Wook Kim , Hyon-Bin Na
IPC分类号： C07F9/09 , C07F9/24 , C07F9/165 , C07F9/146
CPC分类号： C07F9/2408 , C07F9/2458
摘要： The present invention relates to a suspension stabilizer for dispersing inorganic nanoparticles into aqueous medium. More particularly, the present invention is directed to a biocompatible suspension stabilizer which comprises phosphoryl domain having an affinity to the surface of an inorganic nanoparticle and poly(ethylene glycol) having an affinity to the aqueous medium, and which is prepared by reacting a biocompatible poly(ethylene glycol)-derivatized polymer with phosphine oxide having a leaving group.
摘要翻译：本发明涉及将无机纳米颗粒分散在水介质中的悬浮稳定剂。更具体地说，本发明涉及一种生物相容性悬浮稳定剂，它包括对无机纳米颗粒的表面具有亲和性的磷酸结构域和对水性介质具有亲和性的聚（乙二醇），并且其通过使生物相容性聚（乙二醇）衍生化聚合物与具有离去基团的氧化膦。

2. 发明申请

US20120114564A1 MRI T1 CONTRASTING AGENT COMPRISING MANGANESE OXIDE NANOPARTICLE 审中-公开
标题翻译： MRI T1对比剂包含锰氧化物纳米颗粒
公开(公告)号：US20120114564A1
公开(公告)日：2012-05-10
申请号：US12525276
申请日：2008-01-30
申请人： Taeghwan Hyeon , Kwangjin An , Hyon Bin Na , Junghee Lee
发明人： Taeghwan Hyeon , Kwangjin An , Hyon Bin Na , Junghee Lee
IPC分类号： A61K49/12 , A61K49/16 , C01G45/02 , A61K49/10 , A61K49/14 , B82Y5/00 , B82Y40/00
CPC分类号： A61K49/08 , A61K49/126 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , B82Y5/00 , Y10T428/2982
摘要： The present invention relates to the use of and method for using MnO nanoparticles as MRI T1 contrasting agents which reduces T1 of tissue. More specifically, the present invention is directed to MRI T1 contrasting agent comprising MnO nanoparticle coated with a biocompatible material bound to a biologically active material such as a targeting agent, for example tumor marker etc., and methods for diagnosis and treatment of tumor etc. using said MRI T1 contrasting agent, thereby obtaining more detailed images than the conventional MRI T1-weighted images. The MRI T1 contrasting agent of the present invention allows a high resolution anatomic imaging by emphasizing T1 contrast images between tissues based on the difference of accumulation of the contrasting agent in tissues. Also, the MRI T1 contrasting agent of the present invention enables to visualize cellular distribution due to its high intracellular uptake. The MRI T1 contrasting agent of the present invention can be used for target-specific diagnosis and treatment of various diseases such as tumor etc. when targeting agents binding to disease-specific biomarkers are conjugated to the surface of nanoparticles.
摘要翻译：本发明涉及使用MnO纳米颗粒作为降低组织T1的MRI T1对比剂的用途和方法。更具体地，本发明涉及包含结合生物活性材料如靶向剂例如肿瘤标记物等的生物相容性材料的MnO纳米颗粒的MRI T1对比剂，以及用于诊断和治疗肿瘤等的方法。使用所述MRI T1对比剂，从而获得比常规MRI T1加权图像更详细的图像。本发明的MRI T1对比剂基于组织中对比剂积累的差异，通过强调组织之间的T1对比图像来允许高分辨率解剖成像。此外，本发明的MRI T1对比剂能够使细胞内的摄取量高，从而可视化细胞分布。当与疾病特异性生物标志物结合的靶向剂与纳米颗粒的表面共轭时，本发明的MRI T1对比剂可以用于各种疾病如肿瘤等的靶特异性诊断和治疗。

3. 发明申请

US20130323182A1 METHOD OF PREPARING IRON OXIDE NANOPARTICLES COATED WITH HYDROPHILIC MATERIAL, AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT USING THE SAME 有权
标题翻译：制备用氢化物质涂覆的氧化镍纳米粒子的方法和使用其的磁共振成像对比剂
公开(公告)号：US20130323182A1
公开(公告)日：2013-12-05
申请号：US13983367
申请日：2012-02-06
申请人： Taeghwan Hyeon , Yuanzhe Piao , Yong Il Park
发明人： Taeghwan Hyeon , Yuanzhe Piao , Yong Il Park
IPC分类号： A61K49/18
CPC分类号： A61K49/1824 , A61K49/186 , A61K49/1863 , B82Y30/00 , C01G49/02 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/51 , C01P2004/64 , C01P2006/42 , C09C1/24 , C09C3/08
摘要： The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.
摘要翻译：本发明涉及一种制备生物相容性氧化铁纳米粒子的方法，该方法是通过使用具有亲水性材料的盐颗粒进行退火处理和通过包含由其制备的氧化铁纳米粒子的磁共振成像（MRI）造影剂来涂覆具有改善的磁性的氧化铁纳米粒子。在亲水性材料中，羧甲基葡聚糖（CM-葡聚糖）在稳定退火的氧化铁纳米颗粒方面是最有效的，并且具有对比效果。

