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1. 发明申请

WO2006133104A2 BENZOIMIDAZOLONE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS 审中-公开
标题翻译：作为5-HT4受体激动剂的苯并咪唑烷羧酰胺化合物
公开(公告)号：WO2006133104A2
公开(公告)日：2006-12-14
申请号：PCT/US2006021765
申请日：2006-06-06
申请人： THERAVANCE INC , GENDRON ROLAND , CHOI SEOK-KI , FATHEREE PAUL R , GOLDBLUM ADAM A , LONG DANIEL , MARQUESS DANIEL , TURNER S DEREK
发明人： GENDRON ROLAND , CHOI SEOK-KI , FATHEREE PAUL R , GOLDBLUM ADAM A , LONG DANIEL , MARQUESS DANIEL , TURNER S DEREK
CPC分类号： C07D451/04 , A61K31/46 , A61K31/496
摘要： The invention provides novel benzoimidazolone-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT 4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供了新的苯并咪唑酮 - 甲酰胺5-HT 4受体激动剂化合物。本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。

2. 发明申请

WO2007062058A2 CARBAMATE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS 审中-公开
标题翻译：碳酸酯化合物作为5-HT4受体激动剂
公开(公告)号：WO2007062058A2
公开(公告)日：2007-05-31
申请号：PCT/US2006045099
申请日：2006-11-21
申请人： THERAVANCE INC , LONG DANIEL , CHOI SEOK-KI , FATHEREE PAUL R , GOLDBLUM ADAM , MARQUESS DANIEL
发明人： LONG DANIEL , CHOI SEOK-KI , FATHEREE PAUL R , GOLDBLUM ADAM , MARQUESS DANIEL
CPC分类号： C07D451/04
摘要： The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclsoure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5 HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供了新的苯并咪唑酮 - 甲酰胺衍生的式（I）的氨基甲酸酯5-HT 4受体激动剂化合物：其中R1，R2，R3，R4，a和b定义在本发明中。本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。

3. 发明申请

WO2007103187A3 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 8-AZABICYCLO [3.2.1] OCTANE化合物作为阿片受体拮抗剂
公开(公告)号：WO2007103187A3
公开(公告)日：2007-11-01
申请号：PCT/US2007005388
申请日：2007-02-28
申请人： THERAVANCE INC , LONG DANIEL , CHURCH TIMOTHY J , JACOBSEN JOHN R , JIANG LAN , SAITO DAISUKE ROLAND , STERGIADES IOANNA , VAN DYKE PRISCILLA , DALZIEL SEAN , PREZA LETICIA
发明人： LONG DANIEL , CHURCH TIMOTHY J , JACOBSEN JOHN R , JIANG LAN , SAITO DAISUKE ROLAND , STERGIADES IOANNA , VAN DYKE PRISCILLA , DALZIEL SEAN , PREZA LETICIA
IPC分类号： C07D451/02 , A61K31/46 , A61P1/10
CPC分类号： C07D451/02 , A61K31/439 , A61K31/46 , A61K31/485 , A61K45/06
摘要： The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I) wherein R 1 , R 2 , R 3 , A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供式（I）的新的8-氮杂双环[3.2.1]辛烷化合物，其中R 1，R 2，R 3， A和G在本说明书中定义，或其药学上可接受的盐或溶剂合物，其作为μ阿片受体的拮抗剂。本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与阿片样物质受体活性相关的病症的方法，以及可用于制备这些化合物的方法和中间体。

