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1. 发明申请

US20120114564A1 MRI T1 CONTRASTING AGENT COMPRISING MANGANESE OXIDE NANOPARTICLE 审中-公开
标题翻译： MRI T1对比剂包含锰氧化物纳米颗粒
公开(公告)号：US20120114564A1
公开(公告)日：2012-05-10
申请号：US12525276
申请日：2008-01-30
申请人： Taeghwan Hyeon , Kwangjin An , Hyon Bin Na , Junghee Lee
发明人： Taeghwan Hyeon , Kwangjin An , Hyon Bin Na , Junghee Lee
IPC分类号： A61K49/12 , A61K49/16 , C01G45/02 , A61K49/10 , A61K49/14 , B82Y5/00 , B82Y40/00
CPC分类号： A61K49/08 , A61K49/126 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , B82Y5/00 , Y10T428/2982
摘要： The present invention relates to the use of and method for using MnO nanoparticles as MRI T1 contrasting agents which reduces T1 of tissue. More specifically, the present invention is directed to MRI T1 contrasting agent comprising MnO nanoparticle coated with a biocompatible material bound to a biologically active material such as a targeting agent, for example tumor marker etc., and methods for diagnosis and treatment of tumor etc. using said MRI T1 contrasting agent, thereby obtaining more detailed images than the conventional MRI T1-weighted images. The MRI T1 contrasting agent of the present invention allows a high resolution anatomic imaging by emphasizing T1 contrast images between tissues based on the difference of accumulation of the contrasting agent in tissues. Also, the MRI T1 contrasting agent of the present invention enables to visualize cellular distribution due to its high intracellular uptake. The MRI T1 contrasting agent of the present invention can be used for target-specific diagnosis and treatment of various diseases such as tumor etc. when targeting agents binding to disease-specific biomarkers are conjugated to the surface of nanoparticles.
摘要翻译：本发明涉及使用MnO纳米颗粒作为降低组织T1的MRI T1对比剂的用途和方法。更具体地，本发明涉及包含结合生物活性材料如靶向剂例如肿瘤标记物等的生物相容性材料的MnO纳米颗粒的MRI T1对比剂，以及用于诊断和治疗肿瘤等的方法。使用所述MRI T1对比剂，从而获得比常规MRI T1加权图像更详细的图像。本发明的MRI T1对比剂基于组织中对比剂积累的差异，通过强调组织之间的T1对比图像来允许高分辨率解剖成像。此外，本发明的MRI T1对比剂能够使细胞内的摄取量高，从而可视化细胞分布。当与疾病特异性生物标志物结合的靶向剂与纳米颗粒的表面共轭时，本发明的MRI T1对比剂可以用于各种疾病如肿瘤等的靶特异性诊断和治疗。

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