4. 发明申请

US20100247423A1 GOETHITE NANOTUBE AND PROCESS FOR PREPARING THEREOF 审中-公开
标题翻译： GOETHITE NANOTUBE及其制备方法
公开(公告)号：US20100247423A1
公开(公告)日：2010-09-30
申请号：US12739644
申请日：2008-10-24
申请人： Taeghwan Hyeon , Taekyung Yu
发明人： Taeghwan Hyeon , Taekyung Yu
IPC分类号： C01G49/02 , C01G49/06
CPC分类号： D01F9/08 , B01J23/745 , B01J35/0013 , B01J35/002 , B01J37/086 , B01J37/16 , B82Y25/00 , B82Y30/00
摘要： The present invention relates to a goethite nanotube. Particularly, the present invention is directed to goethite nanotubes, which can be used as a catalyst relating to environment or a drug delivery system, and process for preparing the goethite nanotube, and process for preparing magnetite and hematite nanoparticles.
摘要翻译：本发明涉及一种针铁矿纳米管。特别地，本发明涉及可用作与环境或药物输送系统有关的催化剂的针铁矿纳米管，以及制备针铁矿纳米管的方法，以及制备磁铁矿和赤铁矿纳米颗粒的方法。

5. 发明授权

US09169355B2 Biocompatible agent for dispersing nanoparticles into an aqueous medium using mussel adhesive protein-mimetic polymer 有权
标题翻译：使用贻贝粘合蛋白模拟聚合物将纳米颗粒分散到水性介质中的生物相容剂
公开(公告)号：US09169355B2
公开(公告)日：2015-10-27
申请号：US13976705
申请日：2011-12-28
申请人： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park
发明人： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park
IPC分类号： A61K8/00 , C08G73/02 , A61K49/18 , C08L71/02 , C08G81/00 , A61K8/91
CPC分类号： C08G73/024 , A61K8/91 , A61K49/1857 , A61K49/1887 , C08G73/02 , C08G81/00 , C08G2261/128 , C08L71/02 , C08L2205/03 , C08L79/02
摘要： Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
摘要翻译：提供了一种贻贝粘合蛋白模拟分散稳定剂，用于将纳米颗粒分散在水性介质中，包含由分散稳定剂分散和稳定的纳米颗粒的胶体溶液，以及包含胶体溶液的造影剂。更具体地，贻贝粘合蛋白模拟分散稳定剂是聚乙烯亚胺接枝 - （聚乙二醇;聚DOPA）PEI-接枝 - （PEG; PDOPA）。接枝聚合物由两部分组成。一种是用聚乙烯接枝的聚乙二醇，其与水性介质具有亲和力，另一种是与纳米颗粒表面具有亲和性的聚DOPA。由于这些特性，稳定剂显示了纳米颗粒在水性介质中的稳定分散。

6. 发明申请

US20130272965A1 Biocompatible Agent for Dispersing Nanoparticles into an Aqueous Medium Using Mussel Adhesive Protein-Mimetic Polymer 有权
标题翻译：使用贻贝粘合蛋白模拟聚合物将纳米颗粒分散到水性介质中的生物相容性试剂
公开(公告)号：US20130272965A1
公开(公告)日：2013-10-17
申请号：US13976705
申请日：2011-12-28
申请人： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park
发明人： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park
IPC分类号： C08G73/02
CPC分类号： C08G73/024 , A61K8/91 , A61K49/1857 , A61K49/1887 , C08G73/02 , C08G81/00 , C08G2261/128 , C08L71/02 , C08L2205/03 , C08L79/02
摘要： Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
摘要翻译：提供了一种贻贝粘合蛋白模拟分散稳定剂，用于将纳米颗粒分散在水性介质中，包含由分散稳定剂分散和稳定的纳米颗粒的胶体溶液，以及包含胶体溶液的造影剂。更具体地，贻贝粘合蛋白模拟分散稳定剂是聚乙烯亚胺接枝 - （聚乙二醇;聚DOPA）PEI-接枝 - （PEG; PDOPA）。接枝聚合物由两部分组成。一种是用聚乙烯接枝的聚乙二醇，其与水性介质具有亲和力，另一种是与纳米颗粒表面具有亲和性的聚DOPA。由于这些特性，稳定剂显示了纳米颗粒在水性介质中的稳定分散。

