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1. 发明申请

WO2007092418A3 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 审中-公开
标题翻译：聚合，可降解药水和涂层
公开(公告)号：WO2007092418A3
公开(公告)日：2008-08-14
申请号：PCT/US2007003101
申请日：2007-02-06
申请人： TEPHA INC , SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
发明人： SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
IPC分类号： A61L31/04 , A61L31/14
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可以用于制造可提供有利的径向强度，抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以快速部署

2. 发明申请

WO2010017014A2 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 审中-公开
标题翻译：聚合物，可降解药物洗脱支架和涂层
公开(公告)号：WO2010017014A2
公开(公告)日：2010-02-11
申请号：PCT/US2009051024
申请日：2009-07-17
申请人： TEPHA INC , SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
发明人： SCHMITZ KLAUS-PETER , BEHREND DETLEF , STERNBERG KATRIN , GRABOW NIELS , MARTIN DAVID P , WILLIAMS SIMON F
IPC分类号： A61L31/10 , A61F2/82 , A61L31/16
CPC分类号： A61L31/18 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L- lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
摘要翻译：已经开发出具有改进性能的可吸收支架和可吸收支架涂层。这些装置优选包含4-羟基丁酸酯的生物相容性共聚物或均聚物，以及任选的聚-L-乳酸和其他可吸收聚合物和添加剂。这些材料的组合物可用于制造可吸收的支架，其提供有利的径向强度，抵抗反冲和蠕变，可在球囊导管上塑性扩张，并且可在体内快速部署。来源于这些材料的支架涂层提供了生物相容的，均匀的涂层，这些涂层是可延展的，并且可以在没有涂层裂化和/或脱敏的情况下扩张并且可以用作药物掺入的涂层基质。

3. 发明申请

WO2008070428A3 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：WO2008070428A3
公开(公告)日：2009-08-13
申请号：PCT/US2007084991
申请日：2007-11-16
申请人： TEPHA INC , RIZK SAID , MARTIN DAVID P , HO KICHERL , WILLIAMS SIMON F
发明人： RIZK SAID , MARTIN DAVID P , HO KICHERL , WILLIAMS SIMON F
IPC分类号： A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , B29C55/04 , B29C55/12 , C08J5/22
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 µm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。这些可以用于各种目的，包括制造医疗器械。

4. 发明申请

WO2007092464A3 METHODS AND DEVICES FOR ROTATOR CUFF REPAIR 审中-公开
标题翻译： ROTATOR CUFF维修的方法和设备
公开(公告)号：WO2007092464A3
公开(公告)日：2008-07-03
申请号：PCT/US2007003185
申请日：2007-02-05
申请人： TEPHA INC , COLEMAN STRUAN , MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
发明人： COLEMAN STRUAN , MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
IPC分类号： A61L27/18
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0642 , A61B2017/00893 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti- adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
摘要翻译：已经开发了用于腱和韧带修复的包括肩袖修复的插入和增强装置以及使用关节镜方法进行输送的方法。该装置优选衍生自生物相容性聚羟基链烷酸酯，优选衍生自4-羟基丁酸酯的共聚物或均聚物。这些装置可以关节镜地传送，并且提供额外的益处，例如支持手术修复，高初始强度，体内延长的强度保持力，柔韧性，抗粘连性，改善的生物相容性，体内重塑健康组织的能力，最小疾病传播的风险或增强感染的选择，包括足够高的强度的选项，以防止缝合线拉出或植入装置的其他脱离，最终吸收消除异物反应的未来风险或干扰后续程序，有竞争力的成本，长期的机械稳定性。这些装置还特别适用于儿科人群，其最终吸收不应阻碍生长。

5. 发明申请

WO2006081517A2 EMBOLIZATION USING POLY-4-HYDROXYBUTYRATE PARTICLES 审中-公开
标题翻译：使用聚-4-羟基丁酸酯颗粒的嵌段
公开(公告)号：WO2006081517A2
公开(公告)日：2006-08-03
申请号：PCT/US2006003128
申请日：2006-01-27
申请人： TEPHA INC , MARTIN DAVID P , CRABTREE DONALD , WILLIAMS SIMON F
发明人： MARTIN DAVID P , CRABTREE DONALD , WILLIAMS SIMON F
IPC分类号： A61K9/16 , A61P7/00 , A61P9/00
CPC分类号： A61L24/046 , A61K9/0019 , A61K31/765 , A61K47/34 , A61L2430/36 , C08L23/20
摘要： Absorbable particles which comprises poly-4-hydroxybutyrate and/or its copolymers are formulated in injectable suspension suitable for prophylactic or therapeutic embolization, which comprises administering to a human or animal the injectable suspension process for producing particles of the poly-4-hydroxybutyrate and/or its copolymer.
摘要翻译：将包含聚-4-羟基丁酸酯和/或其共聚物的可吸收颗粒配制成适用于预防性或治疗性栓塞的可注射悬浮液，其包括向人或动物施用可注射悬浮液以产生聚-4-羟基丁酸酯和/ 或其共聚物。