4. 发明专利

JP2012211193A 8-AZABICYCLO[3.2.1]OCTANE COMPOUND AS μ OPIOID RECEPTOR ANTAGONIST 审中-公开
标题翻译： 8-AZABICYCLO [3.2.1] OCTAE化合物作为μ阿片受体拮抗剂
公开(公告)号：JP2012211193A
公开(公告)日：2012-11-01
申请号：JP2012171119
申请日：2012-08-01
申请人： Theravance Inc , セラヴァンス, インコーポレーテッド
发明人： LONG DANIEL , CHURCH TIMOTHY J , JACOBSEN JOHN R , JIANG LAN , SAITO DAISUKE ROLAND , STERGIADES IOANNA , VAN DYKE PRISCILLA , DALZIEL SEAN , PREZA LETICIA
IPC分类号： C07D451/02 , A61K31/46 , A61P1/00 , A61P3/04 , A61P25/30
CPC分类号： C07D451/02 , A61K31/439 , A61K31/46 , A61K31/485 , A61K45/06
摘要： PROBLEM TO BE SOLVED: To provide 8-azabicyclo[3.2.1]octane compounds as μ opioid receptor antagonist.SOLUTION: The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R, R, R, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, which are antagonists at the μ opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with μ opioid receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译：待解决的问题：提供8-氮杂双环[3.2.1]辛烷化合物作为μ阿片受体拮抗剂。解决方案：本发明提供式（I）的新型8-氮杂双环[3.2.1]辛烷化合物：其中R 1 ，R

5. 发明专利

GB2502083A MULTI-FUNCTION EXERCISE APPARATUS 未知
公开(公告)号：GB2502083A
公开(公告)日：2013-11-20
申请号：GB201208506
申请日：2012-05-14
申请人： LONG DANIEL
发明人： LONG DANIEL
IPC分类号： A63B69/00 , A61B5/16 , A63F9/00
摘要： A multi-function exercise apparatus comprising a centrally disposed support member 45, a plurality of arms 51 on which there is disposed at least one strike surface (55, fig.12b), a coupling mechanism 49 mounted on the support member for securing the arms, wherein the arms are pivotably radially movable between a storage position and a number of static, deployed, in use positions. The apparatus may also include an electronic controller for generating sequences to be followed by a user to encourage exercise to improve co-ordination, strength, speed and mental acuity, including memory and arithmetic sequency. The controller also allows for pacing, monitoring and scoring a range of exercises and simulations for one or more users. A method of exercising using the apparatus are also disclosed.

6. 发明申请

WO2008057300A9 TRPVI ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译： TRPVI拮抗剂及其用途
公开(公告)号：WO2008057300A9
公开(公告)日：2008-07-24
申请号：PCT/US2007022774
申请日：2007-10-29
申请人： REDPOINT BIO CORP , PALMER R KYLE , LONG DANIEL , DEVANTIER HEATHER , LEE S PAUL , BUBER M N TULU , BRYANT ROBERT
发明人： PALMER R KYLE , LONG DANIEL , DEVANTIER HEATHER , LEE S PAUL , BUBER M N TULU , BRYANT ROBERT
IPC分类号： C07D401/00 , A61K31/497
CPC分类号： A61K31/497
摘要： The present invention is directed to the use of TRPVl antagonists as inhibitors of certain taste perceptions and functions. The invention is also directed to, among other things, compositions comprising the TRPVl antagonists that can be used in pharmaceutical, food, and other products to inhibit certain taste functions and perceptions.
摘要翻译：本发明涉及TRPV1拮抗剂作为某些味觉和功能的抑制剂的用途。本发明还涉及包含可用于药物，食品和其它产品中以抑制某些味觉功能和感知的TRPV1拮抗剂的组合物。

7. 发明申请

WO2008057300A3 TRPVI ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译： TRPVI拮抗剂及其用途
公开(公告)号：WO2008057300A3
公开(公告)日：2008-06-12
申请号：PCT/US2007022774
申请日：2007-10-29
申请人： REDPOINT BIO CORP , PALMER R KYLE , LONG DANIEL , DEVANTIER HEATHER , LEE S PAUL , BUBER M N TULU , BRYANT ROBERT
发明人： PALMER R KYLE , LONG DANIEL , DEVANTIER HEATHER , LEE S PAUL , BUBER M N TULU , BRYANT ROBERT
IPC分类号： C07D401/00 , A61K31/497
CPC分类号： A61K31/497
摘要： The present invention is directed to the use of TRPVl antagonists as inhibitors of certain taste perceptions and functions. The invention is also directed to, among other things, compositions comprising the TRPVl antagonists that can be used in pharmaceutical, food, and other products to inhibit certain taste functions and perceptions.
摘要翻译：本发明涉及TRPV1拮抗剂作为某些味觉和功能的抑制剂的用途。此外，本发明还涉及包含TRPV1拮抗剂的组合物，其可用于药物，食品和其他产品中以抑制某些味觉功能和感知。