7. 发明申请

US20130065995A1 Surface-Modified Tantalum Oxide Nanoparticles, Preparation Method Thereof, and Contrast Medium for X-Ray Computed Tomography and Highly Dielectric Thin Film Using Same 有权
标题翻译：表面改性钽氧化物纳米颗粒，其制备方法和用于X射线计算机断层摄影的对比介质和使用其的高介电性薄膜
公开(公告)号：US20130065995A1
公开(公告)日：2013-03-14
申请号：US13580594
申请日：2011-02-22
申请人： Taeghwan Hyeon , Myoung Hwan Oh
发明人： Taeghwan Hyeon , Myoung Hwan Oh
IPC分类号： C07F9/00 , C08L33/12 , C08K5/50 , C08K5/544 , C07F9/50 , A61K49/04
CPC分类号： A61K49/0428 , B82Y5/00
摘要： The present invention relates to a surface-modified tantalum oxide nanoparticle, a method for preparation thereof, a contrast agent (medium) for X-ray computed tomography, and a highly dielectric (high-K) film using the same. In particular, the present invention is directed to a surface-modified tantalum oxide nanoparticle, a method for preparing surface-modified tantalum oxide nanoparticles, comprising: (i) adding an aqueous phase to an organic solvent which contains a surfactant, to prepare a water-in-oil microemulsion; (ii) introducing a tantalum precursor to said microemulsion; (iii) adding a surface-modifier having an organic silane group or phosphine group to a solution obtained at the step (ii); (iv) removing said organic solvent from a product obtained at the step (iii); and (v) separating surface-modified tantalum oxide nanoparticles from a mixture obtained at the step (iv), a contrast agent for X-ray computed tomography, and a highly dielectric (thin) film using the same.
摘要翻译：本发明涉及表面改性的氧化钽纳米颗粒，其制备方法，用于X射线计算机断层摄影的造影剂（介质）和使用其的高电介质（高K）膜。特别地，本发明涉及一种表面改性的氧化钽纳米颗粒，一种制备表面改性的氧化钽纳米颗粒的方法，包括：（i）将水相加入到含有表面活性剂的有机溶剂中以制备水油微乳液; （ii）向所述微乳液引入钽前体; （iii）向在步骤（ii）获得的溶液中加入具有有机硅烷基或膦基的表面改性剂; （iv）从步骤（iii）获得的产物中除去所述有机溶剂; 和（v）从步骤（iv）获得的混合物，用于X射线计算机断层摄影的造影剂和使用其的高电介质（薄）膜分离表面改性的氧化钽纳米颗粒。

8. 发明申请

US20110098453A1 MAGNETIC NANOCOMPOSITE, AND PROCESS FOR SELECTIVE BINDING, SEPARATION AND PURIFICATION OF PROTEIN USING THE SAME 审中-公开
标题翻译：磁性纳米复合物，以及使用该蛋白质的蛋白质的选择性结合，分离和纯化的方法
公开(公告)号：US20110098453A1
公开(公告)日：2011-04-28
申请号：US12852774
申请日：2010-08-09
申请人： Taeghwan Hyeon , Jae-Yoon Kim , Nohyun Lee , Yuanzhe Piao
发明人： Taeghwan Hyeon , Jae-Yoon Kim , Nohyun Lee , Yuanzhe Piao
IPC分类号： C07K1/14 , B05D5/12 , H01F1/00 , H01F1/01 , B82Y5/00
CPC分类号： C07K1/22 , B82Y5/00 , G01N33/54326
摘要： The present invention relates to a magnetic nanocomposite, a process for production thereof, a reusable protein-binding agent for separation of a protein including the magnetic nanocomposite, and a process for selective binding, separation and purification of a protein using the magnetic nanocomposite. In particular, the present invention is directed to a magnetic nanocomposite with a magnetic nanoparticle core of a magnetic nanoparticle, a silica shell coating said core, and a nanoparticle layer of a fourth period transition metal oxide, which coats said silica shell, a process for production of the magnetic nanocomposite, a reusable protein-binding agent the magnetic nanocomposite, and a process for selective binding, separation and purification of a protein using the magnetic nanocomposite.
摘要翻译：本发明涉及一种磁性纳米复合材料，其制备方法，用于分离包含磁性纳米复合材料的蛋白质的可重复使用的蛋白质结合剂，以及使用磁性纳米复合材料选择性结合，分离和纯化蛋白质的方法。特别地，本发明涉及具有磁性纳米颗粒的磁性纳米颗粒核心的磁性纳米复合材料，涂覆所述芯体的二氧化硅壳和涂覆所述二氧化硅壳体的第四周期过渡金属氧化物的纳米颗粒层，磁性纳米复合材料的制造，磁性纳米复合材料的可重复使用的蛋白质结合剂，以及使用磁性纳米复合材料选择性结合，分离和纯化蛋白质的方法。