6. 发明申请

WO2009085823A8 MEDICAL DEVICES CONTAINING MELT-BLOWN NON-WOVENS OF POLY-R-HYDROXYBUTYRATE AND COPOLYMERS 审中-公开
标题翻译：含有聚-R-羟基丁酸酯和共聚物的熔喷无纺布的医疗器械
公开(公告)号：WO2009085823A8
公开(公告)日：2009-08-27
申请号：PCT/US2008087159
申请日：2008-12-17
申请人： TEPHA INC , HO KICHERL , WILLIAMS SIMON F , RIZK SAID , MARTIN DAVID P
发明人： HO KICHERL , WILLIAMS SIMON F , RIZK SAID , MARTIN DAVID P
IPC分类号： D04H1/56 , A61L17/10
CPC分类号： A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric non- wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 µm to 50 µm, and thickness from 10 µm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4- hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly- 4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non- woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高爆裂强度，平均直径为1μm至50μm的细纤维和10μm至50mm的厚度。通过允许无纺织物的纤维在网收集期间最初保持熔化而使得改进的纤维内聚成为可能。在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方式是聚-4-羟基丁酸酯或其共聚物的非织造物，其中所述非织造物具有大于0.1Kgf的破裂强度，其中所述非织物通过连续熔喷法得到。非织造物可以用于各种目的，包括制造医疗器械。

7. 发明申请

WO2004101002A3 POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS 审中-公开
标题翻译：聚羟基烷基酯医用纺织品和纤维
公开(公告)号：WO2004101002A3
公开(公告)日：2006-10-26
申请号：PCT/US2004013475
申请日：2004-04-30
申请人： TEPHA INC , MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
发明人： MARTIN DAVID P , RIZK SAID , AHUJA AJAY , WILLIAMS SIMON F
IPC分类号： D01F6/62 , A61F2/00 , A61L20060101 , A61L17/10 , A61L27/18 , A61L31/06 , B32B5/02 , D01F6/84
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are formed from fibers of biocompatible copolymers or homopolymers of 4-hydroxybutyrate having a tensile strength of greater than 126 MPa. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和外科网。这些装置由具有拉伸强度大于126MPa的生物相容性共聚物或4-羟基丁酸酯的均聚物的纤维形成。这些装置提供比目前可获得的更广泛的体内强度保留性能，并且可以提供额外的益处，例如抗粘附性能，降低的感染风险或由吸收和最终消除装置而产生的其他手术后问题，以及有竞争力的成本。这些装置还可以特别适用于儿科人群，其吸收不应阻碍生长，并在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合，以提供具有改善的机械，生物和处理性质的植入物。