8. 发明授权

US745634A Piano-tuning apparatus. 失效
标题翻译： PIANO调谐装置。
公开(公告)号：US745634A
公开(公告)日：1903-12-01
申请号：US1901053141
申请日：1901-03-27
申请人： LONG DANIEL
发明人： LONG DANIEL
CPC分类号： G10C9/00

9. 发明专利

AT535523T 未知
公开(公告)号：AT535523T
公开(公告)日：2011-12-15
申请号：AT06760341
申请日：2006-05-24
申请人： THERAVANCE INC
发明人： MCKINNELL ROBERT , GENDRON ROLAND , JIANG LAN , CHOI SEOK-KI , LONG DANIEL , FATHEREE PAUL , MARQUESS DANIEL , DALZIEL SEAN , PHIZACKERLEY KIRSTEN
IPC分类号： C07D401/14 , A61K31/4545 , A61P1/00 , C07D405/14 , C07D409/14
摘要： The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I)wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

10. 发明专利

ES2366058T3 COMPUESTOS DE 8-AZABICICLO[3.2.1]OCTANO COMO ANTAGONISTAS DE LOS RECEPTORES OPIOIDES MU. 未知
公开(公告)号：ES2366058T3
公开(公告)日：2011-10-14
申请号：ES07752111
申请日：2007-02-28
申请人： THERAVANCE INC
发明人： LONG DANIEL , CHURCH TIMOTHY J , JACOBSEN JOHN R , JIANG LAN , SAITO DAISUKE ROLAND , STERGIADES IOANNA , VAN DYKE PRISCILLA
IPC分类号： C07D451/02
摘要： Un compuesto de fórmula (I): **Fórmula** donde: R1 se elige entre-ORa, -C(O)NRaRb, -NHS(O)2Rc, -NRaRb, -C(O)ORa y -CH2OH; A es alquilenilo C1-4; R2 es cicloalquilo C3-12 o arilo C6-10, de modo que cicloalquilo C3-12 y arilo C6-10 están cada uno opcionalmente sustituidos con un -ORa, con uno o dos halógenos, con uno o dos alquilos C1-3 sustituidos con dos o tres halógenos, o con uno, dos, tres o cuatro alquilos C1-3; G es alquilenilo C1-4; R3 se elige entre hidrógeno, -C(O)R4, -C(O)NHR5, -S(O)2Rc y -S(O)2NRaRb; R4 es cicloalquilo C3-6 o alquilo C1-6, donde el cicloalquilo C3-6 está opcionalmente sustituido con un -ORa y el alquilo C1-6 está opcionalmente sustituido con uno o dos sustituyentes escogidos entre -ORa, -C(O)ORa, -S(O)2R6, -C(O)NRaRb, -NRaRb, -NHC(O)NRaRb, -CN, cicloalquilo C3-6 y fenilo, o con un D-(CH2)JR7, donde D es donde j es 1, 2, o 3, n es 1 o 2 y p es 1 o 2, R6 es alquilo C1-6 opcionalmente sustituido con R7, R7 es -C(O)ORa, -C(O)NRaRb, -NRaRb o -NHC(O)NRaRb, R5 es alquilo C1-6, benzo[1.3]dioxol o -(CH2)q-fenilo, donde el fenilo está opcionalmente sustituido con uno o dos sustituyentes escogidos entre halógeno, -ORa, alquilo C1-3 y alcoxi C1-3, donde el alquilo C1-3 y el alcoxi C1-3 están opcionalmente sustituidos con 2 o 3 halógenos, y q es 0, 1 o 2, Ra y Rb son, independientemente, hidrógeno o alquilo C1-4, y Rc es alquilo C1-3, con la condición de que, cuando R2 sea fenilo sustituido en la posición 4 R3 no sea -C(O)R4, donde R4 es alquilo C1-4 sustituido con -C(O)ORa; o una sal o solvato farmacéuticamente aceptable del mismo.

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