9. 发明授权

US07407527B2 Synthesis of mono-disperse and highly crystalline nano-particles of metals, alloys, metal-oxides, and multi-metallic oxides without a size-selection process 有权
标题翻译：金属，合金，金属氧化物和多金属氧化物的单分散和高结晶纳米颗粒的合成，没有尺寸选择过程
公开(公告)号：US07407527B2
公开(公告)日：2008-08-05
申请号：US10490745
申请日：2002-01-22
申请人： Taeghwan Hyeon
发明人： Taeghwan Hyeon
IPC分类号： B22F9/24
CPC分类号： B82Y30/00 , B22F1/0018 , B22F9/305 , B22F2998/00 , B82Y25/00 , C01B13/36 , C01B13/366 , C01P2004/04 , C01P2004/32 , C01P2004/52 , C01P2004/64 , C01P2006/42 , G11B5/70605 , H01F1/0054 , H01F1/009 , B22F1/0085
摘要： A synthetic method of fabricating highly crystalline and monodisperse nanoparticles of metals, multi-metallic alloys, monometallic oxides and multi-metallic oxides without a size selection process are disclosed. A typical synthetic method comprises the steps of, synthesis of a metal surfactant complex from the reaction of a metal precursor and a surfactant, high temperature thermal decomposition of the metal surfactant complex to produce monodisperse metal nanoparticles, and completing the formation of synthesized metal, metal alloy or metal oxide nanoparticles by adding a poor solvent followed by centrifuging. For obtaining highly crystalline monodisperse nanoparticles, additional steps are necessary as described in the invention. The resulting nanoparticles have excellent magnetic property for many applications.
摘要翻译：公开了一种制造金属，多金属合金，单金属氧化物和多金属氧化物而没有尺寸选择过程的高结晶和单分散纳米颗粒的合成方法。典型的合成方法包括以下步骤：从金属前体和表面活性剂的反应合成金属表面活性剂络合物，金属表面活性剂复合物的高温热分解以产生单分散金属纳米颗粒，并完成合成的金属，金属合金或金属氧化物纳米颗粒，然后加入不良溶剂，然后离心。为了获得高度结晶的单分散纳米颗粒，如本发明所述，需要额外的步骤。所得的纳米颗粒具有优异的磁性能用于许多应用。

10. 发明申请

US20050214190A1 Method of synthesizing nanorods by reaction of metal-surfactant complexes injected using a syringe pump 审中-公开
标题翻译：通过使用注射泵注射的金属 - 表面活性剂复合物的反应合成纳米棒的方法
公开(公告)号：US20050214190A1
公开(公告)日：2005-09-29
申请号：US10811504
申请日：2004-03-25
申请人： Taeghwan Hyeon , Jongnam Park
发明人： Taeghwan Hyeon , Jongnam Park
IPC分类号： C01B25/08 , C01G9/02
CPC分类号： C01G9/02 , B82Y30/00 , C01B25/08 , C01P2002/72 , C01P2004/04 , C01P2004/10
摘要： Synthetic methods for producing uniform in diameter and highly crystalline nanorods of metals, alloys, metal oxides, metal nitrides, metal pnictides or metal chalcogenides by reaction of metal-surfactant complexes injected at a constant injection rate using a syringe pump into a surfactant solution in order to induce the one-dimensional growth of the nanostructured materials, where the reaction includes thermal decomposition, reduction, oxidation, sulfidation and phosphidation, are disclosed. The steps of a typical synthetic method consist of forming metal-surfactant complexes from the reaction of metal precursors and surfactant, injecting said metal-surfactant complex into a solution containing a surfactant and a reagent at high temperature using a syringe pump at a constant injection rate, aging at high temperature, and separating as well as precipitating by adding a poor solvent, and finally retrieving the desired nanorods by centrifuging.
摘要翻译：通过使用注射泵以恒定的注射速率注射到金属 - 表面活性剂复合物中的金属 - 表面活性剂复合物按顺序生成金属，合金，金属氧化物，金属氮化物，金属硫化物或金属硫族化物的直径和高结晶纳米棒的均匀化合成方法以诱导纳米结构材料的一维生长，其中反应包括热分解，还原，氧化，硫化和磷化。典型的合成方法的步骤包括从金属前体和表面活性剂的反应形成金属 - 表面活性剂复合物，使用注射泵以恒定的注射速率将所述金属 - 表面活性剂复合物在高温下注入含有表面活性剂和试剂的溶液中，在高温下老化，通过加入不良溶剂进行分离和沉淀，最后通过离心回收所需的纳米棒。

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