8. 发明申请

WO0119361A3 THERAPEUTIC USES OF POLYMERS AND OLIGOMERS COMPRISING GAMMA-HYDROXYBUTYRATE 审中-公开
标题翻译：包含γ-羟基丁酸酯的聚合物和低聚物的治疗用途
公开(公告)号：WO0119361A3
公开(公告)日：2001-10-04
申请号：PCT/US0025261
申请日：2000-09-14
申请人： TEPHA INC , METABOLIX INC
发明人： WILLIAMS SIMON F , MARTIN DAVID P
IPC分类号： A61K31/19 , A61K31/765 , A61P5/00 , A61P9/10 , A61P9/12 , A61P15/00 , A61P21/02 , A61P23/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/32 , A61P29/00 , A61P35/00 , A61P43/00 , A61P25/00 , A61P25/26
CPC分类号： A61K31/19 , A61K31/765
摘要： Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo . Devices for the storage and delivery of these polymers and oligomers are also provided. These oligomers and polymer compositions are useful in a variety of applications. The compositions can be used therapeutically, for example, in the treatment of patients with narcolepsy, chronic schizophrenia, catatonic schizophrenia, atypical psychoses, chronic brain syndrome, neurosis, alcoholism, drug addiction and withdrawal, Parkinson's disease and other neuropharmacological illnesses, hypertension, ischemia, circulatory collapse, radiation exposure, cancer, and myocardial infarction. Other uses for the compositions include anesthesia induction, sedation, growth hormone production, heightened sexual desire, anorectic effects, euphoria, smooth muscle relaxation, muscle mass production, and sleep, including rapid eye movement sleep. In a still further embodiment, the oligomers and polymers may be used to produce absence seizures.
摘要翻译：提供了含有GHB并且在体内给药之后产生GHB的低聚物和聚合物组合物。还提供了用于储存和递送这些聚合物和低聚物的装置。这些低聚物和聚合物组合物可用于各种应用中。组合物可用于治疗例如发作性睡病，慢性精神分裂症，紧张性精神分裂症，非典型精神病，慢性脑综合征，神经症，酒精中毒，药物成瘾和戒断，帕金森病和其他神经药理学疾病，高血压，缺血的患者的治疗，循环衰竭，放射线暴露，癌症和心肌梗死。组合物的其它用途包括麻醉诱导，镇静，生长激素生成，性欲升高，厌食症，欣快，平滑肌松弛，肌肉量产和睡眠，包括快速眼动睡眠。在另一个实施方案中，低聚物和聚合物可以用于产生不发作的发作。

9. 发明申请

WO0051662A9 BIOABSORBABLE, BIOCOMPATIBLE POLYMERS FOR TISSUE ENGINEERING 审中-公开
标题翻译：生物易吸收的组合工程聚合物
公开(公告)号：WO0051662A9
公开(公告)日：2001-11-15
申请号：PCT/US0005676
申请日：2000-03-03
申请人： TEPHA INC
发明人： WILLIAMS SIMON F
IPC分类号： A61L27/18 , A61L31/06
CPC分类号： A61L27/18 , A61L31/06 , Y10T442/2525 , C08L67/04
摘要： Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be prepared with tensile strengths, elongation to breaks, and/or tensile modulus (Young's modulus) values of the tissues of the cardiovascular, gastrointestinal, kidney and genitourinary, musculoskeletal, and nervous systems, as well as those of the oral, dental, periodontal, and skin tissues. Methods for processing the bioabsorbable biocompatible polymers into tissues engineering devices are also provided.
摘要翻译：提供了提供它们的性质与某些组织结构之间良好匹配的生物可吸收的生物相容性聚合物。生物可吸收的生物相容性聚合物可以用心血管，胃肠，肾脏和泌尿生殖器，肌肉骨骼和神经系统的组织的拉伸强度，断裂伸长率和/或拉伸模量（杨氏模量）值以及口腔，牙科，牙周和皮肤组织。还提供了将生物可吸收生物相容性聚合物加工成组织工程装置的方法。

10. 发明申请

WO0115671A2 FLUSHABLE DISPOSABLE POLYMERIC PRODUCTS 审中-公开
标题翻译：可刷洗一次性聚合物产品
公开(公告)号：WO0115671A2
公开(公告)日：2001-03-08
申请号：PCT/US0040772
申请日：2000-08-29
申请人： TEPHA INC
发明人： WILLIAMS SIMON F
IPC分类号： A61M35/00 , A61K9/00 , A61K9/70 , A61K31/7004 , A61K31/715 , A61K38/00 , A61K47/32 , A61K47/34 , A61K47/36 , A61L15/00 , A61L15/26 , A61L15/62 , A61P17/02 , C08L101/16
CPC分类号： A61L15/62 , A61K9/0034 , A61K9/0051 , A61K9/006 , A61K9/7023 , A61L15/26 , B09B2220/14 , C08L67/04
摘要： Materials suitable for preparing components of flushable drug delivery systems are described. These components include drug impermeable and drug permeable materials, including materials that can be used to control the rate of release of drugs from the device, and pressure sensitive adhesive compositions which are drug compatible. Methods for fabricating these devices, including transdermal drug delivery patches, are described.
摘要翻译：描述了适合于制备可冲洗药物递送系统的组件的材料。这些组分包括药物不可渗透的和药物可渗透的材料，包括可用于控制药物从装置中释放速率的材料以及药物相容的压敏粘合剂组合物。描述了制造这些装置的方法，包括透皮药物递送贴片。

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